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改良预处理方式下那西妥单抗治疗神经母细胞瘤安全性研究
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作者 朱佳 邓军 +12 位作者 阙旖 刘龙珍 伍柳红 余婉琪 管惠捷 王娟 路素英 孙斐斐 黄俊廷 宋梦佳 甄子俊 蔡瑞卿 张翼鷟 《中国肿瘤临床》 CSCD 北大核心 2024年第22期1154-1158,共5页
目的:糖皮质激素具有潜在影响那西妥单抗免疫效应,氯胺酮有抑制呼吸副作用。本研究探讨去除糖皮质激素,瑞芬太尼代替氯胺酮的预处理方式对那西妥单抗输注不良事件发生的影响。方法:收集2023年6月至2024年6月于中山大学肿瘤防治中心接受... 目的:糖皮质激素具有潜在影响那西妥单抗免疫效应,氯胺酮有抑制呼吸副作用。本研究探讨去除糖皮质激素,瑞芬太尼代替氯胺酮的预处理方式对那西妥单抗输注不良事件发生的影响。方法:收集2023年6月至2024年6月于中山大学肿瘤防治中心接受那西妥单抗输注的神经母细胞瘤患者临床资料,分析改良预处理后不良事件发生率以及相关因素。结果:17例患者接受201次输注,最常见不良反应为各级别神经痛(93.0%)、高血压(55.7%)、低血压(34.8%)。支气管痉挛和低氧血症的发生率分别为3.0%和10.9%。连续2个周期输注中,发热发生率下降。无患者因严重输注不良反应停止治疗。结论:经改良预处理支持下,那西妥单抗输注不良反应低且可控,安全性好。 展开更多
关键词 纳洛酮 不良反应事件 儿童 神经母细胞瘤 改良调理方案
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Habitat Suitability and Distribution Pattern Response to Global Climate Change in a Widespread Species,the Asiatic Toad(Bufo gargarizans)
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作者 Liuyang YANG Lixin HUANG +6 位作者 Huabin ZHANG Pingshin LEE Naijing ZHANG ruiqing cai En LI Tao PAN Xiaobing WU 《Asian Herpetological Research》 SCIE CSCD 2023年第2期138-146,共9页
The distribution and diversity of the species are closely related to the global climate.As the most widely distributed species of Bufonidae in China,the study of the distribution pattern and habitat suitability of the... The distribution and diversity of the species are closely related to the global climate.As the most widely distributed species of Bufonidae in China,the study of the distribution pattern and habitat suitability of the Asiatic toad under climate change can help us understand the reply pattern of Bufonidae habitat to climate change.Here,combined with the Maxent model and GIS technology,the effects of climate change on the distribution pattern and habitat suitability of the Asiatic toad were comprehensively analyzed.The results show that the rainfall during the wettest season(Bio16)and the mean temperature of the driest season(Bio9)have a considerable impact on the distribution of the Asiatic toad.In the next 30 to 50 years,across the overall spacial scale of the Chinese mainland,the habitat of the Asiatic toad will be primarily in the eastern part of China and less in south part,while its distribution area will expand to the midwest and northwest parts of China.Overall,the area in which it can be distributed will be reduced and suitable habitat will shift to some regions of higher latitude and elevation.In a word,we systematically analyzed the changes of the distribution pattern and habitat suitability of the Asiatic toad with climate change,and we aim to provide data on how climatic variation may impact amphibians. 展开更多
关键词 barycenter migration climate change DISTRIBUTION MAXENT the Asiatic toad
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