Achieving a balance between strength and ductility is of utmost importance for Magnesium matrix composites(MMCs).In this study,AZ31 sheets reinforced with 0.4,0.7,and 1.0 wt.%nano-TC4(Ti-6Al-4V)particles were prepared...Achieving a balance between strength and ductility is of utmost importance for Magnesium matrix composites(MMCs).In this study,AZ31 sheets reinforced with 0.4,0.7,and 1.0 wt.%nano-TC4(Ti-6Al-4V)particles were prepared by stir casting coupled with hot extrusion process.In addition to analyzing the microstructure of the extruded composite sheets,the tensile properties were also investigated.The results showed that the incorporation of nano-TC4 particles led to a reduction in texture strength and a refinement of the grains.As a result of the formation of semicoherent orientation relations at the Ti Al/Mg and Ti3Al/Mg interfaces,strong interfacial bonding was established between the TC4 nanoparticles and the AZ31 matrix.Compared with the AZ31 sheet,the composite sheet with 0.7 wt.%nano-TC4 particles exhibited the best comprehensive tensile properties.The primary factors contributing to the improvement of mechanical properties were mismatch of coefficient of thermal expansion(CTE)between TC4 nanoparticles and AZ31 matrix,grain refinement,Orowan strengthening mechanism,and strong interfacial bonding.展开更多
Adding Ti particles to magnesium alloy simultaneously enhances its strength and ductility.However,how these particles influence on Mg alloy’s corrosion performance is seldom reported.The corrosion behavior of AZ31-Ti...Adding Ti particles to magnesium alloy simultaneously enhances its strength and ductility.However,how these particles influence on Mg alloy’s corrosion performance is seldom reported.The corrosion behavior of AZ31-Ti composites containing titanium nanoparticles(1.5 and 5 wt%)and micron particles(10 wt%)prepared by powder metallurgical in 3.5 wt%NaCl solution was investigated.The results indicate that Ti particles serve as the primary location for the cathodic hydrogen reduction reaction,resulting in intense galvanic corrosion between the Ti and Mg matrix.Ti nanoparticles distributed at the interface of the original AZ31 powder were in a discontinuous mesh structure,thus failing to act as a barrier against corrosion.The corrosion products with the existence of numerous cracks gradually peel off during the corrosion process and cannot protect the matrix.The average corrosion rate P_(w) of AZ31,AZ31-1.5%Ti,AZ31-5%Ti,and AZ31-10%Ti after 7 days of immersion is 27.55,105.65,283.67,and 99.35 mm/y,respectively.Therefore,AZ31-Ti composites can be considered as potential candidates for degradable fracturing tools.Otherwise,it is recommended to improve their corrosion resistance through surface treatment.展开更多
The interfaces between in-situ Al3Ti particles and magnesium(Mg)matrix are crucial role in highperformance titanium(Ti)reinforced AZ31 alloy.Herein,the interfaces between Al3Ti particles and the Mg matrix are fabricat...The interfaces between in-situ Al3Ti particles and magnesium(Mg)matrix are crucial role in highperformance titanium(Ti)reinforced AZ31 alloy.Herein,the interfaces between Al3Ti particles and the Mg matrix are fabricated and investigated using advanced characterization tools and first-principles calculations.The orientation relationship(OR)and atomic interface structure between the Al_(3)Ti particles and matrix are characterized using a high-resolution transmission electron microscope.The OR is determined to be(1010)Mg//(001)Al3Ti;[1213]Mg//[100]Al3Ti.Based on the characterized OR,the interface properties(including atomic structure,work of adhesion,interface energy,and fracture mechanism)are investigated using first-principles calculations.The relaxed interface structure indicates that the TiAl-terminated bridge site configurations(MT1)and hollow site configurations(HCP1)are unstable and would convert into other bridge site configurations(MT).Furthermore,the work of adhesion and interface energy suggests that Al-terminated hollow site configurations(HCP)and bridge site configurations(MT)are more stable than other configurations.In addition,the calculations of work of fracture show that fracture of the interfaces with Al-MT1,Al-HCP,and TiAl-MT configurations may initiate from bulk Mg interior.The findings may help to understand and tailor the deformation mechanisms and mechanical properties of Ti-reinforced Mg alloys.展开更多
Mitochondria are fundamental organelles that play a crucial role in cellular energy metabolism,substance metabolism,and various essential cellular signaling pathways.The dysfunction of mitochondria is significantly im...Mitochondria are fundamental organelles that play a crucial role in cellular energy metabolism,substance metabolism,and various essential cellular signaling pathways.The dysfunction of mitochondria is significantly implicated in the onset and progression of aging,neurodegenerative diseases,metabolic disorders,and tumors,thereby rendering mitochondria-targeted regulation,a vital strategy for disease prevention and treatment.The recently developed mitochondrial membrane chromatography(MMC)technique,which immobilizes mitochondrial proteins as a chromatographic separation medium,has shown great potential for efficiently screening mitochondria-targeted modulators from complex compound library.In contrast to traditional screening methods,MMC has no need to purify mitochondrial proteins and can preserve its in situ and physiological conformation.Consequently,it presents broader application prospects for screening mitochondrial modulators as well as investigating receptor-ligand interactions involving any target protein associated with mitochondria.This review aims to elucidate the critical role of mitochondria in the development and progression of major chronic diseases,discuss recent advancements and applications of MMC,and propose future directions for MMC in the identification of novel mitochondrial modulators.展开更多
基金financially supported by National Key Research and Development Program of China(2022YFB3708400)the Guangdong Major Project of Basic and Applied Basic Research(2020B0301030006)+1 种基金the Guangdong provincial key laboratory project(2023B1212060043)the Guangdong Academy of Science Fund(2020GDASYL-20200101001)。
文摘Achieving a balance between strength and ductility is of utmost importance for Magnesium matrix composites(MMCs).In this study,AZ31 sheets reinforced with 0.4,0.7,and 1.0 wt.%nano-TC4(Ti-6Al-4V)particles were prepared by stir casting coupled with hot extrusion process.In addition to analyzing the microstructure of the extruded composite sheets,the tensile properties were also investigated.The results showed that the incorporation of nano-TC4 particles led to a reduction in texture strength and a refinement of the grains.As a result of the formation of semicoherent orientation relations at the Ti Al/Mg and Ti3Al/Mg interfaces,strong interfacial bonding was established between the TC4 nanoparticles and the AZ31 matrix.Compared with the AZ31 sheet,the composite sheet with 0.7 wt.%nano-TC4 particles exhibited the best comprehensive tensile properties.The primary factors contributing to the improvement of mechanical properties were mismatch of coefficient of thermal expansion(CTE)between TC4 nanoparticles and AZ31 matrix,grain refinement,Orowan strengthening mechanism,and strong interfacial bonding.
