Dopamine,a pivotal excitatory neurotransmitter,plays a crucial role in metabolic,cardiovascular,renal,central nervous,and endocrine systems.Abnormal dopamine within the human body can cause various diseases.Therefore,...Dopamine,a pivotal excitatory neurotransmitter,plays a crucial role in metabolic,cardiovascular,renal,central nervous,and endocrine systems.Abnormal dopamine within the human body can cause various diseases.Therefore,the precise quantification of dopamine levels,both in vivo and in vitro,holds paramount significance for clinical applications and physiological investigations.Carbon dots(CDs)exhibit a plethora of remarkable properties,including a substantial specific surface area,robust electrical conductivity,commendable biocompatibility,minimal toxicity,and high photostability.Considering these unique characteristics,CDs demonstrate substantial potential for fluorescent sensors,colorimetric sensors,and electrochemical sensors for dopamine detection.This review systematically examined the challenges and prospects for the utilization of CDs-based fluorescent sensors,electrochemical biosensors,and colorimetric sensors for monitoring dopamine levels in recent years.These findings unveil promising avenues for further advancements in the field of dopamine detection.展开更多
Biological imaging plays a pivotal role in visualizing and understanding biological structures and processes from molecular to macroscopic levels,enabling clinicians and researchers to noninvasively observe internal a...Biological imaging plays a pivotal role in visualizing and understanding biological structures and processes from molecular to macroscopic levels,enabling clinicians and researchers to noninvasively observe internal anatomy,detect disease at early stages,plan treatments,and monitor therapeutic outcomes.This broad field encompasses a diverse array of imaging modalities such as fluorescence,magnetic resonance imaging(MRI),and positron emission tomography(PET),each relying on distinct physical principles to extract specific biological information.Among them,Raman imaging has emerged as a molecularly specific and powerful technique capable of providing detailed chemical information and generating high-resolution two-or three-dimensional maps that visualize the multiscale distribution of specific molecular components within a sample.展开更多
Electrocatalytic nitrate reduction reaction(NitRR)is an efficient route for simultaneous wastewater treatment and ammonia production,but the conversion of NO_(3)–to NH_(3) involves multiple electron and proton transf...Electrocatalytic nitrate reduction reaction(NitRR)is an efficient route for simultaneous wastewater treatment and ammonia production,but the conversion of NO_(3)–to NH_(3) involves multiple electron and proton transfer processes and diverse by-products.Therefore,developing ammonia catalysts with superior catalytic activity and selectivity is an urgent task.The distinctive electronic structure of Cu enhances the adsorption of nitrogen-containing intermediates,but the insufficient activation capability of Cu for interfacial water restricts the generation of reactive hydrogen and inhibits the hydrogenation process.In this work,a Ce-doped CuO catalyst(Ce_(10)/CuO)was synthesized by in situ oxidative etching and annealing.The redox of Ce^(3+)/Ce^(4+)enables the optimization of the electronic structure of the catalyst,and the presence of Ce^(3+)as a defect indicator introduces more oxygen vacancies.The results demonstrate that Ce10/CuO provides an impressive ammonia yield of 3.88±0.14 mmol·cm^(–2)·h^(–1) at 0.4 V vs.reversible hydrogen electrode(RHE)with an increase of 1.04 mmol·cm^(–2)·h^(–1) compared to that of pure CuO,and the Faradaic efficiencies(FE)reaches 93.2%±3.4%.In situ characterization confirms the doping of Ce facilitates the activation and dissociation of interfacial water,which promotes the production of active hydrogen and thus enhances the ammonia production efficiency.展开更多
