【据Journal of Hepatology 2020年9月报道】题:多代母系肥胖通过miR-27a-3p增加子代肝细胞癌的发病率(作者Sun Y等)肥胖是影响肝细胞癌(HCC)等恶性肿瘤发生发展的独立危险因素。来自武汉大学生命科学学院的Sun等团队前期在Journal of H...【据Journal of Hepatology 2020年9月报道】题:多代母系肥胖通过miR-27a-3p增加子代肝细胞癌的发病率(作者Sun Y等)肥胖是影响肝细胞癌(HCC)等恶性肿瘤发生发展的独立危险因素。来自武汉大学生命科学学院的Sun等团队前期在Journal of Hepatology(2012年)发表研究发现母系肥胖可使子代脂肪肝病变发生传代性累积,但目前领域内尚不清楚母系肥胖是否会影响子代HCC的发生发展。因此,本研究设计有关实验旨在研究这其中的联系及其潜在机制。展开更多
INTRODUCTION Gastric mucosal injury is one of the common disorders,there are many reports subjicted to its pathogenesis treatment and prevention.We investigated the protective effect
The diffusion of La in ε-Fe 2～3N(ε)and γ′-Fe 4N (γ′)phases produced by plasma nitriding was studied. It is found that with increasing nitriding time, the ε phase continuously decomposes into γ′ one under...The diffusion of La in ε-Fe 2～3N(ε)and γ′-Fe 4N (γ′)phases produced by plasma nitriding was studied. It is found that with increasing nitriding time, the ε phase continuously decomposes into γ′ one under employed experimental conditions and compared with γ′ phase or ε+γ′ ones, the mono one ε has an impedient effect on depth of La diffusion. The growth of La layer in dual phases and mono one follows an approximate exponential law and a parabolic one, respectively, and this kinetics law does not change with increasing temperature. The effect of increasing temperature in the range of 520 to 560 ℃ on La diffusion depth is less than that of phase constitution change such as the decomposition of ε phase into γ′ one.展开更多
Liu X, Chen Y, McCoy CW, Zhao T, Quarles DL, Pi M, Bhattacharya SK, King G, Sun Y. Differential regulatory role of soluble Klothos on cardiac fibrogenesis in hypertension. Am J Hypertens ,2016,29（10） ： 1140-1147....Liu X, Chen Y, McCoy CW, Zhao T, Quarles DL, Pi M, Bhattacharya SK, King G, Sun Y. Differential regulatory role of soluble Klothos on cardiac fibrogenesis in hypertension. Am J Hypertens ,2016,29（10） ： 1140-1147.可溶性Klotho蛋白具有内分泌因子的功能，在多种病理生理过程中起重要作用，并存在130和65kD2种不同的异物体，其异物体是否有不同功能仍不清楚。研究者研究2种可溶Klothos蛋白在心肌纤维化反应中的调节作用。方法和结果：在体外培养的小鼠心肌成纤维细胞中研究2种可溶性Klothos蛋白对肌成纤维细胞分化、增殖及胶原蛋白合成或降解的影响。展开更多
文摘【据Journal of Hepatology 2020年9月报道】题:多代母系肥胖通过miR-27a-3p增加子代肝细胞癌的发病率(作者Sun Y等)肥胖是影响肝细胞癌(HCC)等恶性肿瘤发生发展的独立危险因素。来自武汉大学生命科学学院的Sun等团队前期在Journal of Hepatology(2012年)发表研究发现母系肥胖可使子代脂肪肝病变发生传代性累积,但目前领域内尚不清楚母系肥胖是否会影响子代HCC的发生发展。因此,本研究设计有关实验旨在研究这其中的联系及其潜在机制。
文摘INTRODUCTION Gastric mucosal injury is one of the common disorders,there are many reports subjicted to its pathogenesis treatment and prevention.We investigated the protective effect
文摘The diffusion of La in ε-Fe 2～3N(ε)and γ′-Fe 4N (γ′)phases produced by plasma nitriding was studied. It is found that with increasing nitriding time, the ε phase continuously decomposes into γ′ one under employed experimental conditions and compared with γ′ phase or ε+γ′ ones, the mono one ε has an impedient effect on depth of La diffusion. The growth of La layer in dual phases and mono one follows an approximate exponential law and a parabolic one, respectively, and this kinetics law does not change with increasing temperature. The effect of increasing temperature in the range of 520 to 560 ℃ on La diffusion depth is less than that of phase constitution change such as the decomposition of ε phase into γ′ one.
文摘Liu X, Chen Y, McCoy CW, Zhao T, Quarles DL, Pi M, Bhattacharya SK, King G, Sun Y. Differential regulatory role of soluble Klothos on cardiac fibrogenesis in hypertension. Am J Hypertens ,2016,29（10） ： 1140-1147.可溶性Klotho蛋白具有内分泌因子的功能，在多种病理生理过程中起重要作用，并存在130和65kD2种不同的异物体，其异物体是否有不同功能仍不清楚。研究者研究2种可溶Klothos蛋白在心肌纤维化反应中的调节作用。方法和结果：在体外培养的小鼠心肌成纤维细胞中研究2种可溶性Klothos蛋白对肌成纤维细胞分化、增殖及胶原蛋白合成或降解的影响。
