In this work,the Invar 36 alloys were manufactured using cold spray(CS)additive manufacturing technique.The systematic investigations were made on the microstructural evolution,thermal expansion and mechanical propert...In this work,the Invar 36 alloys were manufactured using cold spray(CS)additive manufacturing technique.The systematic investigations were made on the microstructural evolution,thermal expansion and mechanical properties under as-sprayed(AS)and heat-treated(HT)conditions.XRD(X-ray diffraction)and ICP-AES(inductively coupled plasma atomic emission spectroscopy)analyses show that no phase transformation,oxidation,nor element content change have occurred.The X-ray computed tomography(XCT)exhibited a near fully dense structure with a porosity of 0.025%in the helium-produced sample under as-sprayed condition,whereas the nitrogen-produced samples produced at 5 MPa and 800℃show more irregular pore defects.He-AS sample shows a more prominent grain refinement than that of nitrogen samples due to the more extensive plastic deformation.The post heat-treatment exhibited a promoted grain growth,inter-particle diffusion,as well as the formation of annealing twins.Between25℃and 200℃,the nitrogen samples possessed lower CTE(coefficient of thermal expansion)values(1.53×10^(-6)/℃)compared with those produced by casting and laser additive manufacturing.The He-AS samples exhibited a noticeable negative CTE value between 25℃and 200℃,which may due to the significant compressive residual stress(-272 MPa)compensating its displacement with temperature increase during CTE test.The N2-HT and He-HT Invar 36 samples present a notable balance between strength and ductility.In conclusion,the CS technique can be considered as a potential method to produce the Invar36 component with high thermal and mechanical performance.展开更多
The Green quasifunction method is employed to solve the free vibration problem of clamped thin plates.A Green quasifunction is established by using the fundamental solution and boundary equation of the problem.This fu...The Green quasifunction method is employed to solve the free vibration problem of clamped thin plates.A Green quasifunction is established by using the fundamental solution and boundary equation of the problem.This function satisfies the homogeneous boundary condition of the problem.The mode shape differential equation of the free vibration problem of clamped thin plates is reduced to Fredholm integral equation of the second kind by Green formula.Irregularity of the kernel of integral equation is overcome by choosing a suitable form of the normalized boundary equation.Two examples demonstrate the validity of the present method.Comparison with both the series solution and ANSYS finite-element solution shows fine agreement.The present method is a novel and effective mathematical one.展开更多
In this article, the NO3 radical-initiated atmospheric oxidation degradation of DDT was theoretically investigated using molecular orbital theory calculations. All the calculations of intermediates, transition states ...In this article, the NO3 radical-initiated atmospheric oxidation degradation of DDT was theoretically investigated using molecular orbital theory calculations. All the calculations of intermediates, transition states and products were performed at the MPWB1K/6-311＋G（3df,2p）//MPWB1K/6- 31＋G（d,p） level of theory. Several energetically favorable reaction pathways were revealed. The formation mechanisms of secondary pollutants were presented and discussed. The rate constants were deduced over the temperature range of 273-333 K using canonical variational transition-state （CVT） theory with the small curvature tunneling （SCT） method. Our study shows that H abstraction from the alkyl group and NO3 addition to the Ca atom of the benzene ring are the dominant reaction pathways. The rate-temperature formula of the overall rate constants is k（T）（DDT＋NO3） = （7.21 ~ 10-15）exp（-153.81/T） cm3/（mol.sec） over the possible atmospheric temperature range of 273-333 K. The atmospheric lifetime of DDT determined by NO3 radical is about 52.5 days, which indicates that it can be degraded in the gas phase within several months.展开更多
