This study investigates the mechanical response of an underground cavern subjected to cyclic high gas pressure,aiming to establish a theoretical foundation for the design of lined rock caverns(LRCs)for energy storage ...This study investigates the mechanical response of an underground cavern subjected to cyclic high gas pressure,aiming to establish a theoretical foundation for the design of lined rock caverns(LRCs)for energy storage with high internal pressure,e.g.compressed air energy storage(CAES)underground caverns or hydrogen storage caverns.Initially,the stress paths of the surrounding rock during the excavation,pressurization,and depressurization processes are delineated.Analytical expressions for the stress and deformation of the surrounding rock are derived based on the MohreCoulomb criterion.These expressions are then employed to evaluate the displacement of cavern walls under varying qualities of surrounding rock,the contact pressure between the steel lining and the surrounding rock subject to different gas storage pressures,the load-bearing ratio of the surrounding rock,and the impact of lining thickness on the critical gas pressure.Furthermore,the deformation paths of the surrounding rock are evaluated,along with the effects of tunnel depth and diameter on residual deformation of the surrounding rock,and the critical minimum gas pressure at which the surrounding rock and the lining do not detach.The results indicate that residual deformation of the surrounding rock occurs after depressurization under higher internal pressure for higher-quality rock masses,leading to detachment between the surrounding rock and the steel lining.The findings indicate that thicker linings correspond to higher critical minimum gas pressures.However,for lower-quality surrounding rock,thicker linings correspond to lower critical minimum gas pressures.These findings will provide invaluable insights for the design of LRCs for underground energy storage caverns.展开更多
Solid-state batteries are widely recognized as the next-generation energy storage devices with high specific energy,high safety,and high environmental adaptability.However,the research and development of solid-state b...Solid-state batteries are widely recognized as the next-generation energy storage devices with high specific energy,high safety,and high environmental adaptability.However,the research and development of solid-state batteries are resource-intensive and time-consuming due to their complex chemical environment,rendering performance prediction arduous and delaying large-scale industrialization.Artificial intelligence serves as an accelerator for solid-state battery development by enabling efficient material screening and performance prediction.This review will systematically examine how the latest progress in using machine learning(ML)algorithms can be used to mine extensive material databases and accelerate the discovery of high-performance cathode,anode,and electrolyte materials suitable for solid-state batteries.Furthermore,the use of ML technology to accurately estimate and predict key performance indicators in the solid-state battery management system will be discussed,among which are state of charge,state of health,remaining useful life,and battery capacity.Finally,we will summarize the main challenges encountered in the current research,such as data quality issues and poor code portability,and propose possible solutions and development paths.These will provide clear guidance for future research and technological reiteration.展开更多
The integration of surface filtration and catalytic decomposition functions in catalytic bags enables the synergistic removal of multiple pollutants(such as dust,nitrogen oxide,acid gases,and dioxins)in a single react...The integration of surface filtration and catalytic decomposition functions in catalytic bags enables the synergistic removal of multiple pollutants(such as dust,nitrogen oxide,acid gases,and dioxins)in a single reactor,thus effectively reducing the cost and operational difficulties associated with flue gas treatment.In this study,Mn-Ce-Sm-Sn(MCSS)catalysts were prepared and loaded onto hightemperature resistant polyimide(P84)filter through ultrasonic impregnation to create composite catalytic filter.The results demonstrate that the NO conversion rates of the composite catalytic filter consistently achieve above 95%within the temperature range of 160-260℃,with a chlorobenzene T_(90)value of 230℃.The ultrasonic impregnation method effectively loaded the catalyst onto the filter,ensuring high dispersion both on the surface and inside the filter.This increased exposure of catalyst active sites enhances the catalytic activity of the composite catalytic filter.Additionally,increasing the catalyst loading leads to a gradual decrease in permeability,an increase in pressure drops and the long residence time of the flue gas,thereby improving catalytic activity.Compared to ordinary impregnation methods,ultrasonic impregnation improves the bonding strength between the catalyst and filter,as well as the permeability of the composite catalytic filter under the same loading conditions.Overall,this study presents a novel approach to prepare composite catalytic filter for the simultaneous removal of NO and chlorobenzene at low temperatures.展开更多
