The local time-stepping(LTS)algorithm is an adaptive method that adjusts the time step by selecting suitable intervals for different regions based on the spatial scale of each cell and water depth and flow velocity be...The local time-stepping(LTS)algorithm is an adaptive method that adjusts the time step by selecting suitable intervals for different regions based on the spatial scale of each cell and water depth and flow velocity between cells.The method can be optimized by calculating the maximum power of two of the global time step increments in the domain,allowing the optimal time step to be approached throughout the grid.To verify the acceleration and accuracy of LTS in storm surge simulations,we developed a model to simulate astronomical storm surges along the southern coast of China.This model employs the shallow water equations as governing equations,numerical discretization using the finite volume method,and fluxes calculated by the Roe solver.By comparing the simulation results of the traditional global time-stepping algorithm with those of the LTS algorithm,we find that the latter fit the measured data better.Taking the calculation results of Typhoon Sally in 1996 as an example,we show that compared with the traditional global time-stepping algorithm,the LTS algorithm reduces computation time by 2.05 h and increases computation efficiency by 2.64 times while maintaining good accuracy.展开更多
目的探讨血清新型循环免疫炎症相关蛋白复合物(IIRPCs)水平在炎症性肠病(inflammatory bowel disease, IBD)评估中的价值。方法纳入2012年11月至2016年5月于北京协和医院门诊或住院部就诊的69例UC患者和67例CD患者,收集其完整的临床资...目的探讨血清新型循环免疫炎症相关蛋白复合物(IIRPCs)水平在炎症性肠病(inflammatory bowel disease, IBD)评估中的价值。方法纳入2012年11月至2016年5月于北京协和医院门诊或住院部就诊的69例UC患者和67例CD患者,收集其完整的临床资料。收集血清,通过Native-PAGE对IIRPCs进行分离,后进行定量分析。结果对于UC患者,活动期较缓解期白蛋白水平下降,血小板、血沉和hsCRP水平升高,差异均有统计学意义( P 均<0.05)。活动期IIRPCs水平较缓解期升高,其中中度活动组b型的b2、b4、b5水平与缓解期相比,差异有统计学意义( P <0.05),重度活动组a型的a3及b型的b2、b5水平与缓解期相比,差异有统计学意义( P <0.05),b2、b5对UC疾病活动度评估的ROC曲线下面积分别为0.826、0.859。对于CD患者,活动期血红蛋白、白蛋白水平下降,血小板、血沉水平升高,差异有统计学意义( P 均<0.05),活动期IIRPCs水平较缓解期呈升高趋势,但差异无统计学意义( P >0.05)。UC患者中,IIRPCs与ESR、hsCRP呈正相关。结论 IIRPCs与IBD疾病活动度相关,活动期IBD患者血清IIRPCs水平较缓解期升高,且IIRPCs含量与传统炎症指标ESR、hsCRP呈正相关。展开更多
基金National Natural Science Foundation of China(No.52071306)the Natural Science Foundation of Shandong Province(No.ZR2019MEE050)the Natural Science Foundation of Zhejiang Province(No.LZ22E090003).
文摘The local time-stepping(LTS)algorithm is an adaptive method that adjusts the time step by selecting suitable intervals for different regions based on the spatial scale of each cell and water depth and flow velocity between cells.The method can be optimized by calculating the maximum power of two of the global time step increments in the domain,allowing the optimal time step to be approached throughout the grid.To verify the acceleration and accuracy of LTS in storm surge simulations,we developed a model to simulate astronomical storm surges along the southern coast of China.This model employs the shallow water equations as governing equations,numerical discretization using the finite volume method,and fluxes calculated by the Roe solver.By comparing the simulation results of the traditional global time-stepping algorithm with those of the LTS algorithm,we find that the latter fit the measured data better.Taking the calculation results of Typhoon Sally in 1996 as an example,we show that compared with the traditional global time-stepping algorithm,the LTS algorithm reduces computation time by 2.05 h and increases computation efficiency by 2.64 times while maintaining good accuracy.
文摘目的探讨血清新型循环免疫炎症相关蛋白复合物(IIRPCs)水平在炎症性肠病(inflammatory bowel disease, IBD)评估中的价值。方法纳入2012年11月至2016年5月于北京协和医院门诊或住院部就诊的69例UC患者和67例CD患者,收集其完整的临床资料。收集血清,通过Native-PAGE对IIRPCs进行分离,后进行定量分析。结果对于UC患者,活动期较缓解期白蛋白水平下降,血小板、血沉和hsCRP水平升高,差异均有统计学意义( P 均<0.05)。活动期IIRPCs水平较缓解期升高,其中中度活动组b型的b2、b4、b5水平与缓解期相比,差异有统计学意义( P <0.05),重度活动组a型的a3及b型的b2、b5水平与缓解期相比,差异有统计学意义( P <0.05),b2、b5对UC疾病活动度评估的ROC曲线下面积分别为0.826、0.859。对于CD患者,活动期血红蛋白、白蛋白水平下降,血小板、血沉水平升高,差异有统计学意义( P 均<0.05),活动期IIRPCs水平较缓解期呈升高趋势,但差异无统计学意义( P >0.05)。UC患者中,IIRPCs与ESR、hsCRP呈正相关。结论 IIRPCs与IBD疾病活动度相关,活动期IBD患者血清IIRPCs水平较缓解期升高,且IIRPCs含量与传统炎症指标ESR、hsCRP呈正相关。
