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P16/Ki67免疫化学染色在宫颈癌高危人群细胞学与组织学诊断中的应用价值 被引量:1
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作者 孙文燕 赖红梅 +4 位作者 肖名珍 邵云蕾 赖超 李丽 邱晶 《当代医学》 2023年第15期125-128,共4页
目的探讨P16/Ki67免疫化学染色在宫颈癌高危人群细胞学与组织学诊断中的应用价值。方法选取2020年1月至2021年10月本院收治的80例宫颈癌高危人群患者的宫颈脱落细胞及宫颈活体组织作为研究对象。分别进行薄式液基细胞学制片巴氏染色、... 目的探讨P16/Ki67免疫化学染色在宫颈癌高危人群细胞学与组织学诊断中的应用价值。方法选取2020年1月至2021年10月本院收治的80例宫颈癌高危人群患者的宫颈脱落细胞及宫颈活体组织作为研究对象。分别进行薄式液基细胞学制片巴氏染色、组织石蜡切片HE染色,两种标本均于显微镜下进行形态观察,两种标本再进行P16/Ki67免疫化学染色。综合细胞形态学、组织形态学及P16/Ki67免疫化学染色检测结果为病理结果,以病理结果为金标准。分析80例宫颈癌高危人群患者的病理检查结果;统计细胞学形态学和组织形态学的阳性检出率及诊断符合率;细胞形态学、组织形态学分别联合P16/Ki67免疫化学染色结果;比较细胞形态学与细胞形态学联合P16/Ki67免疫化学染色结果、组织形态学与组织形态学联合P16/Ki67免疫化学染色结果。结果病理结果显示,宫颈慢性炎7例、宫颈上皮内瘤变(CIN)130例、CIN223例、CIN312例、宫颈癌8例。细胞学形态学结果显示,阳性45例、阴性35例,阳性检出率为56.25%,诊断符合率为87.50%;组织形态学初诊结果显示,阳性42例、阴性38例,阳性检出率为52.50%,诊断符合率为93.75%。细胞形态学联合P16/Ki67免疫化学染色结果显示,阳性40例、阴性40例,阳性率为50.00%,诊断符合率为93.75%;组织形态学联合P16/Ki67免疫化学染色结果显示,阳性41例、阴性39例,阳性检出率为51.25%,诊断符合率为97.50%。细胞形态学阳性检出率高于细胞形态学联合P16/Ki67免疫化学染色,诊断符合率低于细胞形态学联合P16/Ki67免疫化学染色,但差异无统计学意义;组织形态学阳性检出率高于组织形态学联合P16/Ki67免疫化学染色,诊断符合率低于组织形态学联合P16/Ki67免疫化学染色,但差异无统计学意义。结论P16和Ki67免疫化学染色应用于宫颈癌高危人群中可提高宫颈高级别上皮内病变诊断准确性,减少误诊和漏诊情况,值得临床推广应用。 展开更多
关键词 宫颈癌 高危人群 P16/Ki67免疫化学染色 高级别鳞状上皮内病变
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Effect of Whole Nursing Intervention Combined with Manual Massage on Lactation Time and Breastfeeding after Cesarean Section
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作者 DULili sunwenyan 《外文科技期刊数据库(文摘版)医药卫生》 2022年第7期125-128,共4页
Objective: to explore the effect of whole-course nursing intervention combined with manual massage on lactation time and breast-feeding compliance of pregnant women after cesarean section. Methods: a total of 136 part... Objective: to explore the effect of whole-course nursing intervention combined with manual massage on lactation time and breast-feeding compliance of pregnant women after cesarean section. Methods: a total of 136 parturients who underwent cesarean section in our hospital from January 2020 to January 2021 were selected as the research object of this experiment, and they were divided into control group and experimental group with 68 cases in each group according to the method of random number table. The control group was given routine nursing measures combined with dietary guidance, while the experimental group was given full-course nursing intervention and manual massage on the basis of the control group. After a period of time, the start time of lactation, the amount of lactation at 24h and 48h after operation and the compliance of breastfeeding were compared between the two groups. The feeding rate of breast milk was statistically analyzed one month after the discharge of pregnant women. Results: through analysis, it can be seen that the lactation starting time of pregnant women in the experimental group is obviously shorter than that in the control group, while the lactation amount at 24h and 48h after delivery is higher than that in the control group. One month after discharge, the exclusive breastfeeding rate of pregnant women in the experimental group was as high as 97.06%, which was significantly higher than that of the control group (83.82%, P < 0.05). Conclusion: comprehensive nursing intervention and effective manual massage for pregnant women undergoing cesarean section can significantly improve postpartum lactation, increase lactation, provide more breast milk for newborns, and thus increase breastfeeding rate. 展开更多
关键词 whole nursing intervention MASSAGE cesarean section lactation time BREASTFEEDING COMPLIANCE
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