In the context of post-stimulation shale gas wells,the terms“shut-in”and“flowback”refer to two critical phases that occur after hydraulic fracturing(fracking)has been completed.These stages play a crucial role in ...In the context of post-stimulation shale gas wells,the terms“shut-in”and“flowback”refer to two critical phases that occur after hydraulic fracturing(fracking)has been completed.These stages play a crucial role in determining both the well’s initial production performance and its long-term hydrocarbon recovery.By establishing a comprehensive big data analysis platform,the flowback dynamics of over 1000 shale gas wells were analyzed in this work,leading to the development of an index system for evaluating flowback production capacity.Additionally,a shut-in chart was created for wells with different types of post-stimulation fracture networks,providing a structured approach to optimizing production strategies.A dynamic analysis method for flowback was also developed,using daily pressure drop and artificial fracture conductivity as key indicators.This method offers a systematic and effective approach to managing the shut-in and flowback processes for gas wells.Field trials demonstrated significant improvements:the probability of sand production was reduced,gas breakthrough time was extended,artificial fracture conductivity was enhanced,and the average estimated ultimate recovery(EUR)per well increased.展开更多
Using seismic data of the aftershocks sequence of the April 20, 2013 Lushan earthquake recorded by seismic temporary and permanent stations in the source region, with the visual inspection of particle motion diagrams,...Using seismic data of the aftershocks sequence of the April 20, 2013 Lushan earthquake recorded by seismic temporary and permanent stations in the source region, with the visual inspection of particle motion diagrams, this paper preliminarily contains the polarization directions of fast shear wave and the time-delays of split shear waves at every station, and analyzes the crustal anisotropic characteristics in the source region. In the study area, the polarization direc- tions at stations BAX, TQU, L 132, L 133, L 134, and L 135 are northeast, which is consistent with the strike of Dachuan- Shuangshi fault. There are two polarization directions at MDS and L131, which are northeast and southeast. The scatter of polarization directions suggests the complex stress field around these two stations where two faults intersect. For the normalized time-delays at every station, the range is 1.02-8.64 ms/km. The largest time-delay is from L134 which is closest to the mainshock, and the smallest one is from L133. The variations in time-delays show the decreasing at stations BAX, L134, and L135 because of the stress-relaxation after earthquake.展开更多
Both P- and S-wave arrivals were collected for imaging upper crustal structures in the source region of the April 20, 2013 Lushan earthquake. High-resolution, three- dimensional P and S velocity models were constructe...Both P- and S-wave arrivals were collected for imaging upper crustal structures in the source region of the April 20, 2013 Lushan earthquake. High-resolution, three- dimensional P and S velocity models were constructed by travel-time tomography. Moreover, more than 3700 after- shocks of the Lushan earthquake were relocated via a grid search method. The P- and S-wave velocity images of the upper crust show largely similar characters, with high and low velocity anomalies, which mark the presence of sig- nificant lateral and vertical heterogeneity at the source region of the Lushan earthquake. The characteristics of the velocity anomalies also reflect the associated surface geo- logical tectonics in this region. The distributions of high velocity anomalies of both P- and S-waves to 18 km depth are consistent with the distributions of relocated after- shocks, suggesting that most of the ruptures were localized inside the high velocity region. In contrast, low P and S velocities were found in the surrounding regions without aftershocks, especially in the region to the northeast of the Lushan earthquake. For the relocated aftershocks of the Lushan earthquake from this study, we found that mostaftershocks were concentrated in a zone of about 40 km long and 20 km wide, and were located in the hanging wall of Dayi-Mingshan fault. The focal depths of aftershocks increase from the southeast to the northwest region in the direction perpendicular to the fault strike, suggesting that the fault ruptured at an approximate dip angle of 45°. The main depths of the aftershocks in the northwest of the main shock are significantly shallower than expected, revealing the different seismogenic conditions in the source region.展开更多
The pivotal areas for the extensive and effective exploitation of shale gas in the Southern Sichuan Basin have recently transitioned from mid-deep layers to deep layers.Given challenges such as intricate data analysis...The pivotal areas for the extensive and effective exploitation of shale gas in the Southern Sichuan Basin have recently transitioned from mid-deep layers to deep layers.Given challenges such as intricate data analysis,absence of effective assessment methodologies,real-time control strategies,and scarce knowledge of the factors influencing deep gas wells in the so-called flowback stage,a comprehensive study was undertaken on over 160 deep gas wells in Luzhou block utilizing linear flow models and advanced big data analytics techniques.The research results show that:(1)The flowback stage of a deep gas well presents the characteristics of late gas channeling,high flowback rate after gas channeling,low 30-day flowback rate,and high flowback rate corresponding to peak production;(2)The comprehensive parameter AcmKm1/2 in the flowback stage exhibits a strong correlation with the Estimated Ultimate Recovery(EUR),allowing for the establishment of a standardized chart to evaluate EUR classification in typical shale gas wells during this stage.This enables quantitative assessment of gas well EUR,providing valuable insights into production potential and performance;(3)The spacing range and the initial productivity of gas wells have a significant impact on the overall effectiveness of gas wells.Therefore,it is crucial to further explore rational well patterns and spacing,as well as optimize initial drainage and production technical strategies in order to improve their performance.展开更多
