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Prediction and Sensitivity Analysis of Foam Concrete Compressive Strength Based on Machine Learning Techniques with Hyperparameter Optimization
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作者 sen yang Jie Zhong +5 位作者 Boyu Gan Yi Sun Changming Bu Mingtao Zhang Jiehong Li yang Yu 《Computer Modeling in Engineering & Sciences》 2025年第9期2943-2967,共25页
Foam concrete is widely used in engineering due to its lightweight and high porosity.Its compressive strength,a key performance indicator,is influenced by multiple factors,showing nonlinear variation.As compressive st... Foam concrete is widely used in engineering due to its lightweight and high porosity.Its compressive strength,a key performance indicator,is influenced by multiple factors,showing nonlinear variation.As compressive strength tests for foam concrete take a long time,a fast and accurate prediction method is needed.In recent years,machine learning has become a powerful tool for predicting the compressive strength of cement-based materials.However,existing studies often use a limited number of input parameters,and the prediction accuracy of machine learning models under the influence of multiple parameters and nonlinearity remains unclear.This study selects foam concrete density,water-to-cement ratio(W/C),supplementary cementitious material replacement rate(SCM),fine aggregate to binder ratio(FA/Binder),superplasticizer content(SP),and age of the concrete(Age)as input parameters,with compressive strength as the output.Five different machine learning models were compared,and sensitivity analysis,based on Shapley Additive Explanations(SHAP),was used to assess the contribution of each input parameter.The results show that Gaussian Process Regression(GPR)outperforms the other models,with R2,RMSE,MAE,and MAPE values of 0.95,1.6,0.81,and 0.2,respectively.It is because GPR,optimized through Bayesian methods,better fits complex nonlinear relationships,especially considering a large number of input parameters.Sensitivity analysis indicates that the influence of input parameters on compressive strength decreases in the following order:foam concrete density,W/C,Age,FA/Binder,SP,and SCM. 展开更多
关键词 Foam concrete compressive strength machine learning Gaussian grocess regression shapley additive explanations
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A pressure-sensitive rheological origin of high friction angles of granular matter observed in NASA–MGM project
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作者 程晓辉 肖世泽 +2 位作者 杨森 赵乃峰 Alex Sixie Cao 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第6期559-567,共9页
An abnormally high peak friction angle of Ottawa sand was observed in(National Aeronautics and Space Administration) NASA–(Mechanics of Granular Materials) MGM tests in microgravity conditions on the space shuttle. P... An abnormally high peak friction angle of Ottawa sand was observed in(National Aeronautics and Space Administration) NASA–(Mechanics of Granular Materials) MGM tests in microgravity conditions on the space shuttle. Previous investigations have been unsuccessful in providing a constitutive insight into this behavior of granular materials under extremely low effective stress conditions. Here, a recently proposed unified constitutive model for transient rheological behavior of sand and other granular materials is adopted for the analytical assessment of high peak friction angles. For the first time, this long-eluded behavior of sand is attributed to a hidden rheological transition mechanism, that is not only rate-sensitive, but also pressure-sensitive. The NASA–MGM microgravity conditions show that shear-tests of sand can be performed under abnormally low confining stress conditions. The pressure-sensitive behavior of granular shearing that is previously ignored is studied based on the μ(I) rheology and its variations. Comparisons between the model and the NASA microgravity tests demonstrate a high degree of agreement. The research is highly valid for pressure-sensitive and rate-dependent problems that occur during earthquakes, landslides, and space exploration. 展开更多
关键词 granular matter MICROGRAVITY pressure-sensitive NASA–MGM
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Accurate prediction of magnetocaloric effect in NiMn-based Heusler alloys by prioritizing phase transitions through explainable machine learning 被引量:2
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作者 Yi-Chuan Tang Kai-Yan Cao +7 位作者 Ruo-Nan Ma Jia-Bin Wang Yin Zhang Dong-Yan Zhang Chao Zhou Fang-Hua Tian Min-Xia Fang sen yang 《Rare Metals》 2025年第1期639-651,共13页
