Fusarium ear rot(FER),caused by Fusarium verticillioides,is a destructive fungal disease of maize.FER resistance is a complex,quantitatively inherited trait controlled by multiple minor-effect genes.In this study,we e...Fusarium ear rot(FER),caused by Fusarium verticillioides,is a destructive fungal disease of maize.FER resistance is a complex,quantitatively inherited trait controlled by multiple minor-effect genes.In this study,we employed two recombinant inbred line(RIL)populations with the common resistant parental line CML304 to identify FER-resistance loci.Initial QTL analysis identified 23 FER-resistance QTL,each explaining 5.21%-30.51%of the total phenotypic variation.Notably,one major QTL,qRfv2,on chromosome 2 was repeatedly detected,accounting for 11.92%-30.51%of the total phenotypic variation.qRfv2 was fine mapped to an interval of 1.01 Mb,flanked by the markers IDP8 and IDP10.qRfv2 is a semidominant resistance gene that could reduce the disease severity index(DSI)by 12.4%-20%,suggesting its potential for enhancing FER resistance in maize.Transcriptome analysis showed that 22 of the 28 annotated functional genes in the qRfv2 region displayed differential expression between parental lines in response to FER.One of the candidate genes,ZmLOX6,was validated to presumably provide a positive effect on FER resistance.Our study provides a basis for the potential cloning and application of FER resistance genes in maize breeding.展开更多
In-depth study of the components of polymyxins is the key to controlling the quality of this class of antibiotics.Similarities and variations of components present significant analytical challenges.A two-dimensional(2...In-depth study of the components of polymyxins is the key to controlling the quality of this class of antibiotics.Similarities and variations of components present significant analytical challenges.A two-dimensional(2D)liquid chromatography-mass spectrometry(LC-MS)method was established for screening and comprehensive profiling of compositions of the antibiotic colistimethate sodium(CMS).A high concentration of phosphate buffer mobile phase was used in the first-dimensional LC system to get the components well separated.For efficient and high-accuracy screening of CMS,a targeted method based on a self-constructed high resolution(HR)mass spectrum database of CMS components was established.The database was built based on the commercial MassHunter Personal Compound Database and Library(PCDL)software and its accuracy of the compound matching result was verified with six known components before being applied to genuine sample screening.On this basis,the unknown peaks in the CMS chromatograms were deduced and assigned.The molecular formula,group composition,and origins of a total of 99 compounds,of which the combined area percentage accounted for more than 95%of CMS components,were deduced by this 2D-LC-MS method combined with the MassHunter PCDL.This profiling method was highly efficient and could distinguish hundreds of components within 3 h,providing reliable results for quality control of this kind of complex drugs.展开更多
Recently,CsPbBr_(3)perovskite solar cells(PSCs)have garnered attention due to cost-effectiveness and reliability.However,hole transport limitations lead to charge recombination and lower power conversion efficiency(PC...Recently,CsPbBr_(3)perovskite solar cells(PSCs)have garnered attention due to cost-effectiveness and reliability.However,hole transport limitations lead to charge recombination and lower power conversion efficiency(PCE).Defects in the CsPbBr_(3)layer,poor hole transport at the interface with carbon electrodes,and energy level differences hinder performance.Optimizing the perovskite layer using electrondonating organic molecules containing-NH_(2)groups enhances efficiency and stability by passivating defects and modulating lattice structure.In this work,tetra(4-aminophenyl)ethylene(TPE)and tetra(4-aminobiphenyl)ethylene(TPE-Ph)were employed to optimize the CsPbBr_(3)/carbon electrode interface.Their strong electron-donating properties and amino groups facilitate hole transfer and defect passivation,boosting PCE to 9.38%and enhancing stability.展开更多
Metal-organic frameworks(MOFs)with superior physicochemical properties have great potential for applications in chromatographic separation.However,currently popular methods for the synthesis of MOFbased silica composi...Metal-organic frameworks(MOFs)with superior physicochemical properties have great potential for applications in chromatographic separation.However,currently popular methods for the synthesis of MOFbased silica composite materials usually require the use of harmful organic solvents and long-term hightemperature sealing reactions.In order to respond to the needs of green chromatography,it is urgent to develop a new green organic-solvent-free strategy for the synthesis of MOF@SiO_(2)composites.MIP-202 is a zirconium-MOF constructed from zirconium ion and l-aspartic acid,which features green synthesis as well as good hydrolytic stability and chemical stability.In this paper,SiO_(2)-NH_(2) was first prepared in a hydrophilic deep eutectic solvent,and then an amino acid-based MOF material(MIP-202)was modified on the surface of the SiO_(2)-NH_(2) in an aqueous solution to obtain a MIP-202@SiO_(2) composite material.The multi-mode separation performance of MIP-202@SiO_(2) as a promising liquid chromatographic stationary phase was particularly evaluated and the separation mechanisms were discussed.The MIP-202@SiO_(2) column exhibited excellent separation ability for aromatic positional isomers.In addition,chiral enantiomers and hydrophilic analytes were also satisfactorily detected and separated.This work provides a new approach for the facile synthesis of MOF-based liquid chromatographic separation material by using green deep eutectic solvent and water as the reaction media.展开更多