Lymph node(LN)metastasis is one of the predominant metastatic routes of non-small cell lung cancer(NSCLC)and is considered as a leading cause for the unsatisfactory prognosis of patients.Although lymphangiogenesis is ...Lymph node(LN)metastasis is one of the predominant metastatic routes of non-small cell lung cancer(NSCLC)and is considered as a leading cause for the unsatisfactory prognosis of patients.Although lymphangiogenesis is well-recognized as a crucial process in mediating LN metastasis,the regulatory mechanism involving lymphangiogenesis and LN metastasis in NSCLC remains unclear.In this study,we employed high-throughput sequencing to identify a novel circular RNA(circRNA),circTLCD4-RWDD3,which was significantly upregulated in extracellular vesicles(EVs)from LN metastatic NSCLC and was positively associated with deteriorated OS and DFS of patients with NSCLC from multicenter clinical cohort.Downregulating the expression of EV-packaged circTLCD4-RWDD3 inhibited lymphangiogenesis and LN metastasis of NSCLC both in vitro and in vivo.Mechanically,circTLCD4-RWDD3 physically interacted with hnRNPA2B1 and mediated the SUMO2 modification at K108 residue of hnRNPA2B1 by upregulating UBC9.Subsequently,circTLCD4-RWDD3-induced SUMOylated hnRNPA2B1 was recognized by the SUMO interaction motif(SIM)of ALIX and activated ALIX to recruit ESCRT-III,thereby facilitating the sorting of circTLCD4-RWDD3 into NSCLC cell-derived EVs.Moreover,EV-packaged circTLCD4-RWDD3 was internalized by lymphatic endothelial cells to activate the transcription of PROX1,resulting in the lymphangiogenesis and LN metastasis of NSCLC.Importantly,blocking EV-mediated transmission of circTLCD4-RWDD3 via mutating SIM in ALIX or K108 residue of hnRNPA2B1 inhibited the lymphangiogenesis and LN metastasis of NSCLC in vivo.Our findings reveal a precise mechanism underlying SUMOylated hnRNPA2B1-induced EV packaging of circTLCD4-RWDD3 in facilitating LN metastasis of NSCLC,suggesting that EV-packaged circTLCD4-RWDD3 could be a potential therapeutic target against LN metastatic NSCLC.展开更多
The low electrical conductivity of sulfur,strong volume expansion,shuttle effect,and sluggish redox reactions in Li-S batteries limit their practical application.MoP nanoparticles encapsulated in nitrogen-doped carbon...The low electrical conductivity of sulfur,strong volume expansion,shuttle effect,and sluggish redox reactions in Li-S batteries limit their practical application.MoP nanoparticles encapsulated in nitrogen-doped carbon nanotubes(MoP/NC NTs)were synthesized using MoO_(3) nanorods as templates via a polypyrrole coating,heat-carbonization,MoO_(3) partial reduction,ammonia washing,and phosphorization.The MoP/NC NTs had a hollow nanostructure with a high specific surface area,which can alleviate the volume expansion of the cathode and the shuttle effect of polysulfides.The encapsulated MoP nanoparticles can anchor the polysulfides and enhance the redox reaction kinetics.Thus,the MoP/NC NTs combined with sulfur(MoP/S/NC NTs)exhibited 440.8 mAh·g^(-1) over 500 cycles at 1.0 A·g^(-1) with a decay rate of 0.06%per cycle.The density functional theory calculations and X-ray photoelectron spectroscopy results confirmed that MoP/NC NTs could anchor polysulfides and alleviate the shuttle effect by chemical interactions.This study supplies a novel route to prepare nanoparticle-embedded in N-doped carbon nanotubes for advanced Li-S battery.展开更多
Background:Cancer remains a major cause of mortality and a significant economic burden in China.Exploring the disparities in cancer patterns and control strategies between China and developed countries may offer valua...Background:Cancer remains a major cause of mortality and a significant economic burden in China.Exploring the disparities in cancer patterns and control strategies between China and developed countries may offer valuable insights for policy formulation and enhance cancer management efforts.This study examined the incidence,mortality,and disability-adjusted life year(DALY)burden of cancer in China,and compared these metrics with those observed in the United States(US)and the United Kingdom(UK).Methods:Data on cancer incidence,mortality,and DALYs for China,the US,and the UK were sourced from the GLOBOCAN 2022 online database and the Global Burden of Disease 2021 study(GBD 2021).We utilized Joinpoint regression models to analyze trends in cancer incidence and mortality across these countries,calculating annual percent changes(APCs)and determining the optimal joinpoints.Results:In 2022,China recorded around 4,824,703 new cancer cases and 2,574,176 cancer-related deaths,contributing to 71,037,170 DALYs.China exhibited a lower cancer incidence rate compared to the US and the UK.Although cancer-related mortality in China is slightly lower than that in the UK,it is significantly higher than that in the US.Additionally,China experienced significantly higher DALY rates compared to both the US and UK.The cancer