The corrosion behavior of Ti–6Al–2Zr–1Mo–1V(TA15)alloy fabricated through selective laser melting(SLM)technology and traditional wrought technology in hydrochloric acid solutions was investigated using electrochem...The corrosion behavior of Ti–6Al–2Zr–1Mo–1V(TA15)alloy fabricated through selective laser melting(SLM)technology and traditional wrought technology in hydrochloric acid solutions was investigated using electrochemical testing and surface characterizations,including electron backscattered diffraction,scanning electron microscopy,and X-ray photoelectron spectroscopy analyses.The results showed that both types of TA15 alloy underwent spontaneous passivation reactions in HCl solution,and with the increase in HCl concentration,the surface of SLM-TA15 sample exhibited larger and deeper pits.In comparison to SLM-TA15 sample,the pits on the wrought-TA15 sample were shallower and the surface was more uniform.Analysis of the passive current density,breakdown potential,and electrochemical impedance revealed that the corrosion resistance of both alloys decreased as the concentration of HCl increased,and SLM sample exhibited poorer corrosion resistance compared with the wrought sample.Analysis of Mott–Schottky test curves and calculation of passive film thickness indicated that the passive film of wrought-TA15 sample was superior to that of SLM-TA15 sample.展开更多
Electrochemical impedance(EIS)and thin electrical resistance(ER)sensors were invented for atmospheric corrosion measurement of copper(Cu)during cyclic wetting−drying/high−low temperature tests and field exposure tests...Electrochemical impedance(EIS)and thin electrical resistance(ER)sensors were invented for atmospheric corrosion measurement of copper(Cu)during cyclic wetting−drying/high−low temperature tests and field exposure tests.Three-month field exposure results showed that average corrosion rate of Cu measured by ER sensor was well in accordance with that by weight loss method.During cyclic wetting−drying test,EIS was proven to reflect sensitively time of wetting and drying on the surface of sensor.Although corrosion rate obtained from EIS had a similar tendency to that obtained from ER sensors,the former was more dependent on environmental humidity than the latter.When relative humidity was low than 60%,corrosion rate of Cu measured by EIS was much lower than that by weight loss method,mainly attributing to the fact that impedance sensor failed to detect corrosion current of interlaced Cu electrodes due to the breakdown of conductive passage composed of absorbed thin liquid film under low humidity condition.Promisingly,ER sensor was proven to be more suitable for atmospheric corrosion monitoring than electrochemical techniques because it could sensitively monitor thickness loss of Cu foil according to the Ohmic law,no matter how dry or wet the sensor surface is.展开更多
Transforming growth factor-β1(TGF-β1)acts as a tumor promoter in advanced prostate cancer(PCa).We speculated that microRNAs(miRNAs)that are inhibited by TGF-β1 might exert anti-tumor effects.To assess this,we ident...Transforming growth factor-β1(TGF-β1)acts as a tumor promoter in advanced prostate cancer(PCa).We speculated that microRNAs(miRNAs)that are inhibited by TGF-β1 might exert anti-tumor effects.To assess this,we identified several miRNAs downregulated by TGF-β1 in PCa cell lines and selected miR-3691-3p for detailed analysis as a candidate anti-oncogene miRNA.miR-3691-3p was expressed at significantly lower levels in human PCa tissue compared with paired benign prostatic hyperplasia tissue,and its expression level correlated inversely with aggressive clinical pathological features.Overexpression of miR-3691-3p in PCa cell lines inhibited proliferation,migration,and invasion,and promoted apoptosis.The miR-3691-3p target genes E2F transcription factor 3(E2F3)and PR domain containing 1,with ZNF domain(PRDM1)were upregulated in miR-3691-3p-overexpressing PCa cells,and silencing of E2F3 or PRDM1 suppressed PCa cell proliferation,migration,and invasion.Treatment of mice bearing PCa xenografts with a miR-3691-3p agomir inhibited tumor growth and promoted tumor cell apoptosis.Consistent with the negative regulation of E2F3 and PRDM1 by miR-3691-3p,both proteins were overexpressed in clinical PCa specimens compared with noncancerous prostate tissue.Our results indicate that TGF-β1-regulated miR-3691-3p acts as an anti-oncogene in PCa by downregulating E2F3 and PRDM1.These results provide novel insights into the mechanisms by which TGF-β1 contributes to the progression of PCa.展开更多
