Biomolecular motors have been extensively studied as efficient molecular machines in detection systems owing to their unique signal conversion mechanisms and high energy conversion efficiencies.The application of thes...Biomolecular motors have been extensively studied as efficient molecular machines in detection systems owing to their unique signal conversion mechanisms and high energy conversion efficiencies.The application of these motors in the detection of pathogenic microorganisms is particularly promising.Through reasonable design and optimization,biomolecular motors can enable precise and efficient detection,enhancing clinical diagnostics.This paper reviews recent advances in detection systems utilizing various biomolecular motors,including kinesin,dynein,myosin,DNA polymerase,F_(o)F_(1)-ATPase,and flagellar motors.Detection mechanisms involving these motors are also introduced.Furthermore,the review covers recent progress in detecting antigens,antibodies,bacteria,and small molecules using biomolecular motors.Finally,the challenges and future prospects of biomolecular motor-based detection systems for pathogenic microorganisms are discussed,highlighting their potential as rapid and efficient tools for applications in food safety and medicine.展开更多
基金supported by the National Natural Science Foundation of China(Grant number 22078297)Natural Science Foundation of Zhejiang Province(Grant number LTGC23H200002)+1 种基金Science and Technology Plan Project of Taizhou(Grant number 23ywa37)Special Research Fund of Hospital Pharmacy of Zhejiang Pharmaceutical Association(Grant number 2020ZYY46).
文摘Biomolecular motors have been extensively studied as efficient molecular machines in detection systems owing to their unique signal conversion mechanisms and high energy conversion efficiencies.The application of these motors in the detection of pathogenic microorganisms is particularly promising.Through reasonable design and optimization,biomolecular motors can enable precise and efficient detection,enhancing clinical diagnostics.This paper reviews recent advances in detection systems utilizing various biomolecular motors,including kinesin,dynein,myosin,DNA polymerase,F_(o)F_(1)-ATPase,and flagellar motors.Detection mechanisms involving these motors are also introduced.Furthermore,the review covers recent progress in detecting antigens,antibodies,bacteria,and small molecules using biomolecular motors.Finally,the challenges and future prospects of biomolecular motor-based detection systems for pathogenic microorganisms are discussed,highlighting their potential as rapid and efficient tools for applications in food safety and medicine.
