The two-electron electrochemical oxygen reduction reaction(ORR)affords an appealing alternative for on-site production of hydrogen peroxide(H_(2)O_(2)),which can fulfill the demands of various applications even at low...The two-electron electrochemical oxygen reduction reaction(ORR)affords an appealing alternative for on-site production of hydrogen peroxide(H_(2)O_(2)),which can fulfill the demands of various applications even at low concentrations.Under neutral or near-neutral conditions,the electrolyte environment capable of electrochemically synthesizing H_(2)O_(2) exhibits diversity and holds vast potential for practical applications;however,the electrocatalytic performance is limited without desirable electrode materials.In this contribution,methoxylated nickel hydroxides were proposed for high-performance on-site H_(2)O_(2) electrosynthesis in different potassium fertilizer solutions.The methoxylation compared to pristine Ni(OH)_(2) was demonstrated to optimize the electronic structure with favorable adsorption of reaction intermediates,obviously enhancing the activity and selectivity.In 0.10 M K_(2)SO_(4) solution,H_(2)O_(2) production ranged from 28.1 to 153.6 mg h^(-1) cm^(-2) at current densities of-50 to-250 mA cm^(-2),accompanied by Faradaic efficiency values exceeding 88.0%.An integrated system was devised by combining fertilization,disinfection,and irrigation through the coupling of two-electron ORR with agricultural irrigation,utilizing nutrient solutions as the electrolyte for on-site H_(2)O_(2) electrosynthesis.These findings afford a promising avenue for the practical application of 2e-ORR in neutral environments.展开更多
With the widespread application of lithium batteries in electric vehicles and energy storage systems,battery-related safety and reliability issues have become increasingly prominent.Conventional monitoring methods oft...With the widespread application of lithium batteries in electric vehicles and energy storage systems,battery-related safety and reliability issues have become increasingly prominent.Conventional monitoring methods often struggle to address dynamic changes under complex operando.In recent years,flexible sensing technology has emerged as a promising solution for battery health monitoring due to its high adaptability and conformability to complex structures.Meanwhile,empowered by artificial intelligence(AI)for data analysis,the collected data enables efficient and accurate state assessment,offering robust support for accident prevention.Against this background,this paper first explores the integrated applications of flexible sensors in battery health monitoring and their unique advantages in addressing complex battery operating conditions,while analyzing the potential of AI in battery state analysis.Subsequently,it systematically reviews mainstream flexible sensing technologies(e.g.,film sensors,thermocouples,and optical fiber sensors),elucidating their mechanisms for revealing intricate internal battery processes during operation.Finally,the paper discusses AI’s role in enhancing monitoring efficiency and accuracy,and envisions future research directions and application prospects.This work aims to provide technical references for the battery health monitoring field as well as promote the application of flexible sensing technologies in improving battery system safety and reliability.展开更多
Modern oilseed breeding faces the complex challenge of simultaneously improving yield,nutritional quality,and stress resilience within a sustainable agricultural framework.A predictive,systems-oriented strategy offers...Modern oilseed breeding faces the complex challenge of simultaneously improving yield,nutritional quality,and stress resilience within a sustainable agricultural framework.A predictive,systems-oriented strategy offers a solution by using predictive modeling and precise genetic intervention to engineer target ideotypes.This review synthesizes the integration of genomic selection(GS),genome editing,and epigenetic regulation to operationalize a precision breeding strategy in major oilseed crops.We document how GS,utilizing high-density SNP arrays and sequencing data,has reduced breeding cycles by up to 50%in soybean,enabling rapid selection for complex traits like seed protein content.We highlight the precision of CRISPR-Cas systems in executing design goals,such as creating commercial-grade high-oleic soybeans(>80%oleic acid)by knocking out FAD2 genes.Similarly,editing glucosinolate biosynthesis genes in rapeseed has directly improved meal quality.Furthermore,we explore the emerging role of epigenetic regulation as a tunable layer in trait optimization,where DNA methylation patterns in sunflower are linked to drought stress memory and flowering time.Finally,we present an integrated molecular framework,which synergizes these technologies to develop ideotypes with optimized architectures and composition.Despite challenges in phenotyping and global regulation,the strategic implementation of this molecular toolkit is pioneering a new era of precision breeding for the sustainable intensification of oilseed production.展开更多