With the development of renewable energy technologies such as photovoltaics and wind power,it has become a research hotspot to improve the consumption rate of new energy and reduce energy costs through algorithm impro...With the development of renewable energy technologies such as photovoltaics and wind power,it has become a research hotspot to improve the consumption rate of new energy and reduce energy costs through algorithm improvement.To reduce the operational costs of micro-grid systems and the energy abandonment rate of renewable energy,while simultaneously enhancing user satisfaction on the demand side,this paper introduces an improvedmultiobjective Grey Wolf Optimizer based on Cauchy variation.The proposed approach incorporates a Cauchy variation strategy during the optimizer’s search phase to expand its exploration range and minimize the likelihood of becoming trapped in local optima.At the same time,adoptingmultiple energy storage methods to improve the consumption rate of renewable energy.Subsequently,under different energy balance orders,themulti-objective particle swarmalgorithm,multi-objective grey wolf optimizer,and Cauchy’s variant of the improvedmulti-objective grey wolf optimizer are used for example simulation,solving the Pareto solution set of the model and comparing.The analysis of the results reveals that,compared to the original optimizer,the improved optimizer decreases the daily cost by approximately 100 yuan,and reduces the energy abandonment rate to zero.Meanwhile,it enhances user satisfaction and ensures the stable operation of the micro-grid.展开更多
Cardiac arrest(CA)is considered a state of clinical death in which the heart suddenly loses its ability to effectively expel blood,resulting in circulatory and respiratory arrest.CA is often catastrophic for patients,...Cardiac arrest(CA)is considered a state of clinical death in which the heart suddenly loses its ability to effectively expel blood,resulting in circulatory and respiratory arrest.CA is often catastrophic for patients,as it can cause serious long-term cardiovascular and cerebrovascular complications that affect their quality of life[1].Survey data indicate that the overall incidence rate of intraoperative CA in patients undergoing thoracic surgery in China is currently 0.138%[2].This rate is expected to increase because of the increasing proportion of older individuals(age>60 years)in the population,as well as the increasing pulmonary surgery rates.However,the incidence rate during the perianesthetic period in older patients undergoing thoracic surgery has not yet been comprehensively reported.展开更多
Pygmy lorises are arboreal primates primarily found in forest environments across Southeast Asia(Nekaris 2014).Theyhave a diverse diet,including plant secretions,nectar,fruits,invertebrates,tree bark,and bird eggs.All...Pygmy lorises are arboreal primates primarily found in forest environments across Southeast Asia(Nekaris 2014).Theyhave a diverse diet,including plant secretions,nectar,fruits,invertebrates,tree bark,and bird eggs.All 9 known speciesof pygmy lorises are listed as globally endangered species(Nekaris 2014).Pygmy lorises exhibit a range of unique phenotypic characteristics rarely seen among primates.展开更多
BACKGROUND Endoscopic full-thickness resection(EFTR)is increasingly used for treating gastrointestinal stromal tumors(GISTs)in the stomach.AIM To compare the efficacy,tolerability,and clinical outcomes of EFTR vs surg...BACKGROUND Endoscopic full-thickness resection(EFTR)is increasingly used for treating gastrointestinal stromal tumors(GISTs)in the stomach.AIM To compare the efficacy,tolerability,and clinical outcomes of EFTR vs surgical resection(SR)for gastric GISTs.METHODS We collected clinical data from patients diagnosed with GISTs who underwent either EFTR or SR at our hospital from October 2011 to July 2024.Patients were matched in a 1:1 ratio based on baseline characteristics and tumor clinical-pathological features using propensity score matching.We analyzed perioperative outcomes and follow-up data.The primary outcome measure was progressionfree survival(PFS).RESULTS Out of 912 patients,573 met the inclusion criteria.After matching,each group included 95 patients.The EFTR group demonstrated statistically significant advantages over the SR group in average operative time(P<0.001),length of hospital stay(P<0.001),time to resume liquid diet(P<0.001),incidence of adverse events(P=0.031),and hospitalization costs(P<0.001).The en bloc resection rate was significantly different,with SR group at 100%and EFTR group at 93.7%(P=0.038).The median follow-up was 2451.50 days.Recurrence occurred in 3 patients in the EFTR group and 4 patients in the SR group,with no statistically significant difference(P=1.000).Factors associated with PFS included age,tumor size,high-risk category in the modified National Institutes of Health(NIH)risk score,and resection status.Resection status was identified as an independent prognostic factor for PFS(P=0.0173,hazard ratios=0.0179,95%CI:0.000655-0.491).Notably,there was no statistically significant difference in PFS between the two groups.CONCLUSION This study is a non-inferiority design.The EFTR group significantly outperformed the SR group in terms of operative time,length of hospital stay,time to resume a liquid diet,incidence of adverse events,and hospitalization costs,demonstrating its higher economic efficiency and better tolerability.Additionally,although the en bloc resection rate was lower in the EFTR group compared to the SR group,there were no significant differences in tumor recurrence rates and progression-free survival between the two groups.This study found no statistical difference in the primary endpoint of postoperative recurrence rates between the two groups.However,due to sample size limitations,this result requires further validation in larger-scale studies.The current results should be viewed as exploratory evidence.展开更多
