Oxygen plays a crucial role in oenology. The oxygen leads to changes in the chemical and sensory profile of wines. On one hand, the impact of moderate oxygen exposure of red wine has a positive effect in its colour, a...Oxygen plays a crucial role in oenology. The oxygen leads to changes in the chemical and sensory profile of wines. On one hand, the impact of moderate oxygen exposure of red wine has a positive effect in its colour, aromatic bouquet and mouth-feel properties. On the other hand, oxygen has a negative effect on white wine＇s quality, as well as the sensory and compositional levels. The purpose of this study was to quantify the dissolved oxygen in red and white wine, during different cellar operations such as racking, tartaric stabilization, filtering and bottling. The techniques that contribute most to the enrichment of oxygen in wine are： cold tartaric stabilization （2.29 mg/L, white wines）, bottling （1.38 mg/L red wines and 1.11 mg/L white wines） and bag-in-box filling （2.47 mg/L red wines; 2.22 mg/L white wines）. After identifying the most critical technical operations in wine making, preventive and corrective measures had to be taken to reduce the dissolved oxygen content of wines, as well as preventing their depreciation.展开更多
H+modulated charge-transfer in photoexcited covalent polyoxometalate-bodipy conjugates is described.The hybrid organic/inorganic molecular photoactive dyads are based on Keggin-type polyoxometalates(POMs,where KM=[PM1...H+modulated charge-transfer in photoexcited covalent polyoxometalate-bodipy conjugates is described.The hybrid organic/inorganic molecular photoactive dyads are based on Keggin-type polyoxometalates(POMs,where KM=[PM11O39]and M=Mo or W)covalently grafted via an organotin linker to a bodipy(BOD)photosensitizer.The relative potentials of the photosensitizer and POM are aligned such that lightinduced electron transfer from BOD to POM is permitted for the polyoxomolybdate KMo Sn[BOD]but not effective for the polyoxotungstate analogue K^(W) _(Sn)[BOD].In both cases,the addition of acid shifts the redox potential of the POM only,to increase the driving force for electron transfer.This leads to chargeseparation being switched on for K^(W) _(Sn)[BOD]in the presence of acid.The addition of acid to KMo Sn[BOD]accelerates charge-separation by an order of magnitude(from 2 ns to 200 ps)and is accompanied by a deceleration of charge recombination,leading to a charge-separated state lifetime of up to 1.3μs.This behaviour is consistent with proton coupled electron transfer,which has previously been observed electrochemically for POMs,but this study shows,for the first time,the impact of protonation on photoinduced electron transfer.展开更多
As nano-sized molecular oxides,polyoxometalates(POMs)hold great promise in non-volatile memory materials based on redox-active molecules.Materials processed from solution,by drop-casting,by embedding POMs in polymers,...As nano-sized molecular oxides,polyoxometalates(POMs)hold great promise in non-volatile memory materials based on redox-active molecules.Materials processed from solution,by drop-casting,by embedding POMs in polymers,or using layer-by-layer deposition techniques have thus been reported and successfully investigated.Almost all of these examples are electrostatically assembled materials.We herein propose an original route for the elaboration of robust covalent POM networks.展开更多
Background:Mucopolysaccharidoses type Ⅲ (MPS Ⅲ) are a group of autosomai recessive lysosomal storage diseases,caused by mutations in genes that code for enzymes involved in the lysosomal degradation of heparan sulph...Background:Mucopolysaccharidoses type Ⅲ (MPS Ⅲ) are a group of autosomai recessive lysosomal storage diseases,caused by mutations in genes that code for enzymes involved in the lysosomal degradation of heparan sulphate:heparan sulfate sulfamidase (SGSH),a-N-acetylglucosaminidase (NAGLU),heparan sulfate acetyl-CoA:a-glucosaminide N-acetyltransferase (HGSNAT),and N-acetylglucosamine-6-sulfatase (GNS).Methods:In this study,we have performed the molecular analysis of the SGSH,NAGLU and HGSNAT genes in 10 patients from 6 different MPS Ⅲ Tunisian families.Results:In the SGSH gene,two mutations were identified:one novel (p.D477N) and one already described (p.Q365X).In the NAGLU gene,two novel mutations were discovered (p.L550P and p.E153X).For the novel missense mutations found in these two genes we performed an in silico structural analysis and the results were consistent with the clinical course of the patients harboring those mutations.Finally,in HGSNAT gene,we found the splicesite mutation c.234+1G>A that had already been reported as relatively frequent in MPS ⅢC patients from countries surrounding the basin of the Mediterranean sea.Its presence in two Tunisian MPS ⅢC families points to the hypothesis of its peri Mediterranean origin.With the exception of the c.234+1G>A mutation,that was identified in two unrelated MPS ⅢC families,the other identified mutations were family-specific and were always found in homozygosity in the patients studied,thus reflecting the existence of consanguinity in MPS Ⅲ Tunisian families.Conclusions:Three novel mutations are reported here,further contributing to the knowledge of the molecular basis of these diseases.The results of this study will allow carrier detection in affected families and prenatal molecular diagnosis,leading to an improvement in genetic counseling.展开更多
文摘Oxygen plays a crucial role in oenology. The oxygen leads to changes in the chemical and sensory profile of wines. On one hand, the impact of moderate oxygen exposure of red wine has a positive effect in its colour, aromatic bouquet and mouth-feel properties. On the other hand, oxygen has a negative effect on white wine＇s quality, as well as the sensory and compositional levels. The purpose of this study was to quantify the dissolved oxygen in red and white wine, during different cellar operations such as racking, tartaric stabilization, filtering and bottling. The techniques that contribute most to the enrichment of oxygen in wine are： cold tartaric stabilization （2.29 mg/L, white wines）, bottling （1.38 mg/L red wines and 1.11 mg/L white wines） and bag-in-box filling （2.47 mg/L red wines; 2.22 mg/L white wines）. After identifying the most critical technical operations in wine making, preventive and corrective measures had to be taken to reduce the dissolved oxygen content of wines, as well as preventing their depreciation.
