The exploration of efficient electrocatalysts for the reduction of CO2 to C2H4 is of significant importance but is also a challenging subject.Cu-based bimetallic catalysts are extremely promising for efficient CO2 red...The exploration of efficient electrocatalysts for the reduction of CO2 to C2H4 is of significant importance but is also a challenging subject.Cu-based bimetallic catalysts are extremely promising for efficient CO2 reduction.In this work,we synthesize a series of porous bimetallic Cu–Sb alloys with different compositions for the catalytic reduction of CO2 to C2H4.It is demonstrated that the alloy catalysts are much more efficient than the pure Cu catalyst.The performance of the alloy catalysts depended strongly on the composition.Further,the alloy with a Cu:Sb ratio of 10:1 yielded the best results;it exhibited a high C2H4 Faradaic efficiency of 49.7%and a high current density of 28.5 mA cm?2 at?1.19 V vs.a reversible hydrogen electrode(RHE)in 0.1 M KCl solution.To the best of our knowledge,the electrocatalytic reduction of CO2 to C2H4 using Cu–Sb alloys as catalysts has not been reported.The excellent performance of the porous alloy catalyst is attributed to its favorable electronic configuration,large surface area,high CO2 adsorption rate,and fast charge transfer rate.展开更多
The CuO/CeO_(2) composites with strong metal-support interaction were synthesised,which can efficiently electroreduct CO_(2)to C(2)H_(4).The Faradaic efficiency(FE)of C_(2)H_(4) could reach 50.5%with a current density...The CuO/CeO_(2) composites with strong metal-support interaction were synthesised,which can efficiently electroreduct CO_(2)to C(2)H_(4).The Faradaic efficiency(FE)of C_(2)H_(4) could reach 50.5%with a current density of 18 mA cm^(-2).The strong metal-support interaction could not only enhance the adsorption and activation of CO_(2),but also can stablize the CuO.展开更多
Primary liver cancer is the third leading cause of cancer-related deaths worldwide.However,current treatments have limited efficacy and high side effects.Chrysin,as a nontoxicity dietary flavonoid polyphenolic compoun...Primary liver cancer is the third leading cause of cancer-related deaths worldwide.However,current treatments have limited efficacy and high side effects.Chrysin,as a nontoxicity dietary flavonoid polyphenolic compound,has been reported to have significant efficacy in anti-hepatocellular carcinoma(HCC).Nonetheless,its precise mechanism remains unclear.Flow cytometry was employed to detect apoptosis,cell cycle,and mitochondrial membrane potential.RNA-seq was performed to investigate target signaling pathways.Immunofluorescence were utilized to assess the amount and location of target protein,lysosomal function and mitophagy.The results revealed that chrysin effectively suppressed the proliferation of hepatocellular carcinoma cell.RNA-seq analysis unveiled that the signal pathways modulated by chrysin included p53,energy metabolism,mitophagy,and lysosomes.Further experiments confirmed that chrysin inhibited HepG2 cells viability by triggering DNA damage and activating the p53 pathway.Numerous evidence show that p53 regulated the biogenesis of mitochondrial and mitophagy.Similarly,we found that chrysin induced mitochondrial and lysosomal dysfunction,and subsequently blocked mitophagic flux,ultimately triggering GSDME-dependent pyroptosis.Thus,our results implied that chrysin might exacerbate mitophagy mediated pyroptosis to inhibit the proliferation of HCC cells by targeting p53,suggesting that chrysin was a potential alternative drug for the treatment of HCC.展开更多
文摘The exploration of efficient electrocatalysts for the reduction of CO2 to C2H4 is of significant importance but is also a challenging subject.Cu-based bimetallic catalysts are extremely promising for efficient CO2 reduction.In this work,we synthesize a series of porous bimetallic Cu–Sb alloys with different compositions for the catalytic reduction of CO2 to C2H4.It is demonstrated that the alloy catalysts are much more efficient than the pure Cu catalyst.The performance of the alloy catalysts depended strongly on the composition.Further,the alloy with a Cu:Sb ratio of 10:1 yielded the best results;it exhibited a high C2H4 Faradaic efficiency of 49.7%and a high current density of 28.5 mA cm?2 at?1.19 V vs.a reversible hydrogen electrode(RHE)in 0.1 M KCl solution.To the best of our knowledge,the electrocatalytic reduction of CO2 to C2H4 using Cu–Sb alloys as catalysts has not been reported.The excellent performance of the porous alloy catalyst is attributed to its favorable electronic configuration,large surface area,high CO2 adsorption rate,and fast charge transfer rate.
基金supported by the National Key Research and Development Program of China(2017YFA0403102)National Natural Science Foundation of China(21573073,21733011)+1 种基金Beijing Municipal Science&Technology Commission(Z191100007219009)the Chinese Academy of Sciences(QYZDY-SSW-SLH013)。
文摘The CuO/CeO_(2) composites with strong metal-support interaction were synthesised,which can efficiently electroreduct CO_(2)to C(2)H_(4).The Faradaic efficiency(FE)of C_(2)H_(4) could reach 50.5%with a current density of 18 mA cm^(-2).The strong metal-support interaction could not only enhance the adsorption and activation of CO_(2),but also can stablize the CuO.
基金supported by the National Natural Science Foundation of China(32060538,32260588)the Natural Science Foundation of Jiangxi Province(20224BAB205037)Central Government Guide Local Special Fund Project for Scientific and Technological Development of Jiangxi Province(20221ZDD02001).
文摘Primary liver cancer is the third leading cause of cancer-related deaths worldwide.However,current treatments have limited efficacy and high side effects.Chrysin,as a nontoxicity dietary flavonoid polyphenolic compound,has been reported to have significant efficacy in anti-hepatocellular carcinoma(HCC).Nonetheless,its precise mechanism remains unclear.Flow cytometry was employed to detect apoptosis,cell cycle,and mitochondrial membrane potential.RNA-seq was performed to investigate target signaling pathways.Immunofluorescence were utilized to assess the amount and location of target protein,lysosomal function and mitophagy.The results revealed that chrysin effectively suppressed the proliferation of hepatocellular carcinoma cell.RNA-seq analysis unveiled that the signal pathways modulated by chrysin included p53,energy metabolism,mitophagy,and lysosomes.Further experiments confirmed that chrysin inhibited HepG2 cells viability by triggering DNA damage and activating the p53 pathway.Numerous evidence show that p53 regulated the biogenesis of mitochondrial and mitophagy.Similarly,we found that chrysin induced mitochondrial and lysosomal dysfunction,and subsequently blocked mitophagic flux,ultimately triggering GSDME-dependent pyroptosis.Thus,our results implied that chrysin might exacerbate mitophagy mediated pyroptosis to inhibit the proliferation of HCC cells by targeting p53,suggesting that chrysin was a potential alternative drug for the treatment of HCC.