Vanadium phosphorus oxide(VPO)catalyst is a promising candidate for the condensation reaction of formaldehyde(FA)and acetic acid(HAc)to produce acrylic acid(AA).However,the complexity of the active phases and their dy...Vanadium phosphorus oxide(VPO)catalyst is a promising candidate for the condensation reaction of formaldehyde(FA)and acetic acid(HAc)to produce acrylic acid(AA).However,the complexity of the active phases and their dynamic interconversion under redox conditions has led to controversies regarding the actual active phase in this reaction.To address this,this study systematically investigates the phase transition and underlying mechanism of VPO catalysts under reaction conditions.X-ray diffraction(XRD)patterns,Raman spectra,transmission electron microscopy images and X-ray photoelectron spectroscopy collectively demonstrated that the V^(4+)phase(VO)_(2)P_(2)O_(7)retained the bulk phase structure throughout the reaction,with only minor surface phase transition observed.In contrast,the V^(5+)phase underwent reduction to other phases in both bulk and surface regions.Specifically,theδ-VOPO_(4)phase rapidly transformed into theαII-VOPO_(4)phase,which could reversibly convert into the R1-VOHPO_(4)phase(V^(4+)).Controlled variable experiments,H_(2)-temperature programmed reduction and in-situ XRD experiments in a hydrogen atmosphere further demonstrated that these phase transitions were primarily attributed to the loss of lattice oxygen.The presence of V^(4+)phase in VPO catalysts enhanced the selectivity of acrylic acid,while the existence of V^(5+)phase promoted the activation of acetic acid.This work elucidates the redox-driven phase evolution of VPO catalysts and offers valuable insights for designing efficient catalysts for FA-HAc cross-condensation by balancing phase stability and activity.展开更多
As an innovative endoscopic intervention,endoscopic ultrasound-guided pan-creatic duct drainage(EUS-PD)demonstrates significant clinical value in re-solving pancreatic ductal hypertension syndrome.By integrating real-...As an innovative endoscopic intervention,endoscopic ultrasound-guided pan-creatic duct drainage(EUS-PD)demonstrates significant clinical value in re-solving pancreatic ductal hypertension syndrome.By integrating real-time ultrasound guidance with catheter-based intervention techniques,this approach provides a safe and effective alternative for cases where conventional endoscopic retrograde cholangiopancreatography has failed.Current evidence indicates that EUS-PD achieves technical success rates ranging from 82%to 95%in alleviating symptomatic pancreatic duct hypertension caused by malignant obstructions and chronic pancreatitis-related strictures,with an overall complication rate(15%-20%)substantially lower than surgical interventions.Compared to conventional imaging modalities,EUS-PD offers superior anatomical visualization capabilities:Its high-frequency ultrasound probe enables precise identification of 3 mm-level pancreatic duct branches,while contrast-enhanced imaging significantly improves diagnostic accuracy in differentiating benign from malignant strictures(sensitivity 91%vs 73%,P<0.05).Nevertheless,technical challenges persist,including diffi-cult ductal puncture localization(particularly in pancreatic head lesions),complex guidewire axial control,and postoperative pancreatic fistula risks(7%-12%).This review systematically examines the clinical indications/contraindications,pro-cedural protocols,device selection criteria,and management strategies for early/late complications associated with EUS-PD.Special emphasis is placed on establishing anatomical pathway selection standards for transgastric-pancreatic duct vs transduodenal-pancreatic duct approaches.Advancements in auxiliary technologies(e.g.,three-dimensional elastography,AI-assisted navigation)and multidisciplinary team collab-oration are pivotal to developing standardized protocols.We propose establishing international multicenter registry databases and conducting prospective randomized controlled trials to clarify EUS-PD's position within pancreatic disease management systems.Such initiatives will facilitate the clinical transformation of EUS-PD from an"alternative option"to a"preferred strategy",ultimately enhancing treatment precision and improving clinical outcomes in pancreatic disorders.展开更多
