The letter aims to discuss the pivotal findings of the recent study on oncolytic reovirus(RC402)focusing on its administration route and how this route enhances immunotherapeutic efficacy against advanced cancers.The ...The letter aims to discuss the pivotal findings of the recent study on oncolytic reovirus(RC402)focusing on its administration route and how this route enhances immunotherapeutic efficacy against advanced cancers.The insights gained from this study regarding oral reovirus treatment improve our understanding of oncolytic virotherapy and propose a feasible strategy for enhancing the efficacy of cancer immunotherapy.The research demonstrates that oral administration of RC402 can effectively induce antitumor immunity without significant toxicities.展开更多
Analysis of tropical cyclone(TC) rainfall characteristics helps in understanding and improving quantitative precipitation forecasts of TCs. Based on the Tropical Rainfall Measuring Mission(TRMM) rainfall data for the ...Analysis of tropical cyclone(TC) rainfall characteristics helps in understanding and improving quantitative precipitation forecasts of TCs. Based on the Tropical Rainfall Measuring Mission(TRMM) rainfall data for the period of 2000-2010, a TC rainfall database –Tropical Cyclone Rainfall Analysis for North Indian Ocean(TCRAIN) is developed to study the precipitation characteristics during various stages of life cycle of TCs of the North Indian Ocean(NIO). Three rainfall products, viz., frequency distribution of rain rate, azimuthally averaged radial profile of rain rate and quadrant mean rain rate with respect to the TC centre and the direction of motion of the TC are generated in a Lagrangian frame of coordinate system for 5 intensity stages of life cycle of each cyclone over NIO. Using this TCRAIN database, composites of frequency distribution of rain rates as well as quadrant mean rain rate for TCs of NIO are generated to bring out probable rain rates and asymmetric structure in rainfall distribution. Rainfall profiles for individual cases are likely to deviate from the climatological profiles under different environmental and oceanic conditions. TCRAIN database would serve as a useful tool for carrying out intensity based analytical studies on structure of rainfall associated with cyclones of NIO through ready depiction of TC rainfall profiles.展开更多
文摘The letter aims to discuss the pivotal findings of the recent study on oncolytic reovirus(RC402)focusing on its administration route and how this route enhances immunotherapeutic efficacy against advanced cancers.The insights gained from this study regarding oral reovirus treatment improve our understanding of oncolytic virotherapy and propose a feasible strategy for enhancing the efficacy of cancer immunotherapy.The research demonstrates that oral administration of RC402 can effectively induce antitumor immunity without significant toxicities.
文摘Analysis of tropical cyclone(TC) rainfall characteristics helps in understanding and improving quantitative precipitation forecasts of TCs. Based on the Tropical Rainfall Measuring Mission(TRMM) rainfall data for the period of 2000-2010, a TC rainfall database –Tropical Cyclone Rainfall Analysis for North Indian Ocean(TCRAIN) is developed to study the precipitation characteristics during various stages of life cycle of TCs of the North Indian Ocean(NIO). Three rainfall products, viz., frequency distribution of rain rate, azimuthally averaged radial profile of rain rate and quadrant mean rain rate with respect to the TC centre and the direction of motion of the TC are generated in a Lagrangian frame of coordinate system for 5 intensity stages of life cycle of each cyclone over NIO. Using this TCRAIN database, composites of frequency distribution of rain rates as well as quadrant mean rain rate for TCs of NIO are generated to bring out probable rain rates and asymmetric structure in rainfall distribution. Rainfall profiles for individual cases are likely to deviate from the climatological profiles under different environmental and oceanic conditions. TCRAIN database would serve as a useful tool for carrying out intensity based analytical studies on structure of rainfall associated with cyclones of NIO through ready depiction of TC rainfall profiles.
