Recently,abnormal expression of KIAA1199 has been detected in Epithelial Ovarian Cancer(EOC).However,the underlined anti-ovarian cancer mechanism of KIAA1199 remains to be enlightened.In our study,we performed to eluc...Recently,abnormal expression of KIAA1199 has been detected in Epithelial Ovarian Cancer(EOC).However,the underlined anti-ovarian cancer mechanism of KIAA1199 remains to be enlightened.In our study,we performed to elucidate the effects of KIAA1199 on the advanced biological behavior of EOC cells through activation of the IL-6/STAT3 pathway.Confirmed by immunohistochemistry,KIAA1199 was highly expressed in ovarian borderline and malignant epithelial tumors.A retrospective analysis found that EOC patients with low expression of KIAA1199 had a significantly higher 5-year survival rate than those with high expression.Mechanistically,IL-6 was used to stimulate EOC cells,and the expression of KIAA1199,STAT3 and p-STAT3 increased after IL-6 stimulation.These results could show that KIAA1199 is transcriptionally activated by IL6/STAT3 pathway,thereby accelerating the deterioration of EOC.KIAA1199 could also be used as a poor prognosis factor and potential target in treatment.展开更多
The Chinese lake gudgeon is a small benthopelagic freshwater fish.It is presently threatened by human activities and environmental factors in China.Understanding the genetic diversity and population structure is funda...The Chinese lake gudgeon is a small benthopelagic freshwater fish.It is presently threatened by human activities and environmental factors in China.Understanding the genetic diversity and population structure is fundamental for implementation of appropriate conservation measures and a sustainable management program.However,little is reported about the current genetic diversity and population structure.Here,we used ten microsatellite markers to genotype 175 individuals from six populations.Low levels of genetic diversity were found in all six tested populations.The Xiang river population showed the highest level of genetic diversity.Genetic differentiation was very low but significant among the Changyang,Changqidang and Mayang populations,but the Qiandao lake,Gan river,Xiang river populations all showed significant and strong differentiation from the other three populations.Contemporary gene flow was observed in among Changyang,Changqidang and Mayang populations and between Gan and Xiang river populations,respectively.This is the first genetic study to report the genetic diversity and population structure of S.sinensis and the results will be used to develop management and conservation strategies.展开更多
Uterine infertility is a major global issue causing substantial physical and psychological hardship for individuals struggling to conceive,while endometrium injury is one of the crucial factors causing infertility.Her...Uterine infertility is a major global issue causing substantial physical and psychological hardship for individuals struggling to conceive,while endometrium injury is one of the crucial factors causing infertility.Here,we demonstrate that platelet-derived extracellular vesicles(PEVs)have excellent regenerative ability in treating endometrial injuries,facilitating endometrium regeneration and resulting in a highly efficient live birth rate in the endometrium-injured murine model.We further investigated the underlying mechanisms by which PEVs affect the endometrium,showing their ability to promote neovascularization and suppress fibrosis.More importantly,the regenerative endometrium is more receptive to embrace the embryo,which can sustain the normal pregnancy.Our finding serves as a foundational basis for advancing the clinical translation of platelet-rich plasma(PRP)and therapies for endometrial regeneration.展开更多
基金The National Natural Science Foundation of China,Grant/Award No.81802606.
文摘Recently,abnormal expression of KIAA1199 has been detected in Epithelial Ovarian Cancer(EOC).However,the underlined anti-ovarian cancer mechanism of KIAA1199 remains to be enlightened.In our study,we performed to elucidate the effects of KIAA1199 on the advanced biological behavior of EOC cells through activation of the IL-6/STAT3 pathway.Confirmed by immunohistochemistry,KIAA1199 was highly expressed in ovarian borderline and malignant epithelial tumors.A retrospective analysis found that EOC patients with low expression of KIAA1199 had a significantly higher 5-year survival rate than those with high expression.Mechanistically,IL-6 was used to stimulate EOC cells,and the expression of KIAA1199,STAT3 and p-STAT3 increased after IL-6 stimulation.These results could show that KIAA1199 is transcriptionally activated by IL6/STAT3 pathway,thereby accelerating the deterioration of EOC.KIAA1199 could also be used as a poor prognosis factor and potential target in treatment.
基金supported by the Jiangsu Key Technology R&D Program(BE2011330)。
文摘The Chinese lake gudgeon is a small benthopelagic freshwater fish.It is presently threatened by human activities and environmental factors in China.Understanding the genetic diversity and population structure is fundamental for implementation of appropriate conservation measures and a sustainable management program.However,little is reported about the current genetic diversity and population structure.Here,we used ten microsatellite markers to genotype 175 individuals from six populations.Low levels of genetic diversity were found in all six tested populations.The Xiang river population showed the highest level of genetic diversity.Genetic differentiation was very low but significant among the Changyang,Changqidang and Mayang populations,but the Qiandao lake,Gan river,Xiang river populations all showed significant and strong differentiation from the other three populations.Contemporary gene flow was observed in among Changyang,Changqidang and Mayang populations and between Gan and Xiang river populations,respectively.This is the first genetic study to report the genetic diversity and population structure of S.sinensis and the results will be used to develop management and conservation strategies.
基金This work was partly supported by the National Key R&D Program of China(No.2022YFB3808100)This work was supported by National Natural Science Foundation of China(Nos.81873835 and 82071726)+3 种基金the Suzhou Science and Technology Plan(No.SKY2022005)the Gusu Talent Project of Suzhou(No.GSWS2020011)the Science and Technology Project of Suzhou(No.SKY2023138)the research fund of the Second Affiliated Hospital of Soochow University(No.SDFEYGZ2319).
文摘Uterine infertility is a major global issue causing substantial physical and psychological hardship for individuals struggling to conceive,while endometrium injury is one of the crucial factors causing infertility.Here,we demonstrate that platelet-derived extracellular vesicles(PEVs)have excellent regenerative ability in treating endometrial injuries,facilitating endometrium regeneration and resulting in a highly efficient live birth rate in the endometrium-injured murine model.We further investigated the underlying mechanisms by which PEVs affect the endometrium,showing their ability to promote neovascularization and suppress fibrosis.More importantly,the regenerative endometrium is more receptive to embrace the embryo,which can sustain the normal pregnancy.Our finding serves as a foundational basis for advancing the clinical translation of platelet-rich plasma(PRP)and therapies for endometrial regeneration.
