The creep-slip behavior of creeping landslides is closely related to the creep characteristics of slope rock.This study analyzed the creep behavior of ultra-soft mudstone from the Gaomiao landslide in Haidong City,Qin...The creep-slip behavior of creeping landslides is closely related to the creep characteristics of slope rock.This study analyzed the creep behavior of ultra-soft mudstone from the Gaomiao landslide in Haidong City,Qinghai Province,China.Uniaxial creep tests were carried out on ultra-soft mudstone with various moisture contents.The test results indicated that the creep duration of the rock sample with a natural moisture content of 9%is 2400 times longer than that of the sample with a natural moisture content of 13%,while its accumulated strain is 70%of the latter.For the rock sample with a natural moisture content of 9.80%,the creep duration under 0.5 MPa load is 80%of that under 0.25 MPa load,yet the accumulated strain is 1.4 times greater.Additionally,porosity significantly influences the creep behavior of mudstone.Analysis of the cause of the Gaomiao landslide and field monitoring data indicates that the instability of the Gaomiao landslide is related to the moisture content of the landslip mass and external forces.The creep-slip curves of landslides and the creep deformation curves of rocks share a common trend.Precisely identifying the moment when the shift occurs from steady state creep to accelerated creep is critical for comprehending slope instability and rock failure.Moreover,this study delves deeper into the issue of the consistency between landslide creep and rock deformation.展开更多
Recently,a lot of U.S.TikTok users,who are self-identified as“TikTok Refugees”,have been flocking to the Chinese social media app Xiaohongshu recently.From January 13 to 16,the app Xiaohongshu climbed to first place...Recently,a lot of U.S.TikTok users,who are self-identified as“TikTok Refugees”,have been flocking to the Chinese social media app Xiaohongshu recently.From January 13 to 16,the app Xiaohongshu climbed to first place on the Top Free iOS Ranking(in the past the app did not appear on the ranking list).In the following week,the number of downloads of Xiaohongshu in the U.S.increased by 300%,and the number of active users on the app increased by about 200%.展开更多
目的探究二妙玄府方联合三黄散外敷治疗急性痛风性关节炎(AGA)患者临床疗效及对外周血Beclin-1、超长链脂肪酸延伸酶6(ELOVL6)的影响。方法选取2022年6月-2023年12月甘肃酒泉市人民医院收治的116例AGA患者作为研究对象,按照随机数字表...目的探究二妙玄府方联合三黄散外敷治疗急性痛风性关节炎(AGA)患者临床疗效及对外周血Beclin-1、超长链脂肪酸延伸酶6(ELOVL6)的影响。方法选取2022年6月-2023年12月甘肃酒泉市人民医院收治的116例AGA患者作为研究对象,按照随机数字表法分为常规组(58例)和中西联合组(58例),常规组接受常规西医治疗,中西联合组在常规组的基础上加用二妙玄府方联合三黄散外敷治疗。比较两组患者临床疗效、中医症状积分,治疗前后关节疼痛视觉模拟评分(VAS)、血尿酸(BUA)、24 h尿酸排出量(24 h UUA)、外周血Beclin-1、ELOVL6、血清炎症因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)]及不良反应。结果中西联合组治疗总有效率[93.10%(54/58)vs 79.31%(46/58)]高于常规组(P<0.05);治疗后,两组关节红肿、热痛、屈曲受限、发热口渴、口苦口黏评分均下降(P<0.05),且治疗后中西联合组低于常规组(P<0.05);治疗后,两组VAS评分均下降(P<0.05),且治疗后中西联合组低于常规组(P<0.05);治疗后,两组BUA均下降(P<0.05),24 h UUA均升高(P<0.05),且治疗后组间比较差异具有统计学意义(P<0.05);治疗后,两组Beclin-1、ELOVL6均升高(P<0.05),且治疗后中西联合组高于常规组(P<0.05);治疗后,两组IL-6、CRP、TNF-α均下降(P<0.05),且治疗后中西联合组低于常规组(P<0.05);两组患者试验期间均未见严重恶心呕吐、胃痛、头晕、腹泻等不良反应。结论二妙玄府方联合三黄散外敷治疗AGA临床效果显著,可较好抑制机体炎症反应,缓解疾病进程,且安全可靠。展开更多
Marsdenia tenacissima extract(MTE, trade name: Xiao-Ai-Ping injection) is an extract of a single Chinese plant medicine. It has been used for the treatment of cancer in China for decades, especially for esophageal can...Marsdenia tenacissima extract(MTE, trade name: Xiao-Ai-Ping injection) is an extract of a single Chinese plant medicine. It has been used for the treatment of cancer in China for decades, especially for esophageal cancer and other cancers in the digestive tract. In the present study, the potential mechanism for MTE's activity in esophageal cancer was explored. The effects of MTE on the proliferation of human esophageal cancer cells(KYSE150 and Eca-109) were investigated by the MTT assay, the Brd U(bromodeoxyuridine) incorporation immunofluorescence assay, and flow cytometric analysis. MTE inhibited cell proliferation through inducing G0/G1 cell cycle arrest in KYSE150 and Eca-109. Western blot analysis was employed to determine protein levels in the MTE treated cells. Compared with the control cells, the expression levels of the cell cycle regulatory proteins cyclin D1/D2/D3, cyclin E1, CDK2/4/6(CDK: cyclin dependent kinase), and p-Rb were decreased significantly in the cells treated with MTE at 40 mg·m L-1. In addition, MTE had an inhibitory effect on the MAPK(mitogen-activated protein kinase) signal transduction pathway, including ERK(extracellular signal-regulated kinase), JNK(c-Jun N-terminal kinase), and p38 MAPK. Moreover, MTE showed little additional effects on the regulation of cyclin D1/D3, CDK4/6, and p-Rb when the ERK pathway was already inhibited by the specific ERK inhibitor U0126. In conclusion, these data suggest that MTE inhibits human esophageal cancer cell proliferation through regulation of cell cycle regulatory proteins and the MAPK signaling pathways, which is probably mediated by the inhibition of ERK activation.展开更多
