MicroRNAs(miRNAs) are key regulators involved in various tumors. They regulate cell cycle, apoptosis and cancer stemness, metastasis and chemoresistance by controlling their target gene expressions. Here, we mainly di...MicroRNAs(miRNAs) are key regulators involved in various tumors. They regulate cell cycle, apoptosis and cancer stemness, metastasis and chemoresistance by controlling their target gene expressions. Here, we mainly discuss the potential uses of miR NAs in colorectal cancer(CRC) diagnosis. We also shed light on the important corresponding miR NA targets and on the major regulators of miR NAs. Furthermore, we discuss miR NA activity in assessing the prognosis and recurrence of CRC as well as in modulating responsiveness to chemotherapy. Based on the various pro-oncogenic/anti-oncogenic roles of miR NAs, the advantages of a therapeutic strategy based on the delivery of miR NA mimics are also mentioned. Together, mi RNA seems to be an excellent tool for effectively monitoring and targeting CRC.展开更多
The synthesis of cyclopolymers upon controlling the degree of macrocyclic polymerization,followed by the discovery of new properties has attracted increasing attention in supramolecular chemistry.Herein,a Schiff-base ...The synthesis of cyclopolymers upon controlling the degree of macrocyclic polymerization,followed by the discovery of new properties has attracted increasing attention in supramolecular chemistry.Herein,a Schiff-base condensation method performed at room temperature was used to control the formation of[1+1]and[2+2]macrocycles.In pure MeOH,the isomer[1+1]macrocycles were synthesized and organic particles such as dendritic,rods,and solid microspheres were directly precipitated from the reaction solution.The[1+1]macrocycles can be efficiently converted into their corresponding[2+2]macrocycles accompanied by the tunable morphology of the organic particles when n-hexane was added to the MeOH solution.Further studies showed that these organic particles have potential application toward the selective removal of Cd^(2+)ions with different adsorption ability in MeOH solution.展开更多
基金Supported by Municipal Natural Science Foundation of Beijing of China, No.5102039National Natural Science Foundation of China, Nos.81101859, 81270379, 81070231
文摘MicroRNAs(miRNAs) are key regulators involved in various tumors. They regulate cell cycle, apoptosis and cancer stemness, metastasis and chemoresistance by controlling their target gene expressions. Here, we mainly discuss the potential uses of miR NAs in colorectal cancer(CRC) diagnosis. We also shed light on the important corresponding miR NA targets and on the major regulators of miR NAs. Furthermore, we discuss miR NA activity in assessing the prognosis and recurrence of CRC as well as in modulating responsiveness to chemotherapy. Based on the various pro-oncogenic/anti-oncogenic roles of miR NAs, the advantages of a therapeutic strategy based on the delivery of miR NA mimics are also mentioned. Together, mi RNA seems to be an excellent tool for effectively monitoring and targeting CRC.
基金supported by the National Natural Science Foundation of China(Nos.21961007 and 21871063)the Science and Technology Foundation of Hunan Province(No.2020JJ2021).
文摘The synthesis of cyclopolymers upon controlling the degree of macrocyclic polymerization,followed by the discovery of new properties has attracted increasing attention in supramolecular chemistry.Herein,a Schiff-base condensation method performed at room temperature was used to control the formation of[1+1]and[2+2]macrocycles.In pure MeOH,the isomer[1+1]macrocycles were synthesized and organic particles such as dendritic,rods,and solid microspheres were directly precipitated from the reaction solution.The[1+1]macrocycles can be efficiently converted into their corresponding[2+2]macrocycles accompanied by the tunable morphology of the organic particles when n-hexane was added to the MeOH solution.Further studies showed that these organic particles have potential application toward the selective removal of Cd^(2+)ions with different adsorption ability in MeOH solution.
