目的探究脓毒症患者血浆IL-6水平与抗凝蛋白水平的关系。方法选取2024年1月至2025年5月于安阳市人民医院全球重症监护病房(intensive care units,ICU)治疗的脓毒症患者83例。根据白细胞介素-6(interleukin-6,IL-6)水平(以32.1 pg/mL为...目的探究脓毒症患者血浆IL-6水平与抗凝蛋白水平的关系。方法选取2024年1月至2025年5月于安阳市人民医院全球重症监护病房(intensive care units,ICU)治疗的脓毒症患者83例。根据白细胞介素-6(interleukin-6,IL-6)水平(以32.1 pg/mL为临界值)将患者分为低IL-6水平组(n=28)和高IL-6水平组(n=55),分析两组抗凝蛋白水平的差异。根据确诊脓毒症后30 d内的死亡情况将患者分为死亡组(n=18)和生存组(n=65),比较两组IL-6水平和抗凝蛋白水平的关系。结果高IL-6水平组降钙素原(procalcitonin,PCT)(79.12±29.81)ng/mL、C-反应蛋白(C-reactive protein,CRP)(173.33±63.37)mg/L、序贯器官衰竭评分(sequential organ failure assessment,SOFA)(9.05±3.81)分、APACHEⅡ评分(19.46±5.18)分均明显高于低IL-6水平组(P<0.05),本研究中,共死亡18例,死亡率21.60%,高IL-6水平组的存活率70.00%显著低于低IL-6水平组存活率90.91%(P<0.05)。高IL-6水平组蛋白C(protein C,PC)(37.53±13.27)%、蛋白S(protein S,PS)(69.06±13.28)%和抗凝血酶Ⅲ(antithrombinⅢ,AT-Ⅲ)(56.15±12.19)%水平均显著低于低IL-6水平组。脓毒症死亡组患者中高IL-6水平组PC(34.37±9.19)%、PS(68.38±8.47)%和AT-Ⅲ(49.65±10.45)%水平均显著低于低IL-6水平组(P<0.05)。脓毒症生存组高IL-6水平组PC(42.35±15.18)%、PS(72.42±10.35)%和AT-Ⅲ(60.46±9.33)%水平均显著低于低IL-6水平组(P<0.05)。Pearson相关性分析发现,IL-6与PC(r=-0.623,P<0.001)、AT-Ⅲ(r=-0.598,P<0.001)以及PS(r=-0.112,P=0.025)呈显著负相关。结论脓毒症患者IL-6水平升高是影响抗凝蛋白(PC、AT-Ⅲ以及PS)的因素,其可作为脓毒症凝血病恶化及预后的关键预警指标,有利于临床上监测脓毒症患者病情变化。展开更多
Multiple methods were applied to study the deformation characteristics of hornblende in Archean plagioamphibolite mylonite from the Western Hills(Beijing),including optical microscopy(OM),electron backscatter diffract...Multiple methods were applied to study the deformation characteristics of hornblende in Archean plagioamphibolite mylonite from the Western Hills(Beijing),including optical microscopy(OM),electron backscatter diffraction(EBSD),transmission electron microscopy(TEM),and electron probe microanalysis(EPMA).The hornblendes are σ and δ type porphyroclasts with the new-born needle shaped grains as their tails.The analysis of lattice preferred orientation(LPO) of both the porphyroclasts and the new-born grains shows that the main slip system of the deformed hornblende is(100)<001>,suggesting that the fabric characteristics of new-born grains inherit that of porphyroclasts.Sub-microstructures show the porphyroclast core is dominated by dislocation tangle,little or no dislocations in the new-born grains,and the subgrains confined by dislocations in the transition zone between porphyroclasts and new-born grains.By using plagioclase-hornblende geothermometry and hornblende geobarometry,the estimated temperature and pressure of porphyroclasts are 675.3-702.9℃ and 0.29-0.41 GPa and those of new-born grains are 614.1-679.0℃ and 0.11-0.31 GPa.The bulging recrystallization is summarized as deformation mechanisms of hornblende by the discussions of the microstructures,EBSD fabric,sub-microstructures,and the deformed temperature and pressure.展开更多
Hornblende＇s plastic and superplastic deformation mechanisms were studied on the basis of some new information obtained from amphibolite samples in the Hengshan Mountains （Hengshan, Shanxi, China）.For this purpose,...Hornblende＇s plastic and superplastic deformation mechanisms were studied on the basis of some new information obtained from amphibolite samples in the Hengshan Mountains （Hengshan, Shanxi, China）.For this purpose, the samples were measured and analyzed by optical microscope （OM）, electron probe microanalysis （EPMA）, transmission electron microscope （TEM） and electron backscattered diffraction （EBSD） respectively.Because localized strong strain is more than 1000%, it is presumed that