Iron disulfide(FeS_(2))has been widely used in thermal batteries because of its high theoretical specific capacity and voltage plateau.However,low thermal decomposition temperature,poor conductivity and inferior actua...Iron disulfide(FeS_(2))has been widely used in thermal batteries because of its high theoretical specific capacity and voltage plateau.However,low thermal decomposition temperature,poor conductivity and inferior actual specific capacity limit its wide applications.Herein,we report a gold-doped FeS_(2)(FeS_(2)-Au),which not only reduces the band gap of the FeS_(2)crystals but also enriches the electron transport path of FeS_(2)by the formation of Au nanoparticles.First-principles calculation shows that the diffusion energy barrier of lithium-ion is reduced after the Au-doped FeS_(2).In addition,Au increases the electron cloud density around sulfur atoms,which helps to enhance the stability of Fe-S covalent bonds and thus results in better thermal stability of FeS_(2).When the Au content is 130μg·g^(-1)(FeS_(2)-Au_(4)),the thermal decomposition temperature(TG5%)of FeS_(2)-Au is 72.2℃ higher than that of pristine FeS_(2).At a discharge temperature of 500℃,a current density of 200 mA·cm^(-2) and a cutoff voltage of 1.4 V,FeS_(2)-Au_(4)demonstrates superior specific capacity and high specific energy compared to FeS_(2).More precisely,the specific capacity of FeS_(2)-Au_(4)attains a value of 379 mAh·g^(-1),with a corresponding specific energy of 714 Wh·kg^(-1).In contrast,the discharge specific capacity and specific energy of FeS_(2)are lower,amounting to 348 mAh·g^(-1)and 656 Wh·kg^(-1),respectively.This study offers a novel approach to enhancing the electrochemical performance of FeS_(2)in high-temperature molten salt electrochemical systems(thermal batteries),thereby laying a solid foundation for its potential practical application.展开更多
In machine vision,elliptical targets frequently appear within the camera's region of interest(ROI).Ellipse detection is essential for shape detection and geometric measurements in machine vision.However,existing e...In machine vision,elliptical targets frequently appear within the camera's region of interest(ROI).Ellipse detection is essential for shape detection and geometric measurements in machine vision.However,existing ellipse detection algorithms often face issues such as high computational complexity,strong dependence on initial conditions,sensitivity to noise,and lack of robustness to occlusions.In this paper,we propose a fast and robust ellipse detection method to address these challenges.This method first utilizes edge gradient and curvature information to segment the curve into circular arcs.Next,based on the convexity of the arcs,it divides them into different quadrants of the ellipse,groups and fits the arcs according to multiple geometric constraints at a low computational cost.Finally,it reduces the parameter space for hierarchical clustering and then segments the complete ellipse into several sectors for verification.We compare our method across seven datasets,including five public image datasets and two from industrial camera scenes.Experimental results show that our method achieves a precision ranging from 67.1%to 98.9%,a recall ranging from 48.1%to 92.9%,and an F-measure ranging from 58.0%to 95.8%.The average execution time per image ranges from 25 ms to 192 ms,demonstrating both high accuracy and efficiency.展开更多
Here,a novel real-time monitoring sensor that integrates the oxidation of peroxymonosulfate(PMS)and the in situ monitoring of the pollutant degradation process is proposed.Briefly,FeCo@carbon fiber(FeCo@CF)was utilize...Here,a novel real-time monitoring sensor that integrates the oxidation of peroxymonosulfate(PMS)and the in situ monitoring of the pollutant degradation process is proposed.Briefly,FeCo@carbon fiber(FeCo@CF)was utilized as the anode electrode,while graphite rods served as the cathode electrode in assembling the galvanic cell.The FeCo@CF electrode exhibited rapid reactivity with PMS,generating reactive oxygen species that efficiently degrade organic pollutants.The degradation experiments indicate that complete bisphenol A(BPA)degradation was achieved within 10 min under optimal conditions.The real-time electrochemical signal was measured in time during the catalytic reaction,and a linear relationship between BPA concentration and the real-time charge(Q)was confirmed by the equation ln(C0/C)=4.393Q(correlation coefficients,R^(2)=0.998).Furthermore,experiments conducted with aureomycin and tetracycline further validated the effectiveness of the monitoring sensor.First-principles investigation confirmed the superior adsorption energy and improved electron transfer in FeCo@CF.The integration of pollutant degradation with in situ monitoring of catalytic reactions offers promising prospects for expanding the scope of the monitoring of catalytic processes and making significant contributions to environmental purification.展开更多
