Tumefactive demyelinating lesions (TDLs) are often misdiagnosed as brain tumors. To identify imaging characteristics of TDLs for their proper diagnosis, their differences from malignant gliomas, etc., were investigate...Tumefactive demyelinating lesions (TDLs) are often misdiagnosed as brain tumors. To identify imaging characteristics of TDLs for their proper diagnosis, their differences from malignant gliomas, etc., were investigated based on 3-Tesla magnetic resonance imaging (MRI) and MR spectroscopy data that was obtained from 5 patients diagnosed with TDLs in our hospital. MfRI displayed a paraventricular lesion with a maximum diameter of ≥2 cm. Diffusion-weighted imaging (DWI) displayed a region of bright signal intensity at the margin of the lesion, and apparent diffusion coefficient (ADC) imaging displayed high signal intensity at the core of the lesion. The mass effect was mild relative to the size of the lesion, and the edema around the lesion was mild to moderate. Gadolinium-enhanced MRI displayed a characteristic open-ring sign, in which the ring of enhancement was incomplete (open towards the cortex), with the medullary vein running through the lesion, resulting in the enhancement of the surrounding area. MR spectroscopy displayed an increase in the choline peak, a decrease in the N-acetyl aspartate (NAA) peak, the presence of lactate/lipid peaks, and the presence of β, γ-glutamate-glutamine (GLX) peaks that are slightly shifted to a higher resonance frequency (2.1 - 2.4 ppm) from the NAA peak. Taken together, the following main characteristics were identified as imaging features of TDLs: bright rim on DWI, a high signal core on ADC imaging, an open-ring sign, and β, γ-GLX peaks on proton MR spectroscopy. We concluded that the key to the improvement of neurological symptoms of patients is the prompt initiation of steroid treatment following the accurate diagnosis of TDLs.展开更多
Introduction Pixel detectors fabricated with the silicon-on-insulator(SOI)technology suffered from the digital pickup,due to the capacitive coupling between the sensing electrode and the in-pixel circuit.In order to t...Introduction Pixel detectors fabricated with the silicon-on-insulator(SOI)technology suffered from the digital pickup,due to the capacitive coupling between the sensing electrode and the in-pixel circuit.In order to tackle this issue,an advanced process called double SOI has been developed.A prototype chip CPIXTEG3b adopting this new process was designed and characterized.While optimization concerning the double-SOI design and testing of the single pixel were already presented in a separate publication,this paper focuses on its noise performance of the full matrix and X-ray detection utilizing a synchrotron photon beam.Methods Equivalent noise charge(ENC)of the full pixel matrix was measured with electrical pulse tests.The threshold dispersion was minimized by the DAC tuning in each individual pixel.As a photon-counting X-ray imager,noise count accumulated up to 1 h was measured.Detection efficiency was measured with a micro-focused beam as well as a flat field generated by the X-ray scattering on a glassy carbon at the KEK PF beam line 14A.Results The typical ENC is 52 e−and the sigma of threshold dispersion is 10 e−over the full matrix.A merit of“zero”noise count is also demonstrated,which is consistent with the low ENC.The prototype chip has been tested with microbeam and used to measure the beam profile to be with a full width of 50µm at 2.4%of the maximum height.Both sensor depletion and charge sharing between neighboring pixels have been carefully characterized,providing insights for further development.The homogeneity of response to X-ray photons has been demonstrated in the flat field test.This work has drawn a final conclusion to the solution of digital pickup issue and opened a promising prospect in low-noise and high-resolution X-ray imaging.展开更多
文摘Tumefactive demyelinating lesions (TDLs) are often misdiagnosed as brain tumors. To identify imaging characteristics of TDLs for their proper diagnosis, their differences from malignant gliomas, etc., were investigated based on 3-Tesla magnetic resonance imaging (MRI) and MR spectroscopy data that was obtained from 5 patients diagnosed with TDLs in our hospital. MfRI displayed a paraventricular lesion with a maximum diameter of ≥2 cm. Diffusion-weighted imaging (DWI) displayed a region of bright signal intensity at the margin of the lesion, and apparent diffusion coefficient (ADC) imaging displayed high signal intensity at the core of the lesion. The mass effect was mild relative to the size of the lesion, and the edema around the lesion was mild to moderate. Gadolinium-enhanced MRI displayed a characteristic open-ring sign, in which the ring of enhancement was incomplete (open towards the cortex), with the medullary vein running through the lesion, resulting in the enhancement of the surrounding area. MR spectroscopy displayed an increase in the choline peak, a decrease in the N-acetyl aspartate (NAA) peak, the presence of lactate/lipid peaks, and the presence of β, γ-glutamate-glutamine (GLX) peaks that are slightly shifted to a higher resonance frequency (2.1 - 2.4 ppm) from the NAA peak. Taken together, the following main characteristics were identified as imaging features of TDLs: bright rim on DWI, a high signal core on ADC imaging, an open-ring sign, and β, γ-GLX peaks on proton MR spectroscopy. We concluded that the key to the improvement of neurological symptoms of patients is the prompt initiation of steroid treatment following the accurate diagnosis of TDLs.
基金This work is supported by the National Nature Science Foundation of China,Grant Nos.11375226 and 11575220.
文摘Introduction Pixel detectors fabricated with the silicon-on-insulator(SOI)technology suffered from the digital pickup,due to the capacitive coupling between the sensing electrode and the in-pixel circuit.In order to tackle this issue,an advanced process called double SOI has been developed.A prototype chip CPIXTEG3b adopting this new process was designed and characterized.While optimization concerning the double-SOI design and testing of the single pixel were already presented in a separate publication,this paper focuses on its noise performance of the full matrix and X-ray detection utilizing a synchrotron photon beam.Methods Equivalent noise charge(ENC)of the full pixel matrix was measured with electrical pulse tests.The threshold dispersion was minimized by the DAC tuning in each individual pixel.As a photon-counting X-ray imager,noise count accumulated up to 1 h was measured.Detection efficiency was measured with a micro-focused beam as well as a flat field generated by the X-ray scattering on a glassy carbon at the KEK PF beam line 14A.Results The typical ENC is 52 e−and the sigma of threshold dispersion is 10 e−over the full matrix.A merit of“zero”noise count is also demonstrated,which is consistent with the low ENC.The prototype chip has been tested with microbeam and used to measure the beam profile to be with a full width of 50µm at 2.4%of the maximum height.Both sensor depletion and charge sharing between neighboring pixels have been carefully characterized,providing insights for further development.The homogeneity of response to X-ray photons has been demonstrated in the flat field test.This work has drawn a final conclusion to the solution of digital pickup issue and opened a promising prospect in low-noise and high-resolution X-ray imaging.
