Objective:While albumin and the weight-standardized hand grip strength(HGS/W)serve as valuable prognostic indicators for cancer patients,their correlation with the prognosis in frail cancer patients remains inadequate...Objective:While albumin and the weight-standardized hand grip strength(HGS/W)serve as valuable prognostic indicators for cancer patients,their correlation with the prognosis in frail cancer patients remains inadequately explored.This study aimed to investigate the prognostic importance of the albumin level and HGS/W in cancer patients with frailty and to further investigate their combined prognostic value.Moreover,this comprehensive evaluation aimed to facilitate timely intervention and treatment for frail patients.Methods:The research enrolled 5,794 cancer patients identified with frailty from a multicenter research database.The diagnosis of frailty was based on the FRAIL scale.An Albumin-HGS/W score was constructed by combining the albumin and HGS/W values.Cox proportional hazard regression was utilized to examine the association between the albumin level and HGS/W and patient outcomes.Results:Among these patients,2,543 were females and 3,251 were males,with a median age of 60.0 years.Optimal stratification based on patient survival revealed the ideal threshold for HGS/W to be 0.48 for males and 0.39 for females,and for albumin to be 38 for both sexes.The fully adjusted model revealed that higher Albumin-HGS/W scores were correlated with a poorer patient prognosis.Notably,an Albumin-HGS/W score of 2 was associated with a higher risk of mortality compared with a score of 0 in the total population(HR:1.813,95%CI:1.580-2.080,P<0.001).Conclusions:Low albumin or HGS/W values are associated with low survival in cancer patients with frailty.Elevated Albumin-HGS/W scores were linked to decreased survival rates in cancer patients with frailty.展开更多
Background:Although cancer is a global concern,China has the highest incidence and mortality rates for malignant tumors.The main goals of the present study were to gain a deeper understanding of the current limitation...Background:Although cancer is a global concern,China has the highest incidence and mortality rates for malignant tumors.The main goals of the present study were to gain a deeper understanding of the current limitations and focal points in the field of cancer nutrition research,to identify potential areas for further investigation,and to provide a valuable reference for Chinese researchers who are interested in studying"cancer nutrition." Methods:The Web of Science Core Collection was searched for literature published from 2013 to 2022.The R Language 4.3.1,VOSviewer 1.6.19,and CiteSpace 6.2.2 software programs were adopted to conduct the analysis. Results:Based on the specified inclusion and exclusion criteria,a total of 3,994 documents were gathered.The annual issuance of articles exhibited a fluctuating increase.These documents were authored by 19,577 individuals affiliated with 2,961 institutions and were published in 1,008 journals.The most productive authors in this field were Han-Ping Shi,Qi Zhang,and Wei Li.The most productive institutions were Sun Yat-sen University and Sichuan University.A total of 1,008 journals contributed to this field,and the journals with the most relevant publications were Frontiers in Nutrition and Frontiers in Oncology.The most frequently occurring author keywords were prognosis,gastric cancer,sarcopenia,cancer,and meta-analysis.Oncology was the hottest research area. Conclusions:Cancer nutrition research is a crucial area of study that has significant implications for human health as well as social and economic progress.This study provides a comprehensive overview of the current status and emerging trends in cancer nutrition research in China based on studies published from 2013 to 2022.The research findings presented in this study lay the foundation for further development in this research field.In addition to the traditional research on cancer nutrition,the development of interdisciplinary research should be promoted.展开更多
Cancer is the leading cause of global mortality,resulting in millions of deaths each year.Even a small attenuation in cancer rates through preventive care can have a significant impact.Dietary habits are closely assoc...Cancer is the leading cause of global mortality,resulting in millions of deaths each year.Even a small attenuation in cancer rates through preventive care can have a significant impact.Dietary habits are closely associated with cancer.Unhealthy eating habits may contribute to traditional risk factors and accelerate the progression of cancer.Recent studies have demonstrated the potential of healthy dietary interventions in the prevention and treatment of various cancers,particularly through dietary patterns such as the Mediterranean diet,Dietary Approaches to Stop Hypertension diet,plant-based diet,and ketogenic diet.This review summarizes several studies on the impact of dietary patterns on cancer prognosis and explores the recent findings regarding themechanisms through which dietary interventions influence cancer progression and prognosis.展开更多
基金supported by a Henan Province Science and Technology Research Project(No.252102311033)the National Key Research and Development Program(No.2022YFC2009600 and No.2022YFC2009601).
