Additive manufactured titanium alloys exhibit distinct microstructures and internal defects compared to forged alloys.This has a significant impact on its fatigue failure behavior and fatigue life distribution.Fatigue...Additive manufactured titanium alloys exhibit distinct microstructures and internal defects compared to forged alloys.This has a significant impact on its fatigue failure behavior and fatigue life distribution.Fatigue life dispersity and distribution characteristics of laser direct energy deposited Ti-6.5Al-3.5Mo-1.5Zr-0.3Si alloy were investigated by a relatively large sample fatigue test,fracture morphology characterization,and statistical analytic method.Then,the intrinsic causes of fatigue life dispersity and distribution characteristics were clarified by correlating with fatigue failure origin modes(FFOMs).The test and analysis results indicate that the existence of internal pores significantly influences FFOMs,fatigue life dispersity,and distribution pattern.The FFOMs of microstructure and interior pores have little effect on fatigue life dispersion,In contrast,FFOMs of surface and subsurface pores present a relatively lower fatigue life and are responsible for fatigue life dispersion.Besides,two competitive effects of FFOMs with different applied stress highly affect fatigue life distribution.A bimodal Weibull model is more suitable for describing fatigue life distribution with multiple FFOMs.However,if there is no fast-computing procedure for the parameter estimation of the Bimodal Weibull model,relatively conservative and simple P-S-N curves based on the Weibull distribution model are recommended in engineering applications.展开更多
Objective:To observe the efficacy and safety of stereotactic body radiotherapy(SBRT)in the treatment of extracranial oligometastases.Method:A retrospective analysis of 70 patients with extracranial oligometastasis of ...Objective:To observe the efficacy and safety of stereotactic body radiotherapy(SBRT)in the treatment of extracranial oligometastases.Method:A retrospective analysis of 70 patients with extracranial oligometastasis of malignant tumors who underwent SBRT in our hospital(Shaanxi Provincial People’s Hospital)from January 2019 to December 2021 with≤5 metastases,≤3 metastatic organs,and metastases with diameters of≤5 cm.According to the clinical data of patients,the dose-fractionation mode of SBRT is mainly determined according to the pathology of the primary tumor,the location of the metastatic tumor,and the important structures around the tumor.The local control,survival and adverse reactions were observed.Results:A total of 219 oligometastatic lesions in 70 patients were treated with SBRT.The median follow-up time was 24 months(12-40 months).The local control rate(LCR)of all target lesions assessed 3 months after radiotherapy was 94.1%;the 1-,2-,and 3-year LCRs were 88.6%,74.6%,and 64.9%,respectively.The median progression-free survival(PFS)was 11.8 months(95%CI,8.9-14.7 months),and the 1-and 2-year PFS rates were 48.6%and 32.6%,respectively;the median overall survival(OS)was 31.9 month(95%CI 26.0-37.8 months),the 1-year OS rate was 84.3%.The local control time,PFS,and OS of patients with metastases≤3 cm were significantly better than those with metastases>3 cm,and the differences were statistically significant(P<0.05).Acute adverse reactions after SBRT treatment in oligometastatic patients were mainly bone marrow suppression and gastrointestinal reactions,with incidence rates of 48.98%and 30.61%,respectively;chronic adverse reactions were mainly pain(bone,muscle),radiation enteritis,and radiation pneumonitis,with incidence rates of 38.57%,30.00%,and 24.29%,respectively.The treatment-related adverse reactions were mainly grade 1,which were all improved after symptomatic treatment,except for one patient with bone metastases from lung cancer who had grade 4 myelosuppression.No grade 4 or 5 adverse events occurred in the other patients.Conclusion:The application of SBRT in the treatment of extracranial oligometastases is safe,effective,and has high tolerability.展开更多
The development of the Internet of Things(IoT)has rapidly progressed,revolutionizing numerous industries and transforming how we interact with technology.IoT relies on seamless connectivity between devices,allowing th...The development of the Internet of Things(IoT)has rapidly progressed,revolutionizing numerous industries and transforming how we interact with technology.IoT relies on seamless connectivity between devices,allowing them to collect,share,and analyze data.As a result,compatibility and connectivity have become major concerns for customers adopting smart devices.Achieving compatibility in a smart device is a shared responsibility between the IoT platform provider and the smart device manufacturer.However,the impact of their respective efforts on smart device compatibility depends on investment efficiency and the service level.In this study,we develop a game-theoretical model to examine how investment efficiency affects the incentives of the upstream platform and the downstream manufacturer to exert compatibility efforts under the licensing pricing and revenue sharing models in a supply chain setting.Our findings indicate that,given a certain IoT platform service level,a manufacturer’s effort decreases as the relative weight decreases in the licensing pricing model.Additionally,when the platform’s effort cost is lower,the platform can invest more in compatibility,thereby improving the compatibility of smart devices.In such cases,the manufacturer can benefit from the platform’s incentives to exert compatibility efforts by reducing her efforts.We also identify two effects:the compatibility effect and the service value-added effect.When the relative weight of compatibility is small,the role of platform compatibility diminishes.Consequently,the platform cannot increase technology licensing fees to augment IoT service income,reducing profits.Our results also provide insights into how an IoT platform provider can strategically target a particular IoT service based on their cost characteristics and service level in smart device supply chains.展开更多
基金supported by the National Natural Science Foundation of China(Nos.51775018&52090044)。
文摘Additive manufactured titanium alloys exhibit distinct microstructures and internal defects compared to forged alloys.This has a significant impact on its fatigue failure behavior and fatigue life distribution.Fatigue life dispersity and distribution characteristics of laser direct energy deposited Ti-6.5Al-3.5Mo-1.5Zr-0.3Si alloy were investigated by a relatively large sample fatigue test,fracture morphology characterization,and statistical analytic method.Then,the intrinsic causes of fatigue life dispersity and distribution characteristics were clarified by correlating with fatigue failure origin modes(FFOMs).The test and analysis results indicate that the existence of internal pores significantly influences FFOMs,fatigue life dispersity,and distribution pattern.The FFOMs of microstructure and interior pores have little effect on fatigue life dispersion,In contrast,FFOMs of surface and subsurface pores present a relatively lower fatigue life and are responsible for fatigue life dispersion.Besides,two competitive effects of FFOMs with different applied stress highly affect fatigue life distribution.A bimodal Weibull model is more suitable for describing fatigue life distribution with multiple FFOMs.However,if there is no fast-computing procedure for the parameter estimation of the Bimodal Weibull model,relatively conservative and simple P-S-N curves based on the Weibull distribution model are recommended in engineering applications.
