Lignans are a prominent group of phenolic compounds ubiquitously present in the plant kingdom,playing a critical role in both plant physiology and human health.Structurally they are characterized by the dimerization o...Lignans are a prominent group of phenolic compounds ubiquitously present in the plant kingdom,playing a critical role in both plant physiology and human health.Structurally they are characterized by the dimerization of two phenylpropane units to attain diverse chemical configurations that contribute to their wide range of biological activities.In plants,lignans function primarily as defense molecules,protecting against pathogens,herbivores,and environmental stressors.These compounds also participate in plant growth regulation and lignification processes.From a nutritional and medicinal perspective,lignans are valued for their significant health benefits.They act as phytoestrogens,which can modulate estrogen receptors in humans,thereby offering protective effects against hormone-related diseases such as breast cancer and menopausal symptoms.Additionally,lignans possess potent antioxidant and anti-inflammatory properties,contributing to cardiovascular health and cancer prevention.This review aims to provide a comprehensive overview of the importance of lignans in plants,highlighting their chemical diversity,health-promoting properties and stress adaptation.By synthesizing recent research findings,this review underscores the significance of lignans in enhancing plant resilience under stress and human health.It explores their potential applications in the food and pharmaceutical industries.Besides,it will also focus on the widely used method for enhancing the production of these high-value secondary metabolites in plant cell cultures to meet their requirement in pharmaceutical industries.展开更多
There is a growing concern over the presence of high concentrations of nitrate in orally consumed herbal remedies. Since nitrate accumulation in the plant body can vary with spatial location in plant and plant develop...There is a growing concern over the presence of high concentrations of nitrate in orally consumed herbal remedies. Since nitrate accumulation in the plant body can vary with spatial location in plant and plant development and temporally with photoperiod, understanding the relations between these factors and nitrate contents in the consumed herbs are vital for the development of agrotechnical strategies for nitrate avoidance. Therefore, the distribution profiles of nitrate content and nitrate reductase （NR） activity were analyzed in 14 accessions of Andrographis paniculata （Burm.f.） Wall. ex Nees., a medicinal plant widely used as a component of many herbal teas and medicinal infusions. Significant variation in nitrate accumulation in the plant was observed between the accessions, and most contained nitrate levels beyond the safety limit recommended according to the European Commission＇s Scientific Committee on Food. Nitrate content increased with plant development and leaf age, and that in leaf segment was higher in the middle of the leaf than at its tip or base; the nitrate concentration in plant organ followed the order of petiole 〉 leaf 〉 stem, and it was lower at mid-day than in the early morning or evening. Gradients of NR activity were negatively correlated with nitrate content in all studied temporal and spatial profiles. Identification of the characteristic spatial and developmental profiles of nitrate accumulation and NR activity in A. paniculata can guide the development of harvest strategies, aiming at minimizing nitrate contents in the consumed herbal tissue.展开更多
Quince(Cydonia oblonga)leaves are traditionally reported to alleviate the risk of cardiovascular disease.The study envisaged to explore the in vitro and in vivo phytochemical and cardio protective potential of quince ...Quince(Cydonia oblonga)leaves are traditionally reported to alleviate the risk of cardiovascular disease.The study envisaged to explore the in vitro and in vivo phytochemical and cardio protective potential of quince extract respectively.Different solvent extracts(Aqueous,Ethanolic,Hydroethanolic,Methanolic)of quince leaf obtained via two different extraction methods(Ultrasonication and Reflux)were evaluated for the phytochemical and antioxidant analysis.Among all the extracts,quince ethanolic extract,extracted via sonication was found to have the maximum phenolics(39.89±0.67 mg GAE/g DW),flavonoids(21.51±1.0 mgRE/g DW)and an anti-oxidant potential 2,2-diphenyl-1-picryl-hydrazyl radical(DPPH)with IC_(50) value of 168.88±2.24μg/ml.The High-performance thin layer chromatograph(HPTLC)and ultrahigh performance liquid chromatography mass spectrometry(UPLC-MS)analysis confirmed the presence of bio active compounds.Furthermore,the in vivo activity was ascertained against Doxorubicin(DOX)induced cardio toxicity in rats fed orally with the extract at 160 and 320 mg/kg body weight.The pre-treated groups significantly assuaged the changes induced by DOX in the electrocardiogram(ECG).Additionally,it mitigated the elevation in the blood serum parameters;aspartate transaminase(AST),lactate dehydrogenase(LDH),creatinine kinase-MB(CK-MB)and also repressed glutathione(GSH)depletion and rise in malondialdehyde(MDA)level induced by DOX.Furthermore,improvement in histopathological changes of the heart tissue concomitant to DOX induced toxicity was also observed such as,reduced degeneration,necrosis,inflammation and apoptosis.Thus,it could be concluded that cardioprotective activity of quince extract accredited to the occurrence of phytoconstituents prevented the DOX induced cardiotoxicity and helped to reinstate the cardiac damage in rats.展开更多
基金Ragini Singh is very thankful to the Jamia Hamdard University Grants Commission,India for research grant No.162000681.