Electrochemical reduction reaction of pure CO_(2)(epCO_(2) RR)is highly promising since it could convert CO_(2) pollution into value-added chemicals(e.g.,CO,HCOOH,C_(2)H_(4),C_(2)H_(5) OH)under industrial-level curren...Electrochemical reduction reaction of pure CO_(2)(epCO_(2) RR)is highly promising since it could convert CO_(2) pollution into value-added chemicals(e.g.,CO,HCOOH,C_(2)H_(4),C_(2)H_(5) OH)under industrial-level current density with high selectivity above 90%.While the purification process of industrial flue gas into pure CO_(2) accounts for significant portion of CO_(2)-electrolysis cost.Direct flue-gas electroreduction offers a cost-effective alternative,while its practical implementation faces challenges such as low CO_(2) concentrations(<20 vol%)leading to small current density,competitive reactions such as oxygen reduction reaction,hydrogen evolution reaction,etc.,with more positive thermodynamic potentials than epCO_(2) RR.Therefore,this work reviews strategies to develop efficient and selective electrocatalysts that are resistant to non-CO_(2) active gasses such as O_(2),SO_(x),NO_(x),etc.,and treatment methods for such components in the flue gas.Significantly,the technoeconomic analysis of CO_(2) capture and purification integrated electrolysis process and direct flue gas reduction,is compared.Importantly,future research regarding direct electrochemical reduction of flue gas is proposed,including multifunctional catalyst design,complex reaction mechanism exploration,electrolysis system optimization,etc.展开更多
Bone has long been acknowledged as a fundamental structural entity that provides support and protection to the body’s organs.However,emerging research indicates that bone plays a crucial role in the regulation of sys...Bone has long been acknowledged as a fundamental structural entity that provides support and protection to the body’s organs.However,emerging research indicates that bone plays a crucial role in the regulation of systemic metabolism.This is achieved through the secretion of a variety of hormones,cytokines,metal ions,extracellular vesicles,and other proteins/peptides,collectively referred to as bone-derived factors(BDFs).BDFs act as a medium through which bones can exert targeted regulatory functions upon various organs,thereby underscoring the profound and concrete implications of bone in human physiology.Nevertheless,there remains a pressing need for further investigations to elucidate the underlying mechanisms that inform the effects of bone on other body systems.This review aims to summarize the current findings related to the roles of these significant modulators across different organs and metabolic contexts by regulating critical genes and signaling pathways in vivo.It also addresses their involvement in the pathogenesis of various diseases affecting the musculoskeletal system,circulatory system,glucose and lipid metabolism,central nervous system,urinary system,and reproductive system.The insights gained from this review may contribute to the development of innovative therapeutic strategies through a focused approach to bone secretomes.Continued research into BDFs is expected to enhance our understanding of bone as a multifunctional organ with diverse regulatory roles in human health.展开更多
Carbon materials are considered as prospective anode candidates for potassium ion batteries(PIBs).However,the low-rate capability is hampered by slow K+diffusion kinetics and obstructed electron transport of carbon-ba...Carbon materials are considered as prospective anode candidates for potassium ion batteries(PIBs).However,the low-rate capability is hampered by slow K+diffusion kinetics and obstructed electron transport of carbon-based anodes.In this work,calcium D-gluconate derived mesoporous carbon nanosheets(CGC)were interpenetrated into the architecture of reduced graphene oxides(RGO)to form the composites of two-dimensional(2D)/2D graphene/mesoporous carbon nanosheets(RGO@CGC).CGC as a rigid skeleton can prevent the graphene layers from restacking and maintain the structural stability of the 2D/2D carbon composites of RGO@CGC.The mesopores in CGC can shorten the path of ion diffusion and facilitate the penetration of electrolytes.RGO possesses the high surface-to-volume ratio and superior electron transport capability in the honeycomb-like 2D network consisting of sp^(2)-hybridized carbon atoms.Especially,theπ-πstacking interaction between CGC and RGO enhances stable composite structure formation,expedites interlayer-electron transfer,and establishes three-dimensional(3D)ion transportation pathways.Owing to these unique structure,RGO@CGC exhibits fast and stable potassium storage capability.Furthermore,the effects of binders and electrolytes on the electrochemical performance of RGO@CGC were investigated.Finally,Prussian blue was synthesized as a positive electrode to explore the possibility of RGO@CGC as a full battery application.展开更多
