Dear Editor,The global population of individuals aged 65 and older is projected to reach 1.6 billion by 2050[1].Given that urinary tumors,such as bladder cancer(BCa),kidney cancer(KCa),and prostate cancer(PCa),are mor...Dear Editor,The global population of individuals aged 65 and older is projected to reach 1.6 billion by 2050[1].Given that urinary tumors,such as bladder cancer(BCa),kidney cancer(KCa),and prostate cancer(PCa),are more common in older adults,the burden on the healthcare system is increasing[2].Recently,Zi et al.[3]conducted a comprehensive assessment of the global burden of 6 urinary diseases from 1990 to 2021,based on the Global Burden of Diseases,Injuries,and Risk Factors Study 2021.展开更多
Introduction About 72%of human genome is transcribed to non-coding RNAs,which have captivated researchers a lot for shedding light on their pivotal roles in regulating the initiation and progression of various disease...Introduction About 72%of human genome is transcribed to non-coding RNAs,which have captivated researchers a lot for shedding light on their pivotal roles in regulating the initiation and progression of various diseases,including cancers[1].Among these,long non-coding RNAs(lncRNAs)have emerged as key players in the complex landscape of gene regulation.LncRNAs perform a variety of roles,including scaffolding to encourage the interaction of related proteins,decoys to thwart transcriptional factors from the target gene’s promoter,sponges of linked miRNA to prevent target gene destruction,and guide molecules to recruit components for chromatin remodeling[1].Many cancers are closely related to age[2-5]and such patients are expected be increased gradually as almost 20%of the world’s population will be 65 or older by 2030[6]and those over the age of 65 have an 11-fold higher incidence of cancer than people under that age[7].As one of the typical hallmarks of aging[8],cellular senescence is Cellular senescence is induced by stressful insults and certain physiological processes and is characterized by a prolonged and essentially irreversible cell-cycle arrest with secretory features,macromolecular damage,and altered metabolism[9].Here,we aim to provide insights of the intersection between lncRNAs,cellular senescence,and urinary tumors,unraveling the potential implications and therapeutic avenues within this multifaceted network.展开更多
基金supported by the Chinese Scholarship Council(202206240086,202406240158).
文摘Dear Editor,The global population of individuals aged 65 and older is projected to reach 1.6 billion by 2050[1].Given that urinary tumors,such as bladder cancer(BCa),kidney cancer(KCa),and prostate cancer(PCa),are more common in older adults,the burden on the healthcare system is increasing[2].Recently,Zi et al.[3]conducted a comprehensive assessment of the global burden of 6 urinary diseases from 1990 to 2021,based on the Global Burden of Diseases,Injuries,and Risk Factors Study 2021.
文摘Introduction About 72%of human genome is transcribed to non-coding RNAs,which have captivated researchers a lot for shedding light on their pivotal roles in regulating the initiation and progression of various diseases,including cancers[1].Among these,long non-coding RNAs(lncRNAs)have emerged as key players in the complex landscape of gene regulation.LncRNAs perform a variety of roles,including scaffolding to encourage the interaction of related proteins,decoys to thwart transcriptional factors from the target gene’s promoter,sponges of linked miRNA to prevent target gene destruction,and guide molecules to recruit components for chromatin remodeling[1].Many cancers are closely related to age[2-5]and such patients are expected be increased gradually as almost 20%of the world’s population will be 65 or older by 2030[6]and those over the age of 65 have an 11-fold higher incidence of cancer than people under that age[7].As one of the typical hallmarks of aging[8],cellular senescence is Cellular senescence is induced by stressful insults and certain physiological processes and is characterized by a prolonged and essentially irreversible cell-cycle arrest with secretory features,macromolecular damage,and altered metabolism[9].Here,we aim to provide insights of the intersection between lncRNAs,cellular senescence,and urinary tumors,unraveling the potential implications and therapeutic avenues within this multifaceted network.