landscape in China was also undergoing significant changes,with a rapid rise in the incidence and burden of lung,colorectal,breast,cervical,and prostate cancers.Meanwhile,the incidence and burden of stomach cancer continued to decline.Although the incidence of liver and esophageal cancers was decreasing,the burden of liver cancer was increasing,while the burden of esophageal cancer remained largely unchanged.Conclusions:The cancer profile of China is shifting from that of a developing country to one more typical of a developed country.The ongoing population aging and the rise in unhealthy lifestyles are expected to further escalate the cancer burden in China.Consequently,it is crucial for Chinese authorities to revise the national cancer control program,drawing on successful strategies from developed countries,while also accounting for the regional diversity in cancer types across China.展开更多
Objective Adopting a healthy lifestyle,including regular physical activity,is widely believed to decrease cancer risk.This study aimed to quantitatively establish the dose-response relationships between total physical...Objective Adopting a healthy lifestyle,including regular physical activity,is widely believed to decrease cancer risk.This study aimed to quantitatively establish the dose-response relationships between total physical activity and the risk of breast,colon,lung,gastric,and liver cancers.Methods A systematic review and dose-response analysis were conducted using PubMed and Embase from January 1,1980 to March 20,2023.Prospective cohort studies that examined the association between physical activity and the risks of any of the 5 outcomes were included.The search was confined to publications in the English language with a specific focus on human studies.Physical activity is standardized by using the data from US National Health and Nutrition Examination Surveys(NHANES)and the Global Burden of Disease 2019 database.Results A total of 98 studies,involving a combined population of 16,418,361 individuals,were included in the analysis.Among the included studies,57 focused on breast cancer,17 on lung cancer,23 on colon cancer,5 on gastric cancer,and 7 on liver cancer.Overall,elevated levels of physical activity exhibited an inverse correlation with the risk of cancer.The dose-response curve for lung cancer exhibited a non-linear pattern,with the greatest benefit risk reduction observed at 13,200 MET-minutes/week of physical activity,resulting in a 14.7%reduction in risk(relative risk 0.853,uncertainty interval 0.798 to 0.912)compared to the inactive population.In contrast,the dose-response curves for colon,gastric,breast,and liver cancers showed linear associations,indicating that heightened levels of total physical activity were consistently associated with reduced cancer risks.However,the increase in physical activity yielded a smaller risk reduction for colon and gastric cancers compared to breast and liver cancers.Compared to individuals with insufficient activity(total activity level<600 MET-minutes/week),individuals with high levels of activity(≥8,000 MET-minutes/week)experienced a 10.3%(0.897,0.860 to 0.934)risk reduction for breast cancer;5.9%(0.941,0.884 to 1.001)for lung cancer;7.1%(0.929,0.909 to 0.949)for colon cancer;5.1%(0.949,0.908 to 0.992)for gastric cancer;17.1%(0.829,0.760 to 0.903)for liver cancer.Conclusions This study demonstrated a significant inverse relationship between total physical activity and the risk of breast,gastric,liver,colon,and lung cancers.展开更多
1 LYMPHATIC METASTASIS AND LYMPHANGIOGENESIS IN NON-SMALL CELL LUNG CANCER Lung cancer is the 2nd most common and 1st deadliest cancer worldwide[1].It presents an enormous burden on society in China,because of its hig...1 LYMPHATIC METASTASIS AND LYMPHANGIOGENESIS IN NON-SMALL CELL LUNG CANCER Lung cancer is the 2nd most common and 1st deadliest cancer worldwide[1].It presents an enormous burden on society in China,because of its high incidence andmortality rate[2,3].About 80%-85%of lung cancers are non-small cell lung cancer(NSCLC).Lymphatic metastasis is a critical event in disease progression that influences clinical treatment and determines the prognosis for NSCLC[4].展开更多
基金supported financially by the National Key Research and Development Program of China(No.2019YFA0705300)the Guangdong Special Support Program(No.2019BT02C629)+6 种基金the National Natural Science Foundation of China(No.51690160)the Shanghai Science and Technology Committee(No.19DZ1100704)the Shanghai Sailing Program(No.19YF1415900)Golden Apple Project of Baosteel Co.,Ltd(No.A19EC13500)the Guangdong Basic and Applied Basic Research Foundation(No.2019B1515120016)the Guangzhou Science and Technology Program(Nos.202002030290 and 202007020008)the GDAS’Project of Science and Technology Development(Nos.2019GDASYL-0503006 and 2020GDASYL-20200302011)。
