The presence of bacteria directly affects wound healing.Chitosan-based hydrogel biomaterials are a solution as they offer advantages for wound-healing applications due to their strong antimicrobial properties.Here,a d...The presence of bacteria directly affects wound healing.Chitosan-based hydrogel biomaterials are a solution as they offer advantages for wound-healing applications due to their strong antimicrobial properties.Here,a double-cross-linking chitosanbased hydrogel with antibacterial,self-healing,and injectable properties is reported.Thiolated chitosan was successfully prepared,and the thiolated chitosan molecules were cross-linked by Ag-S coordination to form a supramolecular hydrogel.Subsequently,the amine groups in the thiolated chitosan covalently cross-linked with genipin to further promote hydrogel formation.In vitro experimental results indicate that hydrogel can release Ag^(+)over an extended time,achieving an antibacterial rate of over 99% against Escherichia coli and Staphylococcus aureus.Due to the reversible and dynamic feature of Ag-S coordination,an antibacterial hydrogel exhibited injectable and self-healing capabilities.Additionally,the hydrogel showed excellent biocompatibility and biodegradability.展开更多
基金supported by the National Key R&D Program of China(2020YFD0900205)the China Agriculture Research System(CARS-48).
文摘The presence of bacteria directly affects wound healing.Chitosan-based hydrogel biomaterials are a solution as they offer advantages for wound-healing applications due to their strong antimicrobial properties.Here,a double-cross-linking chitosanbased hydrogel with antibacterial,self-healing,and injectable properties is reported.Thiolated chitosan was successfully prepared,and the thiolated chitosan molecules were cross-linked by Ag-S coordination to form a supramolecular hydrogel.Subsequently,the amine groups in the thiolated chitosan covalently cross-linked with genipin to further promote hydrogel formation.In vitro experimental results indicate that hydrogel can release Ag^(+)over an extended time,achieving an antibacterial rate of over 99% against Escherichia coli and Staphylococcus aureus.Due to the reversible and dynamic feature of Ag-S coordination,an antibacterial hydrogel exhibited injectable and self-healing capabilities.Additionally,the hydrogel showed excellent biocompatibility and biodegradability.