Stroke,a major cerebrovascular disease,has high morbidity and mortality.Effective methods to reduce the risk and improve the prognosis are lacking.Currently,uric acid(UA)is associated with the pathological mechanism,p...Stroke,a major cerebrovascular disease,has high morbidity and mortality.Effective methods to reduce the risk and improve the prognosis are lacking.Currently,uric acid(UA)is associated with the pathological mechanism,prognosis,and therapy of stroke.UA plays pro/anti-oxidative and pro-inflammatory roles in vivo.The specific role of UA in stroke,which may have both neuroprotective and damaging effects,remains unclear.There is a U-shaped association between serum uric acid(SUA)levels and ischemic stroke(IS).UA therapy provides neuroprotection during reperfusion therapy for acute ischemic stroke(AIS).Urate-lowering therapy(ULT)plays a protective role in IS with hyperuricemia or gout.SUA levels are associated with the cerebrovascular injury mechanism,risk,and outcomes of hemorrhagic stroke.In this review,we summarize the current research on the role of UA in stroke,providing potential targets for its prediction and treatment.展开更多
Direct air capture(DAC)is a negative carbon emission technology that faces challenges in scalability and practical deployment due to its exorbitant costs.Hou et al.(2017)integrated DAC technology with fertilization.A ...Direct air capture(DAC)is a negative carbon emission technology that faces challenges in scalability and practical deployment due to its exorbitant costs.Hou et al.(2017)integrated DAC technology with fertilization.A multi-bed desorption system driven by water provides a competitive and sustainable carbon source for indoor agriculture.展开更多
基金the support from the National Natural Science Foundation of China(22478221)China Postdoctoral Science Foundation(2023M741920 and GZC20231259)+1 种基金Huaneng Group Science and Technology Research Project(HNKJ23-H71)Department of Chemical Engineering-iBHE Cooperation Joint Fund Project(DCE-iBHE-2025-3)。
文摘The two-electron electrochemical oxygen reduction reaction(ORR)affords an appealing alternative for on-site production of hydrogen peroxide(H_(2)O_(2)),which can fulfill the demands of various applications even at low concentrations.Under neutral or near-neutral conditions,the electrolyte environment capable of electrochemically synthesizing H_(2)O_(2) exhibits diversity and holds vast potential for practical applications;however,the electrocatalytic performance is limited without desirable electrode materials.In this contribution,methoxylated nickel hydroxides were proposed for high-performance on-site H_(2)O_(2) electrosynthesis in different potassium fertilizer solutions.The methoxylation compared to pristine Ni(OH)_(2) was demonstrated to optimize the electronic structure with favorable adsorption of reaction intermediates,obviously enhancing the activity and selectivity.In 0.10 M K_(2)SO_(4) solution,H_(2)O_(2) production ranged from 28.1 to 153.6 mg h^(-1) cm^(-2) at current densities of-50 to-250 mA cm^(-2),accompanied by Faradaic efficiency values exceeding 88.0%.An integrated system was devised by combining fertilization,disinfection,and irrigation through the coupling of two-electron ORR with agricultural irrigation,utilizing nutrient solutions as the electrolyte for on-site H_(2)O_(2) electrosynthesis.These findings afford a promising avenue for the practical application of 2e-ORR in neutral environments.
基金supported by the grant of State Key Laboratory of Space Environment Interaction with Matters,the Science and Technology on Vacuum Technology and Physics Laboratory Fund(HTKJ2023KL510008)Key Program of the National Natural Science Foundation of China(No.62433017)+6 种基金the National Natural Science Foundation of China(No.62274140)the Fundamental Research Funds for the Central Universities(20720230030)the Xiaomi Young Talents Program/Xiaomi Foundation,Shenzhen Science and Technology Program(JCYJ20230807091401003)the Young Elite Scientist Sponsorship Program by Cast(No.YESS20230523)the State Key Laboratory of Space Environment Interaction with Matters(WDZC-HGD-2022-08)the Gansu Provincial Science and Technology Major Project(2244ZZDD1133GGAA000077)the China Aerospace Science and Technology Group Corporation Young Top Talents.