With the rapid development of artificial intelligence,magnetocaloric materials as well as other materials are being developed with increased efficiency and enhanced performance.However,most studies do not take phase t... With the rapid development of artificial intelligence,magnetocaloric materials as well as other materials are being developed with increased efficiency and enhanced performance.However,most studies do not take phase transitions into account,and as a result,the predictions are usually not accurate enough.In this context,we have established an explicable relationship between alloy compositions and phase transition by feature imputation.A facile machine learning is proposed to screen candidate NiMn-based Heusler alloys with desired magnetic entropy change and magnetic transition temperature with a high accuracy R^(2)≈0.98.As expected,the measured properties of prepared NiMn-based alloys,including phase transition type,magnetic entropy changes and transition temperature,are all in good agreement with the ML predictions.As well as being the first to demonstrate an explicable relationship between alloy compositions,phase transitions and magnetocaloric properties,our proposed ML model is highly predictive and interpretable,which can provide a strong theoretical foundation for identifying high-performance magnetocaloric materials in the future. 展开更多
关键词 NiMn-based Heusler materials Phase transition-type Machine learning Magnetocaloric effect Composition design
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醇硫基丙烷磺酸钠对电解高性能锂电铜箔的影响 被引量:12
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作者 杨森 王文昌 +4 位作者 张然 秦水平 吴敏娴 光崎尚利 陈智栋 《电化学》 CAS CSCD 北大核心 2022年第6期90-101,共12页
电解铜箔因其工艺简单、经济价值高,已广泛应用于印制线路板和锂离子电池领域。研究表明在电解制箔过程中,加入微量添加剂即可大幅度提高电解铜箔性能。因此,在基础电解液(312.5 g·L^(-1)CuSO_(4)·5H_(2)O,100 g·L^(-1)H... 电解铜箔因其工艺简单、经济价值高,已广泛应用于印制线路板和锂离子电池领域。研究表明在电解制箔过程中,加入微量添加剂即可大幅度提高电解铜箔性能。因此,在基础电解液(312.5 g·L^(-1)CuSO_(4)·5H_(2)O,100 g·L^(-1)H_(2)SO_(4),50 mg·L^(-1)Cl^(-))基础上,加入添加剂考察了电解液的电化学行为以及对铜箔表面形貌、结构以及性能的影响。实验选取了醇硫基丙烷磺酸钠(HP)、水解蛋白(HVP)和N,N-二甲基硫代甲酰胺丙烷磺酸钠(DPS)作为组合添加剂,利用扫描电镜(SEM)、X射线洐射(XRD)以及电化学分析等方法,重点考察了组合添加中HP对铜箔表面形貌和物理性能的影响。研究结果表明,在组合添加剂体系中HP具有较强的去极化作用,可以加速铜核的生长,且具有增强铜(200)晶面的择优生长取向。HP与DPS、HVP的协同作用可以进一步减小电解铜箔的晶粒尺寸,降低表面粗糙,提高铜箔力学性能和耐腐蚀性能。所制备的电解铜箔均匀致密,平均晶粒尺寸为29.2 nm、平均粗糙度为1.12μm、平均抗拉强度为399.5 MPa且耐蚀性能优越,是锂离子电池负极集流体的理想材料,具有较高的商业价值。 展开更多
关键词 电解铜箔 添加剂 电化学 抗拉强度 耐腐蚀
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A 4-MA linear transformer driver for X-ray generation
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作者 Hao Wei Mengtong Qiu +21 位作者 Xiaofeng Jiang Zhiguo Wang Hongyu Jiang Weibo Yao Dingguo Lai Hanyu Wu Cheng Lou Jiachen Wang Yaorong yang Fengju Sun Mo Li Liangping Wang Qifu Xu Pengchao Li sen yang Yi Shen Zhen Wu Jinhua Wang Wei Liu Hailiang yang Wei Wu Aici Qiu 《Matter and Radiation at Extremes》 2025年第6期42-50,共9页
We have designed,assembled,and tested a 4-MA,60-ns fast linear transformer driver(LTD),which is the first operating generator featuring multiple LTD modules connected in parallel.The LTD-based accelerator comprises si... We have designed,assembled,and tested a 4-MA,60-ns fast linear transformer driver(LTD),which is the first operating generator featuring multiple LTD modules connected in parallel.The LTD-based accelerator comprises six modules in parallel,each of which has ten-stage cavities stacked in series.The six LTD modules are connected to a water tank of diameter 6 m via a 3-m-long impedance-matched deionized waterinsulated coaxial transmission line.In the water tank,the electrical pulses are transmitted down by six horizontal tri-plate transmission lines.A 2.1-m-diameter two-level vacuum insulator stack is utilized to separate the deionized water region from the vacuum region.In the vacuum,the currents are further transported downstream by a two-level magnetically insulated transmission-line and then converged through four post-hole convolutes.Plasma radiation loads or bremsstrahlung electron beam diodes serve as loads that are expected to generate intense soft X rays or warm X rays.The machine is 3.2 m in height and 22 m in outer diameter,including support systems such as a high-voltage charge supply,magnetic core reset system,trigger system,and support platform for inner stalk installation and maintenance.A total of 1440 individual±100-kV multi-gap spark switches and 2880 individual 100-kV capacitors are employed in the accelerator.A total of 12 fiberoptic laser-controlled trigger generators combining photoconductive and traditional gas spark switch technologies are used to realize the synchronous discharge of the more than 1000 gas switches.At an LTD charge voltage of±85 kV,the accelerator stores an initial energy of about 300 kJ and is expected to deliver a current of 3–5 MA into various loads.To date,the LTD facility has shot into a thick-walled aluminum liner load and a reflex triode load.With a thick-walled aluminum liner of inductance 1.81 nH,a current with peak up to 4.1 MA and rise time(10%–90%)of about 60 ns has been achieved.The current transport efficiency from the insulator stack to the liner load approaches 100%during peak times.The LTD accelerator has been used to drive reflex triode loads generating warm X rays with high energy fluence and large radiation area.It has been demonstrated that this LTD is a promising and high-efficiency prime pulsed power source suitable for use in constructing the next generation of large-scale accelerators with currents of tens of megaamperes. 展开更多