Accurately predicting the estimated ultimate recovery(EUR)of shale gas wells is key to formulating a shale gas reservoir development plan.However,in practice,determining the EUR remains challenging due to the complex ...Accurately predicting the estimated ultimate recovery(EUR)of shale gas wells is key to formulating a shale gas reservoir development plan.However,in practice,determining the EUR remains challenging due to the complex dynamic characteristics of shale gas production,which first decreases rapidly and then slowly.In this study,based on material balance theory and equivalent seepage resistance theory and considering crucial factors including primary water,adsorption,and pore effects,a new production model for fractured horizontal shale gas wells is developed.The calculation process is designed by using Newton's iterative method.The shale gas well EUR prediction method is verified,and the factors influencing the EUR are analyzed.The results show that adsorption has a significant effect on production,especially on the Langmuir volume.Moreover,ignoring the influence of primary water,which exists in shale gas reservoirs in the form of bound water,results in an overestimation of the EUR.Furthermore,production positively correlates with the fracture half-length and the number of fractures,but the action mechanisms of these two factors differ.Unlike the number of fractures,which predominantly affects the initial stage of production,the fracture half-length has a more nuanced role.It is capable of altering the stimulated reservoir volume zone,thereby exerting influence over the entire production life cycle.展开更多
BACKGROUND In recent years,the utilization of artificial intelligence(AI)technology has gained prominence in the field of liver disease.AIM To analyzes AI research in the field of liver disease,summarizes the current ...BACKGROUND In recent years,the utilization of artificial intelligence(AI)technology has gained prominence in the field of liver disease.AIM To analyzes AI research in the field of liver disease,summarizes the current research status and identifies hot spots.METHODS We searched the Web of Science Core Collection database for all articles and reviews on hepatopathy and AI.The time spans from January 2007 to August 2023.We included 4051 studies for further collection of information,including authors,countries,institutions,publication years,keywords and references.VOS viewer,CiteSpace,R 4.3.1 and Scimago Graphica were used to visualize the results.RESULTS A total of 4051 articles were analyzed.China was the leading contributor,with 1568 publications,while the United States had the most international collaborations.The most productive institutions and journals were the Chinese Academy of Sciences and Frontiers in Oncology.Keywords co-occurrence analysis can be roughly summarized into four clusters:Risk prediction,diagnosis,treatment and prognosis of liver diseases."Machine learning","deep learning","convolutional neural network","CT",and"microvascular infiltration"have been popular research topics in recent years.CONCLUSION AI is widely applied in the risk assessment,diagnosis,treatment,and prognosis of liver diseases,with a shift from invasive to noninvasive treatment approaches.展开更多
Under the background of"Digital Commerce for Rural Vitalization",rural E-commerce has experienced rapid development.However,agricultural products like strawberries,often produced by small-scale,fragmented,an...Under the background of"Digital Commerce for Rural Vitalization",rural E-commerce has experienced rapid development.However,agricultural products like strawberries,often produced by small-scale,fragmented,and less competitive individual farmers,struggle to meet the compliance and scalability demands of E-commerce,thereby constraining high-quality local economic development.Aiming to address this issue,this paper,guided by relevant policies and strategies,employs case analysis and logical deduction to explore the industrialization path of the"Cooperative+E-commerce"model for the strawberry industry.The research finds that by optimizing the cooperative's organizational structure,implementing multi-channel E-commerce strategies,upgrading the supply chain(including cold chain and quality traceability),and engaging in collaborative brand building,a robust industrial system can be formed.Supplemented by benefit evaluation,policy support,and regulatory oversight,this system can effectively bridge small-scale production with the broader market.This study concludes that this pathway can enhance the added value of the strawberry industry,increase farmer incomes,and provide practical insights for promoting high-quality local economic development.展开更多
Based on the requirements of local high-quality economic development and addressing the critical task of transformation and upgrading in the tea industry,this paper systematically discusses the necessity and feasibili...Based on the requirements of local high-quality economic development and addressing the critical task of transformation and upgrading in the tea industry,this paper systematically discusses the necessity and feasibility of constructing an optimal industrialization operation system driven by the dual wheels of"branding+standardization".The article first clarifies the connotation of high-quality development and the synergistic mechanism between branding and standardization.It then analyzes the current situation and bottlenecks of China's tea industry development.Subsequently,it proposes a dual-wheel drive strategy where branding enhances value and standardization guarantees quality,and designs a systematic implementation plan involving industrial chain synergy optimization and integrated support from government,industry,academia,research,and application.On this basis,strategies and suggestions are proposed,encompassing the starting point,standard focal points,key effort areas,innovation points,and target achievement points.The aim is to promote the tea industry to break through homogeneous competition,achieve value ascent,and provide important industrial support for regional high-quality development through the construction of the aforementioned system.展开更多