The protective self-assembled monolayers(SAMs)were fabricated on the surface of low-temperature sintered nano-Ag paste electrode in the sodium mercaptobenzothiazole(MBT-Na)solution at room temperature.Electrochemical ...The protective self-assembled monolayers(SAMs)were fabricated on the surface of low-temperature sintered nano-Ag paste electrode in the sodium mercaptobenzothiazole(MBT-Na)solution at room temperature.Electrochemical migration(ECM)behavior was investigated using waterdrop test,andthemeantimeto failure was employed as a parameter to evaluate ECM probability.Some electrochemical meth-ods,including electrochemical impedance,potentiodynamic polarization curves,localized electrochemical impedance spectroscopy and scanning Kelvin probe,have been carried out to clarify the formation process of SAMs.Results indi-cated that growth of tree-like silver dendrites after ECM tests resulted in the short circuit between twin electrodes.The SAMs-coated electrode can reduce the rate of anodic disso-lution and thus retard the growth of dendrite.The ECM inhibition efflciency increased with the concentration of MBT-Na rising.And the optimum self-assembled time was 60 min.A higher applied bias resultedin a shorter failuretime for ECM.And relevant mechanisms have been proposed.展开更多
We are retracting this article due to certain errors in two figures in the article"TGF-β1-regulated miR-3691-3p targets E2F3 and PRDM1 to inhibit prostate cancer progression"which has been published.An imag...We are retracting this article due to certain errors in two figures in the article"TGF-β1-regulated miR-3691-3p targets E2F3 and PRDM1 to inhibit prostate cancer progression"which has been published.An image layout error occurred while processing Figure 3e,and some of the images in Figure 3f,4d,and 4e have errors due to incorrect image grouping.We carried out a detailed investigation and rechecked the original data of these figures.Unfortunately,the original pathological data have not been properly archived;thus,we are unable to investigate this issue.展开更多
To the Editor:We reported a 46-year-old man presented with progressive pain in his left lower extremities for more than 5 years.Physical examination showed short stature,"O"-type bending in his lower extremi...To the Editor:We reported a 46-year-old man presented with progressive pain in his left lower extremities for more than 5 years.Physical examination showed short stature,"O"-type bending in his lower extremities,and"penguin"gait.The family tree of the proband’s pedigree is shown in Figure 1A,and the X-rays of his skull are shown in Figure 1B.X-rays found increased bone mass in his spine[Figure 1C],and left femoral fracture with sclerosis at the fracture edge[Figure 1D and Figure 1E].Dual-energy X-ray absorptiometry(DEXA)scan measured in 2018 revealed increased bone mass in his spine[Supplementary Table 1,http://links.lww.com/CM9/A96].展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.51971067 and 52001080)Beijing Natural Science Foundation(Grant No.3232005).
文摘The corrosion behavior of Ti–6Al–2Zr–1Mo–1V(TA15)alloy fabricated through selective laser melting(SLM)technology and traditional wrought technology in hydrochloric acid solutions was investigated using electrochemical testing and surface characterizations,including electron backscattered diffraction,scanning electron microscopy,and X-ray photoelectron spectroscopy analyses.The results showed that both types of TA15 alloy underwent spontaneous passivation reactions in HCl solution,and with the increase in HCl concentration,the surface of SLM-TA15 sample exhibited larger and deeper pits.In comparison to SLM-TA15 sample,the pits on the wrought-TA15 sample were shallower and the surface was more uniform.Analysis of the passive current density,breakdown potential,and electrochemical impedance revealed that the corrosion resistance of both alloys decreased as the concentration of HCl increased,and SLM sample exhibited poorer corrosion resistance compared with the wrought sample.Analysis of Mott–Schottky test curves and calculation of passive film thickness indicated that the passive film of wrought-TA15 sample was superior to that of SLM-TA15 sample.
基金the National Natural Science Foundation of China(No.51771079)the China Postdoctoral Science Foundation(No.2020M682650).
文摘Electrochemical impedance(EIS)and thin electrical resistance(ER)sensors were invented for atmospheric corrosion measurement of copper(Cu)during cyclic wetting−drying/high−low temperature tests and field exposure tests.Three-month field exposure results showed that average corrosion rate of Cu measured by ER sensor was well in accordance with that by weight loss method.During cyclic wetting−drying test,EIS was proven to reflect sensitively time of wetting and drying on the surface of sensor.Although corrosion rate obtained from EIS had a similar tendency to that obtained from ER sensors,the former was more dependent on environmental humidity than the latter.When relative humidity was low than 60%,corrosion rate of Cu measured by EIS was much lower than that by weight loss method,mainly attributing to the fact that impedance sensor failed to detect corrosion current of interlaced Cu electrodes due to the breakdown of conductive passage composed of absorbed thin liquid film under low humidity condition.Promisingly,ER sensor was proven to be more suitable for atmospheric corrosion monitoring than electrochemical techniques because it could sensitively monitor thickness loss of Cu foil according to the Ohmic law,no matter how dry or wet the sensor surface is.