关键词 X ray Generation Linear Transformer Driver Multi Megampere Accelerator water tank water tankthe Pulsed Power Source linear transformer driver ltd which operating generator
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High-performance magnetostrictive Fe_(83)Ga_(17) alloy with excellent mechanical properties induced by interstitial doping of small-radius boron atoms
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作者 Kun Wang Qi-Zhong Zhao +10 位作者 Tie-Yan Chang Fang-Hua Tian Jia-Le Guo Zhi-Yong Dai Jie Liu Yi-Chuan Tang Si-Ying Yu Yin Zhang Chao Zhou Kai-Yan Cao sen yang 《Rare Metals》 2025年第10期7772-7783,共12页
Excellent magnetostrictive properties and processability are the two most important key factors for the practical application of magnetostrictive materials and research directions of continuous concern.In this study,w... Excellent magnetostrictive properties and processability are the two most important key factors for the practical application of magnetostrictive materials and research directions of continuous concern.In this study,we significantly improved the magnetostriction,ductility,and tensile strength of Fe_(83)Ga_(17)B_(x)(x=0,1,2,3,and 4)alloys by adjusting the small-radius boron(B)doping concentration.When x=3,the maximum magnetostriction value reached 193 ppm,approximately twice that of the undoped alloy(x=0),while the ultimate tensile strength and elongation increased by 147%and 238%,respectively,compared to Fe_(83)Ga_(17)alloys.Both first-principles calculations and experimental results indicate that B doping facilitates the alignment of FeGa crystal growth direction with the easy magnetization axis,thereby significantly improving the magnetostrictive properties of the alloy.Additionally,increasing B content progressively refines the grain size and promotes Fe_(2)B phase formation,thereby enhancing both strength and toughness.At x=3,the material exhibits the highest saturation magnetization and the lowest coercivity.Therefore,the results show that doping small-radius atoms in the interstitial sites can effectively enhance the magnetostrictive and mechanical properties of FeGa materials.This work offers a promising strategy for designing magnetostrictive materials with superior overall properties. 展开更多
关键词 Fe-Ga alloys MAGNETOSTRICTION Mechanical property First-principles calculations Crystallographic orientation
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Microstructural optimization and strengthening mechanisms of in-situ TiB_(2)/Al–Cu composite after multidirectional forging for six passes
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作者 sen yang Zhiren Sun +4 位作者 Zipeng Wang Shuhui Zhao Kaikun Wang Dun Li Xiaokai Wang 《International Journal of Minerals,Metallurgy and Materials》 2025年第7期1703-1718,共16页
In-situ TiB_(2)/Al–Cu composite was processed by multidirectional forging(MDF)for six passes.The microstructure evolution of the forged workpiece was examined across various regions.The mechanical properties of the a... In-situ TiB_(2)/Al–Cu composite was processed by multidirectional forging(MDF)for six passes.The microstructure evolution of the forged workpiece was examined across various regions.The mechanical properties of the as-cast and MDFed composites were compared,and their strengthening mechanisms were analyzed.Results indicate that the grain refinement achieved through the MDF process is mainly due to the subdivision of the original grains through mechanical geometric fragmentation and the occurrence of dynamic recrystallization(DRX).DRX grains are formed through discontinuous DRX,continuous DRX,and recrystallization induced by particle-stimulated nucleation.A rise in accumulated equivalent strain(Σ?ε)results in finerα-Al grains and a more uniform distribution of TiB_(2)particles,which enhance the Vickers hardness of the composite.In addition,the tensile properties of the MDFed composite significantly improve compared with those of the as-cast composites,with ultimate tensile strength and yield strength increasing by 51.2%and 54%,respectively.This enhancement is primarily due to grain refinement strengthening and dislocation strengthening achieved by the MDF process. 展开更多
关键词 in-situ TiB_(2)/Al-Cu composite multidirectional forging grain refinement dynamic recrystallization tensile properties
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Two-dimensional hybrid nanosheets towards room-temperature organic ferrimagnetic semiconductor
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作者 Xiaoling Men Fei Qin +12 位作者 Bo Zhang Kangkang Yao Yin Zhang yangtao Zhou Qifeng Kuang Xiaolei Shang Ruiqi Huang Zhiwei Li sen yang Gang Liu Teng yang Da Li Zhidong Zhang 《Journal of Materials Science & Technology》 2025年第30期280-288,共9页