In this study,the typical Mg-14Gd-0.3Zr alloy was rolled at the high-temperature range of 450–500℃.The rolled Mg alloy plate with thickness of 30 mm exhibits an ultra-high ultimate tensile strength of 428 MPa and el...In this study,the typical Mg-14Gd-0.3Zr alloy was rolled at the high-temperature range of 450–500℃.The rolled Mg alloy plate with thickness of 30 mm exhibits an ultra-high ultimate tensile strength of 428 MPa and elongation of 3.4%,which has rarely been reported,and the strong fiber texture played a critical role in strengthening.The mechanisms underlying the evolution of texture during rolling were systematically investigated.At the early stage of rolling,alloys(450℃and 475℃)exhibited a[10.10]texture due to twinning assisted by Prismaticslipping.At 500℃,the alloy underwent nearly complete dynamic recrystallization(DRX)process.With increasing the rolling reduction,the DRX occurred in the whole temperature range,exhibiting the typical[10.10]–[11.20]double fiber texture.For continuous DRX,Prismaticdislocations accumulate to form grains with 30°[0001]grain boundaries,which exhibit a[10.10]fiber texture.During discontinuous DRX,Prismaticslip induced grain rotation around the[0001]axis,stabilizing either the<10.10>//RD(rolling direction)or<11.20>//RD orientations,leading to the formation of[10.10]–[11.20]double fiber texture.TEM observations confirmed that Prismaticdislocations can accumulate to form sub-grain lamellae,which gradually transform into high-angle grain boundaries by absorbing more Prismaticdislocations.First-principle calculation demonstrated that with increasing Gd content,the unstable stacking fault energy of prismatic slipping significantly decreases,promoting the activation of Prismaticslipping.These findings elucidate the critical role of twinning and Prismaticdislocations in texture evolution and the DRX process during thick plate rolling of the high-Gd content Mg-Gd-Zr alloy.展开更多
As a promising optical and piezoelectric crystal,efficient growth of LGN single crystal is crucial for its practical applications.Herein,a langanite(La_(3)Ga_(5.5)Nb_(0.5)O_(14),LGN)crystal with high quality was succe...As a promising optical and piezoelectric crystal,efficient growth of LGN single crystal is crucial for its practical applications.Herein,a langanite(La_(3)Ga_(5.5)Nb_(0.5)O_(14),LGN)crystal with high quality was successfully grown by the Bridgman method along the Z direction.In order to prepare high-purity polycrystalline precursors for LGN crystal growth,the sintering conditions of LGN polycrystalline precursors were studied in detail.The melting point of LGN was also measured to provide a reference for the crystal growth temperature.For the[001]oriented wafer,the full width at half maximum(EWHM)value of the nigh-resolution X-ray diffraction(HRXRD)analysis is 38.52",demonstrating that the LGN crystal exhibits excellent crystalline quality.In addition,we also measured the thermal properties and transmission spectrum of the as-grown LGN crystal.It is found that the absorption peak at 1.85μm of the LGN crystal grown in air using the Bridgman method disappears compared with previous reports(grown in N_(2+)(1-3)vol%O_(2)atmosphere),which is attributed to the oxygen-enriched growth environment.Similar phenomenon also occurs in other LGS-type disordered crystals.It is believed that these findings may expand the potential applications of LGS series crystals at 1.85μm.展开更多
The China Spallation Neutron Source(CSNS)is the fourth pulsed accelerator-driven neutron source in the world,and it achieved its design target of 100 kW in 2020.The planned China Spallation Neutron Source Phase II(CSN...The China Spallation Neutron Source(CSNS)is the fourth pulsed accelerator-driven neutron source in the world,and it achieved its design target of 100 kW in 2020.The planned China Spallation Neutron Source Phase II(CSNS-II)commenced in 2024.The CSNS-II linac design primarily involves the addition of a radio-frequency ion source and a section of a superconducting linear accelerator composed of two types of superconducting cavities,namely double-spoke and six-cell elliptical cavities,after the drift tube linac(DTL).The development of the double-spoke superconducting cavity began in early 2021,and by January 2023,the welding,post-processing,and vertical tests of two 324 MHz double-spoke cavity prototypes were completed,with vertical test gradients of 11.6 and 15 MV/m,and Q_(0)≥3×10^(10)@E_(acc)≤10 MV/m.The R&D of the cryomodule began in January 2022.In October 2023,the clean assembly of the double-spoke cavity string and cold mass installation of the cryomodule commenced,with the installation of the cryomodule and valve box completing in two months.In January 2024,a horizontal test of the cryomodule was completed,making it the first double-spoke cavity cryomodule in China.The test results showed that the maximum gradients of the two superconducting cavities at a pulse width of 4 ms and repetition frequency of 25 Hz were 12.8 and 15.2 MV/m,respectively.This article provides a detailed introduction to the double-spoke superconducting cavity,tuner,coupler,and cryomodule,elaborates on the clean assembly of the cavity string and cold mass installation of the cryomodule,and provides a detailed analysis of the horizontal test results.展开更多
基金supported by the State Key Laboratory of Disaster Reduction in Civil Engineering(Grant No.SLDRCE23-02)Ningbo PublicWelfare Fund Project(Grant No.2023S100)the National Key Research and Development Program of China(Grant No.2024YFE0105800).