Magnetic stimulation has made significant strides in the treatment of psychiatric disorders.Nonetheless,current magnetic stimulation techniques lack the precision to accurately modulate specific nuclei and cannot real...Magnetic stimulation has made significant strides in the treatment of psychiatric disorders.Nonetheless,current magnetic stimulation techniques lack the precision to accurately modulate specific nuclei and cannot realize deep brain magnetic stimulation.To address this,we utilized superparamagnetic iron oxide nanoparticles as mediators to achieve precise targeting and penetration.We investigated the effects of magnetic fields with varying frequencies on neuronal activity and compared the activation effects on neurons using a 10-Hz precise magneto-stimulation system(pMSS)with repetitive transcranial magnetic stimulation in mice.Oxytocin levels,dendritic morphology and density,and mouse behavior were measured before and after pMSS intervention.Our findings suggest that pMSS can activate oxytocinergic neurons,leading to upregulation of oxytocin secretion and neurite outgrowth.As a result,sociability was rapidly improved after a one-week pMSS treatment regimen.These results demonstrate a promising magneto-stimulation method for regulating neuronal activity in deep brain nuclei and provide a promising therapeutic approach for autism spectrum disorder.展开更多
As environmental pollutants pose a serious threat to socioeconomic and environmental health,the development of simple,efficient,accurate and costeffective methods for pollution monitoring and control remains a major c...As environmental pollutants pose a serious threat to socioeconomic and environmental health,the development of simple,efficient,accurate and costeffective methods for pollution monitoring and control remains a major challenge,but it is an unavoidable issue.In the past decade,the artificial nanozymes have been widely used for environmental pollutant monitoring and control,because of their low cost,high stability,easy mass production,etc.However,the conventional nanozyme technology faces significant challenges in terms of difficulty in regulating the exposed crystal surface,complex composition,low catalytic activity,etc.In contrast,the emerging single-atom nanozymes(SANs)have attracted much attention in the field of environmental monitoring and control,due to their multiple advantages of atomically dispersed active sites,high atom utilization efficiency,tunable coordination environment,etc.To date,the insufficient efforts have been made to comprehensively characterize the applications of SANs in the monitoring and control of environmental pollutants.Building on the recent advances in the field,this review systematically summarizes the main synthesis methods of SANs and highlights their advances in the monitoring and control of environmental pollutants.Finally,we critically evaluate the limitations and challenges of SANs,and provide the insights into their future prospects for the monitoring and control of environmental pollutants.展开更多
Ultrahigh nickel oxides(Ni content>90%)hold great promise for high-performance cathodes for the future generation of lithium-ion batteries(LIBs).However,these cathode materials cause problems such as harmful parasi...Ultrahigh nickel oxides(Ni content>90%)hold great promise for high-performance cathodes for the future generation of lithium-ion batteries(LIBs).However,these cathode materials cause problems such as harmful parasitic reactions at the cathode/electrolyte interface,degradation of the layered structure,and the creation of microcracks.Herein,a microstructural refinement and intergranular coating strategy is proposed to engineer ultrahigh nickel cathode LiNi_(0.96)Co_(0.03)Mn_(0.01)O_(2)(NCM).The W-doping-induced fine-grained microstructure not only endows NCM with excellent mechanical properties but also promotes infiltration of the fluoride-containing coating along the grain boundaries inside the secondary particles,thereby forming intergranular coatings.This combined fine-grained microstructure and intergranular coating strategy reduces the formation of microcracks and suppresses the additional parasitic electrolyte reactions caused by them,thereby inhibiting the degradation of the layered phase.Consequently,the modified NCM cathode achieved exceptional electrochemical properties,especially delivering a high initial capacity of 230.8 mA h g^(-1)(0.1 C)and a capacity retention exceeding 96% after100 cycles at 0.5 C in half cells.After 500 cycles in full cells,the capacity retention increases by 21.2% compared with NCM.This strategy mitigates multiple degradation mechanisms in Ni-rich cathodes and provides a generalized strategy for developing advanced ultrahigh-nickel cathodes for industrial application.展开更多
BACKGROUND The coronavirus disease 2019 pandemic has had an ongoing impact on the public’s mental health that requires long-term attention.Exploring the relationship between mental health indicators would aid in iden...BACKGROUND The coronavirus disease 2019 pandemic has had an ongoing impact on the public’s mental health that requires long-term attention.Exploring the relationship between mental health indicators would aid in identifying solutions to improve public mental health.AIM To investigate the prevalence of anxiety,depression,and insomnia and explore the relationship among neuroticism,cognitive failures,and mental health.METHODS A cross-sectional survey was conducted in December 2023 using an online platform to recruit adult participants.The neuroticism,subjective cognitive function,and mental health of the participants were assessed using the neuroticism subscale of the Chinese Big Five Personality Inventory Brief Version,cognitive failures questionnaire,generalized anxiety disorder-7,patient health questionnaire-9,and insomnia severity index.Pearson's correlation analysis,independent samples t-tests,one-way analysis of variance,and structural equation model were used to examine the relationship between mental health indicators.RESULTS A total of 1011 valid questionnaires