Organic magnetic semiconductors have aroused much attention for spintronic applications. However, it remains challenging to achieve organic semiconductors with strong room-temperature ferromagnetism. Here, we report a... Organic magnetic semiconductors have aroused much attention for spintronic applications. However, it remains challenging to achieve organic semiconductors with strong room-temperature ferromagnetism. Here, we report a two-dimensional (2D) tetragonal organic-inorganic ferrimagnetic (FIM) semiconductor of Fe_(14)Se_(16)(peha)_(0.7) (peha = pentaethylenehexamine) with excellent thermal stability and a Curie temperature (T_(C)) higher than 519 K. Magnetic and Mössbauer measurements reveal a long-range magnetic ordering in single crystalline Fe_(14)Se_(16)(peha)0.7 nanosheets. The saturation magnetization and coercivity are 5.9 emu g^(−1) and 0.42 kOe at 5 K, which slightly reduces to 4.6 emu g^(−1) and ∼0 Oe at 300 K. A direct optical bandgap of 2.22 eV is obtained by tuning electronic structure of β-Fe3Se4 host layers through spacer layers consisting of Fe^(3+) and peha. Electrical and Seebeck coefficient data indicate that the n-type semiconductor follows the thermally-activated conduction mechanism (lnρ ∝ T^(−1)) in a range of 130–300 K with an activation energy (Ea) of 62.69 meV. Thermal conductivity is 2.5 W m^(−1) K^(−1) at 300 K, while the Wiedemann–Franz law is strongly violated according to electrical-thermal transport data due to weak incorporation of organic spacer layers and host layers. This study sets the stage for exploiting new room-temperature organic magnetic semiconductor systems for spintronic materials. 展开更多
关键词 Two-dimensional nanosheets Organic-inorganic hybrid material Ferrimagnetic semiconductor Magnetic properties Semiconducting properties
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A facile high-efficiency preparation strategy for Al-containing multi-component boride microcrystals with superior comprehensive performance
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作者 Yong Fan Jinfeng Nie +7 位作者 Zhigang Ding Yujing Zhang Xiang Chen Wei Liu sen yang Sida Liu Xiangfa Liu Yonghao Zhao 《Journal of Materials Science & Technology》 2025年第1期190-203,共14页
Multi-component transition group metal borides(MMB_(2))have become a research hotspot due to their new composition design concepts and superior properties compared with conventional ceramics.Most of the current method... Multi-component transition group metal borides(MMB_(2))have become a research hotspot due to their new composition design concepts and superior properties compared with conventional ceramics.Most of the current methods,however,are complicated and time-consuming,the mass production remains a chal-lenge.Herein,we proposed a new high-efficiency strategy for synthesis of MMB_(2)using molten aluminum as the medium for the first time.The prepared Al-containing multi-component borides(TiZrHfNbTa)B_(2)microcrystals had a homogeneous composition with a hexagonal AlB_(2)structure and ultra-high hardness value of∼35.3 GPa,which was much higher than data reported in the literature and the rule of mix-ture estimations.Furthermore,combined with the First-principles calculation results,we found that the Poisson’s ratio(v)values exhibit a clearly ascending trend from 0.17 at VEC=3.5 to 0.18 at VEC=3.4,then to 0.201 at VEC=3.2 with the increasing of Al content.This indicates that the intrinsic toughness of multi-component boride microcrystals is obviously enhanced by the trace-doped Al elements.Besides,the fabricated Al-containing multi-component boride microcrystals have superior oxidation activation en-ergy and structural stability.The enhanced oxidation resistance is mainly attributed to the formation of a protective Al2 O3 oxide layer and the lattice distortion,both of which lead to sluggish diffusion of O_(2).These findings propose a new unexplored avenue for the fabrication of MMB_(2)materials with supe-rior comprehensive performance including ultra-hardness and intrinsically improved thermo-mechanical properties. 展开更多
关键词 Multi-component borides First-principles calculations Crystal growth Mechanical properties Oxidation behavior
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Magnetism-structure triple point morphotropic phase boundary and resulting W-type magnetostrictive effect in Ni_(50)Mn_(34)Sb_(16-x)Ga_(x) Heusler alloys
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作者 Qi-Zhong Zhao Fang-Hua Tian +8 位作者 sen Kong Jia-Le Guo Zhi-Yong Dai Tie-Yan Chang Chao Zhou Yin Zhang Kai-Yan Cao sen yang Xiao-Ping Song 《Rare Metals》 2025年第3期1905-1916,共12页