基金This study was supported by Shanghai Changning District Committee of Science and Technology(CNKW2016Y01)Shanghai Tongren Hospital Project(TRYJ201501)+3 种基金Suzhou Science and Technology Development Program(SYS201717)the Second Affiliated Hospital of Soochow University Advance Research Program of the Natural Science Foundation of China Grants(SDFEYGJ1705)Open project of Jiangsu State Key Laboratory of Radiation Medicine and Projection(GJS1963)the Priority Academic Program Development of Jiangsu Higher Education Institutions.
文摘Transforming growth factor-β1(TGF-β1)acts as a tumor promoter in advanced prostate cancer(PCa).We speculated that microRNAs(miRNAs)that are inhibited by TGF-β1 might exert anti-tumor effects.To assess this,we identified several miRNAs downregulated by TGF-β1 in PCa cell lines and selected miR-3691-3p for detailed analysis as a candidate anti-oncogene miRNA.miR-3691-3p was expressed at significantly lower levels in human PCa tissue compared with paired benign prostatic hyperplasia tissue,and its expression level correlated inversely with aggressive clinical pathological features.Overexpression of miR-3691-3p in PCa cell lines inhibited proliferation,migration,and invasion,and promoted apoptosis.The miR-3691-3p target genes E2F transcription factor 3(E2F3)and PR domain containing 1,with ZNF domain(PRDM1)were upregulated in miR-3691-3p-overexpressing PCa cells,and silencing of E2F3 or PRDM1 suppressed PCa cell proliferation,migration,and invasion.Treatment of mice bearing PCa xenografts with a miR-3691-3p agomir inhibited tumor growth and promoted tumor cell apoptosis.Consistent with the negative regulation of E2F3 and PRDM1 by miR-3691-3p,both proteins were overexpressed in clinical PCa specimens compared with noncancerous prostate tissue.Our results indicate that TGF-β1-regulated miR-3691-3p acts as an anti-oncogene in PCa by downregulating E2F3 and PRDM1.These results provide novel insights into the mechanisms by which TGF-β1 contributes to the progression of PCa.
基金financially supported by the National Natural Science Foundation of China (Nos. 52001080 and 51971067)the Science and Technology Research Project of Guangzhou (Nos. 202102020467 and 202002010007)+2 种基金the Platform Research Capability Enhancement Project of Guangzhou University (No. 69-620939)Guangzhou University’s 2020 Training Program for Talent (No. 69-62091109)Provincial Innovation Training Program for College Students of Guangzhou University (No. S202011078017)
文摘The protective self-assembled monolayers(SAMs)were fabricated on the surface of low-temperature sintered nano-Ag paste electrode in the sodium mercaptobenzothiazole(MBT-Na)solution at room temperature.Electrochemical migration(ECM)behavior was investigated using waterdrop test,andthemeantimeto failure was employed as a parameter to evaluate ECM probability.Some electrochemical meth-ods,including electrochemical impedance,potentiodynamic polarization curves,localized electrochemical impedance spectroscopy and scanning Kelvin probe,have been carried out to clarify the formation process of SAMs.Results indi-cated that growth of tree-like silver dendrites after ECM tests resulted in the short circuit between twin electrodes.The SAMs-coated electrode can reduce the rate of anodic disso-lution and thus retard the growth of dendrite.The ECM inhibition efflciency increased with the concentration of MBT-Na rising.And the optimum self-assembled time was 60 min.A higher applied bias resultedin a shorter failuretime for ECM.And relevant mechanisms have been proposed.
文摘We are retracting this article due to certain errors in two figures in the article"TGF-β1-regulated miR-3691-3p targets E2F3 and PRDM1 to inhibit prostate cancer progression"which has been published.An image layout error occurred while processing Figure 3e,and some of the images in Figure 3f,4d,and 4e have errors due to incorrect image grouping.We carried out a detailed investigation and rechecked the original data of these figures.Unfortunately,the original pathological data have not been properly archived;thus,we are unable to investigate this issue.
基金This work was supported by grants from the National Natural Science Foundation of China(Nos.81770875 and 81572639)the Science and Technology Department of Sichuan Province(No.2018SZ0142)+1 种基金Sichuan University(No.2018SCUH0093)the National Clinical Research Center for Geriatrics of West China Hospital(No.Z2018B05).
文摘To the Editor:We reported a 46-year-old man presented with progressive pain in his left lower extremities for more than 5 years.Physical examination showed short stature,"O"-type bending in his lower extremities,and"penguin"gait.The family tree of the proband’s pedigree is shown in Figure 1A,and the X-rays of his skull are shown in Figure 1B.X-rays found increased bone mass in his spine[Figure 1C],and left femoral fracture with sclerosis at the fracture edge[Figure 1D and Figure 1E].Dual-energy X-ray absorptiometry(DEXA)scan measured in 2018 revealed increased bone mass in his spine[Supplementary Table 1,http://links.lww.com/CM9/A96].
