There remain several intractable challenges for chemotherapy in glioma treatment,including the blood-brain barrier(BBB),blood-brain tumor barrier(BBTB),and tumor heterogeneity caused by cancer stem cells(CSCs),which a...There remain several intractable challenges for chemotherapy in glioma treatment,including the blood-brain barrier(BBB),blood-brain tumor barrier(BBTB),and tumor heterogeneity caused by cancer stem cells(CSCs),which are resistant to conventional chemotherapy.Here,we established a nano strategy to kill glioma cells and CSCs,combining carfilzomib and bis(diethyldithiocarbamate)copper.The synergistic drug combination disturbed cell protein metabolism at different stages and induced apoptosis and cuproptosis.The Y-shaped targeting ligand pHA-VAP-modified nanodiscs were designed to help the chemotherapeutic agents cross the BBB/BBTB and finally accumulate in tumor site.This all-stage targeting and all-stage treatment nanomedicine significantly prolonged the survival in glioma-bearing mice and might inspire the rational design of advanced drug delivery platforms.展开更多
Background:Seasonal influenza resurged in China in February 2023,causing a large number of hospitalizations.While influenza epidemics occurred across China during the coronavirus disease 2019(COVID-19)pandemic,the rel...Background:Seasonal influenza resurged in China in February 2023,causing a large number of hospitalizations.While influenza epidemics occurred across China during the coronavirus disease 2019(COVID-19)pandemic,the relaxation of COVID-19 containment measures in December 2022 may have contributed to the spread of acute respiratory infections in winter 2022/2023.Methods:Using a mathematical model incorporating influenza activity as measured by influenza-like illness(ILI)data for northern and southern regions of China,we reconstructed the seasonal influenza incidence from October 2015 to September 2019 before the COVID-19 pandemic.Using this trained model,we predicted influenza activities in northern and southern China from March to September 2023.Results:We estimated the effective reproduction number Re as 1.08[95%confidence interval(CI):0.51,1.65]in northern China and 1.10(95%CI:0.55,1.67)in southern China at the start of the 2022-2023 influenza season.We estimated the infection attack rate of this influenza wave as 18.51%(95%CI:0.00%,37.78%)in northern China and 28.30%(95%CI:14.77%,41.82%)in southern China.Conclusions:The 2023 spring wave of seasonal influenza in China spread until July 2023 and infected a substantial number of people.展开更多
To the Editor:Cardiac resynchronization therapy(CRT)is an effective treatment for advanced chronic heart failure(HF)patients with reduced ejection fraction.Despite its beneficial effects on cardiac function,traditiona...To the Editor:Cardiac resynchronization therapy(CRT)is an effective treatment for advanced chronic heart failure(HF)patients with reduced ejection fraction.Despite its beneficial effects on cardiac function,traditional biventricular epicardial pacing(BiVP-epi)could not reduce ventricular arrhythmias(VAs)burden in all HF patients.展开更多
The rapid emergence and widespread transmission of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)have prompted governments worldwide to enact policies and measures to manage the virus’s spread.These inte...The rapid emergence and widespread transmission of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)have prompted governments worldwide to enact policies and measures to manage the virus’s spread.These interventions have substantially contributed to controlling disease transmission.However,they have also significantly disrupted daily life,leading to increased public fatigue and resistance to sustained control measures,a phenomenon known as pandemic fatigue.To develop a comprehensive understanding of pandemic fatigue,this review systematically explores the concept and identifies quantitative indicators for measuring it.We reviewed studies on pandemic fatigue across various countries,summarized the contributing factors,and analyzed its impact on personal protective behaviors.Our findings indicate that the enforcement of health measures significantly influences the onset of pandemic fatigue,while individual perceptions of risk can negatively affect personal protective behaviors,creating a feedback loop with increasing fatigue.These results underscore the importance of considering the current severity of the pandemic and individual decisionmaking processes in the implementation of interventions.Enhancing our understanding of pandemic fatigue is essential for developing effective policy responses in preparation for future potential epidemics.展开更多
基金sponsored by Shanghai Education Commission Major Project(2017-01-07-00-07-E00052)National Natural Science Foundation of China(No.81773657)+1 种基金Shanghai Sailing Program(No.20YF1404500)Scientific Research Foundation of Huashan Hospital,Fudan University(No.2019QD012).