The mutual coupling of structure and magnetism is crucial for Heusler alloys.In this paper,Ni_(50)Mn_(34)Sb_(16-x)Ga_(x)(0≤x≤16)alloys were prepared by arc melting.Based on the test results of structure and magnetis... The mutual coupling of structure and magnetism is crucial for Heusler alloys.In this paper,Ni_(50)Mn_(34)Sb_(16-x)Ga_(x)(0≤x≤16)alloys were prepared by arc melting.Based on the test results of structure and magnetism,the magnetic-structural phase diagram of Ni_(50)Mn_(34)Sb_(16-x)Ga_(x)(0≤x≤16)was drawn.The structure changes from cubic to monoclinic and finally to tetragonal as the x increases at room temperature.Its phase diagram shows a morphotropic phase boundary(MPB)starting from a tricritical triple point(around the Ni_(50)Mn_(34)Sb_(5)Ga_(11)alloy)of a cubic paramagnetic phase,ferromagnetic monoclinic,and antiferromagnetic tetragonal phases.And Ni_(50)Mn_(34)Sb_(5)Ga_(11)alloy has experienced five different phase states:paramagnetic austenite→ferromagnetic austenite→antiferromagnetic martensite→ferromagnetic martensite→spin glass as the temperature decreased.Further study of the alloys’magnetostrictive properties near the MPB showed that as x increases,a negative strain initially appears,followed by a W-type that crosses negative and positive strains,and then a positive strain.This is caused by the inconsistency in the speed and degree of magnetic domain walls response with monoclinic and tetragonal coexisting structures.This indicates that coupling between structure and magnetism is critical to the properties of materials.This work provides valuable insights into the magnetostrictive behavior and structural evolution of Heusler alloys,particularly in the context of MPB systems,and offers guidance for the design and optimization of material properties through controlled magnetic-structural interactions.Kindly check and confirm the edit made in the title.The edit made in the title has been confirmed to be accurate. 展开更多
关键词 Ferromagnetic shape memory alloy Heusler alloys MAGNETOSTRICTION Martensite transformation Triple point morphotropic phase boundary
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The development of liquid-phase chip by target sequencing and their application in watermelon molecular breeding
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作者 Shixiang Duan Dengke Wang +12 位作者 Qishuai Kang Huazheng Yan Jiaxin Cui Minjuan Zhang Dongming Liu sen yang Yingchun Zhu Huanhuan Niu Wenkai Yan Huayu Zhu Jianbin Hu Junling Dou Luming yang 《Horticultural Plant Journal》 2025年第6期2109-2120,共12页
Genotyping by Target Sequencing(GBTS)technology,known for its flexibility,high efficiency,high throughput,and low cost,has been increasingly employed in molecular breeding.However,there is still limited study on the d... Genotyping by Target Sequencing(GBTS)technology,known for its flexibility,high efficiency,high throughput,and low cost,has been increasingly employed in molecular breeding.However,there is still limited study on the design and development of high-throughput genotyping tools in watermelon.In this study,we identified 112000 high quality SNPs by analyzing the resequencing data of 43 cultivated watermelon accessions.11921 and 6094 SNPs were selected for developing two sets of watermelon liquid-phase chips with different marker densities,named Watermelon 10K and 5K,respectively.Furthermore,the SNPs and Indels of most mapped gene/QTLs for many agronomic important traits in watermelon were also integrated into the two chips for foreground selection.These chips have been tested using GBTS technology in various applications in watermelon.The genotyping of 76 accessions by Watermelon 5K liquid-phase chip showed an average detection rate of 99.28%and 81.78%for cultivated and wild watermelon accessions,respectively.This provided enough markers information for GWAS and two significant QTLs,ssc1.1 and ssc1.2,associated with soluble sugar content were detected.Furthermore,BSA-seq analysis for non-lobed leaf and dwarf traits were validated by liquid-phase chips,and the candidate region was consistent with our previous studies.Additionally,we precisely introduced the Cldw1 and Clbl genes into an elite inbred line WT2 using Watermelon 5K for assisted selection,resulting in the development of three new germplasm with good plant architecture.As a high-throughput genotyping liquid-phase SNP array,the Watermelon 10K and 5K chips will greatly facilitate functional studies and molecular breeding in watermelon. 展开更多
关键词 WATERMELON Genotyping by target sequence Liquid-phase chips Primary mapping Molecular breeding
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The pseudo-type response regulator gene Clsc regulates rind stripe coloration in watermelon
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作者 Dongming Liu Jinfang Liang +10 位作者 Quanquan Liu Yaxin Chen Shixiang Duan Dongling Sun Huayu Zhu Junling Dou Huanhuan Niu sen yang Shouru Sun Jianbin Hu Luming yang 《Journal of Integrative Agriculture》 2025年第1期147-160,共14页
