Objective: to investigate the effect of propofol on sedation in children during anesthesia induction. Methods: the children who were operated in our hospital were selected as the study objects, and 150 patients were i...Objective: to investigate the effect of propofol on sedation in children during anesthesia induction. Methods: the children who were operated in our hospital were selected as the study objects, and 150 patients were included in the study. The operation time was from January 2015 to August 2022. Randomized grouping was carried out by means of computer number drawing, which was divided into control group (n75) and observation group (n75). The control group was anesthetized with a conventional protocol (midazolam+rocuronium), while the observation group was anesthetized with propofol during the induction period. The sedation effect, the incidence of adverse anesthetic reactions, the correlation of operation methods (duration of anesthesia induction, duration of respiratory recovery, duration of consciousness, concentration of propofol effect room, bispectral index of anesthesia EEG) and the hemodynamic index data at different time points were compared between the two groups. Results: the effective rate of sedation in the observation group was 98.67%, which was higher than that in the control group. The difference was significant after statistical software analysis (P<0.05). The incidence of adverse reaction of anesthesia in the observation group was 10.67%, which was insignificant compared with the control group after statistical software analysis (P>0.05). In the observation group, the duration of anesthesia induction was (4.05 ± 0.48) min, the duration of respiratory recovery was (5.35 ± 1.25) min, the duration of conscious awakening was (9.75 ± 3.55) min, the concentration of propofol in the response room was (1.18 ± 0.29) ug/mL, and the bispectral index of anesthesia EEG was (79.65 ± 6.84). Compared with the control group, the differences were significant after statistical software analysis (P<0.05). At 5 minutes after operation, the heart rate (91.58 ± 5.82) times/min, blood oxygen saturation (93.28 ± 6.34)%, and mean arterial pressure (80.35 ± 5.85) mmHg were observed in the observation group. Compared with the control group, the mean arterial pressure in the observation group was statistically significant (P<0.05). Conclusion: propofol can improve the sedative effect, reduce the influence of anesthesia, surgery and other operations on the hemodynamics of children during the induction period of pediatric anesthesia, and has high drug safety, which is worthy of promotion.展开更多
文摘Objective: to investigate the effect of propofol on sedation in children during anesthesia induction. Methods: the children who were operated in our hospital were selected as the study objects, and 150 patients were included in the study. The operation time was from January 2015 to August 2022. Randomized grouping was carried out by means of computer number drawing, which was divided into control group (n75) and observation group (n75). The control group was anesthetized with a conventional protocol (midazolam+rocuronium), while the observation group was anesthetized with propofol during the induction period. The sedation effect, the incidence of adverse anesthetic reactions, the correlation of operation methods (duration of anesthesia induction, duration of respiratory recovery, duration of consciousness, concentration of propofol effect room, bispectral index of anesthesia EEG) and the hemodynamic index data at different time points were compared between the two groups. Results: the effective rate of sedation in the observation group was 98.67%, which was higher than that in the control group. The difference was significant after statistical software analysis (P<0.05). The incidence of adverse reaction of anesthesia in the observation group was 10.67%, which was insignificant compared with the control group after statistical software analysis (P>0.05). In the observation group, the duration of anesthesia induction was (4.05 ± 0.48) min, the duration of respiratory recovery was (5.35 ± 1.25) min, the duration of conscious awakening was (9.75 ± 3.55) min, the concentration of propofol in the response room was (1.18 ± 0.29) ug/mL, and the bispectral index of anesthesia EEG was (79.65 ± 6.84). Compared with the control group, the differences were significant after statistical software analysis (P<0.05). At 5 minutes after operation, the heart rate (91.58 ± 5.82) times/min, blood oxygen saturation (93.28 ± 6.34)%, and mean arterial pressure (80.35 ± 5.85) mmHg were observed in the observation group. Compared with the control group, the mean arterial pressure in the observation group was statistically significant (P<0.05). Conclusion: propofol can improve the sedative effect, reduce the influence of anesthesia, surgery and other operations on the hemodynamics of children during the induction period of pediatric anesthesia, and has high drug safety, which is worthy of promotion.
