OBJECTIVE: To establish a "life system tuning model", which will provide theoretical and methodological basis to solve various medical problems such as the diagnosis and treatment of complex diseases. METHOD...OBJECTIVE: To establish a "life system tuning model", which will provide theoretical and methodological basis to solve various medical problems such as the diagnosis and treatment of complex diseases. METHODS: First of all, by using the approaches of systems biology, bioinformatics, and systems engineering, we set DNA as the center of this model, which severs as a bridge linking the characteristics of a disease with the pharmacological properties of the treating medicine. Secondly, the model shows how to employ molecular markers to dissect the pharmacological property of the drug, and the relation between the pharmacological property of the drug and its clinical administration.Also demonstrates how to discover therapeutic targets and to develop targeted medicine based on the biochemical features of the patients, which reflect their physiological and pathological body environment. Finally, the model uses systems biology data to determine molecular mechanisms underlying the disease and subtype, then employ precision methods to adjust the function of some master molecules. RESULTS: Based on the genetic information, this model integrates the diagnostic information from Western medicine and the disease pattern classification of TCM that is generated from the four diagnostic methods of "inspection, auscultation and olfaction, inquiry and pulse-taking and palpation". This model also integrates various disease intervention approaches including physical methods, chemical methods, and psychological methods. CONCLUSIONS: The establishment of this model provides a basis for personalized treatment of disease using various methods, for the protection and exploration of various natural resources used in TCM, and for the standardization of TCM.展开更多
文摘OBJECTIVE: To establish a "life system tuning model", which will provide theoretical and methodological basis to solve various medical problems such as the diagnosis and treatment of complex diseases. METHODS: First of all, by using the approaches of systems biology, bioinformatics, and systems engineering, we set DNA as the center of this model, which severs as a bridge linking the characteristics of a disease with the pharmacological properties of the treating medicine. Secondly, the model shows how to employ molecular markers to dissect the pharmacological property of the drug, and the relation between the pharmacological property of the drug and its clinical administration.Also demonstrates how to discover therapeutic targets and to develop targeted medicine based on the biochemical features of the patients, which reflect their physiological and pathological body environment. Finally, the model uses systems biology data to determine molecular mechanisms underlying the disease and subtype, then employ precision methods to adjust the function of some master molecules. RESULTS: Based on the genetic information, this model integrates the diagnostic information from Western medicine and the disease pattern classification of TCM that is generated from the four diagnostic methods of "inspection, auscultation and olfaction, inquiry and pulse-taking and palpation". This model also integrates various disease intervention approaches including physical methods, chemical methods, and psychological methods. CONCLUSIONS: The establishment of this model provides a basis for personalized treatment of disease using various methods, for the protection and exploration of various natural resources used in TCM, and for the standardization of TCM.