Analyzing polysorbate 20(PS20)composition and the impact of each component on stability and safety is crucial due to formulation variations and individual tolerance.The similar structures and polarities of PS20 compon...Analyzing polysorbate 20(PS20)composition and the impact of each component on stability and safety is crucial due to formulation variations and individual tolerance.The similar structures and polarities of PS20 components make accurate separation,identification,and quantification challenging.In this work,a high-resolution quantitative method was developed using single-dimensional high-performance liquid chromatography(HPLC)with charged aerosol detection(CAD)to separate 18 key components with multiple esters.The separated components were characterized by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UHPLC-Q-TOF-MS)with an identical gradient as the HPLC-CAD analysis.The polysorbate compound database and library were expanded over 7-time compared to the commercial database.The method investigated differences in PS20 samples from various origins and grades for different dosage forms to evaluate the composition-process relationship.UHPLC-Q-TOF-MS identified 1329 to 1511 compounds in 4 batches of PS20 from different sources.The method observed the impact of 4 degradation conditions on peak components,identifying stable components and their tendencies to change.HPLC-CAD and UHPLC-Q-TOF-MS results provided insights into fingerprint differences,distinguishing quasi products.展开更多
A new series of 12-benzyl matrinic amide/ethanamide derivatives were synthesized from matrinine（1）and evaluated for their anti-HCV activity,taking compound 2 as the lead.SAR revealed that the introduction of a suita...A new series of 12-benzyl matrinic amide/ethanamide derivatives were synthesized from matrinine（1）and evaluated for their anti-HCV activity,taking compound 2 as the lead.SAR revealed that the introduction of a suitable substituent at the N’-end of matrinic amide might greatly enhance the potency.Among them,matrinic acid 17 and N’-substituted matrinic amides 18a-d exhibited promising potency with low micromolar EC50 values ranging from 1.03μmol/L to 7.54 μmol/L,and better therapeutic window with SI from 66 to 132.Moreover,compound 17 displayed an excellent PK and safety profile in vivo,demonstrating good drug-like characteristics.Thus,it has been selected for further investigation,with an advantage of decreased chances of inducing drug-resistance mutations.展开更多
Photocatalytic H2 production and CO2 reduction have attracted considerable attention for clean energy development.In this work,we designed an efficient photocatalyst by integrating lamellar oxygen-doped carbon nitride...Photocatalytic H2 production and CO2 reduction have attracted considerable attention for clean energy development.In this work,we designed an efficient photocatalyst by integrating lamellar oxygen-doped carbon nitride(CNO)nanosheets into ZnIn2S4(ZIS)microflowers by a one-step hydrothermal method.A well-fitted 2D hierarchical hybrid heterostructure was fabricated.Under visible light irradiation,the ZIS@CNO composite with 40 wt%CNO(ZC 40%)showed the highest hydrogen evolution rate from water(188.4μmol·h-1),which was approximately 2.1 times higher than those of CNO and ZIS(88.6 and 90.2μmol·h-1,respectively).Furthermore,the selective CO production rates of ZC 40%(12.69μmol·h-1)were 2.2 and 14.0 times higher than those of ZIS(5.85μmol·h-1)and CNO(0.91μmol·h-1),respectively,and the CH4 production rate of ZC 40%was 1.18μmol·h-1.This enhanced photocatalytic activity of CNO@ZIS is due mainly to the formation of a heterostructure that can promote the transfer of photoinduced electrons and holes between CNO and ZIS,thereby efficiently avoiding recombination of electron-hole pairs.展开更多
Photothermal material applied in environmental governance has attracted growing attention.By combining the Stober method and dopamine-triggered coating strategy,Co-Mn precursor was in situ incorporated into the poly d...Photothermal material applied in environmental governance has attracted growing attention.By combining the Stober method and dopamine-triggered coating strategy,Co-Mn precursor was in situ incorporated into the poly dopamine(PDA)layer over the surface of silica cores.Afterwards,a unique photothermal nanosphere with SiO_(2)core and thin carbon layer and dual Co-Mn oxides shell was allowed to form by sequential heat treatment in the inert atmosphere(SiO_(2)@CoMn/C).The bimetallic fraction of Co/Mn in the carbon layer and post-treatment calcination temperature was comprehensively tuned to optimize the peroxymonosulfate(PMS)activation performance of the catalyst.The state of bimetallic species was studied including their physical distribution,chemical valence,and interplay by various characterizations.Impressively,Co oxides appear as dominant monodispersed nanoparticles(~10 nm),while Mn with cluster-like morphology is observed to uniformly distribute over thin-layer carbon and adhered to the surface of SiO_(2)nanospheres(~250 nm).The calcined temperature could tune the oxidized state of Co species,leading to the optimization of the catalytic performance of introduced dual metal species.As a result,this obtained optimal catalyst integrated the advantages of exposed bimetallic CoMn species and N-doped thin carbon to deliver excellent catalytic PMS activation performance and photothermal synergetic catalytic mineralization ability for diversiform pollutants.Further reactions condition controls and anion interference studies were conducted to identify the adaptability of the optimal catalyst.Moreover,the application of solar-driven interfacial water evaporation using optimal SiO_(2)@Co_3Mn_1/C-600 catalyst was explored,showing a high water evaporation rate of 1.48 kg·m^(-2)·h^(-1)and an efficiency of 95.2%,further revealing a comprehensive governance functionality of obtained material in the complex pollution condition.展开更多
