Bladder cancer is the most common malignant tumours with high morbidity, mortality and recurrence.However, currently developed detection methods for bladder cancer-associated urine biomarkers are hindered by their ext...Bladder cancer is the most common malignant tumours with high morbidity, mortality and recurrence.However, currently developed detection methods for bladder cancer-associated urine biomarkers are hindered by their extremely low abundance. Hence, the exploration of a highly sensitive and selective approach for the detection of trace bladder cancer-associated biomarkers in human urine is of vital importance for the diagnosis of bladder cancer. Herein, we developed a highly reliable indium gallium zinc oxide field effect transistor(IGZO FET) biosensor for the detection of bladder cancer-related biomarker micro RNA. The single-stranded DNA-functionalized IGZO FET biosensors exhibit high sensing reproducibility and stability with an ultralow detection limit of 19.8 amol/L. The device could also be used for quantitative detection of trace micro RNA in human urine samples and can effectively distinguish bladder cancer patients from healthy donors. The development of high performance IGZO FET biosensors presents new opportunities for the achievement of early-stage diagnosis of bladder cancer.展开更多
The turnover of talents in West China enterprises seriously hinders their development. Therefore, the establishment of scientific human resource system is rather important. On the basis of survey to some West China en...The turnover of talents in West China enterprises seriously hinders their development. Therefore, the establishment of scientific human resource system is rather important. On the basis of survey to some West China enterprises, this paper analyzes the needs of employees, discovers that there are differences between the need hierarchy of these employees and the classic need theories, and studies the changes in need hierarchy and need strength among different employee groups.展开更多
基金supported by the National Key Research and Development Program of China (No.2017YFA0208000)the Natural Science Foundation of China (Nos.21904100,21904033)financial support from Wuhan University。
文摘Bladder cancer is the most common malignant tumours with high morbidity, mortality and recurrence.However, currently developed detection methods for bladder cancer-associated urine biomarkers are hindered by their extremely low abundance. Hence, the exploration of a highly sensitive and selective approach for the detection of trace bladder cancer-associated biomarkers in human urine is of vital importance for the diagnosis of bladder cancer. Herein, we developed a highly reliable indium gallium zinc oxide field effect transistor(IGZO FET) biosensor for the detection of bladder cancer-related biomarker micro RNA. The single-stranded DNA-functionalized IGZO FET biosensors exhibit high sensing reproducibility and stability with an ultralow detection limit of 19.8 amol/L. The device could also be used for quantitative detection of trace micro RNA in human urine samples and can effectively distinguish bladder cancer patients from healthy donors. The development of high performance IGZO FET biosensors presents new opportunities for the achievement of early-stage diagnosis of bladder cancer.
文摘The turnover of talents in West China enterprises seriously hinders their development. Therefore, the establishment of scientific human resource system is rather important. On the basis of survey to some West China enterprises, this paper analyzes the needs of employees, discovers that there are differences between the need hierarchy of these employees and the classic need theories, and studies the changes in need hierarchy and need strength among different employee groups.