基金The North East Centre for Energy Materials EP/R021503/1ERC starting grant,p-TYPE 715354 and LaserLab Europe LLC002553+1 种基金G.I.,A.P.,S.B.and Y.B.M’B.thank the French National Research Agency for Grant ANR PhotoCarb(ANR-16-CE05-0025)T.P.P.C.acknowledge financial support from the Swedish Energy Agency,Crafoord Foundation and the Swedish Research Council.
文摘H+modulated charge-transfer in photoexcited covalent polyoxometalate-bodipy conjugates is described.The hybrid organic/inorganic molecular photoactive dyads are based on Keggin-type polyoxometalates(POMs,where KM=[PM11O39]and M=Mo or W)covalently grafted via an organotin linker to a bodipy(BOD)photosensitizer.The relative potentials of the photosensitizer and POM are aligned such that lightinduced electron transfer from BOD to POM is permitted for the polyoxomolybdate KMo Sn[BOD]but not effective for the polyoxotungstate analogue K^(W) _(Sn)[BOD].In both cases,the addition of acid shifts the redox potential of the POM only,to increase the driving force for electron transfer.This leads to chargeseparation being switched on for K^(W) _(Sn)[BOD]in the presence of acid.The addition of acid to KMo Sn[BOD]accelerates charge-separation by an order of magnitude(from 2 ns to 200 ps)and is accompanied by a deceleration of charge recombination,leading to a charge-separated state lifetime of up to 1.3μs.This behaviour is consistent with proton coupled electron transfer,which has previously been observed electrochemically for POMs,but this study shows,for the first time,the impact of protonation on photoinduced electron transfer.
基金supported by Sorbonne Universiteby the CNRS.W.C.Poh was supported by the scholarship awarded by Nanyang Technological University,Singapore.
文摘As nano-sized molecular oxides,polyoxometalates(POMs)hold great promise in non-volatile memory materials based on redox-active molecules.Materials processed from solution,by drop-casting,by embedding POMs in polymers,or using layer-by-layer deposition techniques have thus been reported and successfully investigated.Almost all of these examples are electrostatically assembled materials.We herein propose an original route for the elaboration of robust covalent POM networks.
文摘Background:Mucopolysaccharidoses type Ⅲ (MPS Ⅲ) are a group of autosomai recessive lysosomal storage diseases,caused by mutations in genes that code for enzymes involved in the lysosomal degradation of heparan sulphate:heparan sulfate sulfamidase (SGSH),a-N-acetylglucosaminidase (NAGLU),heparan sulfate acetyl-CoA:a-glucosaminide N-acetyltransferase (HGSNAT),and N-acetylglucosamine-6-sulfatase (GNS).Methods:In this study,we have performed the molecular analysis of the SGSH,NAGLU and HGSNAT genes in 10 patients from 6 different MPS Ⅲ Tunisian families.Results:In the SGSH gene,two mutations were identified:one novel (p.D477N) and one already described (p.Q365X).In the NAGLU gene,two novel mutations were discovered (p.L550P and p.E153X).For the novel missense mutations found in these two genes we performed an in silico structural analysis and the results were consistent with the clinical course of the patients harboring those mutations.Finally,in HGSNAT gene,we found the splicesite mutation c.234+1G>A that had already been reported as relatively frequent in MPS ⅢC patients from countries surrounding the basin of the Mediterranean sea.Its presence in two Tunisian MPS ⅢC families points to the hypothesis of its peri Mediterranean origin.With the exception of the c.234+1G>A mutation,that was identified in two unrelated MPS ⅢC families,the other identified mutations were family-specific and were always found in homozygosity in the patients studied,thus reflecting the existence of consanguinity in MPS Ⅲ Tunisian families.Conclusions:Three novel mutations are reported here,further contributing to the knowledge of the molecular basis of these diseases.The results of this study will allow carrier detection in affected families and prenatal molecular diagnosis,leading to an improvement in genetic counseling.