The development of effective and sustainable solutions for pleiotropic water purification becomes urgent and attractive.Heterogeneous Fenton-like catalysts for activation of peroxymonosulfate(PMS)to purify organic was...The development of effective and sustainable solutions for pleiotropic water purification becomes urgent and attractive.Heterogeneous Fenton-like catalysts for activation of peroxymonosulfate(PMS)to purify organic wastewater show great promise.In this work,by tuning metal loading with an in-situ polydopamine coating strategy,oxygen vacancy-enriched Co_(3)O_(4) loading on N-doped carbon nanotubes(CNTs)were constructed to enhance PMS activation efficiency for pollutants degradation.Impressively,the obtained modified CNTs afford a well-developed N-containing network structure,which is further endowed with abundant Co(Ⅱ)/Co(Ⅲ)redox cycles and significant metal-carbon interactions.In particular,the surface N doping in CNTs might induce the oriented enrichment of pollutants around the catalyst,which reduces the migration distance and correspondingly improves the utilization of reactive oxidative species.The electron transfer efficiency of the catalyst can be further improved by incorporating oxygen vacancy-enriched Co_(3)O_(4).The performance results show that the optimal NC/Co-1 could mineralize 20×10^(-6)of bisphenol A(BPA)by almost 98%in 8 min.A low reaction activation energy(26.05 kJ·mol^(-1))in BPA degradation was demonstrated by the NC/Co-1.More importantly,NC/Co-1 can inherit excellent degradation performance towards oxytetracycline,2,4-dichlorophenol,and tetracycline,showing wide practical flexibility.In addition,by virtue of the photothermal conversion property,NC/Co-1 achieves an additive function for interfacial solar water evaporation(1.84 kg·m^(-2)·h^(-1),112.51%),showing impressive potential for clean water recovery under complicated environmental pollution conditions.展开更多
In recent years,Fe_(3)O_(4)nanomaterials have received much attention in analytical chemistry due to their excellent magnetic and peroxidase-like activity.As the catalytic characteristics of Fe_(3)O_(4)nanomaterials i...In recent years,Fe_(3)O_(4)nanomaterials have received much attention in analytical chemistry due to their excellent magnetic and peroxidase-like activity.As the catalytic characteristics of Fe_(3)O_(4)nanomaterials is similar to those of horseradish peroxidase(HRP),Fe_(3)O_(4)nanomaterials are also used as peroxidase mimics and have achieved a certain development in many fields based on latest research results.To improve the stability and catalytic ability of simple Fe_(3)O_(4)nanomaterials,various modification strategies of Fe_(3)O_(4)nanomaterials have been developed.The recent advances of these strategies have been presented and discussed.In addition,this paper introduces the application of Fe_(3)O_(4)nanozymes in the detection of food and industrial pollutants,as well as in the field of biosafety.展开更多
Owing to the serious potential side-effects on the environment and human health,the rapid detection and removal of antibiotics have become an important research focus.In this work,four zinc-based metal-organic framewo...Owing to the serious potential side-effects on the environment and human health,the rapid detection and removal of antibiotics have become an important research focus.In this work,four zinc-based metal-organic frameworks(MOFs)with different functional groups,i.e.,Zn-MOF,Zn-MOF-CH_(3),Zn-MOF-NO_(2),Zn-MOF-COOH,were utilized for the construction of LDO/MOF composite materials with a nickel-iron-cobalt-based layered double oxide,NiFeCo-LDO.The results showed that the LDO/MOF composites not only had high sensitivity in detecting sulfonamide and quinolone antibiotics,but also had an appreciable ability to adsorb them from wastewater.The maximum adsorption capacities of all the four types of LDO@Zn-MOFs to all antibiotics can at least reach 150 mg/g,and the limits of detection in relation to all four antibiotics were at least as low as 100μg/L.Our work suggested the dual-function extraction performance can be attributed to the synergistic effects between the LDO and the MOFs.Moreover,the strong ferromagnetism derived from the LDO provided great convenience for the separation and regeneration of the LDO/MOF composites.展开更多
Severe sex ratio imbalance at birth is now becoming an important issue in several Asian countries. Its leading immediate cause is prenatal sex-selective abortion following illegal sex identification by ultrasound scan...Severe sex ratio imbalance at birth is now becoming an important issue in several Asian countries. Its leading immediate cause is prenatal sex-selective abortion following illegal sex identification by ultrasound scanning. In this paper, a fast automatic recognition and location algorithm for fetal genital organs is proposed as an effective method to help prevent ultrasound technicians from unethically and illegally identifying the sex of the fetus. This automatic recognition algorithm can be divided into two stages. In the 'rough' stage, a few pixels in the image, which are likely to represent the genital organs, are automatically chosen as points of interest (POIs) according to certain salient characteristics of fetal genital organs. In the 'fine' stage, a specifically supervised learning framework, which fuses an effective feature data preprocessing mechanism into the multiple classifier architecture, is applied to every POI. The basic classifiers in the framework are selected from three widely used classifiers: radial basis function network, backpropagation network, and support vector machine. The classification results of all the POIs are then synthesized to determine whether the fetal genital organ is present in the image, and to locate the genital organ within the positive image. Experiments were designed and carried out based on an image dataset comprising 658 positive images (images with fetal genital organs) and 500 negative images (images without fetal genital organs). The experimental results showed true positive (TP) and true negative (TN) results from 80.5% (265 from 329) and 83.0% (415 from 500) of samples, respectively. The average computation time was 453 ms per image.展开更多
基金financially funded by the National Natural Science Foundation of China(U2004205)the China Agricultural University-Syngenta Project.