The color and pattern of watermelon rind are crucial external traits that directly affect consumer preferences.Watermelons with stripes having a stronger color than the background rind are ideal for studying stripe pa... The color and pattern of watermelon rind are crucial external traits that directly affect consumer preferences.Watermelons with stripes having a stronger color than the background rind are ideal for studying stripe patterns in plants,while there is still limited knowledge about the genetic mechanisms underlying stripe coloration due to the lack of germplasm resources.In this study,we focused on a watermelon germplasm with colorless stripes,and genetic analysis revealed that the trait is controlled by a single recessive gene.The gene Clsc(Citrullus lanatus stripe coloration),which is responsible for the colorless stripe,was localized into a 147.6 kb region on Chr9 by linkage analysis in a large F2 mapping population.Further analysis revealed that the Cla97C09G175170 gene encodes the APRR2 transcription factor,plays a crucial role in determining the watermelon colorless stripe phenotype and was deduced to be related to chlorophyll synthesis and chloroplast development.Physiological experiments indicated that Cla97C09G175170 may significantly influence chloroplast development and chlorophyll synthesis in watermelon.The results of this study provide a better understanding of the molecular mechanism of stripe coloration in watermelon and can be useful in the development of marker-assisted selection(MAS)for new watermelon cultivars. 展开更多
关键词 watermelon stripe COLORATION INHERITANCE gene mapping TRANSCRIPTOME
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改善新疆某铜镍矿半自磨机顽石积累 被引量:4
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作者 张谦 肖庆飞 +2 位作者 王旭东 杨森 马帅 《过程工程学报》 CAS CSCD 北大核心 2020年第9期1089-1096,共8页
针对新疆某铜镍矿半自磨机顽石积累严重,磨矿产品细度不达标的问题,在测定矿石力学性质基础上,采用半自磨机磨矿循环的方法,以钢球介质配比作为单一变量,进行提高磨矿指标的磨矿对比研究,并采用离散元方法验证实验结论,最终确定半自磨... 针对新疆某铜镍矿半自磨机顽石积累严重,磨矿产品细度不达标的问题,在测定矿石力学性质基础上,采用半自磨机磨矿循环的方法,以钢球介质配比作为单一变量,进行提高磨矿指标的磨矿对比研究,并采用离散元方法验证实验结论,最终确定半自磨机的最佳介质配比方案为φ150:φ120=1:2。结果表明,矿石比重平均值为3.36 g/cm^3,硬度系数平均值为7.93,弹性模量平均值为3.11×10^4 MPa,泊松比平均值为0.26,矿石中等偏硬,伴有脆性、韧性较大的矿石存在;在相同磨矿条件下,半自磨机的推荐方案顽石25~80 mm粒级产率逐渐减少,现场方案反之。三次磨矿循环后,推荐方案较现场方案25~80 mm粒级产率低4.19个百分点,+100,-2.5,-0.074 mm三个粒级产率分别提高了0.25, 13.79, 4.80个百分点;与偏大方案相比,推荐方案同样表现出较好的研磨能力,在相同磨矿条件下,三次磨矿循环后顽石25~80 mm粒级产率低3.36个百分点,-0.074 mm磨矿细度高2.24个百分点。推荐方案25~80 mm粒级法向碰撞能量利用率为56.19%,较现场方案及偏大方案分别高1.82和2.30个百分点,推荐方案较其他两个方案顽石破碎能力更好,模拟仿真结果与实验结果一致。综合对比可知,推荐方案具有明显的优势,在保证磨矿产品细度维持在较好水平下,充分解决了顽石积累的问题,为相关厂矿同类问题提供可借鉴的方法。 展开更多
关键词 钢球配比 半自磨机 顽石积累 磨矿产品 细度
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晶粒尺寸和温度对工业纯钛变形机制的影响 被引量:2
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作者 陈才 韩冬生 +5 位作者 宋玉涛 王名川 李玉胜 徐舜 杨森 刘吉梓 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2023年第11期3332-3347,共16页
为了研究晶粒尺寸和加工温度对工业纯钛变形行为的影响,分别在室温和液氮温度下对平均晶粒尺寸为2、9、23和51μm的样品进行单轴拉伸实验,采用背散射电子衍射技术(EBSD)和透射电子显微镜技术(TEM)表征样品的显微组织和织构。结果表明,... 为了研究晶粒尺寸和加工温度对工业纯钛变形行为的影响,分别在室温和液氮温度下对平均晶粒尺寸为2、9、23和51μm的样品进行单轴拉伸实验,采用背散射电子衍射技术(EBSD)和透射电子显微镜技术(TEM)表征样品的显微组织和织构。结果表明,室温条件下位错滑移是主要的变形机制,而液氮温度下拉伸的样品中有丰富的变形孪晶被激活,其中包括{1012}拉伸孪晶、{1122}压缩孪晶和{1122}-{1012}二次孪晶。这揭示液氮温度条件下塑性变形模式从位错滑移到动态孪生的转变,这也是具有较大晶粒尺寸的样品在液氮温度下依然具有优异力学性能的主要原因。另外,还提出了一种改进的Hall-Petch关系式,可用于在液氮温度条件下定量表征平均晶粒尺寸和孪晶对工业纯钛拉伸屈服强度的影响。 展开更多
关键词 工业纯钛 低温拉伸试验 变形孪生 晶粒尺寸 晶体学织构
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疏风明目方超声雾化对过敏性结膜炎患者泪膜稳定性及泪液相关指标的影响 被引量:42
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作者 杨森 唐建明 +3 位作者 忽俊 黄洁 熊毅 顾春燕 《国际眼科杂志》 CAS 北大核心 2019年第6期1068-1071,共4页
目的:观察疏风明目方超声雾化对过敏性结膜炎患者泪膜稳定性及泪液相关指标的影响。方法:将140例过敏性结膜炎患者随机分为两组,对照组70例给予盐酸奥洛他定滴眼液联合生理盐水雾化治疗,观察组70例给予盐酸奥洛他定滴眼液联合疏风明目... 目的:观察疏风明目方超声雾化对过敏性结膜炎患者泪膜稳定性及泪液相关指标的影响。方法:将140例过敏性结膜炎患者随机分为两组,对照组70例给予盐酸奥洛他定滴眼液联合生理盐水雾化治疗,观察组70例给予盐酸奥洛他定滴眼液联合疏风明目方超声雾化治疗。连续治疗14d后,比较两组临床疗效、治疗前后单项症状(流泪、痒感、畏光、异物感)、泪膜稳定性(BUT、FL)、泪液相关指标[嗜酸性细胞阳离子蛋白(ECP)、HA、IgE]。结果:观察组治疗后总有效率高于对照组(90.7%vs74.3%,P<0.05);两组治疗后单项症状积分均低于治疗前,且观察组均低于对照组(P<0.05);两组治疗后BUT均高于治疗前,FL均低于治疗前,且观察组改善程度均优于对照组(P<0.05);两组治疗后泪液HA、ECP、IgE水平均低于治疗前,且观察组改善程度均优于对照组(P<0.05)。结论:疏风明目方超声雾化治疗能够改善过敏性结膜炎患者泪液相关指标,提高泪膜稳定性,有助于缓解局部变态反应,改善患者临床症状。 展开更多
关键词 过敏性结膜炎 疏风明目方 超声雾化 泪膜稳定性 泪液相关指标
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基于小型化Cas蛋白的CRISPR/Gal4BD-Cas供体适配基因编辑系统研究
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作者 杨森 马宝霞 +7 位作者 钱泓润 崔婕妤 张潇筠 李利达 魏泽辉 张智英 王建刚 徐坤 《遗传》 CAS CSCD 北大核心 2024年第9期716-726,共11页
在哺乳动物细胞中,利用同源引导修复(homology-directed repair,HDR)机制的基因编辑策略能够实现精准的点编辑和敲入,但是HDR的低效性严重制约了该策略在精准医疗和分子设计育种中的应用。鉴于HDR机制所需的供体DNA模板不能自主募集到... 在哺乳动物细胞中,利用同源引导修复(homology-directed repair,HDR)机制的基因编辑策略能够实现精准的点编辑和敲入,但是HDR的低效性严重制约了该策略在精准医疗和分子设计育种中的应用。鉴于HDR机制所需的供体DNA模板不能自主募集到基因组双链断裂(double-stranded break,DSB)处,本课题组提出了供体适配系统(donor adapting system,DAS)的概念并开发出CRISPR/SpCas9-Gal4BD供体适配基因编辑系统。由于SpCas9蛋白分子较大,与Gal4BD适配器结合不利于表达、病毒载体包装及活体递送等过程,因此本研究进一步采用两种小型化Cas蛋白——路邓葡萄球菌(Staphylococcus lugdunensis)源SlugCas9变体SlugCas9-HF与氨基酸球菌(Acidaminococcus sp.)源AsCas12a,开发了新型的CRISPR/Gal4BD-SlugCas9和CRISPR/Gal4BD-AsCas12a供体适配基因编辑系统。通过SSA活性报告实验初步证明了Gal4BD与SlugCas9、AsCas12a N-端融合对其打靶活性影响较小。通过HDR效率报告实验进行功能验证并优化供体设计方案,结果表明:对于CRISPR/Gal4BD-AsCas12a DAS,适配器结合序列(binding sequence,BS)与供体5′-端融合(BS-dsDNA)效果较好;对于CRISPR/Gal4BD-SlugCas9 DAS,则BS与供体3′-端融合(dsDNA-BS)较佳。最终,利用CRISPR/Gal4BD-SlugCas9 DAS对HEK293T细胞中的EMX1、NUDT5、AAVS1三个基因位点分别实现了24%、37%、31%的精准编辑,相比对照组得到了显著提高。本研究为供体适配基因编辑系统的进一步优化提供了参考和借鉴,为后续动物分子设计育种应用研究提供了新的基因编辑工具。 展开更多
