BACKGROUND： The gut is capable of inducing multiple organ dysfunction syndrome （MODS）. In the diagnosis and treatment of critical ill patients, doctors should pay particular attention to the protection or recovery ...BACKGROUND： The gut is capable of inducing multiple organ dysfunction syndrome （MODS）. In the diagnosis and treatment of critical ill patients, doctors should pay particular attention to the protection or recovery of intestinal barrier function. However, no reliable diagnostic criteria are available clinically. This study aimed to assess the changes of intestinal mucosal barrier function in surgically critical ill patients as well as their signi？ cance.METHODS： Thirty-eight surgically critical ill patients were enrolled as a study group （APACHE II〉8 scores）, and 15 non-critical ill patients without intestinal dysfunction were selected as a control group （APACHE II〈6）. General information, symptoms, physical signs, and APACHE II scores of the patients were recorded. The patients in the study group were subdivided into an intestinal dysfunction group （n=26） and a non-intestinal dysfunction group （n=12）. Three ml venous blood was collected from the control group on admission and the same volume of plasma was collected from the study group both on admission and in the period of recovery. The plasma concentrations of endotoxin, diamine oxidase （DAO）, D-lactate, and intestinal fatty-acid binding protein （iFABP） were detected respectively. The data collected were analyzed by the SPSS 17.0 software for Windows. RESULTS： The levels of variables were significantly higher in the study group than in the control group （P〈0.01）. They were higher in the intestinal dysfunction group than in the non-intestinal dysfunction group （DAO P〈0.05, endotoxin, D-lactate, iFABP P〈0.01）. In the non-intestinal dysfunction group compared with the control group, the level of endotoxin was not significant （P〉0.05）, but the levels of DAO, D-lactate and iFABP were statistically significant （P〈0.05）. The levels of variables in acute stage were higher than those in recovery stage （P〈0.01）.The death group showed higher levels of variables than the survival group （endotoxin and D-lactate P〈0.01, DAO and iFABP P〈0.05）.CONCLUSION： The plasma concentrations of endotoxin, DAO, D-lactate, and intestinal fatty-acid binding protein （iFABP） could re？ ect a better function of the intestinal mucosa barrier in surgically critical ill patients.展开更多
Gas pool coupled activating TIG(GPCA?TIG) welding put forward in?house can dramatically enhance weld penetration of TIG welding through introducing active element oxygen to reverse the Marangoni convection flow in the...Gas pool coupled activating TIG(GPCA?TIG) welding put forward in?house can dramatically enhance weld penetration of TIG welding through introducing active element oxygen to reverse the Marangoni convection flow in the molten pool. In order to further improve the welding productivity, the normal solid tungsten electrode is replaced by a kind of coupling arc electrode. The changes of arc pressure distribution along anode surface and the weld appearance were evaluated. On this basis, the dependences of weld shape characterized with weld depth, width and undercut on the main welding parameters were discussed. The results indicate, the substitution of coupling arc electrode can lead to an obvious decrease of arc pressure. Compared to hollow tungsten electrode and twin tungsten electrodes, the coupling arc electrode is much easier to manufacture and has more compacter structure. Combined with the symmetric distribution of arc pressure in di erent directions, this electrode has extensive adaptability. In the GPCA?TIG welding with coupling arc electrode, both the substitution of coupling arc electrode and the introduction of outer active gas oxygen can reduce the possibilities of producing humping bead and undercut. Their joint action makes this welding method have the capability of realizing high travel speed and deep penetration welding.展开更多
Fluorescence imaging is a noninvasive and dynamic real-time imaging technique;however,it exhibits poor spatial resolution in centimeter-deep tissues because biological tissues are highly scattering media for optical r...Fluorescence imaging is a noninvasive and dynamic real-time imaging technique;however,it exhibits poor spatial resolution in centimeter-deep tissues because biological tissues are highly scattering media for optical radiation.The recently developed ultrasound-controlled fluorescence(UCF)imaging is a novel imaging technique that can overcome this bottleneck.Previous studies suggest that the effective contrast agent and sensitive imaging system are the two pivotal factors for generating high-resolution UCF images ex vivo and/or in vivo.Here,this review highlights the recent advances(2015e2020)in the design and synthesis of contrast agents and the improvement of imaging systems to realize high-resolution UCF imaging of deep tissues.The imaging performances of various UCF systems,including the signal-to-noise ratio,imaging resolution,and imaging depth,are specifically discussed.In addition,the challenges and prospects are highlighted.With continuously increasing research interest in this field and emerging multidisciplinary applications,UCF imaging with higher spatial resolution and larger imaging depth may be developed shortly,which is expected to have a far-reaching impact on disease surveillance and/or therapy.展开更多
