YCo_(5) alloy is processed by surfactant-assisted high-energy ball milling. Oleic acid is used as the surfactant and is 20% of the starting powder.The resultant particles are flakes of several microns in length and wi...YCo_(5) alloy is processed by surfactant-assisted high-energy ball milling. Oleic acid is used as the surfactant and is 20% of the starting powder.The resultant particles are flakes of several microns in length and width,and 20-200nm in thickness. The flakes have significant crystallographic anisotropy and the c-axis (also easy magnetization axes) is perpendicular to the flake's surface. Maximum coercivity of 192kA/m is obtained in the sample milled for 100 min.Excess milling results in the appearance of Fe and deteriorates the permanent magnetic properties seriously.展开更多
Objective:Keratoconus(KC)is a progressive corneal ectasia disorder,arising from a myriad of causes including genetic predispositions,environmental factors,biomechanical influences,and inflammatory reactions.This study...Objective:Keratoconus(KC)is a progressive corneal ectasia disorder,arising from a myriad of causes including genetic predispositions,environmental factors,biomechanical influences,and inflammatory reactions.This study aims to identify potential pathogenetic gene mutations in patients with sporadic KC in the Han Chinese population.Methods:Twenty-five patients with primary KC as well as 50 unrelated population matched healthy controls,were included in this study to identify potential pathogenic gene mutations among sporadic KC patients in the Han Chinese population.Sanger sequencing and whole-exome sequencing(WES)were used to analyze mutations in the zinc finger protein 469(ZNF469)gene.Bioinformatics analysis was conducted to explore the potential role of ZNF469 in KC pathogenesis.Results:Five novel heterozygous missense variants were identified in KC patients.Among them,2 compound heterozygous variants,c.8986G>C(p.E2996Q)with c.11765A>C(p.D3922A),and c.4423C>G(p.L1475V)with c.10633G>A(p.G3545R),were determined to be possible pathogenic factors for KC.Conclusion:Mutations in the ZNF469 gene may contribute to the development of KC in the Han Chinese population.These mutation sites may provide valuable information for future genetic screening of KC patients and their families.展开更多
基金Supported by the National Natural Science Foundation of China under Grant No 11174104the National Fund for Fostering Talents of Basic Science under Grant No J1103202.
文摘YCo_(5) alloy is processed by surfactant-assisted high-energy ball milling. Oleic acid is used as the surfactant and is 20% of the starting powder.The resultant particles are flakes of several microns in length and width,and 20-200nm in thickness. The flakes have significant crystallographic anisotropy and the c-axis (also easy magnetization axes) is perpendicular to the flake's surface. Maximum coercivity of 192kA/m is obtained in the sample milled for 100 min.Excess milling results in the appearance of Fe and deteriorates the permanent magnetic properties seriously.
基金supported by the National Natural Science Foundation(82271057)the Natural Science Foundation of Hunan Province(2023JJ30818),China。
文摘Objective:Keratoconus(KC)is a progressive corneal ectasia disorder,arising from a myriad of causes including genetic predispositions,environmental factors,biomechanical influences,and inflammatory reactions.This study aims to identify potential pathogenetic gene mutations in patients with sporadic KC in the Han Chinese population.Methods:Twenty-five patients with primary KC as well as 50 unrelated population matched healthy controls,were included in this study to identify potential pathogenic gene mutations among sporadic KC patients in the Han Chinese population.Sanger sequencing and whole-exome sequencing(WES)were used to analyze mutations in the zinc finger protein 469(ZNF469)gene.Bioinformatics analysis was conducted to explore the potential role of ZNF469 in KC pathogenesis.Results:Five novel heterozygous missense variants were identified in KC patients.Among them,2 compound heterozygous variants,c.8986G>C(p.E2996Q)with c.11765A>C(p.D3922A),and c.4423C>G(p.L1475V)with c.10633G>A(p.G3545R),were determined to be possible pathogenic factors for KC.Conclusion:Mutations in the ZNF469 gene may contribute to the development of KC in the Han Chinese population.These mutation sites may provide valuable information for future genetic screening of KC patients and their families.