Hot spot engineering in plasmonic nanostructures plays a significant role in surface-enhanced Raman scattering(SERS)for bioanalysis and cell imaging.However,creating stable,reproducible,and strong SERS signals remains...Hot spot engineering in plasmonic nanostructures plays a significant role in surface-enhanced Raman scattering(SERS)for bioanalysis and cell imaging.However,creating stable,reproducible,and strong SERS signals remains challenging due to the potential interference from surrounding chemicals and locating SERS-active analytes into hot-spot regions.Herein,we developed a straightforward approach to synthesize intra-gap nanoparticles encapsulating 4-nitrobenzenethiol(4-NBT)as a reporter molecule within these gaps to avoid outside interference.We made three kinds of intra-gap nanoparticles using nanorods,bipyramids,and nanospheres as cores,in which the nanorods based intra-gap nanoparticles exhibit the highest SERS activity.The advantage of our method is the ease of preparation of high-yield and stable intra-gap nanoparticles characterized by a short incubation time(10 min)with 4-NBT and quick synthesis without requiring an additional step to centrifuge for the purification of core nanoparticles.The intense localized field in the synthesized hot spots of these plasmonic gap nanostructures holds great promise as a SERS substrate for a broad range of quantitative optical applications.展开更多
Single-atom nanozymes(SANs)are the new emerging catalytic nanomaterials with enzyme-mimetic activities,which have many extraordinary merits,such as low-cost preparation,maximum atom utilization,ideal catalytic activit...Single-atom nanozymes(SANs)are the new emerging catalytic nanomaterials with enzyme-mimetic activities,which have many extraordinary merits,such as low-cost preparation,maximum atom utilization,ideal catalytic activity,and optimized selectivity.With these advantages,SANs have received extensive research attention in the fields of chemistry,energy conversion,and environmental purification.Recently,a growing number of studies have shown the great promise of SANs in biological applications.In this article,we present the most recent developments of SANs in anti-infective treatment,cancer diagnosis and therapy,biosensing,and antioxidative therapy.This text is expected to better guide the readers to understand the current state and future clinical possibilities of SANs in medical applications.展开更多
基金supported by the National Natural Science Foundation of China(Nos.82060599,82360647)the Natural Science Foundation of Jiangxi Province(Nos.20224BAB206091,20232BAB216101)+2 种基金the Science and Technology Project of the Education Department of Jiangxi Province(No.GJJ2201406)the Natural Science Foundation of Ganzhou(No.202101034482)the Science and Technology Project of Health Committee in Jiangxi Province(No.202131033)。
文摘Dopamine,a pivotal excitatory neurotransmitter,plays a crucial role in metabolic,cardiovascular,renal,central nervous,and endocrine systems.Abnormal dopamine within the human body can cause various diseases.Therefore,the precise quantification of dopamine levels,both in vivo and in vitro,holds paramount significance for clinical applications and physiological investigations.Carbon dots(CDs)exhibit a plethora of remarkable properties,including a substantial specific surface area,robust electrical conductivity,commendable biocompatibility,minimal toxicity,and high photostability.Considering these unique characteristics,CDs demonstrate substantial potential for fluorescent sensors,colorimetric sensors,and electrochemical sensors for dopamine detection.This review systematically examined the challenges and prospects for the utilization of CDs-based fluorescent sensors,electrochemical biosensors,and colorimetric sensors for monitoring dopamine levels in recent years.These findings unveil promising avenues for further advancements in the field of dopamine detection.
文摘Biological imaging plays a pivotal role in visualizing and understanding biological structures and processes from molecular to macroscopic levels,enabling clinicians and researchers to noninvasively observe internal anatomy,detect disease at early stages,plan treatments,and monitor therapeutic outcomes.This broad field encompasses a diverse array of imaging modalities such as fluorescence,magnetic resonance imaging(MRI),and positron emission tomography(PET),each relying on distinct physical principles to extract specific biological information.Among them,Raman imaging has emerged as a molecularly specific and powerful technique capable of providing detailed chemical information and generating high-resolution two-or three-dimensional maps that visualize the multiscale distribution of specific molecular components within a sample.
