The adsorptive denitrification performance of MIL-101(Cr)-0.5 toward pyridine,aniline or quinoline in simulated fuels with basic nitrogen content of 1732μg/g was evaluated separately.Furthermore,the effects of adsorp...The adsorptive denitrification performance of MIL-101(Cr)-0.5 toward pyridine,aniline or quinoline in simulated fuels with basic nitrogen content of 1732μg/g was evaluated separately.Furthermore,the effects of adsorption temperature,adsorption time and adsorbent dosage on their adsorptive denitrification performance were systematically investigated.The experimental results demonstrated that under a fixed adsorbent dosage of 0.05 g and a simulated fuel volume of 10 mL,the optimal removal efficiency for aniline was achieved at 30℃ within 30 min,whereas higher temperatures and longer times(40℃and 40 min)were required for effective removal of pyridine and quinoline.Density Functional Theory(DFT)calculations were conducted via Materials Studio(MS)software to study the adsorptive denitrification mechanism of MIL-101(Cr)toward these three basic nitrogen-containing compounds.The simulation calculation results revealed that the interaction between pyridine and MIL-101(Cr)primarily involved coordination adsorption.In contrast,the interaction between aniline or quinoline and MIL-101(Cr)proceeded mainly through coordination,with additional contributions fromπ-complexation and hydrogen bonding.The overall adsorption strength order is pyridine>aniline>quinoline.During the adsorption process,pyridine and quinoline transfer electrons to the MIL-101(Cr)surface through the H→C→N→Cr^(3+)pathway,while aniline transfers electrons to the MIL-101(Cr)surface through various pathways,including N→Cr^(3+),N→C→Cr^(3+)and N→H→O.Furthermore,adsorption kinetics studies indicated that the adsorption processes for all three basic nitrogen-containing compounds followed the quasi second order kinetic models.The experimental results on the effect of benzene on the adsorptive denitrification performance of MIL-101(Cr)-0.5 demonstrated that benzene exerted a more significant impact on the adsorption of aniline and quinoline.Finally,the adsorbent was regenerated using ethanol washing.It was found that MIL-101(Cr)-0.5 retained stable denitrification performance after two regeneration cycles.展开更多
Objective:To explore the therapeutic effect of Shenlan oral liquid on thrombosis rats and hyperlipidemia mice.Methods:Male Wistar rats were divided into four groups randomly:the control group,the Shenlan oral liquid g...Objective:To explore the therapeutic effect of Shenlan oral liquid on thrombosis rats and hyperlipidemia mice.Methods:Male Wistar rats were divided into four groups randomly:the control group,the Shenlan oral liquid groups(high dosage and low dosage),and the positive control group.Rats in the control group were treated with dd water intragastriclly;in the positive control group,rats were treated intragastric with aspirin.Rats were treated with different drugs intragastric for continuous 22 d.In the hyperlipidemia experiment,mice were fed with high-fat diet to induce hyperlipidemia model mice,then randomly divided into five groups;the control group,the model group,the atorvastatin calcium positive control group,and the Shenlan oral liquid groups(high dosage and low dosage).The serum lipid and body weight changes of mice were observed after 6 weeks.Animals in Shenlan oral liquid high and low dosage were treated intragastric with six times and double the clinical dose.Results:After treatment,the mix blocking rate and average blocking rate of the vascular after electrical stimulation were obviously reduced in aspirin group,and Shenlan oral liquid high and low dose groups(P<0.05 or P<0.01).The maximum aggregation rate was significantly lower than that of control group(P<0.05 or P<0.01),and the normal coagulation function was not affected.In the treatment of hyperlipidemia,the effects of Shenlan oral liquid were measured on the total cholesterol(TC),triacylglycerol(total triglyceride,TG),low density lipoprotein(LDL-C)and high-density lipoprotein(HDL-C)with the hyperlipidemia mice.After 2 weeks administration,the serum TG level of Shenlan oral liquid high-dose group decreased compared with the model group.The TG level of serum in Shenlan oral liquid high-dose group significantly decreased compared with the model group from the fourth week(P<0.05).After 6 weeks administration,Shenlan oral liquid high-dose and low-dose group and positive drugs reached to the same therapeutic effect.Compared with model group,serum TG level was significantly decreased(P<0.05 or P<0.01).Conclusion:Shenlan oral liquid can decrease the thrombosis formation in rats and inhibit the lipid level in blood in hyperlipidemia mice.展开更多
