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益糖康对糖尿病合并脑卒中大鼠小肠炎性损伤及TLR4/NF-κB/NLRP3焦亡通路的影响
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作者 陈志超 孙贵炎 +6 位作者 申鑫惠 付子珊 王轲儿 石岩 杨莺 杨宇峰 王金曦 《中国病理生理杂志》 北大核心 2026年第1期138-147,共10页
目的:基于Toll样受体4(Toll-like receptor 4,TLR4)/核因子κB(nuclear factor-κB,NF-κB)/核苷酸结合寡聚化结构域样受体蛋白3(nucleotide-binding oligomerization domain-like receptor protein 3,NLRP3)信号通路观察益糖康对糖尿... 目的:基于Toll样受体4(Toll-like receptor 4,TLR4)/核因子κB(nuclear factor-κB,NF-κB)/核苷酸结合寡聚化结构域样受体蛋白3(nucleotide-binding oligomerization domain-like receptor protein 3,NLRP3)信号通路观察益糖康对糖尿病合并脑卒中大鼠小肠细胞焦亡的影响及对小肠炎性损伤的调控作用。方法:90只Wistar大鼠,选取15只作为假手术组,剩余75只按随机数表法将造模成功大鼠分为模型组、益糖康组和吡格列酮组,每组25只。采用高脂高糖饲料联合腹腔注射链脲佐菌素诱导大鼠糖尿病模型,造模成功后以改良的Zea Longa线栓法制备局灶性大脑中动脉阻塞大鼠模型,期间观察大鼠空腹血糖。给药2周后,进行神经功能评分后处死取材,采用TTC法进行脑组织染色,脑组织含水量检测,ELISA检测血清炎症因子相关指标,HE染色检测小肠及脑组织病理变化,免疫荧光法检测TLR4、NF-κB、NLRP3和胱天蛋白酶1(caspase-1)的表达情况。应用Western blot法检测TLR4、NF-κB、NLRP3、caspase-1、白细胞介素1β(interleukin-1β,IL-1β)和IL-18蛋白的表达情况。结果:与假手术组比较,模型组大鼠脑组织梗死面积明显增大;与模型组比较,益糖康组和吡格列酮组小肠组织和脑组织HE染色改变显著,血清肿瘤坏死因子α(tumor necrosis factorα,TNF-α)和IL-6等炎症因子表达显著降低,免疫荧光TLR4、NF-κB、NLRP3和caspase-1的表达均显著降低(P<0.05),TLR4、NF-κB、NLRP3、caspase-1、IL-1β和IL-18蛋白的表达均显著下降(P<0.05)。结论:益糖康可能通过TLR4/NF-κB/NLRP3信号通路,改善糖尿病合并缺血性脑卒中大鼠小肠细胞焦亡及炎性损伤,起到治疗糖尿病合并缺血性脑卒中大鼠脑损伤的作用。 展开更多
关键词 益糖康 糖尿病 缺血性脑卒中 TLR4/NF-κB/NLRP3信号通路 细胞焦亡
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IPRAN与PeOTN混合组网用于5G承载探讨 被引量:4
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作者 满祥锟 王海军 +1 位作者 庞冉 师严 《信息通信技术与政策》 2018年第9期26-30,共5页
5G网络即将开始试点部署,针对5G前传承载段与回传承载段,各大运营商提出了IP RAN、SPN、MOTN、G.metro等多种技术方案,重点探讨了基于IP RAN与PeOTN混合组网的5G回传承载方案。首先介绍了当前5G回传承载的研究进展,明确了5G回传承载的... 5G网络即将开始试点部署,针对5G前传承载段与回传承载段,各大运营商提出了IP RAN、SPN、MOTN、G.metro等多种技术方案,重点探讨了基于IP RAN与PeOTN混合组网的5G回传承载方案。首先介绍了当前5G回传承载的研究进展,明确了5G回传承载的目标网络架构,提出基于IP RAN与PeOTN混组组网的5G回传承载方案。 展开更多
关键词 5G IP RAN PeOTN
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基于WinDriver的PCIe 1553B总线接口卡驱动设计与实现 被引量:3
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作者 闫海明 史岩 +1 位作者 常于敏 杨北亚 《信息通信》 2018年第5期99-100,共2页
介绍了一种基于Win Driver模型的PCIe 1553B总线接口的驱动程序设计。分析了Win Driver模型的框架结构及驱动程序设计流程,着重讨论了基于自主开发1553B总线接口卡的Win Driver驱动程序开发,主要包括接口设备访问、DMA传输及中断机制等... 介绍了一种基于Win Driver模型的PCIe 1553B总线接口的驱动程序设计。分析了Win Driver模型的框架结构及驱动程序设计流程,着重讨论了基于自主开发1553B总线接口卡的Win Driver驱动程序开发,主要包括接口设备访问、DMA传输及中断机制等内容。经实测,该驱动程序工作稳定可靠,兼容性好。 展开更多
关键词 WINDRIVER PCIe接口 1553B总线 DMA
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Effect of Nitrofurroycin Vaginal Soft Capsule in the Treatment of Vaginitis
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作者 shiyan 《外文科技期刊数据库(文摘版)医药卫生》 2022年第2期195-198,共4页
Objective: to study the application effect of nitrocellulose vaginal soft capsule (blue) in the clinical treatment of vaginitis. Methods: select our hospital during May 2020 to April 202160 vaginitis patients, even pa... Objective: to study the application effect of nitrocellulose vaginal soft capsule (blue) in the clinical treatment of vaginitis. Methods: select our hospital during May 2020 to April 202160 vaginitis patients, even patients, observation and control group 30 cases, control group using conventional treatment plan, observation group auxiliary treatment, compare the two groups of patients treatment efficiency, recurrence rate and incidence of adverse reactions, analyze the treatment cycle and patient satisfaction score. Results: the total treatment efficiency of the observation group was 96.67% (29 / 30), The total treatment efficiency of the control group was 70.00% (21 / 30), Data vary between groups, Statistical significance;The recurrence rate of vaginitis in the observation group was 3.33% (1 in 30), The control group's recurrence rate was 26.67% (8 / 30), Statistical significance (P <0.05);Two cases had heartburn, itching and one case who had nausea in the observation