文摘With the widespread application of lithium batteries in electric vehicles and energy storage systems,battery-related safety and reliability issues have become increasingly prominent.Conventional monitoring methods often struggle to address dynamic changes under complex operando.In recent years,flexible sensing technology has emerged as a promising solution for battery health monitoring due to its high adaptability and conformability to complex structures.Meanwhile,empowered by artificial intelligence(AI)for data analysis,the collected data enables efficient and accurate state assessment,offering robust support for accident prevention.Against this background,this paper first explores the integrated applications of flexible sensors in battery health monitoring and their unique advantages in addressing complex battery operating conditions,while analyzing the potential of AI in battery state analysis.Subsequently,it systematically reviews mainstream flexible sensing technologies(e.g.,film sensors,thermocouples,and optical fiber sensors),elucidating their mechanisms for revealing intricate internal battery processes during operation.Finally,the paper discusses AI’s role in enhancing monitoring efficiency and accuracy,and envisions future research directions and application prospects.This work aims to provide technical references for the battery health monitoring field as well as promote the application of flexible sensing technologies in improving battery system safety and reliability.
基金sponsored by the Inner Mongolia Natural Science Foundation(2025MS03134)National Natural Science Foundation of China(32372566)+3 种基金the Department of Agriculture and Rural Affairs of Zhejiang Province(2025ZDXT02-6)Sichuan rapeseed innovation team(SCCXTD-2024-3)Key Support Projects for Foreign Experts(D20240074)Collaborative Innovation Center for Modern Crop Production co-sponsored by Province and Ministry(CIC-MCP)。
文摘Modern oilseed breeding faces the complex challenge of simultaneously improving yield,nutritional quality,and stress resilience within a sustainable agricultural framework.A predictive,systems-oriented strategy offers a solution by using predictive modeling and precise genetic intervention to engineer target ideotypes.This review synthesizes the integration of genomic selection(GS),genome editing,and epigenetic regulation to operationalize a precision breeding strategy in major oilseed crops.We document how GS,utilizing high-density SNP arrays and sequencing data,has reduced breeding cycles by up to 50%in soybean,enabling rapid selection for complex traits like seed protein content.We highlight the precision of CRISPR-Cas systems in executing design goals,such as creating commercial-grade high-oleic soybeans(>80%oleic acid)by knocking out FAD2 genes.Similarly,editing glucosinolate biosynthesis genes in rapeseed has directly improved meal quality.Furthermore,we explore the emerging role of epigenetic regulation as a tunable layer in trait optimization,where DNA methylation patterns in sunflower are linked to drought stress memory and flowering time.Finally,we present an integrated molecular framework,which synergizes these technologies to develop ideotypes with optimized architectures and composition.Despite challenges in phenotyping and global regulation,the strategic implementation of this molecular toolkit is pioneering a new era of precision breeding for the sustainable intensification of oilseed production.
基金financially supported by the National Natural Science Foundation of China(NSFC,52376193 and 52488201)the Fundamental Research Funds for the Central Universities(30925020107)。
文摘Electrochemical reduction reaction of pure CO_(2)(epCO_(2) RR)is highly promising since it could convert CO_(2) pollution into value-added chemicals(e.g.,CO,HCOOH,C_(2)H_(4),C_(2)H_(5) OH)under industrial-level current density with high selectivity above 90%.While the purification process of industrial flue gas into pure CO_(2) accounts for significant portion of CO_(2)-electrolysis cost.Direct flue-gas electroreduction offers a cost-effective alternative,while its practical implementation faces challenges such as low CO_(2) concentrations(<20 vol%)leading to small current density,competitive reactions such as oxygen reduction reaction,hydrogen evolution reaction,etc.,with more positive thermodynamic potentials than epCO_(2) RR.Therefore,this work reviews strategies to develop efficient and selective electrocatalysts that are resistant to non-CO_(2) active gasses such as O_(2),SO_(x),NO_(x),etc.,and treatment methods for such components in the flue gas.Significantly,the technoeconomic analysis of CO_(2) capture and purification integrated electrolysis process and direct flue gas reduction,is compared.Importantly,future research regarding direct electrochemical reduction of flue gas is proposed,including multifunctional catalyst design,complex reaction mechanism exploration,electrolysis system optimization,etc.