文摘Fusarium ear rot(FER),caused by Fusarium verticillioides,is a destructive fungal disease of maize.FER resistance is a complex,quantitatively inherited trait controlled by multiple minor-effect genes.In this study,we employed two recombinant inbred line(RIL)populations with the common resistant parental line CML304 to identify FER-resistance loci.Initial QTL analysis identified 23 FER-resistance QTL,each explaining 5.21%-30.51%of the total phenotypic variation.Notably,one major QTL,qRfv2,on chromosome 2 was repeatedly detected,accounting for 11.92%-30.51%of the total phenotypic variation.qRfv2 was fine mapped to an interval of 1.01 Mb,flanked by the markers IDP8 and IDP10.qRfv2 is a semidominant resistance gene that could reduce the disease severity index(DSI)by 12.4%-20%,suggesting its potential for enhancing FER resistance in maize.Transcriptome analysis showed that 22 of the 28 annotated functional genes in the qRfv2 region displayed differential expression between parental lines in response to FER.One of the candidate genes,ZmLOX6,was validated to presumably provide a positive effect on FER resistance.Our study provides a basis for the potential cloning and application of FER resistance genes in maize breeding.
基金support from the Science Research Program Project for Drug Regulation,Jiangsu Medical Products Administration,China(Grant No.:202207)the National Drug Standards Revision Project,China(Grant No.:2023Y41)+1 种基金the National Natural Science Foundation of China(Grant No.:22276080)the Foreign Expert Project,China(Grant No.:G2022014096L).
文摘In-depth study of the components of polymyxins is the key to controlling the quality of this class of antibiotics.Similarities and variations of components present significant analytical challenges.A two-dimensional(2D)liquid chromatography-mass spectrometry(LC-MS)method was established for screening and comprehensive profiling of compositions of the antibiotic colistimethate sodium(CMS).A high concentration of phosphate buffer mobile phase was used in the first-dimensional LC system to get the components well separated.For efficient and high-accuracy screening of CMS,a targeted method based on a self-constructed high resolution(HR)mass spectrum database of CMS components was established.The database was built based on the commercial MassHunter Personal Compound Database and Library(PCDL)software and its accuracy of the compound matching result was verified with six known components before being applied to genuine sample screening.On this basis,the unknown peaks in the CMS chromatograms were deduced and assigned.The molecular formula,group composition,and origins of a total of 99 compounds,of which the combined area percentage accounted for more than 95%of CMS components,were deduced by this 2D-LC-MS method combined with the MassHunter PCDL.This profiling method was highly efficient and could distinguish hundreds of components within 3 h,providing reliable results for quality control of this kind of complex drugs.
基金supported by the National Natural Science Foundation of Chinathe authors sincerely thank the National Natural Science Foundation of China(Nos.22271106 and 52073286)Science Foundation of State Key Laboratory of Structural Chemistry(No.20230027)。
文摘Recently,CsPbBr_(3)perovskite solar cells(PSCs)have garnered attention due to cost-effectiveness and reliability.However,hole transport limitations lead to charge recombination and lower power conversion efficiency(PCE).Defects in the CsPbBr_(3)layer,poor hole transport at the interface with carbon electrodes,and energy level differences hinder performance.Optimizing the perovskite layer using electrondonating organic molecules containing-NH_(2)groups enhances efficiency and stability by passivating defects and modulating lattice structure.In this work,tetra(4-aminophenyl)ethylene(TPE)and tetra(4-aminobiphenyl)ethylene(TPE-Ph)were employed to optimize the CsPbBr_(3)/carbon electrode interface.Their strong electron-donating properties and amino groups facilitate hole transfer and defect passivation,boosting PCE to 9.38%and enhancing stability.
基金support of National Natural Science Foundation of China(No.21906124)Natural Science Foundation of Hubei Province(No.2017CFB220)。
文摘Metal-organic frameworks(MOFs)with superior physicochemical properties have great potential for applications in chromatographic separation.However,currently popular methods for the synthesis of MOFbased silica composite materials usually require the use of harmful organic solvents and long-term hightemperature sealing reactions.In order to respond to the needs of green chromatography,it is urgent to develop a new green organic-solvent-free strategy for the synthesis of MOF@SiO_(2)composites.MIP-202 is a zirconium-MOF constructed from zirconium ion and l-aspartic acid,which features green synthesis as well as good hydrolytic stability and chemical stability.In this paper,SiO_(2)-NH_(2) was first prepared in a hydrophilic deep eutectic solvent,and then an amino acid-based MOF material(MIP-202)was modified on the surface of the SiO_(2)-NH_(2) in an aqueous solution to obtain a MIP-202@SiO_(2) composite material.The multi-mode separation performance of MIP-202@SiO_(2) as a promising liquid chromatographic stationary phase was particularly evaluated and the separation mechanisms were discussed.The MIP-202@SiO_(2) column exhibited excellent separation ability for aromatic positional isomers.In addition,chiral enantiomers and hydrophilic analytes were also satisfactorily detected and separated.This work provides a new approach for the facile synthesis of MOF-based liquid chromatographic separation material by using green deep eutectic solvent and water as the reaction media.
基金supported by the Central South University Innovation-Driven Research Programme(No.2023CXQD009).