structural superplastic deformation was developed during the ductile shearing process.It is calculated that deformation occurred at 650-679℃ and 0.770-0.914 GPa, based on the study of plagioclase-hornblende geothermometry and geobarometry.TEM images show that new hornblende grains developed few dislocations and hornblende crystals exhibit straight grain boundaries.EBSD of strongly deformed hornblendes reveals a fabric dominated by a {100} lattice preferred orientation （LPO）, indicative of new grain recrystallization along the lineation direction （X axis）.Thus superplastic deformation of hornblendes from the Hengshan Mountains was developed by mainly solid-state diffusive mass transfer and grain boundary sliding.展开更多
基金supported by the National Natural Science Foundation of China (Grant No.40772133)
文摘Multiple methods were applied to study the deformation characteristics of hornblende in Archean plagioamphibolite mylonite from the Western Hills(Beijing),including optical microscopy(OM),electron backscatter diffraction(EBSD),transmission electron microscopy(TEM),and electron probe microanalysis(EPMA).The hornblendes are σ and δ type porphyroclasts with the new-born needle shaped grains as their tails.The analysis of lattice preferred orientation(LPO) of both the porphyroclasts and the new-born grains shows that the main slip system of the deformed hornblende is(100)<001>,suggesting that the fabric characteristics of new-born grains inherit that of porphyroclasts.Sub-microstructures show the porphyroclast core is dominated by dislocation tangle,little or no dislocations in the new-born grains,and the subgrains confined by dislocations in the transition zone between porphyroclasts and new-born grains.By using plagioclase-hornblende geothermometry and hornblende geobarometry,the estimated temperature and pressure of porphyroclasts are 675.3-702.9℃ and 0.29-0.41 GPa and those of new-born grains are 614.1-679.0℃ and 0.11-0.31 GPa.The bulging recrystallization is summarized as deformation mechanisms of hornblende by the discussions of the microstructures,EBSD fabric,sub-microstructures,and the deformed temperature and pressure.
基金supported by National Natural Science Foundation of China(Grant No.40772133)
文摘Hornblende＇s plastic and superplastic deformation mechanisms were studied on the basis of some new information obtained from amphibolite samples in the Hengshan Mountains （Hengshan, Shanxi, China）.For this purpose, the samples were measured and analyzed by optical microscope （OM）, electron probe microanalysis （EPMA）, transmission electron microscope （TEM） and electron backscattered diffraction （EBSD） respectively.Because localized strong strain is more than 1000%, it is presumed that structural superplastic deformation was developed during the ductile shearing process.It is calculated that deformation occurred at 650-679℃ and 0.770-0.914 GPa, based on the study of plagioclase-hornblende geothermometry and geobarometry.TEM images show that new hornblende grains developed few dislocations and hornblende crystals exhibit straight grain boundaries.EBSD of strongly deformed hornblendes reveals a fabric dominated by a {100} lattice preferred orientation （LPO）, indicative of new grain recrystallization along the lineation direction （X axis）.Thus superplastic deformation of hornblendes from the Hengshan Mountains was developed by mainly solid-state diffusive mass transfer and grain boundary sliding.