were collected,of which 343 were completed by male(33.93%)respondents and 668 were completed by female(66.07%)respondents.The rates of anxiety,depression,and insomnia were 41.3%,44.6%,and 36.3%,respectively,most cases of which were mild.Among the mental health indicators,there were significant differences by age and between those with siblings and those who were only children.Neuroticism and cognitive failures were significantly positively correlated with mental health indicators.Further moderated mediation analysis showed that cognitive failures mediated the relationship between insomnia and anxiety and between insomnia and depression,with neuroticism moderating the first half of this pathway and the effect being greater in the low-neuroticism group.CONCLUSION Cognitive failures and neuroticism play important roles in mental health.Therefore,enhancing subjective cognitive function and regulating emotional stability may contribute to the improvement of mental health.展开更多
Objective:Correlation of serum 25-hydroxyvitamin D level with senile hypertension and its stroke.Methods:Two hundred hypertensive patients admitted to the hospital from February 2022 to December 2023 were classified a...Objective:Correlation of serum 25-hydroxyvitamin D level with senile hypertension and its stroke.Methods:Two hundred hypertensive patients admitted to the hospital from February 2022 to December 2023 were classified as study subjects.They were divided into grade 2 hypertension group and grade 3 hypertension group,and 100 healthy medical checkups admitted during the same period were analyzed as study subjects.Results:Comparison of diagnostic results between grade 2 hypertension and grade 2 hypertensive stroke patients,there was a difference in 25(OH)D,(P<0.05).Comparison of test results between grade 3 hypertension and grade 3 hypertensive stroke patients,there was a difference in age,BMI,25(OH)D,GLU,LDL-C,(P<0.05).Serum 25-hydroxyvitamin D level is a high-risk factor for the occurrence of stroke in elderly hypertensive patients,so the probability of risk is higher,where 25(OH)D(ng/mL),GLU(mmol/L),there is a difference,(P<0.05).Conclusion:There is a greater relationship between the occurrence of stroke and serum 25-hydroxyvitamin D level in elderly hypertensive patients.The occurrence of the disease has a greater relationship with this indicator in patients and is also a high-risk factor that affects the patients’morbidity,so it is necessary to pay attention to the monitoring of this indicator after the onset of the disease in patients.展开更多
A correlation between metabolic alterations of neuroactive steroids and Alzheimer’s disease remains unknown. In the present study, amyloid beta （Aβ） 25-35 （Aβ25-35） injected into the bilateral campus CA1 region...A correlation between metabolic alterations of neuroactive steroids and Alzheimer’s disease remains unknown. In the present study, amyloid beta （Aβ） 25-35 （Aβ25-35） injected into the bilateral campus CA1 region significantly reduced learning and memory. At the biochemical level, hippocampal levels of pregnenolone were significantly reduced with Aβ25-35 treatment. Furthermore, progesterone was considerably decreased in the prefrontal cortex and hippocampus, and 17β-estradiol was signifi-cantly elevated. To our knowledge, this is the first report showing that Aβ25-35, a main etiological factor of Alzheimer’s disease, can alter the level and metabolism of neuroactive steroids in the prefrontal cortex and hippocampus, which are brain regions significantly involved in learning and memory. Aβ25-35 exposure also increased the expression of inflammatory mediators, tumor necrosis factor-αand interleukin-1β. However, subcutaneous injection of progesterone reversed the upregulation of tumor necrosis factor-αand interleukin-1βin a dose-dependent manner. Concomitant with improved cognitive abilities, progesterone blocked Aβ-mediated inflammation and increased the survival rate of hippocampal pyramidal cells. We thus hypothesize that Aβ-mediated cognitive deficits may occur via changes in neuroactive steroids. Moreover, our findings provide a possible therapeutic strategy for Alzheimer’s disease via neuroactive steroids, particularly progesterone.展开更多
The significant influence of tumor stroma on malignant cells has been extensively investigated in this era of targeted therapy. The tumor microenvironment, as a dynamic system, is orchestrated by various cells includi...The significant influence of tumor stroma on malignant cells has been extensively investigated in this era of targeted therapy. The tumor microenvironment, as a dynamic system, is orchestrated by various cells including tumor vascular composing cells, inflammatory cells and fibroblasts. As a major and important component in tumor stroma, increasing evidence has shown that spindle-shaped cancer-associated fibroblasts (CAFs) are a significant modifier of cancer evolution, and promote tumorigenesis, tumor invasion and metastasis by stimulating angiogenesis, malignant cell survival, epithelial-mesenchymal transition (EMT) and proliferation via direct cell-to-cell contact or secretion of soluble factors in most digestive solid tumors. CAFs are thought to be activated, characterized by the expression of α-smooth muscle actin, fibroblast activated protein, fibroblast specific protein, vimentin, fibronectin, etc. They are hypothesized to originate from normal or aged fibroblasts, bone marrow-derived mesenchymal cells, or vascular endothelial cells. EMT may also be an important process generating CAFs, and most probably, CAFs may originate from multiple cells. A close link exists between EMT, tumor stem cells, and chemo-resistance of tumor cells, which is largely orchestrated by CAFs. CAFs significantly induce immunosuppression, and may be a prognostic marker in various malignancies. Targeted therapy toward CAFs has displayed promising anticancer efficacy, which further reinforces the necessity to explore the relationship between CAFs and their hosts.展开更多
基金PetroChina Research Applied Science and Technology Project,“Shale Gas Scale Increase Production and Exploration andDevelopment Technology-Research and Application of Key Technology of Deep Shale Gas Scale Production”(No.2023ZZ21YJ01).
