The objective of this study was to verify the supposition that efflux might be involved in the drug resistance of Riemerella anatipestifer isolates. Two broad-spectrum effiux pump inhibitors, carbonyl cyanide 3-chloro...The objective of this study was to verify the supposition that efflux might be involved in the drug resistance of Riemerella anatipestifer isolates. Two broad-spectrum effiux pump inhibitors, carbonyl cyanide 3-chlorophenylhydrazone （CCCP） and Phe-Arg-β-naphthylamide （PAL3N）, on the contribution of minimum inhibitory concentrations of amikacin, streptomycin, chloramphenicol, tetracycline, ceftdaxone, ceftazidime, nalidixic acid, levofloxacin, enrofloxacin, as well as ciprofloxacin against 69 clinical R. anatipestifer isolates were investigated. We first reported that the two efflux pump inhibitors could restore the antimicrobial susceptibility of R. anatipestiferisolates. It is suggested that active efflux system is possible to be linked with the development of resistance in R. anatipestifer isolates.展开更多
文摘引潮力位(Tidal Generating Potential,TGP)展开是大地测量学和天体测量学的基本理论问题,它不仅具有提高空间大地测量技术归算精度的作用,而且在地球动力学演化和地壳形变监测上也具有重要意义.由于在历史上出现过不同的Laplace展开形式,因此就有不同的潮波(谐波)展开表.这些潮波展开表,除了潮波频率相同外,潮波系数之间无法进行直接比较.通过研究不同引潮力位Laplace展开式所采用的规格化方式,在理论上完整地揭示出了不同潮波表之间的内在联系,给出了任意阶次的不同引潮力位展开表之间的统一转换公式.此外,还指出了IERS(International Earth Rotation and Reference Systems Service)(2010)规范第96页表6.8存在的一个错误,即3阶1次的CT(Cartwright&Tayler)展开与HW(Hartmann&Wenzel)展开系数的比值应该加上负号.
基金supported by the Program for Changjiang Scholars and Innovative Research Team in University of Ministry of Education of China (IRT13063)the National Natural Science Foundation of China (31072169)
文摘The objective of this study was to verify the supposition that efflux might be involved in the drug resistance of Riemerella anatipestifer isolates. Two broad-spectrum effiux pump inhibitors, carbonyl cyanide 3-chlorophenylhydrazone （CCCP） and Phe-Arg-β-naphthylamide （PAL3N）, on the contribution of minimum inhibitory concentrations of amikacin, streptomycin, chloramphenicol, tetracycline, ceftdaxone, ceftazidime, nalidixic acid, levofloxacin, enrofloxacin, as well as ciprofloxacin against 69 clinical R. anatipestifer isolates were investigated. We first reported that the two efflux pump inhibitors could restore the antimicrobial susceptibility of R. anatipestiferisolates. It is suggested that active efflux system is possible to be linked with the development of resistance in R. anatipestifer isolates.