文摘In this work,the Invar 36 alloys were manufactured using cold spray(CS)additive manufacturing technique.The systematic investigations were made on the microstructural evolution,thermal expansion and mechanical properties under as-sprayed(AS)and heat-treated(HT)conditions.XRD(X-ray diffraction)and ICP-AES(inductively coupled plasma atomic emission spectroscopy)analyses show that no phase transformation,oxidation,nor element content change have occurred.The X-ray computed tomography(XCT)exhibited a near fully dense structure with a porosity of 0.025%in the helium-produced sample under as-sprayed condition,whereas the nitrogen-produced samples produced at 5 MPa and 800℃show more irregular pore defects.He-AS sample shows a more prominent grain refinement than that of nitrogen samples due to the more extensive plastic deformation.The post heat-treatment exhibited a promoted grain growth,inter-particle diffusion,as well as the formation of annealing twins.Between25℃and 200℃,the nitrogen samples possessed lower CTE(coefficient of thermal expansion)values(1.53×10^(-6)/℃)compared with those produced by casting and laser additive manufacturing.The He-AS samples exhibited a noticeable negative CTE value between 25℃and 200℃,which may due to the significant compressive residual stress(-272 MPa)compensating its displacement with temperature increase during CTE test.The N2-HT and He-HT Invar 36 samples present a notable balance between strength and ductility.In conclusion,the CS technique can be considered as a potential method to produce the Invar36 component with high thermal and mechanical performance.
文摘The Green quasifunction method is employed to solve the free vibration problem of clamped thin plates.A Green quasifunction is established by using the fundamental solution and boundary equation of the problem.This function satisfies the homogeneous boundary condition of the problem.The mode shape differential equation of the free vibration problem of clamped thin plates is reduced to Fredholm integral equation of the second kind by Green formula.Irregularity of the kernel of integral equation is overcome by choosing a suitable form of the normalized boundary equation.Two examples demonstrate the validity of the present method.Comparison with both the series solution and ANSYS finite-element solution shows fine agreement.The present method is a novel and effective mathematical one.
基金supported by the National Natural Science Foundation of China(No.21337001,21377073)the Independent Innovation Foundation of Shandong University(IIFSDU)(No.2012JC030)
文摘In this article, the NO3 radical-initiated atmospheric oxidation degradation of DDT was theoretically investigated using molecular orbital theory calculations. All the calculations of intermediates, transition states and products were performed at the MPWB1K/6-311＋G（3df,2p）//MPWB1K/6- 31＋G（d,p） level of theory. Several energetically favorable reaction pathways were revealed. The formation mechanisms of secondary pollutants were presented and discussed. The rate constants were deduced over the temperature range of 273-333 K using canonical variational transition-state （CVT） theory with the small curvature tunneling （SCT） method. Our study shows that H abstraction from the alkyl group and NO3 addition to the Ca atom of the benzene ring are the dominant reaction pathways. The rate-temperature formula of the overall rate constants is k（T）（DDT＋NO3） = （7.21 ~ 10-15）exp（-153.81/T） cm3/（mol.sec） over the possible atmospheric temperature range of 273-333 K. The atmospheric lifetime of DDT determined by NO3 radical is about 52.5 days, which indicates that it can be degraded in the gas phase within several months.
基金funded by the National High Level Hospital Clinical Research Funding(Grant No.2022-PUMCH-B-011)the National Key Research and Development Program of China(Grant No.2022YFA1305500)+2 种基金the National Natural Science Foundation of China(Grant No.32322023,82173272,81825016,82173230,82341018,82203662,82173271,82103416,82103536,82173266,82202276,and 81972385)the Key Areas Research and Development Program of Guangdong(Grant No.2022B1515120086,2021B1515020091,2022A1515140175,2021A1515010215,2023A1515011648,2022A1515012288,2021A1515010355)the Science and Technology Program of Guangzhou,China(Grant No.2023A04J2206).