基金funded by the Guangdong Major Project of Basic and Applied Basic Research (Grant No.2020B0301030006)。
文摘Adding Ti particles to magnesium alloy simultaneously enhances its strength and ductility.However,how these particles influence on Mg alloy’s corrosion performance is seldom reported.The corrosion behavior of AZ31-Ti composites containing titanium nanoparticles(1.5 and 5 wt%)and micron particles(10 wt%)prepared by powder metallurgical in 3.5 wt%NaCl solution was investigated.The results indicate that Ti particles serve as the primary location for the cathodic hydrogen reduction reaction,resulting in intense galvanic corrosion between the Ti and Mg matrix.Ti nanoparticles distributed at the interface of the original AZ31 powder were in a discontinuous mesh structure,thus failing to act as a barrier against corrosion.The corrosion products with the existence of numerous cracks gradually peel off during the corrosion process and cannot protect the matrix.The average corrosion rate P_(w) of AZ31,AZ31-1.5%Ti,AZ31-5%Ti,and AZ31-10%Ti after 7 days of immersion is 27.55,105.65,283.67,and 99.35 mm/y,respectively.Therefore,AZ31-Ti composites can be considered as potential candidates for degradable fracturing tools.Otherwise,it is recommended to improve their corrosion resistance through surface treatment.
基金supported by the Guangdong Major Project of Basic and Applied Basic Research(No.2020B0301030006)the financial support from the open research fund of Songshan Lake Materials Laboratory(2021SLABFK06)and start-up funding from Harbin Institute of Technology(Shenzhen).
文摘The interfaces between in-situ Al3Ti particles and magnesium(Mg)matrix are crucial role in highperformance titanium(Ti)reinforced AZ31 alloy.Herein,the interfaces between Al3Ti particles and the Mg matrix are fabricated and investigated using advanced characterization tools and first-principles calculations.The orientation relationship(OR)and atomic interface structure between the Al_(3)Ti particles and matrix are characterized using a high-resolution transmission electron microscope.The OR is determined to be(1010)Mg//(001)Al3Ti;[1213]Mg//[100]Al3Ti.Based on the characterized OR,the interface properties(including atomic structure,work of adhesion,interface energy,and fracture mechanism)are investigated using first-principles calculations.The relaxed interface structure indicates that the TiAl-terminated bridge site configurations(MT1)and hollow site configurations(HCP1)are unstable and would convert into other bridge site configurations(MT).Furthermore,the work of adhesion and interface energy suggests that Al-terminated hollow site configurations(HCP)and bridge site configurations(MT)are more stable than other configurations.In addition,the calculations of work of fracture show that fracture of the interfaces with Al-MT1,Al-HCP,and TiAl-MT configurations may initiate from bulk Mg interior.The findings may help to understand and tailor the deformation mechanisms and mechanical properties of Ti-reinforced Mg alloys.
基金financially supported by,the Space Medical Experiment Project of China Manned Space Program(Program No.:HYZHXM01023)the National Natural Science Foundation of China(Grant No.:31870848)+1 种基金the National foreign experts project(Grant No.:G2022170026L)Key R&D Program of Shaanxi Province(Grant Nos.:2021GXLH-Z-064&2024SF-ZDCYL-03-24).
文摘Mitochondria are fundamental organelles that play a crucial role in cellular energy metabolism,substance metabolism,and various essential cellular signaling pathways.The dysfunction of mitochondria is significantly implicated in the onset and progression of aging,neurodegenerative diseases,metabolic disorders,and tumors,thereby rendering mitochondria-targeted regulation,a vital strategy for disease prevention and treatment.The recently developed mitochondrial membrane chromatography(MMC)technique,which immobilizes mitochondrial proteins as a chromatographic separation medium,has shown great potential for efficiently screening mitochondria-targeted modulators from complex compound library.In contrast to traditional screening methods,MMC has no need to purify mitochondrial proteins and can preserve its in situ and physiological conformation.Consequently,it presents broader application prospects for screening mitochondrial modulators as well as investigating receptor-ligand interactions involving any target protein associated with mitochondria.This review aims to elucidate the critical role of mitochondria in the development and progression of major chronic diseases,discuss recent advancements and applications of MMC,and propose future directions for MMC in the identification of novel mitochondrial modulators.
