Background In a multinational randomized controlled trial,we previously showed that maternal supplementation with myo-inositol,probiotics,and micronutrients was associated with reduced incidence of rapid infant weight...Background In a multinational randomized controlled trial,we previously showed that maternal supplementation with myo-inositol,probiotics,and micronutrients was associated with reduced incidence of rapid infant weight gain and high body mass index(BMI)at two years among offspring.It was unclear whether these differences in weight gain and body mass were due to reduced adiposity.Therefore,we aimed to determine whether there were any differences in body composition.Methods Body composition was measured using bioelectrical impedance spectroscopy at six weeks,six months,one year,and two years among offspring born to mothers who received a nutritional intervention(n=268)or control(n=264)supplement preconception and during pregnancy.Results There were no group-level differences in body composition,except at two years,when fat-free mass was greater among control offspring[adjusted mean difference(aMD)0.14 kg,95%confidence interval(CI)0.03,0.25,P=0.012].However,there were no differences in mean percentage fat mass(%FM)at any time.In both groups,rapid weight gain[Δweight>0.67 standard deviation(SD)from birth to one year]was associated with greater%FM(aMD 2.0%at six months,2.0%at one year,1.4%at two years)compared with those who did not have rapid weight gain.Likewise,high BMI(≥95 percentile)at two years was associated with greater%FM(aMD 2.5%).Conclusions A maternal nutritional intervention did not lead to differences in average offspring body composition in the first two years of life.However,fewer offspring from the supplemented group experienced rapid weight gain and high BMI,characterized by greater%FM.展开更多
基金funding enabled and organized by CAUL and its Member Institutions.Public good funding for this investigator-led study is through the UK Medical Research Council(as part of an MRC award to the MRC Lifecourse Epidemiology Unit(MC_UU_12011/4))the Singapore National Research Foundation,National Medical Research Council(NMRC,NMRC/TCR/012-NUHS/2014)+5 种基金the National University of Singapore(NUS)and the Agency of Science,Technology and Research(as part of the Growth,Development and Metabolism Programme of the Singapore Institute for Clinical Sciences(SICS)(H17/01/a0/005)as part of Gravida,a New Zealand Government Centre of Research Excellence.Funding for provision of the intervention and control drinks and to cover aspects of the fieldwork for the study has been provided by SociétéDes Produits NestléS.A under a Research Agreement with the University of Southampton,Auckland UniServices Ltd,SICS,National University Hospital Singapore PTE Ltd and NUS.KMG is supported by the National Institute for Health Research(NIHR Senior Investigator(NF-SI-0515-10042)NIHR Southampton 1000DaysPlus Global Nutrition Research Group(17/63/154)NIHR Southampton Biomedical Research Center(IS-BRC-1215-20004))British Heart Foundation(RG/15/17/3174)the European Union(Erasmus+Programme ImpENSA 598488-EPP-1-2018-1-DE-EPPKA2-CBHE-JP).SYC is supported by a Singapore NMRC Clinician Scientist Awards(NMRC/CSA-INV/0010/2016,MOH-CSAINV19nov-0002).
文摘Background In a multinational randomized controlled trial,we previously showed that maternal supplementation with myo-inositol,probiotics,and micronutrients was associated with reduced incidence of rapid infant weight gain and high body mass index(BMI)at two years among offspring.It was unclear whether these differences in weight gain and body mass were due to reduced adiposity.Therefore,we aimed to determine whether there were any differences in body composition.Methods Body composition was measured using bioelectrical impedance spectroscopy at six weeks,six months,one year,and two years among offspring born to mothers who received a nutritional intervention(n=268)or control(n=264)supplement preconception and during pregnancy.Results There were no group-level differences in body composition,except at two years,when fat-free mass was greater among control offspring[adjusted mean difference(aMD)0.14 kg,95%confidence interval(CI)0.03,0.25,P=0.012].However,there were no differences in mean percentage fat mass(%FM)at any time.In both groups,rapid weight gain[Δweight>0.67 standard deviation(SD)from birth to one year]was associated with greater%FM(aMD 2.0%at six months,2.0%at one year,1.4%at two years)compared with those who did not have rapid weight gain.Likewise,high BMI(≥95 percentile)at two years was associated with greater%FM(aMD 2.5%).Conclusions A maternal nutritional intervention did not lead to differences in average offspring body composition in the first two years of life.However,fewer offspring from the supplemented group experienced rapid weight gain and high BMI,characterized by greater%FM.
