When certain genes are exposed to repeated stimuli, they can be rapidly reactivated after prior expression and show enhanced expression signals, known as transcriptional memory. Such reinduction memory of gene express...When certain genes are exposed to repeated stimuli, they can be rapidly reactivated after prior expression and show enhanced expression signals, known as transcriptional memory. Such reinduction memory of gene expression is an essential adaptation to the recurring environmental changes, which facilitates divergent organisms evolve the capacity to reduce the need for genetic fitness(New et al., 2014).展开更多
Embodied Intelligence,which integrates physical interaction capabilities with cognitive computation in real-world scenarios,provides a promising path to achieve Artificial General Intelligence(AGI).Recently,the landsc...Embodied Intelligence,which integrates physical interaction capabilities with cognitive computation in real-world scenarios,provides a promising path to achieve Artificial General Intelligence(AGI).Recently,the landscape of embodied intelligence has grown profoundly,empowering robotics,autonomous driving,intelligent manufacturing,and so on.This paper presents a comprehensive survey on the evolution of embodied intelligence,tracing its journey from philosophical roots to contemporary advancements.We emphasize significant progress in the integration of perceptual,cognitive,and behavioral components,rather than focusing on these elements in isolation.Despite these advancements,several challenges remain,including hardware limitations,model generalization,physical world understanding,multimodal integration,and ethical considerations,which are critical for the development of robust and reliable embodied intelligence systems.To address these challenges,we outline future research directions,emphasizing Large Perception-Cognition-Behavior(PCB)models,physical intelligence,and morphological intelligence.Central to these perspectives is the general agent framework termed as Bcent,which integrates perception,cognition,and behavior dynamics.Bcent aims to enhance the adaptability,robustness,and intelligence of embodied systems,aligning with the ongoing progress in robotics,autonomous systems,healthcare,and more.展开更多
Histone H3 Lys36(H3K36)methylation and its associated modifiers are crucial for DNA double-strand break(DSB)repair,but the mechanism governing whether and how different H3K36 methylation forms impact repair pathways i...Histone H3 Lys36(H3K36)methylation and its associated modifiers are crucial for DNA double-strand break(DSB)repair,but the mechanism governing whether and how different H3K36 methylation forms impact repair pathways is unclear.Here,we unveil the distinct roles of H3K36 dimethylation(H3K36me2)and H3K36 trimethylation(H3K36me3)in DSB repair via non-homologous end joining(NHEJ)or homologous recombination(HR).Yeast cells lacking H3K36me2 or H3K36me3 exhibit reduced NHEJ or HR efficiency.y Ku70 and Rfa1 bind H3K36me2-or H3K36me3-modified peptides and chromatin,respectively.Disrupting these interactions impairs y Ku70 and Rfa1 recruitment to damaged H3K36me2-or H3K36me3-rich loci,increasing DNA damage sensitivity and decreasing repair efficiency.Conversely,H3K36me2-enriched intergenic regions and H3K36me3-enriched gene bodies independently recruit y Ku70 or Rfa1 under DSB stress.Importantly,human KU70 and RPA1,the homologs of y Ku70 and Rfa1,exclusively associate with H3K36me2 and H3K36me3 in a conserved manner.These findings provide valuable insights into how H3K36me2 and H3K36me3 regulate distinct DSB repair pathways,highlighting H3K36 methylation as a critical element in the choice of DSB repair pathway.展开更多
基金supported by the National Key R&D Program of China(2019YFA0802501)the National Natural Science Foundation of China(31770843,31971231)。
文摘When certain genes are exposed to repeated stimuli, they can be rapidly reactivated after prior expression and show enhanced expression signals, known as transcriptional memory. Such reinduction memory of gene expression is an essential adaptation to the recurring environmental changes, which facilitates divergent organisms evolve the capacity to reduce the need for genetic fitness(New et al., 2014).
基金supported by the National Science and Technology Major Project of the Ministry of Science and Technology of China(No.2018AAA0102903).
文摘Embodied Intelligence,which integrates physical interaction capabilities with cognitive computation in real-world scenarios,provides a promising path to achieve Artificial General Intelligence(AGI).Recently,the landscape of embodied intelligence has grown profoundly,empowering robotics,autonomous driving,intelligent manufacturing,and so on.This paper presents a comprehensive survey on the evolution of embodied intelligence,tracing its journey from philosophical roots to contemporary advancements.We emphasize significant progress in the integration of perceptual,cognitive,and behavioral components,rather than focusing on these elements in isolation.Despite these advancements,several challenges remain,including hardware limitations,model generalization,physical world understanding,multimodal integration,and ethical considerations,which are critical for the development of robust and reliable embodied intelligence systems.To address these challenges,we outline future research directions,emphasizing Large Perception-Cognition-Behavior(PCB)models,physical intelligence,and morphological intelligence.Central to these perspectives is the general agent framework termed as Bcent,which integrates perception,cognition,and behavior dynamics.Bcent aims to enhance the adaptability,robustness,and intelligence of embodied systems,aligning with the ongoing progress in robotics,autonomous systems,healthcare,and more.
基金supported by the National Key Research and Development Program of China(2019YFA0802501)the National Natural Science Foundation of China(32270617,31971231)+1 种基金the Fundamental Research Funds for the Central Universities(2042022dx0003)the Application Fundamental Frontier Foundation of Wuhan(2020020601012225)。
文摘Histone H3 Lys36(H3K36)methylation and its associated modifiers are crucial for DNA double-strand break(DSB)repair,but the mechanism governing whether and how different H3K36 methylation forms impact repair pathways is unclear.Here,we unveil the distinct roles of H3K36 dimethylation(H3K36me2)and H3K36 trimethylation(H3K36me3)in DSB repair via non-homologous end joining(NHEJ)or homologous recombination(HR).Yeast cells lacking H3K36me2 or H3K36me3 exhibit reduced NHEJ or HR efficiency.y Ku70 and Rfa1 bind H3K36me2-or H3K36me3-modified peptides and chromatin,respectively.Disrupting these interactions impairs y Ku70 and Rfa1 recruitment to damaged H3K36me2-or H3K36me3-rich loci,increasing DNA damage sensitivity and decreasing repair efficiency.Conversely,H3K36me2-enriched intergenic regions and H3K36me3-enriched gene bodies independently recruit y Ku70 or Rfa1 under DSB stress.Importantly,human KU70 and RPA1,the homologs of y Ku70 and Rfa1,exclusively associate with H3K36me2 and H3K36me3 in a conserved manner.These findings provide valuable insights into how H3K36me2 and H3K36me3 regulate distinct DSB repair pathways,highlighting H3K36 methylation as a critical element in the choice of DSB repair pathway.