基金supported, in part, by the National Natural Science Foundation of China Grants (82430078, 82261160395, 82230081, 82004395, 82302767)the Shenzhen Medical Research Funds (B2402033, C2401029)+5 种基金the Shenzhen Fundamental Research Program (JCYJ20220818100617036)the National Key Research and Development Program of China Grants (2019YFA0906004)the Guangdong Provincial Science and Technology Innovation Council Grant (2017B030301018)the Shenzhen Key Laboratory of Cell Microenvironment Grant (ZDSYS20140509142721429)the Hubei Provincial Natural Science Foundation of China (2024AFB610)the Science Foundation of Wuhan Union Hospital (2022xhyn032)
文摘Bone has long been acknowledged as a fundamental structural entity that provides support and protection to the body’s organs.However,emerging research indicates that bone plays a crucial role in the regulation of systemic metabolism.This is achieved through the secretion of a variety of hormones,cytokines,metal ions,extracellular vesicles,and other proteins/peptides,collectively referred to as bone-derived factors(BDFs).BDFs act as a medium through which bones can exert targeted regulatory functions upon various organs,thereby underscoring the profound and concrete implications of bone in human physiology.Nevertheless,there remains a pressing need for further investigations to elucidate the underlying mechanisms that inform the effects of bone on other body systems.This review aims to summarize the current findings related to the roles of these significant modulators across different organs and metabolic contexts by regulating critical genes and signaling pathways in vivo.It also addresses their involvement in the pathogenesis of various diseases affecting the musculoskeletal system,circulatory system,glucose and lipid metabolism,central nervous system,urinary system,and reproductive system.The insights gained from this review may contribute to the development of innovative therapeutic strategies through a focused approach to bone secretomes.Continued research into BDFs is expected to enhance our understanding of bone as a multifunctional organ with diverse regulatory roles in human health.
基金the financial support from the National Natural Science Foundation of China(No.92163124)Foundation for the Sichuan University and Zigong City Joint research project(No.2021CDZG-2)+1 种基金Foundation for the Sichuan University and Yibin City Strategic Cooperation Project(No.2020CDYB-32)Guangxi Key Laboratory of Low Carbon Energy Material(No.2020GKLLCEM02)。
文摘Carbon materials are considered as prospective anode candidates for potassium ion batteries(PIBs).However,the low-rate capability is hampered by slow K+diffusion kinetics and obstructed electron transport of carbon-based anodes.In this work,calcium D-gluconate derived mesoporous carbon nanosheets(CGC)were interpenetrated into the architecture of reduced graphene oxides(RGO)to form the composites of two-dimensional(2D)/2D graphene/mesoporous carbon nanosheets(RGO@CGC).CGC as a rigid skeleton can prevent the graphene layers from restacking and maintain the structural stability of the 2D/2D carbon composites of RGO@CGC.The mesopores in CGC can shorten the path of ion diffusion and facilitate the penetration of electrolytes.RGO possesses the high surface-to-volume ratio and superior electron transport capability in the honeycomb-like 2D network consisting of sp^(2)-hybridized carbon atoms.Especially,theπ-πstacking interaction between CGC and RGO enhances stable composite structure formation,expedites interlayer-electron transfer,and establishes three-dimensional(3D)ion transportation pathways.Owing to these unique structure,RGO@CGC exhibits fast and stable potassium storage capability.Furthermore,the effects of binders and electrolytes on the electrochemical performance of RGO@CGC were investigated.Finally,Prussian blue was synthesized as a positive electrode to explore the possibility of RGO@CGC as a full battery application.
基金supported by the National Natural Science Foundation of China(82371300)Zhejiang Provincial Natural Science Foundation of China(LY23H090014)Zhejiang Province Traditional Chinese Medicine Science and Technology Project(2024ZL1215).
文摘Stroke,a major cerebrovascular disease,has high morbidity and mortality.Effective methods to reduce the risk and improve the prognosis are lacking.Currently,uric acid(UA)is associated with the pathological mechanism,prognosis,and therapy of stroke.UA plays pro/anti-oxidative and pro-inflammatory roles in vivo.The specific role of UA in stroke,which may have both neuroprotective and damaging effects,remains unclear.There is a U-shaped association between serum uric acid(SUA)levels and ischemic stroke(IS).UA therapy provides neuroprotection during reperfusion therapy for acute ischemic stroke(AIS).Urate-lowering therapy(ULT)plays a protective role in IS with hyperuricemia or gout.SUA levels are associated with the cerebrovascular injury mechanism,risk,and outcomes of hemorrhagic stroke.In this review,we summarize the current research on the role of UA in stroke,providing potential targets for its prediction and treatment.
基金supported by the National Natural Science Foundation of China(No.52276022).
文摘Direct air capture(DAC)is a negative carbon emission technology that faces challenges in scalability and practical deployment due to its exorbitant costs.Hou et al.(2017)integrated DAC technology with fertilization.A multi-bed desorption system driven by water provides a competitive and sustainable carbon source for indoor agriculture.