文摘In the context of post-stimulation shale gas wells,the terms“shut-in”and“flowback”refer to two critical phases that occur after hydraulic fracturing(fracking)has been completed.These stages play a crucial role in determining both the well’s initial production performance and its long-term hydrocarbon recovery.By establishing a comprehensive big data analysis platform,the flowback dynamics of over 1000 shale gas wells were analyzed in this work,leading to the development of an index system for evaluating flowback production capacity.Additionally,a shut-in chart was created for wells with different types of post-stimulation fracture networks,providing a structured approach to optimizing production strategies.A dynamic analysis method for flowback was also developed,using daily pressure drop and artificial fracture conductivity as key indicators.This method offers a systematic and effective approach to managing the shut-in and flowback processes for gas wells.Field trials demonstrated significant improvements:the probability of sand production was reduced,gas breakthrough time was extended,artificial fracture conductivity was enhanced,and the average estimated ultimate recovery(EUR)per well increased.
基金supported by Research Project in Earthquake Science(Nos.201308018 and No.201108002) National Natural Science Foundation of China(No.40904012)
文摘Using seismic data of the aftershocks sequence of the April 20, 2013 Lushan earthquake recorded by seismic temporary and permanent stations in the source region, with the visual inspection of particle motion diagrams, this paper preliminarily contains the polarization directions of fast shear wave and the time-delays of split shear waves at every station, and analyzes the crustal anisotropic characteristics in the source region. In the study area, the polarization direc- tions at stations BAX, TQU, L 132, L 133, L 134, and L 135 are northeast, which is consistent with the strike of Dachuan- Shuangshi fault. There are two polarization directions at MDS and L131, which are northeast and southeast. The scatter of polarization directions suggests the complex stress field around these two stations where two faults intersect. For the normalized time-delays at every station, the range is 1.02-8.64 ms/km. The largest time-delay is from L134 which is closest to the mainshock, and the smallest one is from L133. The variations in time-delays show the decreasing at stations BAX, L134, and L135 because of the stress-relaxation after earthquake.
基金supported by Research Project in Earthquake Science(No.201308018,No.201108002)National Natural Science Foundation of China(No.40904012)National Basic Research Program of China(No.2013CB733203,No.2013CB733204)
文摘Both P- and S-wave arrivals were collected for imaging upper crustal structures in the source region of the April 20, 2013 Lushan earthquake. High-resolution, three- dimensional P and S velocity models were constructed by travel-time tomography. Moreover, more than 3700 after- shocks of the Lushan earthquake were relocated via a grid search method. The P- and S-wave velocity images of the upper crust show largely similar characters, with high and low velocity anomalies, which mark the presence of sig- nificant lateral and vertical heterogeneity at the source region of the Lushan earthquake. The characteristics of the velocity anomalies also reflect the associated surface geo- logical tectonics in this region. The distributions of high velocity anomalies of both P- and S-waves to 18 km depth are consistent with the distributions of relocated after- shocks, suggesting that most of the ruptures were localized inside the high velocity region. In contrast, low P and S velocities were found in the surrounding regions without aftershocks, especially in the region to the northeast of the Lushan earthquake. For the relocated aftershocks of the Lushan earthquake from this study, we found that mostaftershocks were concentrated in a zone of about 40 km long and 20 km wide, and were located in the hanging wall of Dayi-Mingshan fault. The focal depths of aftershocks increase from the southeast to the northwest region in the direction perpendicular to the fault strike, suggesting that the fault ruptured at an approximate dip angle of 45°. The main depths of the aftershocks in the northwest of the main shock are significantly shallower than expected, revealing the different seismogenic conditions in the source region.
文摘The pivotal areas for the extensive and effective exploitation of shale gas in the Southern Sichuan Basin have recently transitioned from mid-deep layers to deep layers.Given challenges such as intricate data analysis,absence of effective assessment methodologies,real-time control strategies,and scarce knowledge of the factors influencing deep gas wells in the so-called flowback stage,a comprehensive study was undertaken on over 160 deep gas wells in Luzhou block utilizing linear flow models and advanced big data analytics techniques.The research results show that:(1)The flowback stage of a deep gas well presents the characteristics of late gas channeling,high flowback rate after gas channeling,low 30-day flowback rate,and high flowback rate corresponding to peak production;(2)The comprehensive parameter AcmKm1/2 in the flowback stage exhibits a strong correlation with the Estimated Ultimate Recovery(EUR),allowing for the establishment of a standardized chart to evaluate EUR classification in typical shale gas wells during this stage.This enables quantitative assessment of gas well EUR,providing valuable insights into production potential and performance;(3)The spacing range and the initial productivity of gas wells have a significant impact on the overall effectiveness of gas wells.Therefore,it is crucial to further explore rational well patterns and spacing,as well as optimize initial drainage and production technical strategies in order to improve their performance.
基金supported by the National Natural Science Foundation of China(Grant Nos.52304024,52274034,and 52204035)the Natural Science Foundation of Chongqing,China(Grant No.CSTB2023NSCQ-MSX0264)+1 种基金the Project of Science and Technology Research Program of Chongqing Municipal Education Commission,China(Grant Nos.KJQN202201517 and KJQN202001501)the Research Foundation of the Chongqing University of Science and Technology,China(Grant No.ckrc2022025).
