The conditional kernel correlation is proposed to measure the relationship between two random variables under covariates for multivariate data.Relying on the framework of reproducing kernel Hilbert spaces,we give the ...The conditional kernel correlation is proposed to measure the relationship between two random variables under covariates for multivariate data.Relying on the framework of reproducing kernel Hilbert spaces,we give the definitions of the conditional kernel covariance and conditional kernel correlation.We also provide their respective sample estimators and give the asymptotic properties,which help us construct a conditional independence test.According to the numerical results,the proposed test is more effective compared to the existing one under the considered scenarios.A real data is further analyzed to illustrate the efficacy of the proposed method.展开更多
Distance-based regression model,as a nonparametric multivariate method,has been widely used to detect the association between variations in a distance or dissimilarity matrix for outcomes and predictor variables of in...Distance-based regression model,as a nonparametric multivariate method,has been widely used to detect the association between variations in a distance or dissimilarity matrix for outcomes and predictor variables of interest in genetic association studies,genomic analyses,and many other research areas.Based on it,a pseudo-F statistic which partitions the variation in distance matrices is often constructed to achieve the aim.To the best of our knowledge,the statistical properties of the pseudo-F statistic has not yet been well established in the literature.To fill this gap,the authors study the asymptotic null distribution of the pseudo-F statistic and show that it is asymptotically equivalent to a mixture of chi-squared random variables.Given that the pseudo-F test statistic has unsatisfactory power when the correlations of the response variables are large,the authors propose a square-root F-type test statistic which replaces the similarity matrix with its square root.The asymptotic null distribution of the new test statistic and power of both tests are also investigated.Simulation studies are conducted to validate the asymptotic distributions of the tests and demonstrate that the proposed test has more robust power than the pseudo-F test.Both test statistics are exemplified with a gene expression dataset for a prostate cancer pathway.展开更多
基金partially supported by Knowledge Innovation Program of Hubei Province(No.2019CFB810)partially supported by NSFC(No.12325110)the CAS Project for Young Scientists in Basic Research(No.YSBR-034)。
文摘The conditional kernel correlation is proposed to measure the relationship between two random variables under covariates for multivariate data.Relying on the framework of reproducing kernel Hilbert spaces,we give the definitions of the conditional kernel covariance and conditional kernel correlation.We also provide their respective sample estimators and give the asymptotic properties,which help us construct a conditional independence test.According to the numerical results,the proposed test is more effective compared to the existing one under the considered scenarios.A real data is further analyzed to illustrate the efficacy of the proposed method.
基金partially supported by Beijing Natural Science Foundation under Grant No.Z180006.
文摘Distance-based regression model,as a nonparametric multivariate method,has been widely used to detect the association between variations in a distance or dissimilarity matrix for outcomes and predictor variables of interest in genetic association studies,genomic analyses,and many other research areas.Based on it,a pseudo-F statistic which partitions the variation in distance matrices is often constructed to achieve the aim.To the best of our knowledge,the statistical properties of the pseudo-F statistic has not yet been well established in the literature.To fill this gap,the authors study the asymptotic null distribution of the pseudo-F statistic and show that it is asymptotically equivalent to a mixture of chi-squared random variables.Given that the pseudo-F test statistic has unsatisfactory power when the correlations of the response variables are large,the authors propose a square-root F-type test statistic which replaces the similarity matrix with its square root.The asymptotic null distribution of the new test statistic and power of both tests are also investigated.Simulation studies are conducted to validate the asymptotic distributions of the tests and demonstrate that the proposed test has more robust power than the pseudo-F test.Both test statistics are exemplified with a gene expression dataset for a prostate cancer pathway.