基金Shaanxi Provincial People’s Hospital 2022 Science and Technology Talent Support Program Funding Project-Elite Talents(2022JY-08)Shaanxi Province Key Research and Development Plan(2021SF-306)。
文摘Objective:To observe the efficacy and safety of stereotactic body radiotherapy(SBRT)in the treatment of extracranial oligometastases.Method:A retrospective analysis of 70 patients with extracranial oligometastasis of malignant tumors who underwent SBRT in our hospital(Shaanxi Provincial People’s Hospital)from January 2019 to December 2021 with≤5 metastases,≤3 metastatic organs,and metastases with diameters of≤5 cm.According to the clinical data of patients,the dose-fractionation mode of SBRT is mainly determined according to the pathology of the primary tumor,the location of the metastatic tumor,and the important structures around the tumor.The local control,survival and adverse reactions were observed.Results:A total of 219 oligometastatic lesions in 70 patients were treated with SBRT.The median follow-up time was 24 months(12-40 months).The local control rate(LCR)of all target lesions assessed 3 months after radiotherapy was 94.1%;the 1-,2-,and 3-year LCRs were 88.6%,74.6%,and 64.9%,respectively.The median progression-free survival(PFS)was 11.8 months(95%CI,8.9-14.7 months),and the 1-and 2-year PFS rates were 48.6%and 32.6%,respectively;the median overall survival(OS)was 31.9 month(95%CI 26.0-37.8 months),the 1-year OS rate was 84.3%.The local control time,PFS,and OS of patients with metastases≤3 cm were significantly better than those with metastases>3 cm,and the differences were statistically significant(P<0.05).Acute adverse reactions after SBRT treatment in oligometastatic patients were mainly bone marrow suppression and gastrointestinal reactions,with incidence rates of 48.98%and 30.61%,respectively;chronic adverse reactions were mainly pain(bone,muscle),radiation enteritis,and radiation pneumonitis,with incidence rates of 38.57%,30.00%,and 24.29%,respectively.The treatment-related adverse reactions were mainly grade 1,which were all improved after symptomatic treatment,except for one patient with bone metastases from lung cancer who had grade 4 myelosuppression.No grade 4 or 5 adverse events occurred in the other patients.Conclusion:The application of SBRT in the treatment of extracranial oligometastases is safe,effective,and has high tolerability.
基金supported in part by International Chinese Language Education Research Foundation of Ministry of Education of China,under Grant No.23YH39DPhilosophical and Social Science Planning Project of Tianjin,under grants No.TJGLQN23-006。
文摘The development of the Internet of Things(IoT)has rapidly progressed,revolutionizing numerous industries and transforming how we interact with technology.IoT relies on seamless connectivity between devices,allowing them to collect,share,and analyze data.As a result,compatibility and connectivity have become major concerns for customers adopting smart devices.Achieving compatibility in a smart device is a shared responsibility between the IoT platform provider and the smart device manufacturer.However,the impact of their respective efforts on smart device compatibility depends on investment efficiency and the service level.In this study,we develop a game-theoretical model to examine how investment efficiency affects the incentives of the upstream platform and the downstream manufacturer to exert compatibility efforts under the licensing pricing and revenue sharing models in a supply chain setting.Our findings indicate that,given a certain IoT platform service level,a manufacturer’s effort decreases as the relative weight decreases in the licensing pricing model.Additionally,when the platform’s effort cost is lower,the platform can invest more in compatibility,thereby improving the compatibility of smart devices.In such cases,the manufacturer can benefit from the platform’s incentives to exert compatibility efforts by reducing her efforts.We also identify two effects:the compatibility effect and the service value-added effect.When the relative weight of compatibility is small,the role of platform compatibility diminishes.Consequently,the platform cannot increase technology licensing fees to augment IoT service income,reducing profits.Our results also provide insights into how an IoT platform provider can strategically target a particular IoT service based on their cost characteristics and service level in smart device supply chains.