文摘Accurately predicting the estimated ultimate recovery(EUR)of shale gas wells is key to formulating a shale gas reservoir development plan.However,in practice,determining the EUR remains challenging due to the complex dynamic characteristics of shale gas production,which first decreases rapidly and then slowly.In this study,based on material balance theory and equivalent seepage resistance theory and considering crucial factors including primary water,adsorption,and pore effects,a new production model for fractured horizontal shale gas wells is developed.The calculation process is designed by using Newton's iterative method.The shale gas well EUR prediction method is verified,and the factors influencing the EUR are analyzed.The results show that adsorption has a significant effect on production,especially on the Langmuir volume.Moreover,ignoring the influence of primary water,which exists in shale gas reservoirs in the form of bound water,results in an overestimation of the EUR.Furthermore,production positively correlates with the fracture half-length and the number of fractures,but the action mechanisms of these two factors differ.Unlike the number of fractures,which predominantly affects the initial stage of production,the fracture half-length has a more nuanced role.It is capable of altering the stimulated reservoir volume zone,thereby exerting influence over the entire production life cycle.
基金Supported by Natural Science Foundation of Sichuan Province,China,No.2022NSFSC1378.
文摘BACKGROUND In recent years,the utilization of artificial intelligence(AI)technology has gained prominence in the field of liver disease.AIM To analyzes AI research in the field of liver disease,summarizes the current research status and identifies hot spots.METHODS We searched the Web of Science Core Collection database for all articles and reviews on hepatopathy and AI.The time spans from January 2007 to August 2023.We included 4051 studies for further collection of information,including authors,countries,institutions,publication years,keywords and references.VOS viewer,CiteSpace,R 4.3.1 and Scimago Graphica were used to visualize the results.RESULTS A total of 4051 articles were analyzed.China was the leading contributor,with 1568 publications,while the United States had the most international collaborations.The most productive institutions and journals were the Chinese Academy of Sciences and Frontiers in Oncology.Keywords co-occurrence analysis can be roughly summarized into four clusters:Risk prediction,diagnosis,treatment and prognosis of liver diseases."Machine learning","deep learning","convolutional neural network","CT",and"microvascular infiltration"have been popular research topics in recent years.CONCLUSION AI is widely applied in the risk assessment,diagnosis,treatment,and prognosis of liver diseases,with a shift from invasive to noninvasive treatment approaches.
基金General Project of Philosophy and Social Sciences Research in Universities of Jiangsu Province,2024(2024SJYB1650).
文摘Under the background of"Digital Commerce for Rural Vitalization",rural E-commerce has experienced rapid development.However,agricultural products like strawberries,often produced by small-scale,fragmented,and less competitive individual farmers,struggle to meet the compliance and scalability demands of E-commerce,thereby constraining high-quality local economic development.Aiming to address this issue,this paper,guided by relevant policies and strategies,employs case analysis and logical deduction to explore the industrialization path of the"Cooperative+E-commerce"model for the strawberry industry.The research finds that by optimizing the cooperative's organizational structure,implementing multi-channel E-commerce strategies,upgrading the supply chain(including cold chain and quality traceability),and engaging in collaborative brand building,a robust industrial system can be formed.Supplemented by benefit evaluation,policy support,and regulatory oversight,this system can effectively bridge small-scale production with the broader market.This study concludes that this pathway can enhance the added value of the strawberry industry,increase farmer incomes,and provide practical insights for promoting high-quality local economic development.
基金Supported by General Project of Philosophy and Social Sciences Research in Universities of Jiangsu Province,2024(2024SJYB1650).
文摘Based on the requirements of local high-quality economic development and addressing the critical task of transformation and upgrading in the tea industry,this paper systematically discusses the necessity and feasibility of constructing an optimal industrialization operation system driven by the dual wheels of"branding+standardization".The article first clarifies the connotation of high-quality development and the synergistic mechanism between branding and standardization.It then analyzes the current situation and bottlenecks of China's tea industry development.Subsequently,it proposes a dual-wheel drive strategy where branding enhances value and standardization guarantees quality,and designs a systematic implementation plan involving industrial chain synergy optimization and integrated support from government,industry,academia,research,and application.On this basis,strategies and suggestions are proposed,encompassing the starting point,standard focal points,key effort areas,innovation points,and target achievement points.The aim is to promote the tea industry to break through homogeneous competition,achieve value ascent,and provide important industrial support for regional high-quality development through the construction of the aforementioned system.
基金supported by the China Science and Technology Innovation 2030-Major Project(2022ZD0211700)the Major Program of the National Natural Science Foundation of China(62394312)+2 种基金the National Natural Science Foundation of China(82471536)the Wenzhou Science and Technology Projects(ZY2023006,2024R2002)Oujiang Laboratory(OJQD2022002).