Internal soliton forces on oil-platform piles in the ocean are estimated with the Morison Formula. Different from sur- face wave forces, which change only in magnitude along a pile, internal soliton forces can be dist...Internal soliton forces on oil-platform piles in the ocean are estimated with the Morison Formula. Different from sur- face wave forces, which change only in magnitude along a pile, internal soliton forces can be distributed over the entire pile in the water and they change not only in magnitude but also in direction with depth. Our calculations show that the maximum total force caused by a soliton with its associated current of 2.1 m s-1 is nearly equal to the maximum total force exerted by a surface wave with a wavelength of 300 m and a wave-height of 18 m. The total internal soliton force is large enough to affect the operations of marine oil platforms and other facilities. Therefore, the influence of internal solitons should not be neglected in the design of oil platforms.展开更多
AIM： To investigate the anticancer activity of DT-13 under normoxia and determine the underlying mechanisms of action. METHODS： MDA-MB-435 cell proliferation, migration, and adhesion were performed to assess the ant...AIM： To investigate the anticancer activity of DT-13 under normoxia and determine the underlying mechanisms of action. METHODS： MDA-MB-435 cell proliferation, migration, and adhesion were performed to assess the anticancer activity of DT-13, a saponin from Ophiopogonjaponicus, in vitro. In addition, the effects of DT-13 on tumor growth and metastasis in vivo were evaluated by orthotopic implantation of MDA-MB-435 cells into nude mice; mRNA levels of vascular endothelial growth factor （VEGF）, C-C chemokine receptor type 5 （CCR5） and hypoxia-inducible factor 1a （HIF-1a） were evaluated by real-time quantitative PCR; and CCR5 protein levels were detected by Western blot assay. RESULTS： At 0.01 to 1 umol·L -1, DT-13 inhibited MDA-MB-435 cell proliferation, migration, and adhesion significantly in vitro. DT-13 reduced VEGF and CCR5 mRNAs, and decreased CCR5 protein expression by down-regulating HIF-1 a. In addition, DT-13 inhibited MDA-MB-435 cell lung metastasis, and restricted tumor growth slightly in vivo. CONCLUSION： DT-13 inhibited MDA-MB-435 cell proliferation, adhesion, and migration in vitro, and lung metastasis in vivo by reducing VEGF, CCR5, and HIF-la expression.展开更多
In recent years, sinmlated annealing algo-rithms have been extensively developed and uti-lized to solve nmlti-objective optimization problems. In order to obtain better optimization perfonmnce, this paper proposes a N...In recent years, sinmlated annealing algo-rithms have been extensively developed and uti-lized to solve nmlti-objective optimization problems. In order to obtain better optimization perfonmnce, this paper proposes a Novel Adaptive Simulated Annealing （NASA） algorithm for constrained multi-objective optimization based on Archived Multi-objective Simulated Annealing （AMOSA）. For han-dling multi-objective, NASA makes improverrents in three aspects： sub-iteration search, sub-archive and adaptive search, which effectively strengthen the stability and efficiency of the algorithnm For handling constraints, NASA introduces corresponding solution acceptance criterion. Furtherrrore, NASA has also been applied to optimize TD-LTE network perform-ance by adjusting antenna paranleters; it can achieve better extension and convergence than AMOSA, NS-GAII and MOPSO. Analytical studies and simulations indicate that the proposed NASA algorithm can play an important role in improving multi-objective optimi-zation performance.展开更多
基金The work described in this paper is partially supported by the Second Tibetan Plateau Scientific Expedition and Research Grant(2019QZKK0708)ARC Discovery Project grants(DP210100437,DP230100126),for which the authors are very grateful.
