In this paper,it has proposed a realtime implementation of low-density paritycheck(LDPC)decoder with less complexity used for satellite communication on FPGA platform.By adopting a(2048.4096)irregular quasi-cyclic(QC)...In this paper,it has proposed a realtime implementation of low-density paritycheck(LDPC)decoder with less complexity used for satellite communication on FPGA platform.By adopting a(2048.4096)irregular quasi-cyclic(QC)LDPC code,the proposed partly parallel decoding structure balances the complexity between the check node unit(CNU)and the variable node unit(VNU)based on min-sum(MS)algorithm,thereby achieving less Slice resources and superior clock performance.Moreover,as a lookup table(LUT)is utilized in this paper to search the node message stored in timeshare memory unit,it is simple to reuse and save large amount of storage resources.The implementation results on Xilinx FPGA chip illustrate that,compared with conventional structure,the proposed scheme can achieve at last 28.6%and 8%cost reduction in RAM and Slice respectively.The clock frequency is also increased to 280 MHz without decoding performance deterioration and convergence speed reduction.展开更多
目的探讨DARA-Fab片段处理经抗CD38单克隆抗体雷达木(daratumumab,DARA)治疗后的多发性骨髓瘤(multiple myeloma,MM)患者输血相容性检测方法的可行性,并通过对比二硫苏糖醇(Dithiothreitol,DTT)方法评估其输血疗效。方法将DARA使用Pierc...目的探讨DARA-Fab片段处理经抗CD38单克隆抗体雷达木(daratumumab,DARA)治疗后的多发性骨髓瘤(multiple myeloma,MM)患者输血相容性检测方法的可行性,并通过对比二硫苏糖醇(Dithiothreitol,DTT)方法评估其输血疗效。方法将DARA使用PierceFab制备试剂盒制备成DARA-Fab片段后,确认不同体积(5、10、15、30μL)DARA-Fab片段对于抗筛细胞和抗体鉴定细胞的中和效果;DARA-Fab片段和明确相应抗原的抗筛细胞与对应的单抗试剂为试验组,以添加同体积的生理盐水为对照组孵育后离心;各选取20名经DARA治疗后的MM患者,分别使用DARA-Fab封闭RBC表面抗原和与DTT破坏红细胞表面抗原的方法来进行输血相容性检测,对其输血前后实验室指标进行统计分析,并比较2种配血方法。结果15、30μL DARA-Fab片段与抗筛细胞与混有DARA的血清孵育离心后结果为阴性,5、10μL DARA-Fab结果为阳性,15μL DARA-Fab处理抗体鉴定细胞(2、3、4、5、7、9、11)后为阴性,抗体鉴定细胞(1、6、8、10、12)经30μL DARA-Fab片段处理后,结果为阴性;添加DARA-Fab的实验组对MNS系统、Duffy、Kidd、Kell、Lewis、Rh血型系统和对照组结果一致;DARA-Fab片段这20名患者输注RBC后Hb(hemoglobin,Hb)(73.90±1.90)(g/L)比输血前(63.60±1.58)明显提高,统计学差异明显(P<0.01);患者总胆红素(total bilirubin,TBil)(μmol/L)(16.25±3.54 vs 17.87±3.57)、直接胆红素(direct bilirubin,DBIL)(μmol/L)(6.31±2.32 vs 7.10±2.80)和间接胆红素(Indirect Bilirubin,I-Bil)(9.94±1.38 vs 10.77±1.22)输注前后无明显差异,无统计学差异(P>0.05)。DTT处理方法与DARA-Fab片段封闭方法的输血前后Hb差值(10.75±1.04 vs 10.30±0.98)、TBil差值(3.31±1.47 vs 3.31±0.55)、DBIL差值(2.76±1.24 vs 2.60±0.83)和I-Bil差值(1.97±0.40 vs 2.82±0.53)无明显差异,无统计学差异(P>0.05)。结论DARA-Fab片段可通过封闭RBC表面CD38抗原,来去除DARA对红细胞输血相容性检测的干扰,这种封闭方法对于红细胞临床常见血型系统的抗原无影响,且通过这种配血方法实验室指标输血疗效明显,与DTT方法的输血疗效无差异。展开更多
文摘In this paper,it has proposed a realtime implementation of low-density paritycheck(LDPC)decoder with less complexity used for satellite communication on FPGA platform.By adopting a(2048.4096)irregular quasi-cyclic(QC)LDPC code,the proposed partly parallel decoding structure balances the complexity between the check node unit(CNU)and the variable node unit(VNU)based on min-sum(MS)algorithm,thereby achieving less Slice resources and superior clock performance.Moreover,as a lookup table(LUT)is utilized in this paper to search the node message stored in timeshare memory unit,it is simple to reuse and save large amount of storage resources.The implementation results on Xilinx FPGA chip illustrate that,compared with conventional structure,the proposed scheme can achieve at last 28.6%and 8%cost reduction in RAM and Slice respectively.The clock frequency is also increased to 280 MHz without decoding performance deterioration and convergence speed reduction.
