Primary γ'phase instead of carbides and borides plays an important role in suppressing grain growth during solution at 1433 K of Ni-based FGH98 superalloys.Results illustrate that as-fabricated FGH98 superalloy h...Primary γ'phase instead of carbides and borides plays an important role in suppressing grain growth during solution at 1433 K of Ni-based FGH98 superalloys.Results illustrate that as-fabricated FGH98 superalloy has equiaxed grain structure,and after heat treatment,grains remain equiaxed but grow larger.In order to clarify the effects of the size and volume fraction of the primaryγ'phase on the grain growth during heat treatment,a 2D cellular automata(CA)model was established based on the thermal activation and the lowest energy principle.The CA results are compared with the experimental results and show a good fit with an error less than 10%.Grain growth kinetics are depicted,and simulations in real time for various sizes and volume fractions of primaryγ'particles work out well with the Zener relation.The coefficient n value which reflects the pinning ability in Zener relation is theoretically calculated,and its minimum value is 0.23 when the radius of primaryγ'phase is 2.8μm.展开更多
AIM:To conduct a systematic review and meta-analysis into the efficacy,safety,and dosage regimens of degarelix for treating prostate cancer(PCa). METHODS:Pub Med,EMBASE,the Cochrane Library,and Web of Science was syst...AIM:To conduct a systematic review and meta-analysis into the efficacy,safety,and dosage regimens of degarelix for treating prostate cancer(PCa). METHODS:Pub Med,EMBASE,the Cochrane Library,and Web of Science was systematically searched to identify randomized controlled trials(RCTs) comparing degarelix(240/80 mg vs 240/160 mg) to the gonadotropin-releasing hormone agonists,goserelin and leuprolide,for the treatment of PCa. Two independent reviewers screened putative studies,assessed the risk of bias,and then extracted pertinent data. Analyses were performed using Review Manager 5.2. RESULTS:Seven papers from six RCTs,involving 1204 patients,were identified. The present meta-analysis showed that treatment with 240/160 mg degarelix is more effective and has fewer adverse events(AEs) relative to conventional 240/80 mg regimen. Degarelix significantly decreased International Prostate Symptom Scores [standardized mean differences(SMD) =-0.32,95%CI:-0.51 to-0.12,P = 0.02] and caused fewer AEs(SMD =-0.28,95%CI:-0.48 to-0.07,P = 0.008) than goserelin. Degarelix suppressed testosterone and prostate-specific antigen significantly faster than leuprolide. CONCLUSION:Degarelix is a useful option in the treatment of advanced PCa. Degarelix 240/160 mgregimen was superior to a 240/80 mg regimen. More rigorously designed RCTs are urgently needed to confirm the efficacy of degarelix.展开更多
Chronic periodontitis is the most common infectious periodontal disease caused by plaque biofilm.Pili is an important bacterial component of Porphyromonas gingivalis.Epidemiological studies have shown that chronic per...Chronic periodontitis is the most common infectious periodontal disease caused by plaque biofilm.Pili is an important bacterial component of Porphyromonas gingivalis.Epidemiological studies have shown that chronic periodontitis can increase the risk of cardiovascular disease,and atherosclerosis is the pathological basis of cardiovascular disease.This article will summarize the mechanism of Porphyromonas gingivalis pili protein mediated chronic periodontitis and atherosclerosis,in order to expand new ideas of disease prevention and treatment.展开更多
BACKGROUND & OBJECTIVE: Little is known about the relative efficacies of percutaneous coronary intervention (PCI) with drug-eluting stents (DES) and bare-metal stents (BMS) in elderly patients。 The objective of t...BACKGROUND & OBJECTIVE: Little is known about the relative efficacies of percutaneous coronary intervention (PCI) with drug-eluting stents (DES) and bare-metal stents (BMS) in elderly patients。 The objective of this study was to evaluate the clinical outcome for geriatric patients who received either DES or BMS。 METHODS: From January 2002 to October 2005, 199 consecutive Chinese geriatric patients (≥ 75 years old) underwent PCI with coronary DES or BMS implantation at our institution。 We analyzed the major clinical end points that included all-cause mortality, cardiovascular death, myocardial infarction, target lesion revascularization (TLR), stent thrombosis, and bleeding complications。 RESULTS: The three-year cumulative rates of all-cause mortality, cardiovascular death, and myocardial infarction were significantly lower in the DES group (6.3%,3.6%,5.4%) compared with the BMS group (16.2%,11.5%,14.9%; P <0.05)。 No significant differences were found in the three-year cumulative rate for target lesion revascularization (6.3% vs4.6%, P =0.61) or stent thrombosis (3.6% vs2.3%, P =0.70)。 Likewise, there were no statistically significant differences in the cumulative rate for intracranial hemorrhage, or major and minor hemorrhage at three years。 CONCLUSIONS: DES-based PCI was associated with a significant reduction in the three-year cumulative rate of all-cause mortality, cardiovascular death, and myocardial infarction compared with BMS, without increased risk of TLR, stent thrombosis, or bleeding complications at three years in this group of Chinese geriatric patients。展开更多
基金National Major Science and Technology Project(2017-VI-0009-0079)Basic and Applied Basic Research Foundation of Guangdong Province(2020B0301030001).