group;The control group had 4 cases of external heartburn, itching and 4 cases of nausea, There were 3 cases of dizziness, The incidence of adverse reactions in the observed group was 10.00% lower than 36.67% in the control group, Comparison between groups were obvious, Statistically significant (P <0.05).Treatment cycle (20.41 ± 2.28) d, satisfaction score (94.35 ± 2.08), treatment cycle (22.23 ± 3.12) d, satisfaction score (93.42 ± 1.150), P <0.05 after data comparison. Conclusion: in the clinical treatment of vaginitis, the use of nitrofurthil ycin is very effective, which can improve the overall efficiency of treatment and control the incidence of disease recurrence and adverse reactions. Relevant treatment methods are also conducive to shortening the rehabilitation treatment cycle and improving the patient satisfaction score, which is of great significance to accelerate the treatment process of patients, and can be promoted. 展开更多
关键词 VAGINITIS nitrofurtyamycin vaginal soft capsule adjuvant therapy EFFECT
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Effect Evaluation of the Various Cervical Cancer Screening Methods in Women's Physical Examination
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作者 TANXiaoyan LIUJing +2 位作者 ZHAOXuejing LIXia shiyan 《外文科技期刊数据库(文摘版)医药卫生》 2022年第7期129-133,共5页
Objective: to analyze the positive rate of cervical cancer by TCT and HPV in cervical cancer screening, so as to improve the clinical screening ability of cervical cancer and provide the basis for cervical cancer scre... Objective: to analyze the positive rate of cervical cancer by TCT and HPV in cervical cancer screening, so as to improve the clinical screening ability of cervical cancer and provide the basis for cervical cancer screening in the future. Methods: 3902 women in womens health examination in our department were selected as the research objects. In the physical examination, each research object underwent HPV test and TCT test, and then the results of TCT test, HPV test and TCT combined with HPV test were compared one by one. The diagnostic gold standard was biopsy results. Results: among the 3902 cervical cancer screeners, there were 1575 cases with CIN and 2327 cases with chronic inflammation by histopathological examination. TCT was positive in 1864 cases and negative in 2038 cases, with sensitivity of 59.68%, false negative rate of 40.32%, specificity of 60.29%, false positive rate of 39.71% and correct index of 0.1997. There were 3245 positive HPV cases and 657 negative HPV cases, with sensitivity of 83.81%, false negative rate of 16.19%, specificity of 17.27%, and false positive rate of 82.72% and correct index of 0.0108. TCT+HPV was positive in 1503 cases and negative in 2399 cases, with sensitivity of 94.22%, false negative rate of 5.78%, specificity of 99.18%, false positive rate of 0.82% and correct index of 0.934. Conclusion: single HPV test and TCT test in patients with cervical cancer have high sensitivity and specificity, while TCT+HPV test has the highest sensitivity, specificity and correctness. It is helpful to improve the diagnosis rate of cervical cancer by combining the two test methods clinically. 展开更多
关键词 cervical cancer TCT inspection detection of HPV HPV vaccine
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慢性阻塞性肺疾病早期诊断方法的研究进展 被引量:13
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作者 谭颖 宋氏妍 +2 位作者 王珺 王岷 陈玉娟 《实用心脑肺血管病杂志》 2019年第7期9-11,共3页
慢性阻塞性肺疾病(COPD)是临床常见慢性病之一,患病率和病死率均较高。COPD早期肺功能下降速度较快,但多数COPD患者确诊时已出现重度肺功能障碍且病程不可逆。近年来COPD患者数量不断增多,但COPD的早期诊断尚未受到足够重视。本文综述了... 慢性阻塞性肺疾病(COPD)是临床常见慢性病之一,患病率和病死率均较高。COPD早期肺功能下降速度较快,但多数COPD患者确诊时已出现重度肺功能障碍且病程不可逆。近年来COPD患者数量不断增多,但COPD的早期诊断尚未受到足够重视。本文综述了COPD的早期诊断方法,以期为减少COPD的漏诊漏治,促进COPD的早防早治提供参考。 展开更多
关键词 慢性阻塞性肺疾病 早期诊断 呼吸功能试验 综述
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