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免疫相关不良事件在肺癌中发生和结局的真实世界研究 被引量:8
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作者 崔少华 葛晓晓 李向阳 《中国肺癌杂志》 CAS CSCD 北大核心 2023年第4期257-264,共8页
背景与目的免疫相关不良事件(immune-related adverse events,ir AEs)常发生于免疫检查点抑制剂应用的患者,但关于肺癌中ir AEs发生和结局的国内证据相对缺乏。本研究旨在评估中国肺癌患者接受免疫治疗后ir AEs的发生和转归。方法纳入2... 背景与目的免疫相关不良事件(immune-related adverse events,ir AEs)常发生于免疫检查点抑制剂应用的患者,但关于肺癌中ir AEs发生和结局的国内证据相对缺乏。本研究旨在评估中国肺癌患者接受免疫治疗后ir AEs的发生和转归。方法纳入2018年1月-2021年9月在复旦大学附属华东医院接受过至少1次免疫检查点抑制剂治疗的肺癌患者的临床和随访资料,通过统计描述、Kaplan-Meier等方法分析ir AEs总体发生情况及各类ir AEs的发生与结局。结果共纳入135例患者,106例(78.5%)至少发生一种ir AEs,首次发生的中位时间为28 d。多数ir AEs发生于治疗早期,多为轻-中度、可恢复。57例(42.2%)患者死亡;严重ir AEs致死率为12.6%(n=17),其中7例(41.2%)死于肺炎。整体人群的中位无进展生存期(progression-free survival,PFS)为505 d(95%CI:352-658),中位总生存期(overall survival,OS)为625 d(95%CI:491-759)。发生任一ir AEs患者的PFS长于治疗未发生者(中位PFS分别为533d和179d,P=0.037;HR=0.57);发生皮肤毒性者的OS长于未发生者(中位OS分别为797d和469d,P=0.006;HR=0.70)。结论真实世界中肺癌患者ir AEs普遍发生,其中肺炎为最常见的致死性ir AEs,发生ir AEs患者群体存在PFS上的优势。 展开更多
关键词 肺肿瘤 免疫相关不良事件 免疫治疗 生存期
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Balancing Bus Punctuality and Heterogeneous Flow Stability Under a Connected Environment
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作者 Lichao Wang Ziyi Zhou shaohua cui 《Automotive Innovation》 2025年第3期724-738,共15页
Previous studies on the collaborative control of signals and vehicles—including both connected autonomous vehicles and connected autonomous buses(CABs)—in networked intersections predominantly emphasized enhancing t... Previous studies on the collaborative control of signals and vehicles—including both connected autonomous vehicles and connected autonomous buses(CABs)—in networked intersections predominantly emphasized enhancing the stability of heterogeneous flows to augment intersection efficiency.However,these studies often overlooked the crucial criterion of CAB punctuality.Addressing this significant gap,the present paper introduces a CAB travel time estimation model and a punctuality evaluation index into optimization problems to ensure the adherence to bus schedules.A mixed integer linear programming model,incorporating binary signal state variables,is established with the goals of heterogeneous platoon operation stability,bus arrival punctuality,and intersection efficiency.To ensure efficient model resolution,binary auxiliary logic variables are employed to linearize the relationship between signal transitions and the operational state of the heterogeneous flow.An evaluation is conducted using a standard four-arm intersection,wherein parameters like CAB proportions and overall traffic volume are varied for comprehensive testing.Simulation outcomes compellingly show that the proposed approach markedly improves CAB punctuality and diminishes energy consumption by enhancing heterogeneous flow stability.Specifically,there is an average increase of 22.3%in punctuality and a reduction of at least 15.1%in energy consumption. 展开更多
关键词 Bus punctuality Heterogeneous flow stability Connected environment Optimized control
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Evaluating the sustainability of electric buses during operation via field data
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作者 Baozhen Yao Zhihao Qi +4 位作者 Ziqi Liu Minke Zhu shaohua cui Radu-Emil Precup Raul-Cristian Roman 《Journal of Intelligent and Connected Vehicles》 2025年第3期17-33,共17页
Environmental sustainability is a crucial issue for all human beings,and vehicle emissions significantly contribute to climate change.This has prompted many countries,including China,Norway,and Germany,to focus on ele... Environmental sustainability is a crucial issue for all human beings,and vehicle emissions significantly contribute to climate change.This has prompted many countries,including China,Norway,and Germany,to focus on electrifying transportation.This study quantifies the life cycle carbon dioxide(CO_(2))emissions of electric buses(EBs)in Guangzhou,China,via a life cycle analysis methodology,revealing an average life cycle emission of 1,097.07 g CO_(2)·km−1·vehicle−1.The operation and charging stage contributes the most to the lifespan of CO_(2)emissions at 69.6%,driven by carbon-intensive power grid.Compared with conventional internal combustion engine buses,EBs result in significant emission reductions,but regional grid carbon intensity variations across China mean that their benefits depend on nationwide green energy adoption.By 2030,emissions are projected to decline by 15.28%,aligning with carbon peak goals.The findings emphasize that transitioning to renewable energy grids and hybrid technologies is critical for sustainable transportation. 展开更多
关键词 EBS GHG emissions life cycle analysis(LCA) electrification of transportation
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Data-driven rolling eco-speed optimization for autonomous vehicles
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作者 Ying YANG Kun GAO +3 位作者 shaohua cui Yongjie XUE Arsalan NAJAFI Jelena ANDRIC 《Frontiers of Engineering Management》 CSCD 2024年第4期620-632,共13页
In urban settings,fluctuating traffic conditions and closely spaced signalized intersections lead to frequent emergency acceleration,deceleration,and idling in vehicles.These maneuvers contribute to elevated energy us... In urban settings,fluctuating traffic conditions and closely spaced signalized intersections lead to frequent emergency acceleration,deceleration,and idling in vehicles.These maneuvers contribute to elevated energy use and emissions.Advances in vehicle-to-vehicle and vehicleto-infrastructure communication technologies allow autonomous vehicles(AVs)to perceive signals over long distances and coordinate with other vehicles,thereby mitigating environmentally harmful maneuvers.This paper introduces a data-driven algorithm for rolling eco-speed optimization in AVs aimed at enhancing vehicle operation.The algorithm integrates a deep belief network with a back propagation neural network to formulate a traffic state perception mechanism for predicting feasible speed ranges.Fuel consumption data from the Argonne National Laboratory in the United States serves as the basis for establishing the quantitative correlation between the fuel consumption rate and speed.A spatiotemporal network is subsequently developed to achieve eco-speed optimization for AVs within the projected speed limits.The proposed algorithm results in a 12.2%reduction in energy consumption relative to standard driving practices,without a significant extension in travel time. 展开更多
关键词 data-driven learning speed optimization autonomous vehicles energy saving
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