文摘Lignans are a prominent group of phenolic compounds ubiquitously present in the plant kingdom,playing a critical role in both plant physiology and human health.Structurally they are characterized by the dimerization of two phenylpropane units to attain diverse chemical configurations that contribute to their wide range of biological activities.In plants,lignans function primarily as defense molecules,protecting against pathogens,herbivores,and environmental stressors.These compounds also participate in plant growth regulation and lignification processes.From a nutritional and medicinal perspective,lignans are valued for their significant health benefits.They act as phytoestrogens,which can modulate estrogen receptors in humans,thereby offering protective effects against hormone-related diseases such as breast cancer and menopausal symptoms.Additionally,lignans possess potent antioxidant and anti-inflammatory properties,contributing to cardiovascular health and cancer prevention.This review aims to provide a comprehensive overview of the importance of lignans in plants,highlighting their chemical diversity,health-promoting properties and stress adaptation.By synthesizing recent research findings,this review underscores the significance of lignans in enhancing plant resilience under stress and human health.It explores their potential applications in the food and pharmaceutical industries.Besides,it will also focus on the widely used method for enhancing the production of these high-value secondary metabolites in plant cell cultures to meet their requirement in pharmaceutical industries.
文摘There is a growing concern over the presence of high concentrations of nitrate in orally consumed herbal remedies. Since nitrate accumulation in the plant body can vary with spatial location in plant and plant development and temporally with photoperiod, understanding the relations between these factors and nitrate contents in the consumed herbs are vital for the development of agrotechnical strategies for nitrate avoidance. Therefore, the distribution profiles of nitrate content and nitrate reductase （NR） activity were analyzed in 14 accessions of Andrographis paniculata （Burm.f.） Wall. ex Nees., a medicinal plant widely used as a component of many herbal teas and medicinal infusions. Significant variation in nitrate accumulation in the plant was observed between the accessions, and most contained nitrate levels beyond the safety limit recommended according to the European Commission＇s Scientific Committee on Food. Nitrate content increased with plant development and leaf age, and that in leaf segment was higher in the middle of the leaf than at its tip or base; the nitrate concentration in plant organ followed the order of petiole 〉 leaf 〉 stem, and it was lower at mid-day than in the early morning or evening. Gradients of NR activity were negatively correlated with nitrate content in all studied temporal and spatial profiles. Identification of the characteristic spatial and developmental profiles of nitrate accumulation and NR activity in A. paniculata can guide the development of harvest strategies, aiming at minimizing nitrate contents in the consumed herbal tissue.
基金Department of Science and Technology(DST),New Delhi,India,for providing the fellowship to Entesar Hanan(DST/INSPIRE Fellowship/IF170403)。
文摘Quince(Cydonia oblonga)leaves are traditionally reported to alleviate the risk of cardiovascular disease.The study envisaged to explore the in vitro and in vivo phytochemical and cardio protective potential of quince extract respectively.Different solvent extracts(Aqueous,Ethanolic,Hydroethanolic,Methanolic)of quince leaf obtained via two different extraction methods(Ultrasonication and Reflux)were evaluated for the phytochemical and antioxidant analysis.Among all the extracts,quince ethanolic extract,extracted via sonication was found to have the maximum phenolics(39.89±0.67 mg GAE/g DW),flavonoids(21.51±1.0 mgRE/g DW)and an anti-oxidant potential 2,2-diphenyl-1-picryl-hydrazyl radical(DPPH)with IC_(50) value of 168.88±2.24μg/ml.The High-performance thin layer chromatograph(HPTLC)and ultrahigh performance liquid chromatography mass spectrometry(UPLC-MS)analysis confirmed the presence of bio active compounds.Furthermore,the in vivo activity was ascertained against Doxorubicin(DOX)induced cardio toxicity in rats fed orally with the extract at 160 and 320 mg/kg body weight.The pre-treated groups significantly assuaged the changes induced by DOX in the electrocardiogram(ECG).Additionally,it mitigated the elevation in the blood serum parameters;aspartate transaminase(AST),lactate dehydrogenase(LDH),creatinine kinase-MB(CK-MB)and also repressed glutathione(GSH)depletion and rise in malondialdehyde(MDA)level induced by DOX.Furthermore,improvement in histopathological changes of the heart tissue concomitant to DOX induced toxicity was also observed such as,reduced degeneration,necrosis,inflammation and apoptosis.Thus,it could be concluded that cardioprotective activity of quince extract accredited to the occurrence of phytoconstituents prevented the DOX induced cardiotoxicity and helped to reinstate the cardiac damage in rats.