随着配电网复杂性日益增加以及对电能质量要求不断提高,谐波污染和网络损耗已成为影响新型电力系统稳定性和运行效率的关键因素。通过同步优化电容器和有源功率滤波器(active power filter,APF)的配置,实现谐波抑制与网络损耗最小化的...随着配电网复杂性日益增加以及对电能质量要求不断提高,谐波污染和网络损耗已成为影响新型电力系统稳定性和运行效率的关键因素。通过同步优化电容器和有源功率滤波器(active power filter,APF)的配置,实现谐波抑制与网络损耗最小化的双重目标。利用谐波功率流分析模型进行谐波评估,根据谐波穿透法进行频域建模。对失真配电网络中的电容器和APF的同步配置建模,利用粒子群优化(particle swarm optimization,PSO)算法解决电容器和APF同步配置的混合整数非线性规划问题。实验结果表明:适当配置电容器和APF能够显著改善网络的电压质量,所提的同步优化方法不仅在降低系统成本的同时,显著提高了新型电力系统配电网的电能质量和运行效率。展开更多
在萸连汤的定性"制剂质量标志物"的基础上,筛选出其定量"制剂质量标志物",并探讨一法通用策略用于分析中药饮片-制剂-血浆间的移行情况。采用定量分析的HPLC-MS/MS,建立同时测定萸连汤中28种化学成分的方法,并用该...在萸连汤的定性"制剂质量标志物"的基础上,筛选出其定量"制剂质量标志物",并探讨一法通用策略用于分析中药饮片-制剂-血浆间的移行情况。采用定量分析的HPLC-MS/MS,建立同时测定萸连汤中28种化学成分的方法,并用该方法同时分析萸连汤饮片、萸连汤冻干粉制剂和萸连汤给药后大鼠血浆移行成分。液相色谱分离采用C18反相色谱柱(2.1 mm×100 mm, 1.8μm),流动相为乙腈-水(含0.1%甲酸),梯度洗脱,流速为0.2 mL·min^(-1);质谱检测采用电喷雾离子源,正负离子模式同时扫描,多反应监测方式。方法经线性范围、加样回收率、精密度、稳定性和重复性等考察确证适合萸连汤中以上成分的测定。加样回收率为95.48%~103.4%,精密度RSD为0.45%~3.8%,重复性RSD为5.6%~14%。萸连汤冻干粉中化学成分质量分数小檗碱大于5%,木兰花碱、表小檗碱、黄连碱、巴马汀和柠檬苦素质量分数在1%~5%,去氢吴茱萸碱、吴茱萸碱、吴茱萸次碱、木香烃内酯和去氢木香内酯质量分数在0.002%~1%;饮片中检测的28种成分有27种可向冻干粉转移,其中11种可在大鼠血浆中发现。结合萸连汤的定性"制剂质量标志物",初步确定定量"制剂质量标志物"15种,分别为小檗碱、表小檗碱、黄连碱、巴马汀、吴茱萸碱、吴茱萸次碱、柠檬苦素、木香烃内酯、去氢木香内酯、木兰花碱、药根碱、非洲防己碱、格兰地新、绿原酸和新绿原酸。建立的HPLC-MS/MS一法通用策略分析中药饮片-制剂-血浆多成分转移是可行的,可为萸连汤定量"制剂质量标志物"的筛选及多指标质量控制提供方法基础。展开更多
基金Supported by Basic Scientific Research Project of the Liaoning Provincial Department of Education Has Been Unveiled to Facilitate Local Project Funding (JYTMS20230835)Enhanced Scientific Research Project Funded by the Departmentof Higher Education in Liaoning Province (General program)(JYTMS20230852)。
文摘The adsorptive denitrification performance of MIL-101(Cr)-0.5 toward pyridine,aniline or quinoline in simulated fuels with basic nitrogen content of 1732μg/g was evaluated separately.Furthermore,the effects of adsorption temperature,adsorption time and adsorbent dosage on their adsorptive denitrification performance were systematically investigated.The experimental results demonstrated that under a fixed adsorbent dosage of 0.05 g and a simulated fuel volume of 10 mL,the optimal removal efficiency for aniline was achieved at 30℃ within 30 min,whereas higher temperatures and longer times(40℃and 40 min)were required for effective removal of pyridine and quinoline.Density Functional Theory(DFT)calculations were conducted via Materials Studio(MS)software to study the adsorptive denitrification mechanism of MIL-101(Cr)toward these three basic nitrogen-containing compounds.The simulation calculation results revealed that the interaction between pyridine and MIL-101(Cr)primarily involved coordination adsorption.In contrast,the interaction between aniline or quinoline and MIL-101(Cr)proceeded mainly through coordination,with additional contributions fromπ-complexation and hydrogen bonding.The overall adsorption strength order is pyridine>aniline>quinoline.During the adsorption process,pyridine and quinoline transfer electrons to the MIL-101(Cr)surface through the H→C→N→Cr^(3+)pathway,while aniline transfers electrons to the MIL-101(Cr)surface through various pathways,including N→Cr^(3+),N→C→Cr^(3+)and N→H→O.Furthermore,adsorption kinetics studies indicated that the adsorption processes for all three basic nitrogen-containing compounds followed the quasi second order kinetic models.The experimental results on the effect of benzene on the adsorptive denitrification performance of MIL-101(Cr)-0.5 demonstrated that benzene exerted a more significant impact on the adsorption of aniline and quinoline.Finally,the adsorbent was regenerated using ethanol washing.It was found that MIL-101(Cr)-0.5 retained stable denitrification performance after two regeneration cycles.