关键词 基因编辑 同源引导修复 供体适配 小型化Cas蛋白 适配器
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In-situ TiC Reinforced Composite Coating Produced by Powder Feeding Laser Cladding 被引量:9
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作者 sen yang Wenjin LIU Minlin ZHONG 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2006年第4期519-525,共7页
A Ni-base alloy composite coating reinforced with TiC particles of various shapes and sizes on medium carbon steel substrate was produced by multilayer laser cladding. The chemical compositions, microstructures and su... A Ni-base alloy composite coating reinforced with TiC particles of various shapes and sizes on medium carbon steel substrate was produced by multilayer laser cladding. The chemical compositions, microstructures and surface morphology of the cladded layer were analyzed using energy dispersive X-ray spectroscopy (EDX), scanning electron microscope (SEM), and X-ray diffractometry (XRD). The experimental results showed that an excellent metallurgical bonding between the coating and the substrate was obtained. The microstructure of the coating was mainly composed of γ-Ni dendrites, a small amount of CrB, Ni3B, M23C6 and dispersed TiC particles. Much more and larger TiC particles formed in the overlapping zone, which led to a slightly higher microhardness of this zone. The maximum microhardness of the coating was about HV0.21200. The effects of the laser processing parameters on the microstructures and properties of coating were also investigated. 展开更多
关键词 Laser cladding In-situ synthesized Powder feeding TiC particle
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First genetic assessment of brackish water polychaete Tylorrhynchus heterochaetus: mitochondrial CO/sequences reveal strong genetic differentiation and population expansion in samples collected from southeast China and north Vietnam 被引量:6
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作者 Xing-Han Chen sen yang +5 位作者 Wei yang Yuan-Yuan Si Rui-Wen Xu Bin Fan Le Wang Zi-Ning Meng 《Zoological Research》 SCIE CAS CSCD 2020年第1期61-69,共9页
Tylorrhynchus heterochaetus is a widespread benthic polychaete worm found in coastal brackish waters of the west Pacific.It has high ecological and economic value as a biomarker of water quality and as a high-quality ... Tylorrhynchus heterochaetus is a widespread benthic polychaete worm found in coastal brackish waters of the west Pacific.It has high ecological and economic value as a biomarker of water quality and as a high-quality feed in aquaculture and fisheries and is considered a delicacy in some areas of Asia.However,it has experienced a marked reduction in recent years due to overexploitation as well as changes in the environment and climate.Here,to comprehensively understand its genetic background and thus provide insights for better conservation and utilization of this species,we assessed the genetic variability and demographic history of T.heterochaetus individuals sampled from eight locations along the coasts of southeast China and north Vietnam based on mitochondrial cytochrome c oxidase I(COI)sequences.We observed high haplotype diversity(Hd),with an average of 0.926,but relatively low nucleotide diversity(π),with a mean of 0.032 across all samples.A total of 94 polymorphic sites and 85 haplotypes were identified among 320 individuals.The pairwise genetic distances among haplotypes ranged from 0.001 to 0.067,with the high intraspecific divergence possibly reflecting geographic isolation and gene pool fragmentation.Significant genetic structures were revealed among the studied locations;specifically,the eight locations could be treated as six genetically different populations based on pairwiseΦST results(0.026–0.951,P<0.01).A significant pattern of isolation-by-distance was detected between the genetic and geographic distances(r=0.873,P=0.001).Three geographic lineages were defined based on phylogenetic tree and network analyses of COI haplotypes.AMOVA results indicated that genetic variations mainly occurred among the three lineages(89.96%).Tests of neutrality and mismatch distribution suggested that T.heterochaetus underwent recent population expansion.These results provide the first report on the genetic status of T.heterochaetus and will be valuable for the management of genetic resources and better understanding of the ecology and evolution in this species. 展开更多
关键词 Tylorrhynchus heterochaetus Mitochondrial DNA Genetic diversity Population structure Demographic history