文摘This study investigates the mechanical response of an underground cavern subjected to cyclic high gas pressure,aiming to establish a theoretical foundation for the design of lined rock caverns(LRCs)for energy storage with high internal pressure,e.g.compressed air energy storage(CAES)underground caverns or hydrogen storage caverns.Initially,the stress paths of the surrounding rock during the excavation,pressurization,and depressurization processes are delineated.Analytical expressions for the stress and deformation of the surrounding rock are derived based on the MohreCoulomb criterion.These expressions are then employed to evaluate the displacement of cavern walls under varying qualities of surrounding rock,the contact pressure between the steel lining and the surrounding rock subject to different gas storage pressures,the load-bearing ratio of the surrounding rock,and the impact of lining thickness on the critical gas pressure.Furthermore,the deformation paths of the surrounding rock are evaluated,along with the effects of tunnel depth and diameter on residual deformation of the surrounding rock,and the critical minimum gas pressure at which the surrounding rock and the lining do not detach.The results indicate that residual deformation of the surrounding rock occurs after depressurization under higher internal pressure for higher-quality rock masses,leading to detachment between the surrounding rock and the steel lining.The findings indicate that thicker linings correspond to higher critical minimum gas pressures.However,for lower-quality surrounding rock,thicker linings correspond to lower critical minimum gas pressures.These findings will provide invaluable insights for the design of LRCs for underground energy storage caverns.
基金the National Key Research Program of China under granted No.92164201National Natural Science Foundation of China for Distinguished Young Scholars No.62325403+2 种基金Natural Science Foundation of Jiangsu Province(BK20230498)Jiangsu Funding Program for Excellent Postdoctoral Talent(2024ZB427)the National Natural Science Foundation of China(62304147).
文摘Solid-state batteries are widely recognized as the next-generation energy storage devices with high specific energy,high safety,and high environmental adaptability.However,the research and development of solid-state batteries are resource-intensive and time-consuming due to their complex chemical environment,rendering performance prediction arduous and delaying large-scale industrialization.Artificial intelligence serves as an accelerator for solid-state battery development by enabling efficient material screening and performance prediction.This review will systematically examine how the latest progress in using machine learning(ML)algorithms can be used to mine extensive material databases and accelerate the discovery of high-performance cathode,anode,and electrolyte materials suitable for solid-state batteries.Furthermore,the use of ML technology to accurately estimate and predict key performance indicators in the solid-state battery management system will be discussed,among which are state of charge,state of health,remaining useful life,and battery capacity.Finally,we will summarize the main challenges encountered in the current research,such as data quality issues and poor code portability,and propose possible solutions and development paths.These will provide clear guidance for future research and technological reiteration.
基金Project supported by the National Key Research and Development Program of China(2021YFB3500600,2021YFB3500605)Natural Science Foundation of Jiangsu Province(BK20220365)+5 种基金Key R&D Program of Jiangsu Province(BE2022142)Natural Science Foundation of the Jiangsu Higher Education Institutions of China(22KJB610002)Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX23_1419)Science and Technology Plan of Yangzhou(YZ2022030,YZ2023020)the State Key Laboratory of Clean and Efficient Coal-fired Power Generation and Pollution Control(D2022FK098)。
文摘The integration of surface filtration and catalytic decomposition functions in catalytic bags enables the synergistic removal of multiple pollutants(such as dust,nitrogen oxide,acid gases,and dioxins)in a single reactor,thus effectively reducing the cost and operational difficulties associated with flue gas treatment.In this study,Mn-Ce-Sm-Sn(MCSS)catalysts were prepared and loaded onto hightemperature resistant polyimide(P84)filter through ultrasonic impregnation to create composite catalytic filter.The results demonstrate that the NO conversion rates of the composite catalytic filter consistently achieve above 95%within the temperature range of 160-260℃,with a chlorobenzene T_(90)value of 230℃.The ultrasonic impregnation method effectively loaded the catalyst onto the filter,ensuring high dispersion both on the surface and inside the filter.This increased exposure of catalyst active sites enhances the catalytic activity of the composite catalytic filter.Additionally,increasing the catalyst loading leads to a gradual decrease in permeability,an increase in pressure drops and the long residence time of the flue gas,thereby improving catalytic activity.Compared to ordinary impregnation methods,ultrasonic impregnation improves the bonding strength between the catalyst and filter,as well as the permeability of the composite catalytic filter under the same loading conditions.Overall,this study presents a novel approach to prepare composite catalytic filter for the simultaneous removal of NO and chlorobenzene at low temperatures.