基金This work was supported by the National Natural Science Foundation of China(Nos.52072152 and 51802126)the Jiangsu University Jinshan Professor Fund,the Jiangsu Specially-Appointed Professor Fund,Open Fund from Guangxi Key Laboratory of Electrochemical Energy Materials,Zhenjiang“Jinshan Talents”Project 2021,China Post Doctoral Science Foundation(No.2022M721372)+2 种基金“Doctor of Entrepreneurship and Innovation”in Jiangsu Province(No.JSSCBS20221197)the Postgraduate Research&Practice Innovation Program of Jiangsu Province(Nos.KYCX22_3645 and KYCX24_3964)Student Research Project of Jiangsu University(Nos.23A586 and 23A804).
文摘Electrocatalytic nitrate reduction reaction(NitRR)is an efficient route for simultaneous wastewater treatment and ammonia production,but the conversion of NO_(3)–to NH_(3) involves multiple electron and proton transfer processes and diverse by-products.Therefore,developing ammonia catalysts with superior catalytic activity and selectivity is an urgent task.The distinctive electronic structure of Cu enhances the adsorption of nitrogen-containing intermediates,but the insufficient activation capability of Cu for interfacial water restricts the generation of reactive hydrogen and inhibits the hydrogenation process.In this work,a Ce-doped CuO catalyst(Ce_(10)/CuO)was synthesized by in situ oxidative etching and annealing.The redox of Ce^(3+)/Ce^(4+)enables the optimization of the electronic structure of the catalyst,and the presence of Ce^(3+)as a defect indicator introduces more oxygen vacancies.The results demonstrate that Ce10/CuO provides an impressive ammonia yield of 3.88±0.14 mmol·cm^(–2)·h^(–1) at 0.4 V vs.reversible hydrogen electrode(RHE)with an increase of 1.04 mmol·cm^(–2)·h^(–1) compared to that of pure CuO,and the Faradaic efficiencies(FE)reaches 93.2%±3.4%.In situ characterization confirms the doping of Ce facilitates the activation and dissociation of interfacial water,which promotes the production of active hydrogen and thus enhances the ammonia production efficiency.
基金supported by the National Institutes of Health award R01-GM109988the financial support from the National Natural Science Foundation of China(No.82272054)Shanghai Jiao Tong University(No.YG2024LC09).
文摘Hot spot engineering in plasmonic nanostructures plays a significant role in surface-enhanced Raman scattering(SERS)for bioanalysis and cell imaging.However,creating stable,reproducible,and strong SERS signals remains challenging due to the potential interference from surrounding chemicals and locating SERS-active analytes into hot-spot regions.Herein,we developed a straightforward approach to synthesize intra-gap nanoparticles encapsulating 4-nitrobenzenethiol(4-NBT)as a reporter molecule within these gaps to avoid outside interference.We made three kinds of intra-gap nanoparticles using nanorods,bipyramids,and nanospheres as cores,in which the nanorods based intra-gap nanoparticles exhibit the highest SERS activity.The advantage of our method is the ease of preparation of high-yield and stable intra-gap nanoparticles characterized by a short incubation time(10 min)with 4-NBT and quick synthesis without requiring an additional step to centrifuge for the purification of core nanoparticles.The intense localized field in the synthesized hot spots of these plasmonic gap nanostructures holds great promise as a SERS substrate for a broad range of quantitative optical applications.
文摘Single-atom nanozymes(SANs)are the new emerging catalytic nanomaterials with enzyme-mimetic activities,which have many extraordinary merits,such as low-cost preparation,maximum atom utilization,ideal catalytic activity,and optimized selectivity.With these advantages,SANs have received extensive research attention in the fields of chemistry,energy conversion,and environmental purification.Recently,a growing number of studies have shown the great promise of SANs in biological applications.In this article,we present the most recent developments of SANs in anti-infective treatment,cancer diagnosis and therapy,biosensing,and antioxidative therapy.This text is expected to better guide the readers to understand the current state and future clinical possibilities of SANs in medical applications.