文摘目的探讨DARA-Fab片段处理经抗CD38单克隆抗体雷达木(daratumumab,DARA)治疗后的多发性骨髓瘤(multiple myeloma,MM)患者输血相容性检测方法的可行性,并通过对比二硫苏糖醇(Dithiothreitol,DTT)方法评估其输血疗效。方法将DARA使用PierceFab制备试剂盒制备成DARA-Fab片段后,确认不同体积(5、10、15、30μL)DARA-Fab片段对于抗筛细胞和抗体鉴定细胞的中和效果;DARA-Fab片段和明确相应抗原的抗筛细胞与对应的单抗试剂为试验组,以添加同体积的生理盐水为对照组孵育后离心;各选取20名经DARA治疗后的MM患者,分别使用DARA-Fab封闭RBC表面抗原和与DTT破坏红细胞表面抗原的方法来进行输血相容性检测,对其输血前后实验室指标进行统计分析,并比较2种配血方法。结果15、30μL DARA-Fab片段与抗筛细胞与混有DARA的血清孵育离心后结果为阴性,5、10μL DARA-Fab结果为阳性,15μL DARA-Fab处理抗体鉴定细胞(2、3、4、5、7、9、11)后为阴性,抗体鉴定细胞(1、6、8、10、12)经30μL DARA-Fab片段处理后,结果为阴性;添加DARA-Fab的实验组对MNS系统、Duffy、Kidd、Kell、Lewis、Rh血型系统和对照组结果一致;DARA-Fab片段这20名患者输注RBC后Hb(hemoglobin,Hb)(73.90±1.90)(g/L)比输血前(63.60±1.58)明显提高,统计学差异明显(P<0.01);患者总胆红素(total bilirubin,TBil)(μmol/L)(16.25±3.54 vs 17.87±3.57)、直接胆红素(direct bilirubin,DBIL)(μmol/L)(6.31±2.32 vs 7.10±2.80)和间接胆红素(Indirect Bilirubin,I-Bil)(9.94±1.38 vs 10.77±1.22)输注前后无明显差异,无统计学差异(P>0.05)。DTT处理方法与DARA-Fab片段封闭方法的输血前后Hb差值(10.75±1.04 vs 10.30±0.98)、TBil差值(3.31±1.47 vs 3.31±0.55)、DBIL差值(2.76±1.24 vs 2.60±0.83)和I-Bil差值(1.97±0.40 vs 2.82±0.53)无明显差异,无统计学差异(P>0.05)。结论DARA-Fab片段可通过封闭RBC表面CD38抗原,来去除DARA对红细胞输血相容性检测的干扰,这种封闭方法对于红细胞临床常见血型系统的抗原无影响,且通过这种配血方法实验室指标输血疗效明显,与DTT方法的输血疗效无差异。