文摘Iron disulfide(FeS_(2))has been widely used in thermal batteries because of its high theoretical specific capacity and voltage plateau.However,low thermal decomposition temperature,poor conductivity and inferior actual specific capacity limit its wide applications.Herein,we report a gold-doped FeS_(2)(FeS_(2)-Au),which not only reduces the band gap of the FeS_(2)crystals but also enriches the electron transport path of FeS_(2)by the formation of Au nanoparticles.First-principles calculation shows that the diffusion energy barrier of lithium-ion is reduced after the Au-doped FeS_(2).In addition,Au increases the electron cloud density around sulfur atoms,which helps to enhance the stability of Fe-S covalent bonds and thus results in better thermal stability of FeS_(2).When the Au content is 130μg·g^(-1)(FeS_(2)-Au_(4)),the thermal decomposition temperature(TG5%)of FeS_(2)-Au is 72.2℃ higher than that of pristine FeS_(2).At a discharge temperature of 500℃,a current density of 200 mA·cm^(-2) and a cutoff voltage of 1.4 V,FeS_(2)-Au_(4)demonstrates superior specific capacity and high specific energy compared to FeS_(2).More precisely,the specific capacity of FeS_(2)-Au_(4)attains a value of 379 mAh·g^(-1),with a corresponding specific energy of 714 Wh·kg^(-1).In contrast,the discharge specific capacity and specific energy of FeS_(2)are lower,amounting to 348 mAh·g^(-1)and 656 Wh·kg^(-1),respectively.This study offers a novel approach to enhancing the electrochemical performance of FeS_(2)in high-temperature molten salt electrochemical systems(thermal batteries),thereby laying a solid foundation for its potential practical application.
基金supported by National Major Scientific Research Instrument Development Project of China(No.51927804)Science Fund for Shaanxi Provincial Department of Education's Youth Innovation Team Research Plan under Grant(No.23JP169).
文摘In machine vision,elliptical targets frequently appear within the camera's region of interest(ROI).Ellipse detection is essential for shape detection and geometric measurements in machine vision.However,existing ellipse detection algorithms often face issues such as high computational complexity,strong dependence on initial conditions,sensitivity to noise,and lack of robustness to occlusions.In this paper,we propose a fast and robust ellipse detection method to address these challenges.This method first utilizes edge gradient and curvature information to segment the curve into circular arcs.Next,based on the convexity of the arcs,it divides them into different quadrants of the ellipse,groups and fits the arcs according to multiple geometric constraints at a low computational cost.Finally,it reduces the parameter space for hierarchical clustering and then segments the complete ellipse into several sectors for verification.We compare our method across seven datasets,including five public image datasets and two from industrial camera scenes.Experimental results show that our method achieves a precision ranging from 67.1%to 98.9%,a recall ranging from 48.1%to 92.9%,and an F-measure ranging from 58.0%to 95.8%.The average execution time per image ranges from 25 ms to 192 ms,demonstrating both high accuracy and efficiency.
基金supported by the National Natural Science Foundation of China(No.22306076)the Natural Science Foundation of Jiangsu Province(No.BK20230676)the Natural Science Foundation of Jiangsu Higher Education Institutions of China(No.22KJB610011).
文摘Here,a novel real-time monitoring sensor that integrates the oxidation of peroxymonosulfate(PMS)and the in situ monitoring of the pollutant degradation process is proposed.Briefly,FeCo@carbon fiber(FeCo@CF)was utilized as the anode electrode,while graphite rods served as the cathode electrode in assembling the galvanic cell.The FeCo@CF electrode exhibited rapid reactivity with PMS,generating reactive oxygen species that efficiently degrade organic pollutants.The degradation experiments indicate that complete bisphenol A(BPA)degradation was achieved within 10 min under optimal conditions.The real-time electrochemical signal was measured in time during the catalytic reaction,and a linear relationship between BPA concentration and the real-time charge(Q)was confirmed by the equation ln(C0/C)=4.393Q(correlation coefficients,R^(2)=0.998).Furthermore,experiments conducted with aureomycin and tetracycline further validated the effectiveness of the monitoring sensor.First-principles investigation confirmed the superior adsorption energy and improved electron transfer in FeCo@CF.The integration of pollutant degradation with in situ monitoring of catalytic reactions offers promising prospects for expanding the scope of the monitoring of catalytic processes and making significant contributions to environmental purification.
基金financial support from the Science Research Program Project for Drug Regulation,Jiangsu Drug Administration,China(Grant No.:202207)the National Drug Standards Revision Project,China(Grant No.:2023Y41)+1 种基金the National Natural Science Foundation of China(Grant No.:22276080)the Foreign Expert Project,China(Grant No.:G2022014096L).
文摘Analyzing polysorbate 20(PS20)composition and the impact of each component on stability and safety is crucial due to formulation variations and individual tolerance.The similar structures and polarities of PS20 components make accurate separation,identification,and quantification challenging.In this work,a high-resolution quantitative method was developed using single-dimensional high-performance liquid chromatography(HPLC)with charged aerosol detection(CAD)to separate 18 key components with multiple esters.The separated components were characterized by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UHPLC-Q-TOF-MS)with an identical gradient as the HPLC-CAD analysis.The polysorbate compound database and library were expanded over 7-time compared to the commercial database.The method investigated differences in PS20 samples from various origins and grades for different dosage forms to evaluate the composition-process relationship.UHPLC-Q-TOF-MS identified 1329 to 1511 compounds in 4 batches of PS20 from different sources.The method observed the impact of 4 degradation conditions on peak components,identifying stable components and their tendencies to change.HPLC-CAD and UHPLC-Q-TOF-MS results provided insights into fingerprint differences,distinguishing quasi products.