基金supported by the Open Fund of Guangxi Key Laboratory of Building New Energy and Energy Conservation(Project Number:Guike Energy 17-J-21-3).
文摘With the development of renewable energy technologies such as photovoltaics and wind power,it has become a research hotspot to improve the consumption rate of new energy and reduce energy costs through algorithm improvement.To reduce the operational costs of micro-grid systems and the energy abandonment rate of renewable energy,while simultaneously enhancing user satisfaction on the demand side,this paper introduces an improvedmultiobjective Grey Wolf Optimizer based on Cauchy variation.The proposed approach incorporates a Cauchy variation strategy during the optimizer’s search phase to expand its exploration range and minimize the likelihood of becoming trapped in local optima.At the same time,adoptingmultiple energy storage methods to improve the consumption rate of renewable energy.Subsequently,under different energy balance orders,themulti-objective particle swarmalgorithm,multi-objective grey wolf optimizer,and Cauchy’s variant of the improvedmulti-objective grey wolf optimizer are used for example simulation,solving the Pareto solution set of the model and comparing.The analysis of the results reveals that,compared to the original optimizer,the improved optimizer decreases the daily cost by approximately 100 yuan,and reduces the energy abandonment rate to zero.Meanwhile,it enhances user satisfaction and ensures the stable operation of the micro-grid.
基金supported by the Regional Science Foundation Project of the National Natural Science Foundation of China(Project No:82160157)the Beijing High-Level Public Health Technology Talent Construction Project(Project No.:Leading Talents-03-10).
文摘Cardiac arrest(CA)is considered a state of clinical death in which the heart suddenly loses its ability to effectively expel blood,resulting in circulatory and respiratory arrest.CA is often catastrophic for patients,as it can cause serious long-term cardiovascular and cerebrovascular complications that affect their quality of life[1].Survey data indicate that the overall incidence rate of intraoperative CA in patients undergoing thoracic surgery in China is currently 0.138%[2].This rate is expected to increase because of the increasing proportion of older individuals(age>60 years)in the population,as well as the increasing pulmonary surgery rates.However,the incidence rate during the perianesthetic period in older patients undergoing thoracic surgery has not yet been comprehensively reported.
基金supported by the Shaanxi FundamentalScience Research Project for Chemistry&Biology(grant no.22JHQ049)Basic Research Program of Natural Sciencesof Shaanxi Province(2019JM-339).
文摘Pygmy lorises are arboreal primates primarily found in forest environments across Southeast Asia(Nekaris 2014).Theyhave a diverse diet,including plant secretions,nectar,fruits,invertebrates,tree bark,and bird eggs.All 9 known speciesof pygmy lorises are listed as globally endangered species(Nekaris 2014).Pygmy lorises exhibit a range of unique phenotypic characteristics rarely seen among primates.
文摘BACKGROUND Endoscopic full-thickness resection(EFTR)is increasingly used for treating gastrointestinal stromal tumors(GISTs)in the stomach.AIM To compare the efficacy,tolerability,and clinical outcomes of EFTR vs surgical resection(SR)for gastric GISTs.METHODS We collected clinical data from patients diagnosed with GISTs who underwent either EFTR or SR at our hospital from October 2011 to July 2024.Patients were matched in a 1:1 ratio based on baseline characteristics and tumor clinical-pathological features using propensity score matching.We analyzed perioperative outcomes and follow-up data.The primary outcome measure was progressionfree survival(PFS).RESULTS Out of 912 patients,573 met the inclusion criteria.After matching,each group included 95 patients.The EFTR group demonstrated statistically significant advantages over the SR group in average operative time(P<0.001),length of hospital stay(P<0.001),time to resume liquid diet(P<0.001),incidence of adverse events(P=0.031),and hospitalization costs(P<0.001).The en bloc resection rate was significantly different,with SR group at 100%and EFTR group at 93.7%(P=0.038).The median follow-up was 2451.50 days.Recurrence occurred in 3 patients in the EFTR group and 4 patients in the SR group,with no statistically significant difference(P=1.000).Factors associated with PFS included age,tumor size,high-risk category in the modified National Institutes of Health(NIH)risk score,and resection status.Resection status was identified as an independent prognostic factor for PFS(P=0.0173,hazard ratios=0.0179,95%CI:0.000655-0.491).Notably,there was no statistically significant difference in PFS between the two groups.CONCLUSION This study is a non-inferiority design.The EFTR group significantly outperformed the SR group in terms of operative time,length of hospital stay,time to resume a liquid diet,incidence of adverse events,and hospitalization costs,demonstrating its higher economic efficiency and better tolerability.Additionally,although the en bloc resection rate was lower in the EFTR group compared to the SR group,there were no significant differences in tumor recurrence rates and progression-free survival between the two groups.This study found no statistical difference in the primary endpoint of postoperative recurrence rates between the two groups.However,due to sample size limitations,this result requires further validation in larger-scale studies.The current results should be viewed as exploratory evidence.