文摘Lymph node(LN)metastasis is one of the predominant metastatic routes of non-small cell lung cancer(NSCLC)and is considered as a leading cause for the unsatisfactory prognosis of patients.Although lymphangiogenesis is well-recognized as a crucial process in mediating LN metastasis,the regulatory mechanism involving lymphangiogenesis and LN metastasis in NSCLC remains unclear.In this study,we employed high-throughput sequencing to identify a novel circular RNA(circRNA),circTLCD4-RWDD3,which was significantly upregulated in extracellular vesicles(EVs)from LN metastatic NSCLC and was positively associated with deteriorated OS and DFS of patients with NSCLC from multicenter clinical cohort.Downregulating the expression of EV-packaged circTLCD4-RWDD3 inhibited lymphangiogenesis and LN metastasis of NSCLC both in vitro and in vivo.Mechanically,circTLCD4-RWDD3 physically interacted with hnRNPA2B1 and mediated the SUMO2 modification at K108 residue of hnRNPA2B1 by upregulating UBC9.Subsequently,circTLCD4-RWDD3-induced SUMOylated hnRNPA2B1 was recognized by the SUMO interaction motif(SIM)of ALIX and activated ALIX to recruit ESCRT-III,thereby facilitating the sorting of circTLCD4-RWDD3 into NSCLC cell-derived EVs.Moreover,EV-packaged circTLCD4-RWDD3 was internalized by lymphatic endothelial cells to activate the transcription of PROX1,resulting in the lymphangiogenesis and LN metastasis of NSCLC.Importantly,blocking EV-mediated transmission of circTLCD4-RWDD3 via mutating SIM in ALIX or K108 residue of hnRNPA2B1 inhibited the lymphangiogenesis and LN metastasis of NSCLC in vivo.Our findings reveal a precise mechanism underlying SUMOylated hnRNPA2B1-induced EV packaging of circTLCD4-RWDD3 in facilitating LN metastasis of NSCLC,suggesting that EV-packaged circTLCD4-RWDD3 could be a potential therapeutic target against LN metastatic NSCLC.
基金funded by grant NRF-2019R1A5A8080290 of the National Research Foundation of KoreaExcellent Scientific Research and Innovation Team of Anhui Colleges(No.2022AH010098)The University Synergy Innovation Program of Anhui Province(Nos.GXXT-2020-073 and GXXT-2020-074).
文摘The low electrical conductivity of sulfur,strong volume expansion,shuttle effect,and sluggish redox reactions in Li-S batteries limit their practical application.MoP nanoparticles encapsulated in nitrogen-doped carbon nanotubes(MoP/NC NTs)were synthesized using MoO_(3) nanorods as templates via a polypyrrole coating,heat-carbonization,MoO_(3) partial reduction,ammonia washing,and phosphorization.The MoP/NC NTs had a hollow nanostructure with a high specific surface area,which can alleviate the volume expansion of the cathode and the shuttle effect of polysulfides.The encapsulated MoP nanoparticles can anchor the polysulfides and enhance the redox reaction kinetics.Thus,the MoP/NC NTs combined with sulfur(MoP/S/NC NTs)exhibited 440.8 mAh·g^(-1) over 500 cycles at 1.0 A·g^(-1) with a decay rate of 0.06%per cycle.The density functional theory calculations and X-ray photoelectron spectroscopy results confirmed that MoP/NC NTs could anchor polysulfides and alleviate the shuttle effect by chemical interactions.This study supplies a novel route to prepare nanoparticle-embedded in N-doped carbon nanotubes for advanced Li-S battery.