文摘The creep-slip behavior of creeping landslides is closely related to the creep characteristics of slope rock.This study analyzed the creep behavior of ultra-soft mudstone from the Gaomiao landslide in Haidong City,Qinghai Province,China.Uniaxial creep tests were carried out on ultra-soft mudstone with various moisture contents.The test results indicated that the creep duration of the rock sample with a natural moisture content of 9%is 2400 times longer than that of the sample with a natural moisture content of 13%,while its accumulated strain is 70%of the latter.For the rock sample with a natural moisture content of 9.80%,the creep duration under 0.5 MPa load is 80%of that under 0.25 MPa load,yet the accumulated strain is 1.4 times greater.Additionally,porosity significantly influences the creep behavior of mudstone.Analysis of the cause of the Gaomiao landslide and field monitoring data indicates that the instability of the Gaomiao landslide is related to the moisture content of the landslip mass and external forces.The creep-slip curves of landslides and the creep deformation curves of rocks share a common trend.Precisely identifying the moment when the shift occurs from steady state creep to accelerated creep is critical for comprehending slope instability and rock failure.Moreover,this study delves deeper into the issue of the consistency between landslide creep and rock deformation.
文摘Recently,a lot of U.S.TikTok users,who are self-identified as“TikTok Refugees”,have been flocking to the Chinese social media app Xiaohongshu recently.From January 13 to 16,the app Xiaohongshu climbed to first place on the Top Free iOS Ranking(in the past the app did not appear on the ranking list).In the following week,the number of downloads of Xiaohongshu in the U.S.increased by 300%,and the number of active users on the app increased by about 200%.
文摘目的探究二妙玄府方联合三黄散外敷治疗急性痛风性关节炎(AGA)患者临床疗效及对外周血Beclin-1、超长链脂肪酸延伸酶6(ELOVL6)的影响。方法选取2022年6月-2023年12月甘肃酒泉市人民医院收治的116例AGA患者作为研究对象,按照随机数字表法分为常规组(58例)和中西联合组(58例),常规组接受常规西医治疗,中西联合组在常规组的基础上加用二妙玄府方联合三黄散外敷治疗。比较两组患者临床疗效、中医症状积分,治疗前后关节疼痛视觉模拟评分(VAS)、血尿酸(BUA)、24 h尿酸排出量(24 h UUA)、外周血Beclin-1、ELOVL6、血清炎症因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)]及不良反应。结果中西联合组治疗总有效率[93.10%(54/58)vs 79.31%(46/58)]高于常规组(P<0.05);治疗后,两组关节红肿、热痛、屈曲受限、发热口渴、口苦口黏评分均下降(P<0.05),且治疗后中西联合组低于常规组(P<0.05);治疗后,两组VAS评分均下降(P<0.05),且治疗后中西联合组低于常规组(P<0.05);治疗后,两组BUA均下降(P<0.05),24 h UUA均升高(P<0.05),且治疗后组间比较差异具有统计学意义(P<0.05);治疗后,两组Beclin-1、ELOVL6均升高(P<0.05),且治疗后中西联合组高于常规组(P<0.05);治疗后,两组IL-6、CRP、TNF-α均下降(P<0.05),且治疗后中西联合组低于常规组(P<0.05);两组患者试验期间均未见严重恶心呕吐、胃痛、头晕、腹泻等不良反应。结论二妙玄府方联合三黄散外敷治疗AGA临床效果显著,可较好抑制机体炎症反应,缓解疾病进程,且安全可靠。
基金financially supported by National Natural Science Foundation of China(Nos.81302794,81071841,81102853)the Study of Marsdenia tenacissima extract(MTE):Study on quality control of antitumor traditional Chinese medicine Xiao-Ai-Ping injection(No.2011ZX09201-201)
文摘Marsdenia tenacissima extract(MTE, trade name: Xiao-Ai-Ping injection) is an extract of a single Chinese plant medicine. It has been used for the treatment of cancer in China for decades, especially for esophageal cancer and other cancers in the digestive tract. In the present study, the potential mechanism for MTE's activity in esophageal cancer was explored. The effects of MTE on the proliferation of human esophageal cancer cells(KYSE150 and Eca-109) were investigated by the MTT assay, the Brd U(bromodeoxyuridine) incorporation immunofluorescence assay, and flow cytometric analysis. MTE inhibited cell proliferation through inducing G0/G1 cell cycle arrest in KYSE150 and Eca-109. Western blot analysis was employed to determine protein levels in the MTE treated cells. Compared with the control cells, the expression levels of the cell cycle regulatory proteins cyclin D1/D2/D3, cyclin E1, CDK2/4/6(CDK: cyclin dependent kinase), and p-Rb were decreased significantly in the cells treated with MTE at 40 mg·m L-1. In addition, MTE had an inhibitory effect on the MAPK(mitogen-activated protein kinase) signal transduction pathway, including ERK(extracellular signal-regulated kinase), JNK(c-Jun N-terminal kinase), and p38 MAPK. Moreover, MTE showed little additional effects on the regulation of cyclin D1/D3, CDK4/6, and p-Rb when the ERK pathway was already inhibited by the specific ERK inhibitor U0126. In conclusion, these data suggest that MTE inhibits human esophageal cancer cell proliferation through regulation of cell cycle regulatory proteins and the MAPK signaling pathways, which is probably mediated by the inhibition of ERK activation.
