Cochlear implantation(CI)offers a dependable treatment for sensorineural hearing loss,with precision electroa-coustic stimulation parameters showing great potential in improving auditory outcomes in CI patients.Here,w...Cochlear implantation(CI)offers a dependable treatment for sensorineural hearing loss,with precision electroa-coustic stimulation parameters showing great potential in improving auditory outcomes in CI patients.Here,we report the attachment of MXene into CI systems which effectively mimic the neural electrode interface due to MXene’s excellent electrical conductivity and biocompatibility.Low-frequency short-term biphasic electrical pulses emitted by the MXenes-based CI promoted the outgrowth of spiral ganglion neuron(SGN)neurites and growth cones,substantially boosting the calcium activity in SGNs.This study lays a theoretical foundation for the precision medicine approaches in CI patient care,and informs the selection of materials for cochlear implant electrode materials in the future.展开更多
基金supported by grants from National Key R&D Program of China(Nos.2020YFA0113600,2021YFA1101300,2021YFA1101800,2020YFA0112503)National Natural Science Foundation of China(Nos.82330033,82030029,92149304,82201292)+7 种基金Natural Science Foundation of Jiangsu Province(BK20232007)Jiangsu Provincial Scientific Research Center of Applied Mathematics(BK20233002)Shenzhen Fundamental Research Program(JCYJ20190814093401920,JCYJ20210324125608022)Open Project Fund of Guangdong Academy of Medical Sciences(YKY-KF202201)Beijing Natural Science Foundation(No.Z200019)China National Postdoctoral Program for Innovative Talent(BX20230070)China Postdoctoral Science Foundation(2023M740606)Jiangsu Funding Program for Excellent Postdoctoral Talent(2023ZB597).
文摘Cochlear implantation(CI)offers a dependable treatment for sensorineural hearing loss,with precision electroa-coustic stimulation parameters showing great potential in improving auditory outcomes in CI patients.Here,we report the attachment of MXene into CI systems which effectively mimic the neural electrode interface due to MXene’s excellent electrical conductivity and biocompatibility.Low-frequency short-term biphasic electrical pulses emitted by the MXenes-based CI promoted the outgrowth of spiral ganglion neuron(SGN)neurites and growth cones,substantially boosting the calcium activity in SGNs.This study lays a theoretical foundation for the precision medicine approaches in CI patient care,and informs the selection of materials for cochlear implant electrode materials in the future.
