In order to support just-in-time reconfiguration of business process execution language （BPEL） process, a template-based mapping method is proposed to map business level process to BPEL process. The method builds up...In order to support just-in-time reconfiguration of business process execution language （BPEL） process, a template-based mapping method is proposed to map business level process to BPEL process. The method builds up mapping relationships between the key points of business level process and BPEL process, which helps users to adjust the business level process with simplified operations, and automatically maps the changes to BPEL. In addition, a case of the application of the method in a clothing enterprise was illustrated.展开更多
This work aims to investigate the relationship between the senescence of testicular Leydig cells and the regulation of insulin/IGF-1 signaling pathway in rats delayed by Heshouwuyin.The oxidative damage technique was ...This work aims to investigate the relationship between the senescence of testicular Leydig cells and the regulation of insulin/IGF-1 signaling pathway in rats delayed by Heshouwuyin.The oxidative damage technique was used to establish Leydig cell aging model.Flow cytometry was used to detect the changes of cell cycle in each group.Detection of mRNA and protein expression levels of key genes of insulin/IGF-1 signaling pathway in Leydig cells by Real-time PCR,immunofluorescence and Western blotting.Cells were treated with insulin receptor/IGF receptor specific inhibitor BMS 754807,flow cytometry was used to detect the apoptotic level of Leydig cells.The results showed that compared with the normal group,the proportion ofβgalactosidase positive cells in the aging group was more than 60%(P<0.05),and the proportion of G1 phase increased significantly,while that of S phase decreased significantly(P<0.05);Changes in the expression of key genes of the insulin/IGF-1 signaling pathway:The expression levels of INSR,IRS1,IRS2,IGF-1 mRNA and protein in the aging group were significantly lower than those in the normal group(P<0.05),and the mRNA expression of IGFBP3 was significantly higher than in the normal group(P<0.05),Heshouwuyin can reverse the above phenomenon.展开更多
Application of silicon in high capacity electrodes of lithium ion battery suffers from stress effects and, in turn, affects voltage performance of battery. This paper established a reaction-diffusion-stress coupled mo...Application of silicon in high capacity electrodes of lithium ion battery suffers from stress effects and, in turn, affects voltage performance of battery. This paper established a reaction-diffusion-stress coupled model and investigated the stress induced voltage hysteresis with consideration of diffusion induced stress, surface effects and interparticle compression. It was found stress and stress induced voltage hysteresis depended on particle size. In big particles, diffusion induced stress is dominant and leads to significant hysteresis in both stress and voltage, indicating energy dissipation due to stress effects. In small particles, e.g.,radius of dozens nanometers, diffusion induced stress was negligible while surface effects played dominant role, leading to nearly vanished voltage hysteresis shifting away from equilibrium potential. According to calculation, particle sizes around 100 nm are appropriate choice for electrode design as both diffusion induced stress and surface effects are insignificant. Finally,interparticle compression pushed the stress hysteresis to compressive side and led to early termination of lithiation at cut-off voltage. Denser electrode would enhance this effect. It indicated that there must be a limit of mixing ratio of silicon because higher interparticle compressive stress due to more introduced silicon would impede the battery from fully charged.展开更多
基金the National High-Technology Research and Development Program of China (863 Program) (2006AA04Z158, 2006AA01A106)the National Basic Research Program of China (973 Program) (2005CB 321807, 2007CB310805)
文摘In order to support just-in-time reconfiguration of business process execution language （BPEL） process, a template-based mapping method is proposed to map business level process to BPEL process. The method builds up mapping relationships between the key points of business level process and BPEL process, which helps users to adjust the business level process with simplified operations, and automatically maps the changes to BPEL. In addition, a case of the application of the method in a clothing enterprise was illustrated.
文摘This work aims to investigate the relationship between the senescence of testicular Leydig cells and the regulation of insulin/IGF-1 signaling pathway in rats delayed by Heshouwuyin.The oxidative damage technique was used to establish Leydig cell aging model.Flow cytometry was used to detect the changes of cell cycle in each group.Detection of mRNA and protein expression levels of key genes of insulin/IGF-1 signaling pathway in Leydig cells by Real-time PCR,immunofluorescence and Western blotting.Cells were treated with insulin receptor/IGF receptor specific inhibitor BMS 754807,flow cytometry was used to detect the apoptotic level of Leydig cells.The results showed that compared with the normal group,the proportion ofβgalactosidase positive cells in the aging group was more than 60%(P<0.05),and the proportion of G1 phase increased significantly,while that of S phase decreased significantly(P<0.05);Changes in the expression of key genes of the insulin/IGF-1 signaling pathway:The expression levels of INSR,IRS1,IRS2,IGF-1 mRNA and protein in the aging group were significantly lower than those in the normal group(P<0.05),and the mRNA expression of IGFBP3 was significantly higher than in the normal group(P<0.05),Heshouwuyin can reverse the above phenomenon.
基金the financial supports of the National Natural Science Foundation of China (Grant Nos. 11672170, 11332005, 11702166)the Natural Science Foundation of Shanghai (Grant No. 16ZR1412200)+1 种基金the support provided by the 2017 Monash University Malaysia Strategic Large Grant Scheme (Grant No. LG-2017-04-ENG)Advanced Engineering Programme Cluster funding
文摘Application of silicon in high capacity electrodes of lithium ion battery suffers from stress effects and, in turn, affects voltage performance of battery. This paper established a reaction-diffusion-stress coupled model and investigated the stress induced voltage hysteresis with consideration of diffusion induced stress, surface effects and interparticle compression. It was found stress and stress induced voltage hysteresis depended on particle size. In big particles, diffusion induced stress is dominant and leads to significant hysteresis in both stress and voltage, indicating energy dissipation due to stress effects. In small particles, e.g.,radius of dozens nanometers, diffusion induced stress was negligible while surface effects played dominant role, leading to nearly vanished voltage hysteresis shifting away from equilibrium potential. According to calculation, particle sizes around 100 nm are appropriate choice for electrode design as both diffusion induced stress and surface effects are insignificant. Finally,interparticle compression pushed the stress hysteresis to compressive side and led to early termination of lithiation at cut-off voltage. Denser electrode would enhance this effect. It indicated that there must be a limit of mixing ratio of silicon because higher interparticle compressive stress due to more introduced silicon would impede the battery from fully charged.