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Comprehensive analysis of NAC transcription factors and their expression during fruit spine development in cucumber (Cucumis sativus L.) 被引量:14
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作者 Xingwang Liu Ting wang +8 位作者 Ezra Bartholomew Kezia Black Mingming Dong Yaqi Zhang sen yang Yanling Cai Shudan Xue Yiqun Weng Huazhong Ren 《Horticulture Research》 SCIE 2018年第1期556-569,共14页
The cucumber(Cucumis sativus L.)is an important vegetable crop worldwide,and fruit trichomes or spines are an important trait for external fruit quality.The mechanisms underlying spine formation are not well understoo... The cucumber(Cucumis sativus L.)is an important vegetable crop worldwide,and fruit trichomes or spines are an important trait for external fruit quality.The mechanisms underlying spine formation are not well understood,but the plant-specific NAC family of transcription factors may play important roles in fruit spine initiation and development.In this study,we conducted a genome-wide survey and identified 91 NAC gene homologs in the cucumber genome.Clustering analysis classified these genes into six subfamilies;each contained a varying number of NAC family members with a similar intron–exon structure and conserved motifs.Quantitative real-time PCR analysis revealed tissue-specific expression patterns of these genes,including 10 and 12 that exhibited preferential expression in the stem and fruit,respectively.Thirteen of the 91 NAC genes showed higher expression in the wild-type plant than in its near-isogenic trichome mutant,suggesting their important roles in fruit spine development.Exogenous application of four plant hormones promoted spine formation and increased spine density on the cucumber fruits;several NAC genes showed differential expression over time in response to phytohormone treatments on cucumber fruit,implying their essential roles in fruit-trichome development.Among the NAC genes identified,12 were found to be targets of 13 known cucumber micro-RNAs.Collectively,these findings provide a useful resource for further analysis of the interactions between NAC genes and genes underlying trichome organogenesis and development during fruit spine development in cucumber. 展开更多
关键词 development. analysis SPINE
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Impacts of electroacupuncture at auricular concha on gastrointestinal motility in the rats with type 2 diabetes 被引量:5
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作者 sen yang Yu-rui WU +2 位作者 Zheng ZHAN Yan-hong PAN Jin-feng JIANG 《World Journal of Acupuncture-Moxibustion》 CSCD 2022年第2期142-148,共7页
Objective:To observe the impacts of electroacupuncture(EA)at auricular concha on gastrointestinal motility in the rats with type 2 diabetes(T2D).Methods:A total of 30 SD male rats were collected.8 rats of them were in... Objective:To observe the impacts of electroacupuncture(EA)at auricular concha on gastrointestinal motility in the rats with type 2 diabetes(T2D).Methods:A total of 30 SD male rats were collected.8 rats of them were in a control group and the rest22 rats were prepared as the model of T2D by intraperitoneal injection with streptozotocin(STZ)and high-fat forage.Blood glucose≥16.7 mmol/L for 3 times was considered as modeling success in rats,thus the rats were collected in a T2D group(n=16).These 16 T2D rats were divided into a model group(n=8)and an intradermal auricular electroacupuncture stimulation(iaES)group(n=8)according to random number table.In the iaES group,intervention with EA was applied at auricular concha unilaterally each time,once daily,on both sides alternatively,5-day treatment as 1 course,at the interval of 2 days between courses,totally for 4 weeks.No any intervention was given in the model group and the control group.At the end of 4 weeks of intervention,the gastric emptying and intestinal propulsion were determined,ELISA method was adopted to determine gastrin(GAS)and motilin(MTL),and random blood glucose value and food intake were recorded in the iaES group,the model group and the control group successively.Results:After modeling,as compared with the control group,the food intake and random blood glucose were increased significantly(both P<0.001)and body weight was reduced obviously(P<0.01)in the T2D group.After intervention for 4 weeks,compared with the model group,the food intake and gastric content weight were obviously reduced(both P<0.05),the serum GAS content,gastric emptying and intestinal transit rate,as well as random blood glucose reduction were all higher(all P<0.05)in the rats of the iaES group,but the difference was not significant in MTL between the iaES groups and the model group(P>0.05).Conclusion:Electroacupuncture at auricular concha improves gastrointestinal motility in T2D model rats. 展开更多
关键词 DIABETES Type 2 diabetes mellitus Vagus nerve Gastrointestinal motility Auricular concha Electroacupuncture(EA)
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