基金supported by Free Exploration Project Funded by Central Public Welfare Research Institutes(ZZ13-YQ-103)。
文摘Objective:To explore the therapeutic effect of Shenlan oral liquid on thrombosis rats and hyperlipidemia mice.Methods:Male Wistar rats were divided into four groups randomly:the control group,the Shenlan oral liquid groups(high dosage and low dosage),and the positive control group.Rats in the control group were treated with dd water intragastriclly;in the positive control group,rats were treated intragastric with aspirin.Rats were treated with different drugs intragastric for continuous 22 d.In the hyperlipidemia experiment,mice were fed with high-fat diet to induce hyperlipidemia model mice,then randomly divided into five groups;the control group,the model group,the atorvastatin calcium positive control group,and the Shenlan oral liquid groups(high dosage and low dosage).The serum lipid and body weight changes of mice were observed after 6 weeks.Animals in Shenlan oral liquid high and low dosage were treated intragastric with six times and double the clinical dose.Results:After treatment,the mix blocking rate and average blocking rate of the vascular after electrical stimulation were obviously reduced in aspirin group,and Shenlan oral liquid high and low dose groups(P<0.05 or P<0.01).The maximum aggregation rate was significantly lower than that of control group(P<0.05 or P<0.01),and the normal coagulation function was not affected.In the treatment of hyperlipidemia,the effects of Shenlan oral liquid were measured on the total cholesterol(TC),triacylglycerol(total triglyceride,TG),low density lipoprotein(LDL-C)and high-density lipoprotein(HDL-C)with the hyperlipidemia mice.After 2 weeks administration,the serum TG level of Shenlan oral liquid high-dose group decreased compared with the model group.The TG level of serum in Shenlan oral liquid high-dose group significantly decreased compared with the model group from the fourth week(P<0.05).After 6 weeks administration,Shenlan oral liquid high-dose and low-dose group and positive drugs reached to the same therapeutic effect.Compared with model group,serum TG level was significantly decreased(P<0.05 or P<0.01).Conclusion:Shenlan oral liquid can decrease the thrombosis formation in rats and inhibit the lipid level in blood in hyperlipidemia mice.
文摘随着配电网复杂性日益增加以及对电能质量要求不断提高,谐波污染和网络损耗已成为影响新型电力系统稳定性和运行效率的关键因素。通过同步优化电容器和有源功率滤波器(active power filter,APF)的配置,实现谐波抑制与网络损耗最小化的双重目标。利用谐波功率流分析模型进行谐波评估,根据谐波穿透法进行频域建模。对失真配电网络中的电容器和APF的同步配置建模,利用粒子群优化(particle swarm optimization,PSO)算法解决电容器和APF同步配置的混合整数非线性规划问题。实验结果表明:适当配置电容器和APF能够显著改善网络的电压质量,所提的同步优化方法不仅在降低系统成本的同时,显著提高了新型电力系统配电网的电能质量和运行效率。
文摘在萸连汤的定性"制剂质量标志物"的基础上,筛选出其定量"制剂质量标志物",并探讨一法通用策略用于分析中药饮片-制剂-血浆间的移行情况。采用定量分析的HPLC-MS/MS,建立同时测定萸连汤中28种化学成分的方法,并用该方法同时分析萸连汤饮片、萸连汤冻干粉制剂和萸连汤给药后大鼠血浆移行成分。液相色谱分离采用C18反相色谱柱(2.1 mm×100 mm, 1.8μm),流动相为乙腈-水(含0.1%甲酸),梯度洗脱,流速为0.2 mL·min^(-1);质谱检测采用电喷雾离子源,正负离子模式同时扫描,多反应监测方式。方法经线性范围、加样回收率、精密度、稳定性和重复性等考察确证适合萸连汤中以上成分的测定。加样回收率为95.48%~103.4%,精密度RSD为0.45%~3.8%,重复性RSD为5.6%~14%。萸连汤冻干粉中化学成分质量分数小檗碱大于5%,木兰花碱、表小檗碱、黄连碱、巴马汀和柠檬苦素质量分数在1%~5%,去氢吴茱萸碱、吴茱萸碱、吴茱萸次碱、木香烃内酯和去氢木香内酯质量分数在0.002%~1%;饮片中检测的28种成分有27种可向冻干粉转移,其中11种可在大鼠血浆中发现。结合萸连汤的定性"制剂质量标志物",初步确定定量"制剂质量标志物"15种,分别为小檗碱、表小檗碱、黄连碱、巴马汀、吴茱萸碱、吴茱萸次碱、柠檬苦素、木香烃内酯、去氢木香内酯、木兰花碱、药根碱、非洲防己碱、格兰地新、绿原酸和新绿原酸。建立的HPLC-MS/MS一法通用策略分析中药饮片-制剂-血浆多成分转移是可行的,可为萸连汤定量"制剂质量标志物"的筛选及多指标质量控制提供方法基础。