基金This study is supported by the National Natural Science Foundation of China(Projects under contract Nos.40506007,49676275 and 49976002)the Natural Science Foundation of Shandong Province(No.Y2000E04)Microwave Imaging National Key Laboratory Foundation(No.51442020103JW1002).
文摘Internal soliton forces on oil-platform piles in the ocean are estimated with the Morison Formula. Different from sur- face wave forces, which change only in magnitude along a pile, internal soliton forces can be distributed over the entire pile in the water and they change not only in magnitude but also in direction with depth. Our calculations show that the maximum total force caused by a soliton with its associated current of 2.1 m s-1 is nearly equal to the maximum total force exerted by a surface wave with a wavelength of 300 m and a wave-height of 18 m. The total internal soliton force is large enough to affect the operations of marine oil platforms and other facilities. Therefore, the influence of internal solitons should not be neglected in the design of oil platforms.
基金supported by the National Natural Science Foundation(Nos.81102853,81071841)the 2011’Program for Excellent Scientific and Technological Innovation Team of Jiangsu Higher Education
文摘AIM： To investigate the anticancer activity of DT-13 under normoxia and determine the underlying mechanisms of action. METHODS： MDA-MB-435 cell proliferation, migration, and adhesion were performed to assess the anticancer activity of DT-13, a saponin from Ophiopogonjaponicus, in vitro. In addition, the effects of DT-13 on tumor growth and metastasis in vivo were evaluated by orthotopic implantation of MDA-MB-435 cells into nude mice; mRNA levels of vascular endothelial growth factor （VEGF）, C-C chemokine receptor type 5 （CCR5） and hypoxia-inducible factor 1a （HIF-1a） were evaluated by real-time quantitative PCR; and CCR5 protein levels were detected by Western blot assay. RESULTS： At 0.01 to 1 umol·L -1, DT-13 inhibited MDA-MB-435 cell proliferation, migration, and adhesion significantly in vitro. DT-13 reduced VEGF and CCR5 mRNAs, and decreased CCR5 protein expression by down-regulating HIF-1 a. In addition, DT-13 inhibited MDA-MB-435 cell lung metastasis, and restricted tumor growth slightly in vivo. CONCLUSION： DT-13 inhibited MDA-MB-435 cell proliferation, adhesion, and migration in vitro, and lung metastasis in vivo by reducing VEGF, CCR5, and HIF-la expression.
基金supported by the Major National Science & Technology Specific Project of China under Grants No.2010ZX03002-007-02,No.2009ZX03002-002,No.2010ZX03002-002-03
文摘In recent years, sinmlated annealing algo-rithms have been extensively developed and uti-lized to solve nmlti-objective optimization problems. In order to obtain better optimization perfonmnce, this paper proposes a Novel Adaptive Simulated Annealing （NASA） algorithm for constrained multi-objective optimization based on Archived Multi-objective Simulated Annealing （AMOSA）. For han-dling multi-objective, NASA makes improverrents in three aspects： sub-iteration search, sub-archive and adaptive search, which effectively strengthen the stability and efficiency of the algorithnm For handling constraints, NASA introduces corresponding solution acceptance criterion. Furtherrrore, NASA has also been applied to optimize TD-LTE network perform-ance by adjusting antenna paranleters; it can achieve better extension and convergence than AMOSA, NS-GAII and MOPSO. Analytical studies and simulations indicate that the proposed NASA algorithm can play an important role in improving multi-objective optimi-zation performance.