文摘Objective:While albumin and the weight-standardized hand grip strength(HGS/W)serve as valuable prognostic indicators for cancer patients,their correlation with the prognosis in frail cancer patients remains inadequately explored.This study aimed to investigate the prognostic importance of the albumin level and HGS/W in cancer patients with frailty and to further investigate their combined prognostic value.Moreover,this comprehensive evaluation aimed to facilitate timely intervention and treatment for frail patients.Methods:The research enrolled 5,794 cancer patients identified with frailty from a multicenter research database.The diagnosis of frailty was based on the FRAIL scale.An Albumin-HGS/W score was constructed by combining the albumin and HGS/W values.Cox proportional hazard regression was utilized to examine the association between the albumin level and HGS/W and patient outcomes.Results:Among these patients,2,543 were females and 3,251 were males,with a median age of 60.0 years.Optimal stratification based on patient survival revealed the ideal threshold for HGS/W to be 0.48 for males and 0.39 for females,and for albumin to be 38 for both sexes.The fully adjusted model revealed that higher Albumin-HGS/W scores were correlated with a poorer patient prognosis.Notably,an Albumin-HGS/W score of 2 was associated with a higher risk of mortality compared with a score of 0 in the total population(HR:1.813,95%CI:1.580-2.080,P<0.001).Conclusions:Low albumin or HGS/W values are associated with low survival in cancer patients with frailty.Elevated Albumin-HGS/W scores were linked to decreased survival rates in cancer patients with frailty.
基金supported by the National Key Research and Development Program (No.2022YFC2009600)
文摘Background:Although cancer is a global concern,China has the highest incidence and mortality rates for malignant tumors.The main goals of the present study were to gain a deeper understanding of the current limitations and focal points in the field of cancer nutrition research,to identify potential areas for further investigation,and to provide a valuable reference for Chinese researchers who are interested in studying"cancer nutrition." Methods:The Web of Science Core Collection was searched for literature published from 2013 to 2022.The R Language 4.3.1,VOSviewer 1.6.19,and CiteSpace 6.2.2 software programs were adopted to conduct the analysis. Results:Based on the specified inclusion and exclusion criteria,a total of 3,994 documents were gathered.The annual issuance of articles exhibited a fluctuating increase.These documents were authored by 19,577 individuals affiliated with 2,961 institutions and were published in 1,008 journals.The most productive authors in this field were Han-Ping Shi,Qi Zhang,and Wei Li.The most productive institutions were Sun Yat-sen University and Sichuan University.A total of 1,008 journals contributed to this field,and the journals with the most relevant publications were Frontiers in Nutrition and Frontiers in Oncology.The most frequently occurring author keywords were prognosis,gastric cancer,sarcopenia,cancer,and meta-analysis.Oncology was the hottest research area. Conclusions:Cancer nutrition research is a crucial area of study that has significant implications for human health as well as social and economic progress.This study provides a comprehensive overview of the current status and emerging trends in cancer nutrition research in China based on studies published from 2013 to 2022.The research findings presented in this study lay the foundation for further development in this research field.In addition to the traditional research on cancer nutrition,the development of interdisciplinary research should be promoted.
基金supported by the National KeyResearch and Development Program(No.2022YFC2009600 and No.2022YFC2009601).
文摘Cancer is the leading cause of global mortality,resulting in millions of deaths each year.Even a small attenuation in cancer rates through preventive care can have a significant impact.Dietary habits are closely associated with cancer.Unhealthy eating habits may contribute to traditional risk factors and accelerate the progression of cancer.Recent studies have demonstrated the potential of healthy dietary interventions in the prevention and treatment of various cancers,particularly through dietary patterns such as the Mediterranean diet,Dietary Approaches to Stop Hypertension diet,plant-based diet,and ketogenic diet.This review summarizes several studies on the impact of dietary patterns on cancer prognosis and explores the recent findings regarding themechanisms through which dietary interventions influence cancer progression and prognosis.