文摘Magnetic stimulation has made significant strides in the treatment of psychiatric disorders.Nonetheless,current magnetic stimulation techniques lack the precision to accurately modulate specific nuclei and cannot realize deep brain magnetic stimulation.To address this,we utilized superparamagnetic iron oxide nanoparticles as mediators to achieve precise targeting and penetration.We investigated the effects of magnetic fields with varying frequencies on neuronal activity and compared the activation effects on neurons using a 10-Hz precise magneto-stimulation system(pMSS)with repetitive transcranial magnetic stimulation in mice.Oxytocin levels,dendritic morphology and density,and mouse behavior were measured before and after pMSS intervention.Our findings suggest that pMSS can activate oxytocinergic neurons,leading to upregulation of oxytocin secretion and neurite outgrowth.As a result,sociability was rapidly improved after a one-week pMSS treatment regimen.These results demonstrate a promising magneto-stimulation method for regulating neuronal activity in deep brain nuclei and provide a promising therapeutic approach for autism spectrum disorder.
基金supported by the National Natural Science Foundation of China(22422604,32472435)the National Key Research and Development Program of China(2021YFD1700300)+1 种基金the Agricultural Science and Technology Innovation Program of CAAS(CAAS-ASTIP-IQSTAP-04)the State Key Laboratory of Analytical Chemistry for Life Science。
文摘As environmental pollutants pose a serious threat to socioeconomic and environmental health,the development of simple,efficient,accurate and costeffective methods for pollution monitoring and control remains a major challenge,but it is an unavoidable issue.In the past decade,the artificial nanozymes have been widely used for environmental pollutant monitoring and control,because of their low cost,high stability,easy mass production,etc.However,the conventional nanozyme technology faces significant challenges in terms of difficulty in regulating the exposed crystal surface,complex composition,low catalytic activity,etc.In contrast,the emerging single-atom nanozymes(SANs)have attracted much attention in the field of environmental monitoring and control,due to their multiple advantages of atomically dispersed active sites,high atom utilization efficiency,tunable coordination environment,etc.To date,the insufficient efforts have been made to comprehensively characterize the applications of SANs in the monitoring and control of environmental pollutants.Building on the recent advances in the field,this review systematically summarizes the main synthesis methods of SANs and highlights their advances in the monitoring and control of environmental pollutants.Finally,we critically evaluate the limitations and challenges of SANs,and provide the insights into their future prospects for the monitoring and control of environmental pollutants.
基金financially supported by the National Natural Science Foundation of China(52071073)the Fundamental Research Funds for the Central Universities(2024GFZD002)+3 种基金the Natural Science Foundation of Hebei Province(E2024501015)the Liaoning Applied Basic Research Program(2023JH2/101300011)the Basic Scientific Research Project of Liaoning Province Department of Education(LJKZZ20220024)the Shenyang Science and Technology Project(23-407-3-13)。
文摘Ultrahigh nickel oxides(Ni content>90%)hold great promise for high-performance cathodes for the future generation of lithium-ion batteries(LIBs).However,these cathode materials cause problems such as harmful parasitic reactions at the cathode/electrolyte interface,degradation of the layered structure,and the creation of microcracks.Herein,a microstructural refinement and intergranular coating strategy is proposed to engineer ultrahigh nickel cathode LiNi_(0.96)Co_(0.03)Mn_(0.01)O_(2)(NCM).The W-doping-induced fine-grained microstructure not only endows NCM with excellent mechanical properties but also promotes infiltration of the fluoride-containing coating along the grain boundaries inside the secondary particles,thereby forming intergranular coatings.This combined fine-grained microstructure and intergranular coating strategy reduces the formation of microcracks and suppresses the additional parasitic electrolyte reactions caused by them,thereby inhibiting the degradation of the layered phase.Consequently,the modified NCM cathode achieved exceptional electrochemical properties,especially delivering a high initial capacity of 230.8 mA h g^(-1)(0.1 C)and a capacity retention exceeding 96% after100 cycles at 0.5 C in half cells.After 500 cycles in full cells,the capacity retention increases by 21.2% compared with NCM.This strategy mitigates multiple degradation mechanisms in Ni-rich cathodes and provides a generalized strategy for developing advanced ultrahigh-nickel cathodes for industrial application.
基金Supported by National Natural Science Foundation of China,No.82271546 and No.82301744The Shanxi Province Science and Technology Innovation Think Tank Construction Research Project,No.KXKT202317+1 种基金Fundamental Research Program of Shanxi Province,No.202303021222346 and No.202103021223224The Research Foundation of The First Hospital of Shanxi Medical University,No.YQ2208.