基金supported by the National Natural Science Foundation of China (Nos. 21472246 and 81321004)the Beijing Natural Science Foundation (No. 7152097)National Mega-Project for Innovation Drugs (No. 2012ZX09103101-037)
文摘A new series of 12-benzyl matrinic amide/ethanamide derivatives were synthesized from matrinine（1）and evaluated for their anti-HCV activity,taking compound 2 as the lead.SAR revealed that the introduction of a suitable substituent at the N’-end of matrinic amide might greatly enhance the potency.Among them,matrinic acid 17 and N’-substituted matrinic amides 18a-d exhibited promising potency with low micromolar EC50 values ranging from 1.03μmol/L to 7.54 μmol/L,and better therapeutic window with SI from 66 to 132.Moreover,compound 17 displayed an excellent PK and safety profile in vivo,demonstrating good drug-like characteristics.Thus,it has been selected for further investigation,with an advantage of decreased chances of inducing drug-resistance mutations.
基金supported by the National Natural Science Foundation of China(21503096,21407067)the Natural Science Foundation of Educational Committee of Anhui Province(KJ2018A0387),ChinaProject of Anhui Province for Excellent Young Talents in Universities(gxyq2019029),China
文摘Photocatalytic H2 production and CO2 reduction have attracted considerable attention for clean energy development.In this work,we designed an efficient photocatalyst by integrating lamellar oxygen-doped carbon nitride(CNO)nanosheets into ZnIn2S4(ZIS)microflowers by a one-step hydrothermal method.A well-fitted 2D hierarchical hybrid heterostructure was fabricated.Under visible light irradiation,the ZIS@CNO composite with 40 wt%CNO(ZC 40%)showed the highest hydrogen evolution rate from water(188.4μmol·h-1),which was approximately 2.1 times higher than those of CNO and ZIS(88.6 and 90.2μmol·h-1,respectively).Furthermore,the selective CO production rates of ZC 40%(12.69μmol·h-1)were 2.2 and 14.0 times higher than those of ZIS(5.85μmol·h-1)and CNO(0.91μmol·h-1),respectively,and the CH4 production rate of ZC 40%was 1.18μmol·h-1.This enhanced photocatalytic activity of CNO@ZIS is due mainly to the formation of a heterostructure that can promote the transfer of photoinduced electrons and holes between CNO and ZIS,thereby efficiently avoiding recombination of electron-hole pairs.
基金financially supported by the China National Natural Science Foundation(No.21908085)China Postdoctoral Science Foundation(No.2022M711686)Jiangsu Provincial Founds for the Young Scholars(No.BK20190961)。
文摘Photothermal material applied in environmental governance has attracted growing attention.By combining the Stober method and dopamine-triggered coating strategy,Co-Mn precursor was in situ incorporated into the poly dopamine(PDA)layer over the surface of silica cores.Afterwards,a unique photothermal nanosphere with SiO_(2)core and thin carbon layer and dual Co-Mn oxides shell was allowed to form by sequential heat treatment in the inert atmosphere(SiO_(2)@CoMn/C).The bimetallic fraction of Co/Mn in the carbon layer and post-treatment calcination temperature was comprehensively tuned to optimize the peroxymonosulfate(PMS)activation performance of the catalyst.The state of bimetallic species was studied including their physical distribution,chemical valence,and interplay by various characterizations.Impressively,Co oxides appear as dominant monodispersed nanoparticles(~10 nm),while Mn with cluster-like morphology is observed to uniformly distribute over thin-layer carbon and adhered to the surface of SiO_(2)nanospheres(~250 nm).The calcined temperature could tune the oxidized state of Co species,leading to the optimization of the catalytic performance of introduced dual metal species.As a result,this obtained optimal catalyst integrated the advantages of exposed bimetallic CoMn species and N-doped thin carbon to deliver excellent catalytic PMS activation performance and photothermal synergetic catalytic mineralization ability for diversiform pollutants.Further reactions condition controls and anion interference studies were conducted to identify the adaptability of the optimal catalyst.Moreover,the application of solar-driven interfacial water evaporation using optimal SiO_(2)@Co_3Mn_1/C-600 catalyst was explored,showing a high water evaporation rate of 1.48 kg·m^(-2)·h^(-1)and an efficiency of 95.2%,further revealing a comprehensive governance functionality of obtained material in the complex pollution condition.