文摘BACKGROUND： The gut is capable of inducing multiple organ dysfunction syndrome （MODS）. In the diagnosis and treatment of critical ill patients, doctors should pay particular attention to the protection or recovery of intestinal barrier function. However, no reliable diagnostic criteria are available clinically. This study aimed to assess the changes of intestinal mucosal barrier function in surgically critical ill patients as well as their signi？ cance.METHODS： Thirty-eight surgically critical ill patients were enrolled as a study group （APACHE II〉8 scores）, and 15 non-critical ill patients without intestinal dysfunction were selected as a control group （APACHE II〈6）. General information, symptoms, physical signs, and APACHE II scores of the patients were recorded. The patients in the study group were subdivided into an intestinal dysfunction group （n=26） and a non-intestinal dysfunction group （n=12）. Three ml venous blood was collected from the control group on admission and the same volume of plasma was collected from the study group both on admission and in the period of recovery. The plasma concentrations of endotoxin, diamine oxidase （DAO）, D-lactate, and intestinal fatty-acid binding protein （iFABP） were detected respectively. The data collected were analyzed by the SPSS 17.0 software for Windows. RESULTS： The levels of variables were significantly higher in the study group than in the control group （P〈0.01）. They were higher in the intestinal dysfunction group than in the non-intestinal dysfunction group （DAO P〈0.05, endotoxin, D-lactate, iFABP P〈0.01）. In the non-intestinal dysfunction group compared with the control group, the level of endotoxin was not significant （P〉0.05）, but the levels of DAO, D-lactate and iFABP were statistically significant （P〈0.05）. The levels of variables in acute stage were higher than those in recovery stage （P〈0.01）.The death group showed higher levels of variables than the survival group （endotoxin and D-lactate P〈0.01, DAO and iFABP P〈0.05）.CONCLUSION： The plasma concentrations of endotoxin, DAO, D-lactate, and intestinal fatty-acid binding protein （iFABP） could re？ ect a better function of the intestinal mucosa barrier in surgically critical ill patients.
基金National Natural Science Foundation of China(Grant No.51265029)
文摘Gas pool coupled activating TIG(GPCA?TIG) welding put forward in?house can dramatically enhance weld penetration of TIG welding through introducing active element oxygen to reverse the Marangoni convection flow in the molten pool. In order to further improve the welding productivity, the normal solid tungsten electrode is replaced by a kind of coupling arc electrode. The changes of arc pressure distribution along anode surface and the weld appearance were evaluated. On this basis, the dependences of weld shape characterized with weld depth, width and undercut on the main welding parameters were discussed. The results indicate, the substitution of coupling arc electrode can lead to an obvious decrease of arc pressure. Compared to hollow tungsten electrode and twin tungsten electrodes, the coupling arc electrode is much easier to manufacture and has more compacter structure. Combined with the symmetric distribution of arc pressure in di erent directions, this electrode has extensive adaptability. In the GPCA?TIG welding with coupling arc electrode, both the substitution of coupling arc electrode and the introduction of outer active gas oxygen can reduce the possibilities of producing humping bead and undercut. Their joint action makes this welding method have the capability of realizing high travel speed and deep penetration welding.
基金supported by the National Natural Science Foundation of China(Grant No.:81703466)the Outstanding Talents Research Start-up Fund of Xuzhou Medical University,China(Grant No.:RC20552107)Xuzhou Science and Technology Bureau,China(Grant No.:KC21292).
文摘Fluorescence imaging is a noninvasive and dynamic real-time imaging technique;however,it exhibits poor spatial resolution in centimeter-deep tissues because biological tissues are highly scattering media for optical radiation.The recently developed ultrasound-controlled fluorescence(UCF)imaging is a novel imaging technique that can overcome this bottleneck.Previous studies suggest that the effective contrast agent and sensitive imaging system are the two pivotal factors for generating high-resolution UCF images ex vivo and/or in vivo.Here,this review highlights the recent advances(2015e2020)in the design and synthesis of contrast agents and the improvement of imaging systems to realize high-resolution UCF imaging of deep tissues.The imaging performances of various UCF systems,including the signal-to-noise ratio,imaging resolution,and imaging depth,are specifically discussed.In addition,the challenges and prospects are highlighted.With continuously increasing research interest in this field and emerging multidisciplinary applications,UCF imaging with higher spatial resolution and larger imaging depth may be developed shortly,which is expected to have a far-reaching impact on disease surveillance and/or therapy.