文摘There remain several intractable challenges for chemotherapy in glioma treatment,including the blood-brain barrier(BBB),blood-brain tumor barrier(BBTB),and tumor heterogeneity caused by cancer stem cells(CSCs),which are resistant to conventional chemotherapy.Here,we established a nano strategy to kill glioma cells and CSCs,combining carfilzomib and bis(diethyldithiocarbamate)copper.The synergistic drug combination disturbed cell protein metabolism at different stages and induced apoptosis and cuproptosis.The Y-shaped targeting ligand pHA-VAP-modified nanodiscs were designed to help the chemotherapeutic agents cross the BBB/BBTB and finally accumulate in tumor site.This all-stage targeting and all-stage treatment nanomedicine significantly prolonged the survival in glioma-bearing mice and might inspire the rational design of advanced drug delivery platforms.
基金Supported by grants from the AIR@InnoHK Programme of the Innovation and Technology Commission of the Government of the Hong Kong Special Administrative Region and the Theme-based Research Scheme(T11-712/19-N)of the Research Grants Council of the Hong Kong SAR Government.
文摘Background:Seasonal influenza resurged in China in February 2023,causing a large number of hospitalizations.While influenza epidemics occurred across China during the coronavirus disease 2019(COVID-19)pandemic,the relaxation of COVID-19 containment measures in December 2022 may have contributed to the spread of acute respiratory infections in winter 2022/2023.Methods:Using a mathematical model incorporating influenza activity as measured by influenza-like illness(ILI)data for northern and southern regions of China,we reconstructed the seasonal influenza incidence from October 2015 to September 2019 before the COVID-19 pandemic.Using this trained model,we predicted influenza activities in northern and southern China from March to September 2023.Results:We estimated the effective reproduction number Re as 1.08[95%confidence interval(CI):0.51,1.65]in northern China and 1.10(95%CI:0.55,1.67)in southern China at the start of the 2022-2023 influenza season.We estimated the infection attack rate of this influenza wave as 18.51%(95%CI:0.00%,37.78%)in northern China and 28.30%(95%CI:14.77%,41.82%)in southern China.Conclusions:The 2023 spring wave of seasonal influenza in China spread until July 2023 and infected a substantial number of people.
基金grants from the National Natural Science Foundation of China(No.81870260)the Central Public-Interest Scientific Institution Basal Research Fund:Chinese Academy of Medical Sciences(Internal No.2018-F01)
文摘To the Editor:Cardiac resynchronization therapy(CRT)is an effective treatment for advanced chronic heart failure(HF)patients with reduced ejection fraction.Despite its beneficial effects on cardiac function,traditional biventricular epicardial pacing(BiVP-epi)could not reduce ventricular arrhythmias(VAs)burden in all HF patients.
基金Supported by the National Key R&D Program of China(No.2022YFE0112300)the Shenzhen-Hong Kong-Macao Science and Technology Project(Category C)(Project no:SGDX20230821091559022)+2 种基金the National Natural Science Foundation of China(grant no.72104208)the General Research Fund(grant no.17103122)from the Research Grants Council,and the Health and Medical Research Fund(grant no.21200632)along with the HMRF Research Fellowship Scheme(grant no.07210147)both financed by the Food and Health Bureau of the Government of Hong Kong S.A.R.,China.
文摘The rapid emergence and widespread transmission of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)have prompted governments worldwide to enact policies and measures to manage the virus’s spread.These interventions have substantially contributed to controlling disease transmission.However,they have also significantly disrupted daily life,leading to increased public fatigue and resistance to sustained control measures,a phenomenon known as pandemic fatigue.To develop a comprehensive understanding of pandemic fatigue,this review systematically explores the concept and identifies quantitative indicators for measuring it.We reviewed studies on pandemic fatigue across various countries,summarized the contributing factors,and analyzed its impact on personal protective behaviors.Our findings indicate that the enforcement of health measures significantly influences the onset of pandemic fatigue,while individual perceptions of risk can negatively affect personal protective behaviors,creating a feedback loop with increasing fatigue.These results underscore the importance of considering the current severity of the pandemic and individual decisionmaking processes in the implementation of interventions.Enhancing our understanding of pandemic fatigue is essential for developing effective policy responses in preparation for future potential epidemics.