基金financially supported by the China National Natural Science Foundation(No.201808085)the National Key Research and Development Program of China(No.2022YFB3504100)+2 种基金Jiangsu Provincial Founds for Young Scholars(No.BK20190961)the Natural Science Foundation of Jiangsu Higher Education Institutions of China(No.22KJB610012)the International Cooperation Foundation for the Chunhui Plan Program of Ministry of Education of China(No.HZKY20220136)。
文摘The development of effective and sustainable solutions for pleiotropic water purification becomes urgent and attractive.Heterogeneous Fenton-like catalysts for activation of peroxymonosulfate(PMS)to purify organic wastewater show great promise.In this work,by tuning metal loading with an in-situ polydopamine coating strategy,oxygen vacancy-enriched Co_(3)O_(4) loading on N-doped carbon nanotubes(CNTs)were constructed to enhance PMS activation efficiency for pollutants degradation.Impressively,the obtained modified CNTs afford a well-developed N-containing network structure,which is further endowed with abundant Co(Ⅱ)/Co(Ⅲ)redox cycles and significant metal-carbon interactions.In particular,the surface N doping in CNTs might induce the oriented enrichment of pollutants around the catalyst,which reduces the migration distance and correspondingly improves the utilization of reactive oxidative species.The electron transfer efficiency of the catalyst can be further improved by incorporating oxygen vacancy-enriched Co_(3)O_(4).The performance results show that the optimal NC/Co-1 could mineralize 20×10^(-6)of bisphenol A(BPA)by almost 98%in 8 min.A low reaction activation energy(26.05 kJ·mol^(-1))in BPA degradation was demonstrated by the NC/Co-1.More importantly,NC/Co-1 can inherit excellent degradation performance towards oxytetracycline,2,4-dichlorophenol,and tetracycline,showing wide practical flexibility.In addition,by virtue of the photothermal conversion property,NC/Co-1 achieves an additive function for interfacial solar water evaporation(1.84 kg·m^(-2)·h^(-1),112.51%),showing impressive potential for clean water recovery under complicated environmental pollution conditions.
基金the financial support from the National Natural Science Foundation of China(Nos.31901799,21705060,21605105 and 32001804)the Natural Science Foundation of Jiangsu Province,China(Nos.BK20211340 and BK20180979)+1 种基金Opening Project of Key Laboratory of Impurity Spectrum of Chemical Drug,China(No.NMPA-KLIPCD-2020-09)the Emerging science and technology innovation team funding of JUST(No.1182921902)。
文摘In recent years,Fe_(3)O_(4)nanomaterials have received much attention in analytical chemistry due to their excellent magnetic and peroxidase-like activity.As the catalytic characteristics of Fe_(3)O_(4)nanomaterials is similar to those of horseradish peroxidase(HRP),Fe_(3)O_(4)nanomaterials are also used as peroxidase mimics and have achieved a certain development in many fields based on latest research results.To improve the stability and catalytic ability of simple Fe_(3)O_(4)nanomaterials,various modification strategies of Fe_(3)O_(4)nanomaterials have been developed.The recent advances of these strategies have been presented and discussed.In addition,this paper introduces the application of Fe_(3)O_(4)nanozymes in the detection of food and industrial pollutants,as well as in the field of biosafety.
基金support from the National Natural Science Foundation of China(Nos.22276080,21605105)the Foreign Expert Project,China(No.G2022014096L)+1 种基金the Natural Science Foundation of Jiangsu Province,China(No.BK20211340)Graduate Research and Practice Innovation Program of Jiangsu Province,China(No.KYCX22_3835).
文摘Owing to the serious potential side-effects on the environment and human health,the rapid detection and removal of antibiotics have become an important research focus.In this work,four zinc-based metal-organic frameworks(MOFs)with different functional groups,i.e.,Zn-MOF,Zn-MOF-CH_(3),Zn-MOF-NO_(2),Zn-MOF-COOH,were utilized for the construction of LDO/MOF composite materials with a nickel-iron-cobalt-based layered double oxide,NiFeCo-LDO.The results showed that the LDO/MOF composites not only had high sensitivity in detecting sulfonamide and quinolone antibiotics,but also had an appreciable ability to adsorb them from wastewater.The maximum adsorption capacities of all the four types of LDO@Zn-MOFs to all antibiotics can at least reach 150 mg/g,and the limits of detection in relation to all four antibiotics were at least as low as 100μg/L.Our work suggested the dual-function extraction performance can be attributed to the synergistic effects between the LDO and the MOFs.Moreover,the strong ferromagnetism derived from the LDO provided great convenience for the separation and regeneration of the LDO/MOF composites.
文摘Severe sex ratio imbalance at birth is now becoming an important issue in several Asian countries. Its leading immediate cause is prenatal sex-selective abortion following illegal sex identification by ultrasound scanning. In this paper, a fast automatic recognition and location algorithm for fetal genital organs is proposed as an effective method to help prevent ultrasound technicians from unethically and illegally identifying the sex of the fetus. This automatic recognition algorithm can be divided into two stages. In the 'rough' stage, a few pixels in the image, which are likely to represent the genital organs, are automatically chosen as points of interest (POIs) according to certain salient characteristics of fetal genital organs. In the 'fine' stage, a specifically supervised learning framework, which fuses an effective feature data preprocessing mechanism into the multiple classifier architecture, is applied to every POI. The basic classifiers in the framework are selected from three widely used classifiers: radial basis function network, backpropagation network, and support vector machine. The classification results of all the POIs are then synthesized to determine whether the fetal genital organ is present in the image, and to locate the genital organ within the positive image. Experiments were designed and carried out based on an image dataset comprising 658 positive images (images with fetal genital organs) and 500 negative images (images without fetal genital organs). The experimental results showed true positive (TP) and true negative (TN) results from 80.5% (265 from 329) and 83.0% (415 from 500) of samples, respectively. The average computation time was 453 ms per image.