文摘BACKGROUND The coronavirus disease 2019 pandemic has had an ongoing impact on the public’s mental health that requires long-term attention.Exploring the relationship between mental health indicators would aid in identifying solutions to improve public mental health.AIM To investigate the prevalence of anxiety,depression,and insomnia and explore the relationship among neuroticism,cognitive failures,and mental health.METHODS A cross-sectional survey was conducted in December 2023 using an online platform to recruit adult participants.The neuroticism,subjective cognitive function,and mental health of the participants were assessed using the neuroticism subscale of the Chinese Big Five Personality Inventory Brief Version,cognitive failures questionnaire,generalized anxiety disorder-7,patient health questionnaire-9,and insomnia severity index.Pearson's correlation analysis,independent samples t-tests,one-way analysis of variance,and structural equation model were used to examine the relationship between mental health indicators.RESULTS A total of 1011 valid questionnaires were collected,of which 343 were completed by male(33.93%)respondents and 668 were completed by female(66.07%)respondents.The rates of anxiety,depression,and insomnia were 41.3%,44.6%,and 36.3%,respectively,most cases of which were mild.Among the mental health indicators,there were significant differences by age and between those with siblings and those who were only children.Neuroticism and cognitive failures were significantly positively correlated with mental health indicators.Further moderated mediation analysis showed that cognitive failures mediated the relationship between insomnia and anxiety and between insomnia and depression,with neuroticism moderating the first half of this pathway and the effect being greater in the low-neuroticism group.CONCLUSION Cognitive failures and neuroticism play important roles in mental health.Therefore,enhancing subjective cognitive function and regulating emotional stability may contribute to the improvement of mental health.
基金Analysis of a Clinical Study of Vitamin D Supplementation in Improving the Prognosis of H-type Hypertension in the Elderly(Project No.:2341ZF140)。
文摘Objective:Correlation of serum 25-hydroxyvitamin D level with senile hypertension and its stroke.Methods:Two hundred hypertensive patients admitted to the hospital from February 2022 to December 2023 were classified as study subjects.They were divided into grade 2 hypertension group and grade 3 hypertension group,and 100 healthy medical checkups admitted during the same period were analyzed as study subjects.Results:Comparison of diagnostic results between grade 2 hypertension and grade 2 hypertensive stroke patients,there was a difference in 25(OH)D,(P<0.05).Comparison of test results between grade 3 hypertension and grade 3 hypertensive stroke patients,there was a difference in age,BMI,25(OH)D,GLU,LDL-C,(P<0.05).Serum 25-hydroxyvitamin D level is a high-risk factor for the occurrence of stroke in elderly hypertensive patients,so the probability of risk is higher,where 25(OH)D(ng/mL),GLU(mmol/L),there is a difference,(P<0.05).Conclusion:There is a greater relationship between the occurrence of stroke and serum 25-hydroxyvitamin D level in elderly hypertensive patients.The occurrence of the disease has a greater relationship with this indicator in patients and is also a high-risk factor that affects the patients’morbidity,so it is necessary to pay attention to the monitoring of this indicator after the onset of the disease in patients.
基金the Department of Pathophysiology of Hebei Medical University, China for their help
文摘A correlation between metabolic alterations of neuroactive steroids and Alzheimer’s disease remains unknown. In the present study, amyloid beta （Aβ） 25-35 （Aβ25-35） injected into the bilateral campus CA1 region significantly reduced learning and memory. At the biochemical level, hippocampal levels of pregnenolone were significantly reduced with Aβ25-35 treatment. Furthermore, progesterone was considerably decreased in the prefrontal cortex and hippocampus, and 17β-estradiol was signifi-cantly elevated. To our knowledge, this is the first report showing that Aβ25-35, a main etiological factor of Alzheimer’s disease, can alter the level and metabolism of neuroactive steroids in the prefrontal cortex and hippocampus, which are brain regions significantly involved in learning and memory. Aβ25-35 exposure also increased the expression of inflammatory mediators, tumor necrosis factor-αand interleukin-1β. However, subcutaneous injection of progesterone reversed the upregulation of tumor necrosis factor-αand interleukin-1βin a dose-dependent manner. Concomitant with improved cognitive abilities, progesterone blocked Aβ-mediated inflammation and increased the survival rate of hippocampal pyramidal cells. We thus hypothesize that Aβ-mediated cognitive deficits may occur via changes in neuroactive steroids. Moreover, our findings provide a possible therapeutic strategy for Alzheimer’s disease via neuroactive steroids, particularly progesterone.
文摘The significant influence of tumor stroma on malignant cells has been extensively investigated in this era of targeted therapy. The tumor microenvironment, as a dynamic system, is orchestrated by various cells including tumor vascular composing cells, inflammatory cells and fibroblasts. As a major and important component in tumor stroma, increasing evidence has shown that spindle-shaped cancer-associated fibroblasts (CAFs) are a significant modifier of cancer evolution, and promote tumorigenesis, tumor invasion and metastasis by stimulating angiogenesis, malignant cell survival, epithelial-mesenchymal transition (EMT) and proliferation via direct cell-to-cell contact or secretion of soluble factors in most digestive solid tumors. CAFs are thought to be activated, characterized by the expression of α-smooth muscle actin, fibroblast activated protein, fibroblast specific protein, vimentin, fibronectin, etc. They are hypothesized to originate from normal or aged fibroblasts, bone marrow-derived mesenchymal cells, or vascular endothelial cells. EMT may also be an important process generating CAFs, and most probably, CAFs may originate from multiple cells. A close link exists between EMT, tumor stem cells, and chemo-resistance of tumor cells, which is largely orchestrated by CAFs. CAFs significantly induce immunosuppression, and may be a prognostic marker in various malignancies. Targeted therapy toward CAFs has displayed promising anticancer efficacy, which further reinforces the necessity to explore the relationship between CAFs and their hosts.