文摘Primary γ'phase instead of carbides and borides plays an important role in suppressing grain growth during solution at 1433 K of Ni-based FGH98 superalloys.Results illustrate that as-fabricated FGH98 superalloy has equiaxed grain structure,and after heat treatment,grains remain equiaxed but grow larger.In order to clarify the effects of the size and volume fraction of the primaryγ'phase on the grain growth during heat treatment,a 2D cellular automata(CA)model was established based on the thermal activation and the lowest energy principle.The CA results are compared with the experimental results and show a good fit with an error less than 10%.Grain growth kinetics are depicted,and simulations in real time for various sizes and volume fractions of primaryγ'particles work out well with the Zener relation.The coefficient n value which reflects the pinning ability in Zener relation is theoretically calculated,and its minimum value is 0.23 when the radius of primaryγ'phase is 2.8μm.
文摘AIM:To conduct a systematic review and meta-analysis into the efficacy,safety,and dosage regimens of degarelix for treating prostate cancer(PCa). METHODS:Pub Med,EMBASE,the Cochrane Library,and Web of Science was systematically searched to identify randomized controlled trials(RCTs) comparing degarelix(240/80 mg vs 240/160 mg) to the gonadotropin-releasing hormone agonists,goserelin and leuprolide,for the treatment of PCa. Two independent reviewers screened putative studies,assessed the risk of bias,and then extracted pertinent data. Analyses were performed using Review Manager 5.2. RESULTS:Seven papers from six RCTs,involving 1204 patients,were identified. The present meta-analysis showed that treatment with 240/160 mg degarelix is more effective and has fewer adverse events(AEs) relative to conventional 240/80 mg regimen. Degarelix significantly decreased International Prostate Symptom Scores [standardized mean differences(SMD) =-0.32,95%CI:-0.51 to-0.12,P = 0.02] and caused fewer AEs(SMD =-0.28,95%CI:-0.48 to-0.07,P = 0.008) than goserelin. Degarelix suppressed testosterone and prostate-specific antigen significantly faster than leuprolide. CONCLUSION:Degarelix is a useful option in the treatment of advanced PCa. Degarelix 240/160 mgregimen was superior to a 240/80 mg regimen. More rigorously designed RCTs are urgently needed to confirm the efficacy of degarelix.
基金Key scientific Research Project of Hainan Universities(No.Hnky2018ZD-7)Hainan Science and Technology Association Young Science and Technology talents Academic Innovation Program project(No.QCXM201817)Hainan Humanities medical research base planning project(No.QRYZH201811(YB))Education science research project of Hainan Medical College(No.HYYB202014)
文摘Chronic periodontitis is the most common infectious periodontal disease caused by plaque biofilm.Pili is an important bacterial component of Porphyromonas gingivalis.Epidemiological studies have shown that chronic periodontitis can increase the risk of cardiovascular disease,and atherosclerosis is the pathological basis of cardiovascular disease.This article will summarize the mechanism of Porphyromonas gingivalis pili protein mediated chronic periodontitis and atherosclerosis,in order to expand new ideas of disease prevention and treatment.
文摘BACKGROUND & OBJECTIVE: Little is known about the relative efficacies of percutaneous coronary intervention (PCI) with drug-eluting stents (DES) and bare-metal stents (BMS) in elderly patients。 The objective of this study was to evaluate the clinical outcome for geriatric patients who received either DES or BMS。 METHODS: From January 2002 to October 2005, 199 consecutive Chinese geriatric patients (≥ 75 years old) underwent PCI with coronary DES or BMS implantation at our institution。 We analyzed the major clinical end points that included all-cause mortality, cardiovascular death, myocardial infarction, target lesion revascularization (TLR), stent thrombosis, and bleeding complications。 RESULTS: The three-year cumulative rates of all-cause mortality, cardiovascular death, and myocardial infarction were significantly lower in the DES group (6.3%,3.6%,5.4%) compared with the BMS group (16.2%,11.5%,14.9%; P <0.05)。 No significant differences were found in the three-year cumulative rate for target lesion revascularization (6.3% vs4.6%, P =0.61) or stent thrombosis (3.6% vs2.3%, P =0.70)。 Likewise, there were no statistically significant differences in the cumulative rate for intracranial hemorrhage, or major and minor hemorrhage at three years。 CONCLUSIONS: DES-based PCI was associated with a significant reduction in the three-year cumulative rate of all-cause mortality, cardiovascular death, and myocardial infarction compared with BMS, without increased risk of TLR, stent thrombosis, or bleeding complications at three years in this group of Chinese geriatric patients。
