Palmitoylation plays a key role in liver cancer(HCC)initiation,progression,and drug resistance.This review highlights palmitoyltransferases(PATs),like ZDHHC family enzymes,and their impact on HCC and immune evasion.We...Palmitoylation plays a key role in liver cancer(HCC)initiation,progression,and drug resistance.This review highlights palmitoyltransferases(PATs),like ZDHHC family enzymes,and their impact on HCC and immune evasion.We discuss small-molecule inhibitors targeting these enzymes,such as ZDHHC9 and PPT1 inhibitors,showing promising results.The role of palmitoylation in immune checkpoint molecules like TIM-3 is explored,along with its potential in combination therapy.Additionally,we examine palmitoylation-related biomarkers for non-invasive diagnosis,prognosis,and treatment monitoring in liver cancer.展开更多
基金supported by the Clinical Research Project of Investigator-Initiated Trials(IIT)Medical-Industry Integration Program of the Pudong New Area Health Commission(2025-PWYC-04)+1 种基金the Shanghai Oriental Talent Program(QNJY2024191)the National Natural Science Foundation of China(Youth Program,No.82303349).
文摘Palmitoylation plays a key role in liver cancer(HCC)initiation,progression,and drug resistance.This review highlights palmitoyltransferases(PATs),like ZDHHC family enzymes,and their impact on HCC and immune evasion.We discuss small-molecule inhibitors targeting these enzymes,such as ZDHHC9 and PPT1 inhibitors,showing promising results.The role of palmitoylation in immune checkpoint molecules like TIM-3 is explored,along with its potential in combination therapy.Additionally,we examine palmitoylation-related biomarkers for non-invasive diagnosis,prognosis,and treatment monitoring in liver cancer.
