Dendrobium officinale(DO)is a well-recognized medicinal and edible plant with a long history of application in traditional medicinal practices across China and Southeast Asia.Recent studies have demonstrated that DOis...Dendrobium officinale(DO)is a well-recognized medicinal and edible plant with a long history of application in traditional medicinal practices across China and Southeast Asia.Recent studies have demonstrated that DOis abundant in diverse bioactive compounds,including polysaccharides(DOP),flavonoids,alkaloids,and bibenzyls thought to exert a range of pharmacological effects,such as anti-tumor and immunomodulatory effects.However,our comprehensive understanding of two key aspects-pharmacological functions and biosynthetic mechanisms-of DO’s major constituents remains limited,especiallywhen considered within the clinical contexts of traditional use.To address this gap,this study reviews DO’s historical applications,clinical effects,and related formulations through an analysis of ancient texts spanning nearly two millennia-with special attention to region-specific traditional medical texts.This provides a historical and empirical foundation for further exploration of its modern pharmacological potential.Given the central role of DOP in DO’s biological activities,this paper further summarizes its therapeutic applications across various diseases and the underlying mechanisms,with special emphasis on structure-activity relationships.This focus is particularly important because the structural characteristics of DOP are highly dependent on extraction and analytical methods,which have contributed to inconsistencies in pharmacological findings over the past two decades.Finally,the review highlights recent advances in the understanding of the in vivo biosynthesis and regulatory mechanisms of themajor bioactive components inDO,with a particular focus onmolecular regulation and responses to agricultural interventions.These factors are critical for the production of high-quality DO.Overall,this study develops a comprehensive knowledge framework that connects DO’s traditional applications of DO to its two key research areas:pharmacological functions and quality formation.We anticipate this framework will offer clear guidance for future research from a clinical perspective.展开更多
Integrated water and fertilizer technology has the advantages of saving water,fertilizer and labour,which is widely applied in tomato plantation. Integrated water and fertilizer technology in topdressing and whole pro...Integrated water and fertilizer technology has the advantages of saving water,fertilizer and labour,which is widely applied in tomato plantation. Integrated water and fertilizer technology in topdressing and whole process of big and small tomatoes were studied,and their application effects were contrasted and analyzed,and application advantages and scopes of the two models were concluded.展开更多
基金funded by the Scientific and technological innovation project of China Academy of Chinese Medical Sciences(CI2023E002,CI2024E003)National Natural Science Foundation of China(82304663)+1 种基金the Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ16-XRZ-072,ZZ17-YQ-025,ZXKT22052,and ZXKT22060)the National Key Research and Development Program(2022YFC3501803).
文摘Dendrobium officinale(DO)is a well-recognized medicinal and edible plant with a long history of application in traditional medicinal practices across China and Southeast Asia.Recent studies have demonstrated that DOis abundant in diverse bioactive compounds,including polysaccharides(DOP),flavonoids,alkaloids,and bibenzyls thought to exert a range of pharmacological effects,such as anti-tumor and immunomodulatory effects.However,our comprehensive understanding of two key aspects-pharmacological functions and biosynthetic mechanisms-of DO’s major constituents remains limited,especiallywhen considered within the clinical contexts of traditional use.To address this gap,this study reviews DO’s historical applications,clinical effects,and related formulations through an analysis of ancient texts spanning nearly two millennia-with special attention to region-specific traditional medical texts.This provides a historical and empirical foundation for further exploration of its modern pharmacological potential.Given the central role of DOP in DO’s biological activities,this paper further summarizes its therapeutic applications across various diseases and the underlying mechanisms,with special emphasis on structure-activity relationships.This focus is particularly important because the structural characteristics of DOP are highly dependent on extraction and analytical methods,which have contributed to inconsistencies in pharmacological findings over the past two decades.Finally,the review highlights recent advances in the understanding of the in vivo biosynthesis and regulatory mechanisms of themajor bioactive components inDO,with a particular focus onmolecular regulation and responses to agricultural interventions.These factors are critical for the production of high-quality DO.Overall,this study develops a comprehensive knowledge framework that connects DO’s traditional applications of DO to its two key research areas:pharmacological functions and quality formation.We anticipate this framework will offer clear guidance for future research from a clinical perspective.
基金Supported by "Sannongliufang" Technology Collaboration Program in Zhejiang Province in 2014
文摘Integrated water and fertilizer technology has the advantages of saving water,fertilizer and labour,which is widely applied in tomato plantation. Integrated water and fertilizer technology in topdressing and whole process of big and small tomatoes were studied,and their application effects were contrasted and analyzed,and application advantages and scopes of the two models were concluded.
