The SnCo1-xFex/C （x=0.1, 0.2, 0.3, 0.4） composites as novel anode materials for lithium-ion batteries with large capacity were prepared by ball milling first and then solid-state sintering. The influences of the par...The SnCo1-xFex/C （x=0.1, 0.2, 0.3, 0.4） composites as novel anode materials for lithium-ion batteries with large capacity were prepared by ball milling first and then solid-state sintering. The influences of the partial substitution of inert metal Fe for Co on material structures and the electrochemical properties were investigated. Structure analyses show that the uniform solid dissolution of Fe into CoSn phase promotes the formation of CoSn2 impurity phase. With the growth of x, the cell volumes of CoSn phase is enlarged, the grain size decreases and the content of CoSn2 increases. Carbon black is mainly physically mixed with other phases on the surface of particles. Electrochemical analyses reveal that the reversible capacity and cycle performance are both improved through the introduction of Fe. When x is 0.2, the cycle performance is up to the maximum, 85.1% of the reversible capacity after 50 cycles. During cycling, among SnCo/C, SnCo0.8Fe0.2/C and SnCo0.6Fe0.4/C samples, the grain size of CoSn phase for SnCo0.8Fe0.2/C sample increases leastly. It is usually believed that the comprehensive effects of grain size, structure stability and impurity-phase content lead to the maximum of the cycle performance at appropriate content of Fe （x=0.2）.展开更多
Several cases such as myeloproliferative neoplasms(MPN)with the coexistence of JAK2 and BCR-ABL have been reported.However,cases of transformation of essential thrombocythemia(ET)into chronic myeloid leukemia(CML)duri...Several cases such as myeloproliferative neoplasms(MPN)with the coexistence of JAK2 and BCR-ABL have been reported.However,cases of transformation of essential thrombocythemia(ET)into chronic myeloid leukemia(CML)during the disease progression were rarely reported.Here,we report the case of a patient with JAK2 V617F-positive ET who subsequently acquired BCR–ABL1,which transformed the disease into CML after 10 years from the initial diagnosis.In this study,we dynamically monitored JAK2 V617F and BCR-ABL and observed multiple gene mutations,including IDH2,IDH1,ASXL1,KRAS,and RUNX1.It is important to be aware of this potentially clone evolution in disease progression.展开更多
Neuronostatin(NST)is a peptide encoded by the somatostatin gene that serves important physiological functions in diverse tissues.Previous studies have shown that intracerebroventricular administration of NST induces a...Neuronostatin(NST)is a peptide encoded by the somatostatin gene that serves important physiological functions in diverse tissues.Previous studies have shown that intracerebroventricular administration of NST induces antinociceptive effects and hyperalgesic effects as determined by the tail immersion assay and formalin test,respectively.In the present study,we aimed to evaluate the effects of intrathecal(i.t.)injection of NST on nociception in a model of visceral pain,and determine possible mechanisms of action in mice.NST(1,3,6,or 12 nmol)was administered to mice,leading to a dose-dependent antinociceptive effect as determined by the acetic acid-induced writhing test in mice.NST(1 nmol)also enhanced the antinociceptive effect of morphine(2.5 and 5μg/kg)in the spine.Naloxone andβ-funaltrexamine hydrochloride significantly antagonized the antinociceptive effect of NST.The expression of G-protein-coupled receptor 107(GPR107)protein and the phosphorylation of PKA at Thr197 were increased after i.t.administration of NST,suggesting that theμ-opioid receptor and GPR107/PKA signaling pathway are involved in the analgesic response.In conclusion,i.t.injection of NST may potentially be used as a new approach in the mediation of visceral pain.展开更多
基金supported by the Natural ScienceFoundation of Liaoning Province(No.20072206)
文摘The SnCo1-xFex/C （x=0.1, 0.2, 0.3, 0.4） composites as novel anode materials for lithium-ion batteries with large capacity were prepared by ball milling first and then solid-state sintering. The influences of the partial substitution of inert metal Fe for Co on material structures and the electrochemical properties were investigated. Structure analyses show that the uniform solid dissolution of Fe into CoSn phase promotes the formation of CoSn2 impurity phase. With the growth of x, the cell volumes of CoSn phase is enlarged, the grain size decreases and the content of CoSn2 increases. Carbon black is mainly physically mixed with other phases on the surface of particles. Electrochemical analyses reveal that the reversible capacity and cycle performance are both improved through the introduction of Fe. When x is 0.2, the cycle performance is up to the maximum, 85.1% of the reversible capacity after 50 cycles. During cycling, among SnCo/C, SnCo0.8Fe0.2/C and SnCo0.6Fe0.4/C samples, the grain size of CoSn phase for SnCo0.8Fe0.2/C sample increases leastly. It is usually believed that the comprehensive effects of grain size, structure stability and impurity-phase content lead to the maximum of the cycle performance at appropriate content of Fe （x=0.2）.
文摘Several cases such as myeloproliferative neoplasms(MPN)with the coexistence of JAK2 and BCR-ABL have been reported.However,cases of transformation of essential thrombocythemia(ET)into chronic myeloid leukemia(CML)during the disease progression were rarely reported.Here,we report the case of a patient with JAK2 V617F-positive ET who subsequently acquired BCR–ABL1,which transformed the disease into CML after 10 years from the initial diagnosis.In this study,we dynamically monitored JAK2 V617F and BCR-ABL and observed multiple gene mutations,including IDH2,IDH1,ASXL1,KRAS,and RUNX1.It is important to be aware of this potentially clone evolution in disease progression.
基金funded by the Natural Science Foundation of Gansu Province(Grant No.18JR3RA101)Youth Science and Technology Talents Lifting Project Foundation of Gansu Provincethe Doctoral Launching Foundation of Northwest Normal University
文摘Neuronostatin(NST)is a peptide encoded by the somatostatin gene that serves important physiological functions in diverse tissues.Previous studies have shown that intracerebroventricular administration of NST induces antinociceptive effects and hyperalgesic effects as determined by the tail immersion assay and formalin test,respectively.In the present study,we aimed to evaluate the effects of intrathecal(i.t.)injection of NST on nociception in a model of visceral pain,and determine possible mechanisms of action in mice.NST(1,3,6,or 12 nmol)was administered to mice,leading to a dose-dependent antinociceptive effect as determined by the acetic acid-induced writhing test in mice.NST(1 nmol)also enhanced the antinociceptive effect of morphine(2.5 and 5μg/kg)in the spine.Naloxone andβ-funaltrexamine hydrochloride significantly antagonized the antinociceptive effect of NST.The expression of G-protein-coupled receptor 107(GPR107)protein and the phosphorylation of PKA at Thr197 were increased after i.t.administration of NST,suggesting that theμ-opioid receptor and GPR107/PKA signaling pathway are involved in the analgesic response.In conclusion,i.t.injection of NST may potentially be used as a new approach in the mediation of visceral pain.
