In this study, molecular interactions of the ligands, quercetin, gallic acid, and metformin with various diabetes mellitus-related protein targets, such as glycogen phosphorylase and peroxisome proliferatoractivated r...In this study, molecular interactions of the ligands, quercetin, gallic acid, and metformin with various diabetes mellitus-related protein targets, such as glycogen phosphorylase and peroxisome proliferatoractivated receptor gamma, were assessed. It was revealed that quercetin possesses good binding affinity to both targets. Quercetin is a major constituent of methanolic extracts of Phyllanthus emblica fruit. The antihyperglycemic effect of quercetin in streptozotocin(STZ)-induced diabetic rats was examined. The isolated quercetin administered at a dose of 75 mg/kg body weight produced a maximum decrease of14.78% in blood glucose levels in the diabetic rats after 7 days of treatment. Furthermore, quercetin doses of 50 and 75 mg/kg were shown to significantly improve the profiles of triglycerides, high-density lipoprotein, very-low-density lipoprotein, low-density lipoprotein, and total cholesterol at the end of the study in STZ-induced diabetic rats. The administration of quercetin(25, 50, and 75 mg/kg body weight)daily for 28 days in STZ-induced diabetic rats resulted in a significant decrease in blood glucose and urine sugar levels, with a considerable rise in plasma insulin and hemoglobin levels. Therefore, quercetin is a potential drug with antidiabetic and antihyperglycemic action mediated by changes in the levels of glucose, cholesterol, and triglycerides as indicated by in silico and in vivo studies.展开更多
Undoped and fluorine doped ZnO （ZnO：F） thin films were deposited onto glass substrates by employing a simplified spray pyrolysis technique using a perfume atomizer. The fluorine doping level in the starting solutio...Undoped and fluorine doped ZnO （ZnO：F） thin films were deposited onto glass substrates by employing a simplified spray pyrolysis technique using a perfume atomizer. The fluorine doping level in the starting solution was varied from 0 to 20 at.% in steps of 5 at.~g and the effects of fluorine doping level on the structural, optical, surface morphological properties along with their antibacterial activity against Escherichia coil （E. coli） and Bacillus subtilis （B. subtilis） bacteria were studied and reported. The X-ray diffraction studies revealed that despite the orientation ofcrystallites was strongly influenced by fluorine doping, the preferential orientation was retained in favor of （002） plane even at the highest doping level. The crystallite size decreased as the F doping level was increased and the reason for this variation has been explained on the basis of Zener pinning effect. The average optical transparency in the visible range was about 80%-90g for doped films and the optical band gap was found to be slightly increased with the F doping level. The antibacterial efficiency of the F doped ZnO films was found to be enhanced as the F doping level was increased. The antibacterial efficiency was more pronounced in the case of B. subtilis （Gram-positive） when compared with E. coil （Gram-negative）.展开更多
Nanomaterials with countless potential applications in the Natural Science and Clinical Pharmaceutics have offered the prospects of developing new nanomaterials.The analysis of green TiO_(2) nanoparticles synthesized ...Nanomaterials with countless potential applications in the Natural Science and Clinical Pharmaceutics have offered the prospects of developing new nanomaterials.The analysis of green TiO_(2) nanoparticles synthesized with Limonia acidissima(L.acidissima)aqueous peel extract was described in this study.The green fabricated TiO_(2) nanoparticles were characterized by UV-vis spectrum,XRD,FT-IR,and FE-SEM with EDX.Green TiO_(2) nanoparticles exhibited excellent antimicrobial and photodegradation activities.Further it has demonstrated the release of reactive oxygen species(ROS)and proven mitochondrial membrane potential in a dosage manner of 0-100μg/mL.The statistics were also examined with P values<0.05 selected significant high accuracy of the effects.The planned approach envisages the TiO_(2) nanoparticles as a function of L.acidissima aqueous extracts with a wide range of multidisciplinary applications.展开更多
