Objective: Acute myeloid leukemia (AML) is a heterogeneous, hematologic malignancy at which short survival may be seen. Our study aims to evaluate the effect of the neutrophil-to-lymphocyte ratio (NLR) on the course o...Objective: Acute myeloid leukemia (AML) is a heterogeneous, hematologic malignancy at which short survival may be seen. Our study aims to evaluate the effect of the neutrophil-to-lymphocyte ratio (NLR) on the course of the disease, response to therapy, and overall survival (OS). Materials and Methods: A total of 124 patients followed-up with the diagnosis of AML from 2016 to 2019 were retrospectively examined. Results: 69 of the cases (55.6%) were men and 55 (44.3%) were women. The average age at the time of diagnosis was 53.44 ± 30.3 years old. We determined the NLR as median 0.46 (0.16 - 1.1). In AML, 69 patients were responsive to the induction regimen (57.9%) while 46 patients were unresponsive (37.8%). 5 patients died before completing the regimen. D-dimer was found to be higher and fibrinogen was found to be lower in the responsive group. Lower OS was observed in cases of >60 years of age, male gender, non-APL AML, high NLR, and recurrence at diagnosis. Recurrences were detected in 23 patients (18.5%) and the median time to the recurrence was 416 (236 - 639) days. Fibrinogen level and the bone marrow blast ratio at the time of application were determined to be associated with recurrence. The median follow-up time was 856 (143 - 1276) days. Final condition analysis reveals that 74 patients (59.6%) are alive. Conclusion: We determined in our study that the NLR is effective on survival. Medical literature on this subject is scanty and prospective studies with large patient groups are needed.展开更多
Objective: Transfusion of blood and blood products is life-saving in the right indication;however, it may cause serious complications that may lead to mortality. This study aimed to determine the level of knowledge of...Objective: Transfusion of blood and blood products is life-saving in the right indication;however, it may cause serious complications that may lead to mortality. This study aimed to determine the level of knowledge of allied health personnel about blood and blood product transfusion and to raise awareness about this issue as a result. Materials and Methods: In our study, 191 assistant healthcare professionals serving the adult age group in Konya Training and Research Hospital were surveyed with 24 questions via the website. Results: The rate of correctly knowing all the symptoms related to the transfusion reaction was 31.9%, and 37.6% of the signs. After the grouping of years of service, the rate of correctly knowing transfusion symptoms and signs was similar between the groups, while the rate of knowing the right approach in case of reaction was higher in those with a service year of >20 years. The rate of recognizing the symptoms suggestive of transfusion reaction was higher in those who received transfusion training compared to those who did not receive training (39.1% - 25.3%). Conclusion: It was deduced that the training should be repeated at frequent intervals since it was determined that the rate of correct answers to the survey questions was high among those who have worked in the profession for a longer period and those who have received transfusion training.展开更多
文摘Objective: Acute myeloid leukemia (AML) is a heterogeneous, hematologic malignancy at which short survival may be seen. Our study aims to evaluate the effect of the neutrophil-to-lymphocyte ratio (NLR) on the course of the disease, response to therapy, and overall survival (OS). Materials and Methods: A total of 124 patients followed-up with the diagnosis of AML from 2016 to 2019 were retrospectively examined. Results: 69 of the cases (55.6%) were men and 55 (44.3%) were women. The average age at the time of diagnosis was 53.44 ± 30.3 years old. We determined the NLR as median 0.46 (0.16 - 1.1). In AML, 69 patients were responsive to the induction regimen (57.9%) while 46 patients were unresponsive (37.8%). 5 patients died before completing the regimen. D-dimer was found to be higher and fibrinogen was found to be lower in the responsive group. Lower OS was observed in cases of >60 years of age, male gender, non-APL AML, high NLR, and recurrence at diagnosis. Recurrences were detected in 23 patients (18.5%) and the median time to the recurrence was 416 (236 - 639) days. Fibrinogen level and the bone marrow blast ratio at the time of application were determined to be associated with recurrence. The median follow-up time was 856 (143 - 1276) days. Final condition analysis reveals that 74 patients (59.6%) are alive. Conclusion: We determined in our study that the NLR is effective on survival. Medical literature on this subject is scanty and prospective studies with large patient groups are needed.
文摘Objective: Transfusion of blood and blood products is life-saving in the right indication;however, it may cause serious complications that may lead to mortality. This study aimed to determine the level of knowledge of allied health personnel about blood and blood product transfusion and to raise awareness about this issue as a result. Materials and Methods: In our study, 191 assistant healthcare professionals serving the adult age group in Konya Training and Research Hospital were surveyed with 24 questions via the website. Results: The rate of correctly knowing all the symptoms related to the transfusion reaction was 31.9%, and 37.6% of the signs. After the grouping of years of service, the rate of correctly knowing transfusion symptoms and signs was similar between the groups, while the rate of knowing the right approach in case of reaction was higher in those with a service year of >20 years. The rate of recognizing the symptoms suggestive of transfusion reaction was higher in those who received transfusion training compared to those who did not receive training (39.1% - 25.3%). Conclusion: It was deduced that the training should be repeated at frequent intervals since it was determined that the rate of correct answers to the survey questions was high among those who have worked in the profession for a longer period and those who have received transfusion training.