文摘Vanadium phosphorus oxide(VPO)catalyst is a promising candidate for the condensation reaction of formaldehyde(FA)and acetic acid(HAc)to produce acrylic acid(AA).However,the complexity of the active phases and their dynamic interconversion under redox conditions has led to controversies regarding the actual active phase in this reaction.To address this,this study systematically investigates the phase transition and underlying mechanism of VPO catalysts under reaction conditions.X-ray diffraction(XRD)patterns,Raman spectra,transmission electron microscopy images and X-ray photoelectron spectroscopy collectively demonstrated that the V^(4+)phase(VO)_(2)P_(2)O_(7)retained the bulk phase structure throughout the reaction,with only minor surface phase transition observed.In contrast,the V^(5+)phase underwent reduction to other phases in both bulk and surface regions.Specifically,theδ-VOPO_(4)phase rapidly transformed into theαII-VOPO_(4)phase,which could reversibly convert into the R1-VOHPO_(4)phase(V^(4+)).Controlled variable experiments,H_(2)-temperature programmed reduction and in-situ XRD experiments in a hydrogen atmosphere further demonstrated that these phase transitions were primarily attributed to the loss of lattice oxygen.The presence of V^(4+)phase in VPO catalysts enhanced the selectivity of acrylic acid,while the existence of V^(5+)phase promoted the activation of acetic acid.This work elucidates the redox-driven phase evolution of VPO catalysts and offers valuable insights for designing efficient catalysts for FA-HAc cross-condensation by balancing phase stability and activity.
基金Supported by the Liaoning Provincial Science and Technology Plan Joint Program(Applied Basic Research Project),Undertaken by Shengjing Hospital of China Medical University in Collaboration with China Resources Health(Liaoning)Group Co.,Ltd.,No.2023JHZ/101700190.
文摘As an innovative endoscopic intervention,endoscopic ultrasound-guided pan-creatic duct drainage(EUS-PD)demonstrates significant clinical value in re-solving pancreatic ductal hypertension syndrome.By integrating real-time ultrasound guidance with catheter-based intervention techniques,this approach provides a safe and effective alternative for cases where conventional endoscopic retrograde cholangiopancreatography has failed.Current evidence indicates that EUS-PD achieves technical success rates ranging from 82%to 95%in alleviating symptomatic pancreatic duct hypertension caused by malignant obstructions and chronic pancreatitis-related strictures,with an overall complication rate(15%-20%)substantially lower than surgical interventions.Compared to conventional imaging modalities,EUS-PD offers superior anatomical visualization capabilities:Its high-frequency ultrasound probe enables precise identification of 3 mm-level pancreatic duct branches,while contrast-enhanced imaging significantly improves diagnostic accuracy in differentiating benign from malignant strictures(sensitivity 91%vs 73%,P<0.05).Nevertheless,technical challenges persist,including diffi-cult ductal puncture localization(particularly in pancreatic head lesions),complex guidewire axial control,and postoperative pancreatic fistula risks(7%-12%).This review systematically examines the clinical indications/contraindications,pro-cedural protocols,device selection criteria,and management strategies for early/late complications associated with EUS-PD.Special emphasis is placed on establishing anatomical pathway selection standards for transgastric-pancreatic duct vs transduodenal-pancreatic duct approaches.Advancements in auxiliary technologies(e.g.,three-dimensional elastography,AI-assisted navigation)and multidisciplinary team collab-oration are pivotal to developing standardized protocols.We propose establishing international multicenter registry databases and conducting prospective randomized controlled trials to clarify EUS-PD's position within pancreatic disease management systems.Such initiatives will facilitate the clinical transformation of EUS-PD from an"alternative option"to a"preferred strategy",ultimately enhancing treatment precision and improving clinical outcomes in pancreatic disorders.
基金the National Key Research and Development Program(2023YFB3710903)the National Natural Science Foundation of China(U2167213)+1 种基金the Fundamental Research Funds for the Central Universities(N25GFZ006)the Xingliao Talent Plan Program(XLYC2203202).