基金the DST-SERB Major Research Project,New Delhi,India[Project File No.SB/YS/LS-109/2014]for funding this projectthe Management of A.V.V.M.Sri Pushpam College(Autonomous)+1 种基金Poondi,and Sharmila Institute of Medicinal Products Research Academy(SIMPRA)Thanjavur,India,for providing necessary facilities and support in carrying out this work
文摘In this study, molecular interactions of the ligands, quercetin, gallic acid, and metformin with various diabetes mellitus-related protein targets, such as glycogen phosphorylase and peroxisome proliferatoractivated receptor gamma, were assessed. It was revealed that quercetin possesses good binding affinity to both targets. Quercetin is a major constituent of methanolic extracts of Phyllanthus emblica fruit. The antihyperglycemic effect of quercetin in streptozotocin(STZ)-induced diabetic rats was examined. The isolated quercetin administered at a dose of 75 mg/kg body weight produced a maximum decrease of14.78% in blood glucose levels in the diabetic rats after 7 days of treatment. Furthermore, quercetin doses of 50 and 75 mg/kg were shown to significantly improve the profiles of triglycerides, high-density lipoprotein, very-low-density lipoprotein, low-density lipoprotein, and total cholesterol at the end of the study in STZ-induced diabetic rats. The administration of quercetin(25, 50, and 75 mg/kg body weight)daily for 28 days in STZ-induced diabetic rats resulted in a significant decrease in blood glucose and urine sugar levels, with a considerable rise in plasma insulin and hemoglobin levels. Therefore, quercetin is a potential drug with antidiabetic and antihyperglycemic action mediated by changes in the levels of glucose, cholesterol, and triglycerides as indicated by in silico and in vivo studies.
基金Financial support from the University Grants Commission India through the Major Research Project(F.No.40-28/2011(SR))
文摘Undoped and fluorine doped ZnO （ZnO：F） thin films were deposited onto glass substrates by employing a simplified spray pyrolysis technique using a perfume atomizer. The fluorine doping level in the starting solution was varied from 0 to 20 at.% in steps of 5 at.~g and the effects of fluorine doping level on the structural, optical, surface morphological properties along with their antibacterial activity against Escherichia coil （E. coli） and Bacillus subtilis （B. subtilis） bacteria were studied and reported. The X-ray diffraction studies revealed that despite the orientation ofcrystallites was strongly influenced by fluorine doping, the preferential orientation was retained in favor of （002） plane even at the highest doping level. The crystallite size decreased as the F doping level was increased and the reason for this variation has been explained on the basis of Zener pinning effect. The average optical transparency in the visible range was about 80%-90g for doped films and the optical band gap was found to be slightly increased with the F doping level. The antibacterial efficiency of the F doped ZnO films was found to be enhanced as the F doping level was increased. The antibacterial efficiency was more pronounced in the case of B. subtilis （Gram-positive） when compared with E. coil （Gram-negative）.
基金The authors are grateful to the DST-SERB(No.SB/YS/LS-109/2014)DST-FIST(No.SR/FST/College-222/2014)for providing financial assistant in this project.We sincerely express our thanks to the management of A.V.V.M.Sri Pushpam College(Autonomous),Poondi,for providing us necessary facilities and support to carry out this work.
文摘Nanomaterials with countless potential applications in the Natural Science and Clinical Pharmaceutics have offered the prospects of developing new nanomaterials.The analysis of green TiO_(2) nanoparticles synthesized with Limonia acidissima(L.acidissima)aqueous peel extract was described in this study.The green fabricated TiO_(2) nanoparticles were characterized by UV-vis spectrum,XRD,FT-IR,and FE-SEM with EDX.Green TiO_(2) nanoparticles exhibited excellent antimicrobial and photodegradation activities.Further it has demonstrated the release of reactive oxygen species(ROS)and proven mitochondrial membrane potential in a dosage manner of 0-100μg/mL.The statistics were also examined with P values<0.05 selected significant high accuracy of the effects.The planned approach envisages the TiO_(2) nanoparticles as a function of L.acidissima aqueous extracts with a wide range of multidisciplinary applications.
