Metabolic dysfunction-associated steatotic liver disease(MASLD)is the most common chronic liver disease with a continually rising global prevalence and significant mortality rates.Emerging evidence suggests a strong a...Metabolic dysfunction-associated steatotic liver disease(MASLD)is the most common chronic liver disease with a continually rising global prevalence and significant mortality rates.Emerging evidence suggests a strong association between MASLD and mental health disorders such as depression and anxiety.In addition to the shared risk factors such as obesity,type 2 diabetes and insulin resistance which contribute to this relationship through mechanisms involving systemic inflammation and oxidative stress;other pathophysiological mechanisms such as dysregulation of hypothalamic-pituitary-adrenal axis,neurotransmitter imbalances and gut dysbiosis have also been proposed to play a significant role.The current paper aims to review the pathophysiological mechanisms underlying the association between MASLD and mood disorders such as depression and anxiety.We note a bidirectional relationship between these two disorders,and the dual burden of both these disease processes can be alleviated by early detection and encouraging a more proactive and holistic approach through diet and lifestyle changes.This review summarizes the existing literature on association between MASLD and depression.展开更多
文摘Metabolic dysfunction-associated steatotic liver disease(MASLD)is the most common chronic liver disease with a continually rising global prevalence and significant mortality rates.Emerging evidence suggests a strong association between MASLD and mental health disorders such as depression and anxiety.In addition to the shared risk factors such as obesity,type 2 diabetes and insulin resistance which contribute to this relationship through mechanisms involving systemic inflammation and oxidative stress;other pathophysiological mechanisms such as dysregulation of hypothalamic-pituitary-adrenal axis,neurotransmitter imbalances and gut dysbiosis have also been proposed to play a significant role.The current paper aims to review the pathophysiological mechanisms underlying the association between MASLD and mood disorders such as depression and anxiety.We note a bidirectional relationship between these two disorders,and the dual burden of both these disease processes can be alleviated by early detection and encouraging a more proactive and holistic approach through diet and lifestyle changes.This review summarizes the existing literature on association between MASLD and depression.