文摘In this study,the typical Mg-14Gd-0.3Zr alloy was rolled at the high-temperature range of 450–500℃.The rolled Mg alloy plate with thickness of 30 mm exhibits an ultra-high ultimate tensile strength of 428 MPa and elongation of 3.4%,which has rarely been reported,and the strong fiber texture played a critical role in strengthening.The mechanisms underlying the evolution of texture during rolling were systematically investigated.At the early stage of rolling,alloys(450℃and 475℃)exhibited a[10.10]texture due to twinning assisted by Prismaticslipping.At 500℃,the alloy underwent nearly complete dynamic recrystallization(DRX)process.With increasing the rolling reduction,the DRX occurred in the whole temperature range,exhibiting the typical[10.10]–[11.20]double fiber texture.For continuous DRX,Prismaticdislocations accumulate to form grains with 30°[0001]grain boundaries,which exhibit a[10.10]fiber texture.During discontinuous DRX,Prismaticslip induced grain rotation around the[0001]axis,stabilizing either the<10.10>//RD(rolling direction)or<11.20>//RD orientations,leading to the formation of[10.10]–[11.20]double fiber texture.TEM observations confirmed that Prismaticdislocations can accumulate to form sub-grain lamellae,which gradually transform into high-angle grain boundaries by absorbing more Prismaticdislocations.First-principle calculation demonstrated that with increasing Gd content,the unstable stacking fault energy of prismatic slipping significantly decreases,promoting the activation of Prismaticslipping.These findings elucidate the critical role of twinning and Prismaticdislocations in texture evolution and the DRX process during thick plate rolling of the high-Gd content Mg-Gd-Zr alloy.
基金Project supported by the National Key R&D Program of China(2022YFB3204000)National Natural Science Foundation of China(51832009)。
文摘As a promising optical and piezoelectric crystal,efficient growth of LGN single crystal is crucial for its practical applications.Herein,a langanite(La_(3)Ga_(5.5)Nb_(0.5)O_(14),LGN)crystal with high quality was successfully grown by the Bridgman method along the Z direction.In order to prepare high-purity polycrystalline precursors for LGN crystal growth,the sintering conditions of LGN polycrystalline precursors were studied in detail.The melting point of LGN was also measured to provide a reference for the crystal growth temperature.For the[001]oriented wafer,the full width at half maximum(EWHM)value of the nigh-resolution X-ray diffraction(HRXRD)analysis is 38.52",demonstrating that the LGN crystal exhibits excellent crystalline quality.In addition,we also measured the thermal properties and transmission spectrum of the as-grown LGN crystal.It is found that the absorption peak at 1.85μm of the LGN crystal grown in air using the Bridgman method disappears compared with previous reports(grown in N_(2+)(1-3)vol%O_(2)atmosphere),which is attributed to the oxygen-enriched growth environment.Similar phenomenon also occurs in other LGS-type disordered crystals.It is believed that these findings may expand the potential applications of LGS series crystals at 1.85μm.
文摘The China Spallation Neutron Source(CSNS)is the fourth pulsed accelerator-driven neutron source in the world,and it achieved its design target of 100 kW in 2020.The planned China Spallation Neutron Source Phase II(CSNS-II)commenced in 2024.The CSNS-II linac design primarily involves the addition of a radio-frequency ion source and a section of a superconducting linear accelerator composed of two types of superconducting cavities,namely double-spoke and six-cell elliptical cavities,after the drift tube linac(DTL).The development of the double-spoke superconducting cavity began in early 2021,and by January 2023,the welding,post-processing,and vertical tests of two 324 MHz double-spoke cavity prototypes were completed,with vertical test gradients of 11.6 and 15 MV/m,and Q_(0)≥3×10^(10)@E_(acc)≤10 MV/m.The R&D of the cryomodule began in January 2022.In October 2023,the clean assembly of the double-spoke cavity string and cold mass installation of the cryomodule commenced,with the installation of the cryomodule and valve box completing in two months.In January 2024,a horizontal test of the cryomodule was completed,making it the first double-spoke cavity cryomodule in China.The test results showed that the maximum gradients of the two superconducting cavities at a pulse width of 4 ms and repetition frequency of 25 Hz were 12.8 and 15.2 MV/m,respectively.This article provides a detailed introduction to the double-spoke superconducting cavity,tuner,coupler,and cryomodule,elaborates on the clean assembly of the cavity string and cold mass installation of the cryomodule,and provides a detailed analysis of the horizontal test results.