基金National Postdoctoral Innovation Talent Support Program,Grant/Award Number:BX20240042National High-Level Hospital Clinical Research Funding,Grant/Award Number:2022-PUMCH-B-011+1 种基金Natural Science Foundation of Guangdong Province,Grant/Award Number:2022A1515012347Beijing CSCO research fund,Grant/Award Number:Y-2019Roche-157。
文摘Background:Cancer remains a major cause of mortality and a significant economic burden in China.Exploring the disparities in cancer patterns and control strategies between China and developed countries may offer valuable insights for policy formulation and enhance cancer management efforts.This study examined the incidence,mortality,and disability-adjusted life year(DALY)burden of cancer in China,and compared these metrics with those observed in the United States(US)and the United Kingdom(UK).Methods:Data on cancer incidence,mortality,and DALYs for China,the US,and the UK were sourced from the GLOBOCAN 2022 online database and the Global Burden of Disease 2021 study(GBD 2021).We utilized Joinpoint regression models to analyze trends in cancer incidence and mortality across these countries,calculating annual percent changes(APCs)and determining the optimal joinpoints.Results:In 2022,China recorded around 4,824,703 new cancer cases and 2,574,176 cancer-related deaths,contributing to 71,037,170 DALYs.China exhibited a lower cancer incidence rate compared to the US and the UK.Although cancer-related mortality in China is slightly lower than that in the UK,it is significantly higher than that in the US.Additionally,China experienced significantly higher DALY rates compared to both the US and UK.The cancer landscape in China was also undergoing significant changes,with a rapid rise in the incidence and burden of lung,colorectal,breast,cervical,and prostate cancers.Meanwhile,the incidence and burden of stomach cancer continued to decline.Although the incidence of liver and esophageal cancers was decreasing,the burden of liver cancer was increasing,while the burden of esophageal cancer remained largely unchanged.Conclusions:The cancer profile of China is shifting from that of a developing country to one more typical of a developed country.The ongoing population aging and the rise in unhealthy lifestyles are expected to further escalate the cancer burden in China.Consequently,it is crucial for Chinese authorities to revise the national cancer control program,drawing on successful strategies from developed countries,while also accounting for the regional diversity in cancer types across China.
基金supported by the Natural Science Foundation of Guangdong Province(2022A1515012347)the Beijing CSCO research fund(Y-2019Roche-157)+2 种基金the Science and Technology Project of Guangdong(2014A020212331)the National Natural Science Foundation of China(82001672)the National High Level Hospital Clinical Research Funding(2022-PUMCH-B-011).
文摘Objective Adopting a healthy lifestyle,including regular physical activity,is widely believed to decrease cancer risk.This study aimed to quantitatively establish the dose-response relationships between total physical activity and the risk of breast,colon,lung,gastric,and liver cancers.Methods A systematic review and dose-response analysis were conducted using PubMed and Embase from January 1,1980 to March 20,2023.Prospective cohort studies that examined the association between physical activity and the risks of any of the 5 outcomes were included.The search was confined to publications in the English language with a specific focus on human studies.Physical activity is standardized by using the data from US National Health and Nutrition Examination Surveys(NHANES)and the Global Burden of Disease 2019 database.Results A total of 98 studies,involving a combined population of 16,418,361 individuals,were included in the analysis.Among the included studies,57 focused on breast cancer,17 on lung cancer,23 on colon cancer,5 on gastric cancer,and 7 on liver cancer.Overall,elevated levels of physical activity exhibited an inverse correlation with the risk of cancer.The dose-response curve for lung cancer exhibited a non-linear pattern,with the greatest benefit risk reduction observed at 13,200 MET-minutes/week of physical activity,resulting in a 14.7%reduction in risk(relative risk 0.853,uncertainty interval 0.798 to 0.912)compared to the inactive population.In contrast,the dose-response curves for colon,gastric,breast,and liver cancers showed linear associations,indicating that heightened levels of total physical activity were consistently associated with reduced cancer risks.However,the increase in physical activity yielded a smaller risk reduction for colon and gastric cancers compared to breast and liver cancers.Compared to individuals with insufficient activity(total activity level<600 MET-minutes/week),individuals with high levels of activity(≥8,000 MET-minutes/week)experienced a 10.3%(0.897,0.860 to 0.934)risk reduction for breast cancer;5.9%(0.941,0.884 to 1.001)for lung cancer;7.1%(0.929,0.909 to 0.949)for colon cancer;5.1%(0.949,0.908 to 0.992)for gastric cancer;17.1%(0.829,0.760 to 0.903)for liver cancer.Conclusions This study demonstrated a significant inverse relationship between total physical activity and the risk of breast,gastric,liver,colon,and lung cancers.
基金National High Level Hospital Clinical Research Funding,Grant/Award Number:2022-PUMCH-A-259the CAMS Initiative for Innovative Medicine,Grant/Award Number:2021-I2M-1-015。
文摘1 LYMPHATIC METASTASIS AND LYMPHANGIOGENESIS IN NON-SMALL CELL LUNG CANCER Lung cancer is the 2nd most common and 1st deadliest cancer worldwide[1].It presents an enormous burden on society in China,because of its high incidence andmortality rate[2,3].About 80%-85%of lung cancers are non-small cell lung cancer(NSCLC).Lymphatic metastasis is a critical event in disease progression that influences clinical treatment and determines the prognosis for NSCLC[4].
